This bulletin covers sarcomas, soft tissue tumours and bone cancers, and should be of interest to multidisciplinary teams working in this area.

Sections can include:

·  Combined Modality Therapies

·  Drug Therapy

·  Pathology, Staging, Polymorphisms & Biomarkers

·  Prognosis, Survival & Risk Factors

·  Radiotherapy & Imaging

·  Supportive Care & Symptom Management

·  Surgery

Many of the following articles are available online via the NHS Scotland Knowledge Network. Please use the links where provided and your ATHENS password. A complete list of available online journals and registration for ATHENS can be found at www.knowledge.scot.nhs.uk/

If the article you require is not available via the NHS Scotland Knowledge Network and you would like to request a print copy, please submit your request online at www.quest.scot.nhs.uk

This bulletin contains a selection of material gathered from a search of the evidence base, and is not intended to be comprehensive. Professional judgment should be exercised when appraising the material. The Library takes no responsibility for the wording, content and accuracy of the information supplied, which has been extracted in good faith from reputable sources. NHSGGC is not responsible for the content of external internet sites.

Compiled by:

Kirsty Coltart

Subject Librarian

Beatson West of Scotland Cancer Centre

0141 301 7285,

General

Bianchi, G., Charoenlap, C., Cocchi, S., et al. (2014). Clear cell sarcoma of soft tissue: a retrospective review and analysis of 31 cases treated at Istituto Ortopedico Rizzoli. European Journal of Surgical Oncology 40,5:505-510.

Blay, J.Y., Sleijfer, S., Schoffski, P., et al. (2014). International expert opinion on patient-tailored management of soft tissue sarcomas. European journal of cancer 50,4:679-689..

Egas-Bejar, D. and Huh, W.W. (2014). Rhabdomyosarcoma in adolescent and young adult patients: current perspectives. Adolescent Health Medicine & Therapeutics 5,115-125.

Haddox, C.L., Han, G., Anijar, L., et al. (2014). Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome. Sarcoma 2014,402509.

Henderson, M., Neumeister, M.W. and Bueno, R.A.,Jr. (2014). Hand tumors: II. Benign and malignant bone tumors of the hand. Plastic & Reconstructive Surgery 133,6:814e-821e.

Hyman, D.M., Grisham, R.N. and Hensley, M.L. (2014). Management of advanced uterine leiomyosarcoma. Current opinion in oncology 26,4:422-427.

Kerouanton, A., Jimenez, I., Cellier, C., et al. (2014). Synovial sarcoma in children and adolescents. Journal of Pediatric Hematology/Oncology 36,4:257-262.

Luetke, A., Meyers, P.A., Lewis, I., et al. (2014). Osteosarcoma treatment - where do we stand? A state of the art review. Cancer treatment reviews 40,4:523-532.

McCullough, A.L., Scotland, T.R., Dundas, S.R., et al. (2014). The impact of a managed clinical network on referral patterns of sarcoma patients in Grampian. Scottish medical journal 59,2:108-113.

Messina C. Ferreri AJ. Govi S. Bruno-Ventre M. Gracia Medina EA. Porter D. Radford J. Heo DS. Park HY. Pro B. Jayamohan J. Visco C. Scarfo L. Zucca E. Gospodarowicz M. Christie D. International Extranodal Lymphoma Study Group (I.E.L.S.G.). (2014). Clinical features, management and prognosis of multifocal primary bone lymphoma: a retrospective study of the international extranodal lymphoma study group (the IELSG 14 study). British journal of haematology 164,6:834-840.

Prasad, S.C., D'Orazio, F., Medina, M., et al. (2014). State of the art in temporal bone malignancies. Current Opinion in Otolaryngology & Head & Neck Surgery 22,2:154-165.

Radaelli, S., Stacchiotti, S., Casali, P.G., et al. (2014). Emerging therapies for adult soft tissue sarcoma. Expert Review of Anticancer Therapy 14,6:689-704.

von Mehren, M., Randall, R.L., Benjamin, R.S., et al. (2014). Soft tissue sarcoma, version 2.2014. Journal of the National Comprehensive Cancer Network 12,4:473-483.

Weiss, A., Gill, J., Goldberg, J., et al. (2014). Advances in therapy for pediatric sarcomas. Current oncology reports 16,8:395.

Combined Modality Therapies

Gronchi, A., De Paoli, A., Dani, C., et al. (2014). Preoperative chemo-radiation therapy for localised retroperitoneal sarcoma: a phase I-II study from the Italian Sarcoma Group. European journal of cancer 50,4:784-792.

Roeder, F., Lehner, B., Schmitt, T., et al. (2014). Excellent local control with IOERT and postoperative EBRT in high grade extremity sarcoma: results from a subgroup analysis of a prospective trial. BMC Cancer 14,350.

Schenone, A.D., Luo, J., Montgomery, L., et al. (2014). Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy. Cancer Medicine 3,3:603-612.

Sherman, K.L., Wayne, J.D., Chung, J., et al. (2014). Assessment of multimodality therapy use for extremity sarcoma in the United States. Journal of surgical oncology 109,5:395-404.

Stucky, C.C., Wasif, N., Ashman, J.B., et al. (2014). Excellent local control with preoperative radiation therapy, surgical resection, and intra-operative electron radiation therapy for retroperitoneal sarcoma. Journal of surgical oncology 109,8:798-803.

Drug & Targeted Therapy

Ahmed, A.A., Zia, H. and Wagner, L. (2014). Therapy resistance mechanisms in Ewing's sarcoma family tumors. Cancer Chemotherapy & Pharmacology 73,4:657-663.

Blay, J.Y., Leahy, M.G., Nguyen, B.B., et al. (2014). Randomised phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas. European journal of cancer 50,6:1137-1147.

Boye, K., Del Prever, A.B., Eriksson, M., et al. (2014). High-dose chemotherapy with stem cell rescue in the primary treatment of metastatic and pelvic osteosarcoma: final results of the ISG/SSG II study. Pediatric Blood & Cancer 61,5:840-845.

Bramswig, K., Ploner, F., Martel, A., et al. (2014). Sorafenib in advanced, heavily pretreated patients with soft tissue sarcomas. Anti-Cancer Drugs 25,7:848-853.

Campana, L.G., Bianchi, G., Mocellin, S., et al. (2014). Electrochemotherapy treatment of locally advanced and metastatic soft tissue sarcomas: results of a non-comparative phase II study. World journal of surgery 38,4:813-822.

D'Angelo, S.P., Tap, W.D., Schwartz, G.K., et al. (2014). Sarcoma immunotherapy: past approaches and future directions. Sarcoma 2014,391967.

Judson, I., Verweij, J., Gelderblom, H., et al. (2014). Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. Lancet Oncology 15,4:415-423.

Kawaguchi, S., Sun, T., Lin, P.P., et al. (2014). Does ifosfamide therapy improve survival of patients with dedifferentiated chondrosarcoma?. Clinical Orthopaedics & Related Research 472,3:983-989.

Linch, M., Miah, A.B., Thway, K., et al. (2014). Systemic treatment of soft-tissue sarcoma-gold standard and novel therapies. Nature Reviews Clinical Oncology 11,4:187-202.

O'Donnell, P.W., Manivel, J.C., Cheng, E.Y., et al. (2014). Chemotherapy influences the pseudocapsule composition in soft tissue sarcomas. Clinical Orthopaedics & Related Research 472,3:849-855.

Palmerini, E., Paioli, A. and Ferrari, S. (2014). Emerging therapeutic targets for synovial sarcoma. Expert Review of Anticancer Therapy 14,7:791-806.

Sun, L., Li, Y., Li, H., et al. (2014). Analysis of chemotherapy dosage and dosage intensity and survival outcomes of high-grade osteosarcoma patients younger than 40 years. Clinical therapeutics 36,4:567-578.

Turner, D.C., Navid, F., Daw, N.C., et al. (2014). Population pharmacokinetics of bevacizumab in children with osteosarcoma: implications for dosing. Clinical Cancer Research 20,10:2783-2792.

Wang, W., Wang, Z.C., Shen, H., et al. (2014). Dose-intensive versus dose-control chemotherapy for high-grade osteosarcoma: a meta-analysis. European Review for Medical & Pharmacological Sciences 18,9:1383-1390.

Pathology, Staging, Polymorphisms & Biomarkers

Doyle, L.A. (2014). Sarcoma classification: an update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone. Cancer 120,12:1763-1774.

Kang, S., Han, I., Lee, S., et al. (2014). Clinicopathological characteristics and prognostic factors of T1 (5 cm) soft tissue sarcoma. European Journal of Surgical Oncology 40,4:406-411.

Klijanienko, J., Colin, P., Couturier, J., et al. (2014). Fine-needle aspiration in desmoplastic small round cell tumor: a report of 10 new tumors in 8 patients with clinicopathological and molecular correlations with review of the literature. Cancer Cytopathology 122,5:386-393.

Toulmonde, M., Bonvalot, S., Meeus, P., et al. (2014). Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group. Annals of Oncology 25,3:735-742.

Vormoor, B. and Curtin, N.J. (2014). Poly(ADP-ribose) polymerase inhibitors in Ewing sarcoma. Current opinion in oncology 26,4:428-433.

Prognosis, Survival & Risk Factors

Biswas, B., Rastogi, S., Khan, S.A., et al. (2014). Outcomes and prognostic factors for Ewing-family tumors of the extremities. Journal of Bone & Joint Surgery - American Volume 96,10:841-849.

Brasme, J.F., Chalumeau, M., Oberlin, O., et al. (2014). Time to diagnosis of ewing tumors in children and adolescents is not associated with metastasis or survival: a prospective multicenter study of 436 patients. Journal of Clinical Oncology 32,18:1935-1940.

Kang, S., Kim, H.S., Kim, S., et al. (2014). Post-metastasis survival in extremity soft tissue sarcoma: a recursive partitioning analysis of prognostic factors. European journal of cancer 50,9:1649-1656.

Puri, A., Gulia, A., Hawaldar, R., et al. (2014). Does intensity of surveillance affect survival after surgery for sarcomas? Results of a randomized noninferiority trial. Clinical Orthopaedics & Related Research 472,5:1568-1575.

Putz, C., Gantz, S., Bruckner, T., et al. (2014). Preoperative scoring and limits of prognostication: functional outcome after surgical decompression in metastatic spinal cord compression. Oncology 86,3:177-184.

Sawamura, C., Matsumoto, S., Shimoji, T., et al. (2014). How long should we follow patients with soft tissue sarcomas?. Clinical Orthopaedics & Related Research 472,3:842-848.

Radiotherapy & Imaging

Bagaria, S.P., Ashman, J.B., Daugherty, L.C., et al. (2014). Compliance with National Comprehensive Cancer Network guidelines in the use of radiation therapy for extremity and superficial trunk soft tissue sarcoma in the United States. Journal of surgical oncology 109,7:633-638.

Beane, J.D., Yang, J.C., White, D., et al. (2014). Efficacy of Adjuvant Radiation Therapy in the Treatment of Soft Tissue Sarcoma of the Extremity: 20-year Follow-Up of a Randomized Prospective Trial. Annals of Surgical Oncology 21,8:2484-2489.

Casey, D.L., Wexler, L.H., LaQuaglia, M.P., et al. (2014). Patterns of failure for rhabdomyosarcoma of the perineal and perianal region. International journal of radiation oncology, biology, physics 89,1:82-87.

Cheney, M.D., Giraud, C., Goldberg, S.I., et al. (2014). MRI surveillance following treatment of extremity soft tissue sarcoma. Journal of surgical oncology 109,6:593-596.

Del Grande, F., Subhawong, T., Weber, K., et al. (2014). Detection of soft-tissue sarcoma recurrence: added value of functional MR imaging techniques at 3.0 T. Radiology 271,2:499-511.

Hong, S.P., Lee, S.E., Choi, Y.L., et al. (2014). Prognostic value of 18F-FDG PET/CT in patients with soft tissue sarcoma: comparisons between metabolic parameters. Skeletal radiology 43,5:641-648.

Hurwitz, M.D., Ghanouni, P., Kanaev, S.V., et al. (2014). Magnetic resonance-guided focused ultrasound for patients with painful bone metastases: phase III trial results. Journal of the National Cancer Institute 106,5:

Jeon, D.G., Song, W.S., Cho, W.H., et al. (2014). Proximal tumor location and fluid-fluid levels on MRI predict resistance to chemotherapy in stage IIB osteosarcoma. Clinical Orthopaedics & Related Research 472,6:1911-1920.

Joensuu, H., Reichardt, P., Eriksson, M., et al. (2014). Gastrointestinal stromal tumor: a method for optimizing the timing of CT scans in the follow-up of cancer patients. Radiology 271,1:96-103.

Kawaguchi, S., Weiss, I., Lin, P.P., et al. (2014). Radiation therapy is associated with fewer recurrences in mesenchymal chondrosarcoma. Clinical Orthopaedics & Related Research 472,3:856-864.

le Grange, F., Cassoni, A.M. and Seddon, B.M. (2014). Tumour volume changes following pre-operative radiotherapy in borderline resectable limb and trunk soft tissue sarcoma. European Journal of Surgical Oncology 40,4:394-401.

Uhl, M., Mattke, M., Welzel, T., et al. (2014). High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: first report of long-term results. Cancer 120,10:1579-1585.

Wang, D. and Abrams, R.A. (2014). Radiotherapy for soft tissue sarcoma: 50 years of change and improvement. American Society of Clinical Oncology Educational Book 244-251.

Zhao, F., Ahlawat, S., Farahani, S.J., et al. (2014). Can MR Imaging Be Used to Predict Tumor Grade in Soft-Tissue Sarcoma?. Radiology 272,1:192-201.

Supportive Care & Symptom Management

Abate, M.E., Sanchez, O.E., Boschi, R., et al. (2014). Analysis of risk factors for central venous catheter-related complications: a prospective observational study in pediatric patients with bone sarcomas. Cancer nursing 37,4:292-298.

Cormie, P., Galvao, D.A., Spry, N., et al. (2014). Functional benefits are sustained after a program of supervised resistance exercise in cancer patients with bone metastases: longitudinal results of a pilot study. Supportive Care in Cancer 22,6:1537-1548.

DE Iuliis, F., Taglieri, L., Amoroso, L., et al. (2014). Prevention of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates. Anticancer Research 34,5:2477-2480.

Henry, D., Vadhan-Raj, S., Hirsh, V., et al. (2014). Delaying skeletal-related events in a randomized phase 3 study of denosumab versus zoledronic acid in patients with advanced cancer: an analysis of data from patients with solid tumors. Supportive Care in Cancer 22,3:679-687.

King, E.A., Hanauer, D.A., Choi, S.W., et al. (2014). Osteochondromas after radiation for pediatric malignancies: a role for expanded counseling for skeletal side effects. Journal of pediatric orthopedics 34,3:331-335.

Muller, C., Winter, C., Boos, J., et al. (2014). Effects of an exercise intervention on bone mass in pediatric bone tumor patients. International Journal of Sports Medicine 35,8:696-703.

Tripathy, D., Durie, B.G., Mautner, B., et al. (2014). Awareness, concern, and communication between physicians and patients on bone health in cancer. Supportive Care in Cancer 22,6:1601-1610.

Surgery

Anderson, M.E., Miller, P.E., van Nostrand, K., et al. (2014). Frozen section versus gross examination for bone marrow margin assessment during sarcoma resection. Clinical Orthopaedics & Related Research 472,3:836-841.

Angelini, A., Mavrogenis, A.F., Gambarotti, M., et al. (2014). Surgical treatment and results of 62 patients with epithelioid hemangioendothelioma of bone. Journal of surgical oncology 109,8:791-797.

Behnke, N.K., Alamanda, V.K., Song, Y., et al. (2014). Does postoperative infection after soft tissue sarcoma resection affect oncologic outcomes?. Journal of surgical oncology 109,5:415-420.

Choi, E.S., Kim, H.S. and Han, I. (2014). Elevated preoperative systemic inflammatory markers predict poor outcome in localized soft tissue sarcoma. Annals of Surgical Oncology 21,3:778-785.

Chung, S.W., Han, I., Oh, J.H., et al. (2014). Prognostic effect of erroneous surgical procedures in patients with osteosarcoma: evaluation using propensity score matching. Journal of Bone & Joint Surgery - American Volume 96,8:e60.

Mundinger, G.S., Prucz, R.B., Frassica, F.J., et al. (2014). Concomitant upper extremity soft tissue sarcoma limb-sparing resection and functional reconstruction: assessment of outcomes and costs of surgery. Hand 9,2:196-204.