The Molecular Taxonomy of Cancer

The 2004 CNIO Symposium

Madrid, Spain

3-6 February 2004

FEBRUARY 3rd

TO TAKE PLACE AT THE CNIO – Calle Mélchor Fernández Almagro, 3, 28029 Madrid

  • 1800h – 1900h Registration and Group Tours of the CNIO
  • 1900h – 2100hWelcome Address and Party

FEBRUARY 4th

SYMPOSIUM VENUE: Auditorium Hospital Clínico San Carlos, Pabellón San Carlos, Prof. Martín Lagos, s/n, 28040 Madrid

Keynote Lecture:

0830h – 0915h - Peter Goodfellow - Glaxo-SmithKline, UK

Converting Knowledge Into Treatments

Session I: The Cancer Genome

Session Sponsor: Agilent Technologies

  • 0915h-0955h - Bob Weinberg - Whitehead Institute MIT, Cambridge, USA

Genetic and Biological Rules Governing Human Cancer Cell Formation

  • 0955h-1035h - Mike Stratton - Wellcome Trust Sanger Institute, Cambridge, UK

Genome-Wide Searches for Somatic Mutations in Cancer

  • 1035h-1115h - Olli Kallioniemi - VTT Technical Research Centre of Finland, Turku, Finland

Integration of molecular, cellular and clinical biochip technologies in molecular oncology research and therapy development

1115h – 1155h – Coffee/Poster Viewing and Sponsored Talk – Agilent Technologies

  • 1155h-1235h - Mary-Claire King - University of Washington, Seattle, Washington, USA

Genetic Analysis of Breast and Ovarian Cancer

  • 1235h-1315h - Manel Esteller – Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

Cancer as an Epigenetic Disease: Unveiling DNA Methylation and Chromatin Alterations

Selected Oral Presentations

  • 1315h-1330h – Chris Boshoff – Cancer Research UK, London, UK

Gene Expression Microarrays reveal the Lymphatic Endothelial Lineage and Cytokine Network of Kaposi Sarcoma

  • 1330h-1345h – Marta Sánchez Carbayo – Memorial Sloan-Kettering Cancer Center, NewYork, USA

1345h-1445h – Lunch Break

Session II: Profiles in Carcinogenesis

Session Sponsor: Affymetrix

  • 1445h-1525h - Louis Staudt - Center for Cancer Research, NIH, Bethesda, USA

Molecular Diagnosis and Molecular Targets in Lymphomas by Gene Expression Profiling

  • 1525h-1605h -Miguel A. Piris – Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

Expression Profiling and Cancer Pathogenesis

Invited Short Talk

  • 1605h-1625h - Adolfo Ferrando – Dana Farber Cancer Institute, Boston, USA

Molecular Pathogenesis of T-Cell Leukemia: Defining Therapeutic Targets

1625h-1655h Coffee/Poster Viewing and Sponsored Talk by Affymetrix

  • 1655h-1735h - Laura Van´t Veer - The Netherlands Cancer Institute, Amsterdam, The Netherlands

Expression Profiling to Change Clinical Practice in Breast Cancer

  • 1735h-1815h - Todd R. Golub - HHMI/Dana Farber Cancer Institute, Boston, USA

Genomic Information and Cancer

  • 1815h-1855h - Emanuel Petricoin - Food and Drug Administration, Bethesda, USA

Clinical Proteomics: Patient Tailored Therapy and Early Detection of Human Malignancies

FEBRUARY 5th

Session III: Hallmarks of Cancer

  • 0900h-0940h - Gerard Evan - UCSF Comprehensive Cancer Center, San Francisco, USA

Determining the Requirements for Tumour Maintenance in vivo

  • 0940h-1020h - Karen Vousden - Beatson Institute for Cancer Research, Glasgow, UK

The p53 tumor suppressor as a target for tumor therapy

Selected Oral Presentations

  • 1020h-1035h - José Fernández Piqueras - Universidad Autónoma de Madrid, Spain

Defective expresión of Notch 1 and Notch 2 in connection to alterations of c-Myc and Ikaros in y-radiation induced mouse thymic lymphomas

  • 1035h-1050h – Isabel López de Silanes – National Institute on Ageing, NIH, Baltimore, USA

Identification of HuR target mRNAs in colon cancer cells

1050h-1130h – Coffee/Poster Viewing and Technology Presentation, Qaigen

  • 1130h-1210h - James R. Downing - St. Jude Children´s Research Hospital, Memphis, USA

The Molecular Pathology of Acute Leukemia: A Genomic View

  • 1210h-1250h - Mariano Barbacid – Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

Manipulating the Mouse Genome: A New Generation of Animal Tumour Models

Selected Oral Presentation

  • 1250h-1305h – Myriam Alcalay – FIRC Institute of Molecular Oncology, Milan, Italy

Acute Myeloid Leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA Repair

Invited Short Talk

  • 1305h-1325h – Cathy Lofton Day – Epigenomics Inc., Seattle, USA

DNA Methylation profiling for the diagnosis of colorectal cancer

1325h-1435h - Lunch Break/Technology Presentation, Becton Dickinson

Session IV: Cancer in silico

  • 1435h-1515h - John Quackenbush - The Institute for Genomic Research, Rockville, USA

Using Expression Profiles to Classify Tumors and Discover Biology

  • 1515h – 1555h - Joaquín Dopazo – Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

Using gene ontology on genome-scale studies to find significant associations of biologically relevant terms to groups of genes

  • 1555h-1635h - Chris Sander - Memorial-Sloan Kettering Cancer Center, New York, USA

Computational Biology and Cancer Research

1635h-1720h – Coffee/Poster Viewing and Technology Presentation, Bruker

  • 1720h – 1800h -Colin Hill - Gene Network Sciences, Ithaca,USA

Determining Efficacy of Targets and Lead Compounds via a Data-Driven Computer Simulation of Human Cancer Cells

Selected Oral Presentations

  • 1800h-1820h - Alfonso Valencia, Centro Nacional de Biotecnología (CNB), Madrid, Spain

Bioinformatics and Computational Biology in the study of protein interaction networks

  • 1820h-1840h – Jian-Bing Fan, Illumina Inc., San Diego, USA

Gene Expression Profiling in Formalin-Fixed, Paraffin-Embedded Tissues Using Universal Bead Arrays

Evening Sponsored Talk and Aperitif – Amersham Europe

FEBRUARY 6th

Session V: Targets and Therapeutics

Session Sponsor: Roche Farma S.L.

  • 0900h-0940h - Nicholas C. Dracopoli - Bristol Myers Squibb, Princeton, USA

Pharmacogenomic Applications in Oncology Drug Development

  • 0940h-1020h - Josep Baselga - Hospital Vall d´Hebrón, Barcelona, Spain

Pharmacodynamic Endpoints and Patient Selection with Targeted Therapies

  • 1020-1100h - Carlos García-Echeverría– Novartis Institutes for Biomedical Research, Basel, Switzerland

Targeted Anticancer Drugs — Dream or Reality?

1100h-1145h – Coffee/Poster Viewing

  • 1145h-1225h - Greg Hannon - Cold Spring Harbor Laboratory, Cold Spring Harbor, USA

RNAi: Mechanism, Biological Functions and Applications

Selected Oral Presentations

  • 1225h-1240h – Carlos Moreno – Emory University, Atlanta, USA

Loss of HOXC6 Expression Induces Apoptosis in Androgen-dependent and Androgen-independent Prostate Cancer Cells

  • 1240h-1255h – Peter Reigman – Erasmus MC, Rotterdam, The Netherlands

The European Human Frozen Tumour Tissue Bank (Tubafrost)

Closing Keynote

  • 1255h-1340h - Sir John Maddox, Editor Emeritus, Nature, UK

What lies ahead?

Concluding Remarks

  • 1340h-1350h – Miguel A. Piris – Centro Nacional de Investigaciones Oncológicas, Madrid, Spain