Helena Karlström

LIST OF PUBLICATIONS

PEER REVIEW PAPERS

1. Clarke DL Johanson CB, Wilbertz J, Veress B, Nilsson E, Karlström H, Lendahl U and Frisen J. Generalized potential of adult neural stem cells. (2000).

Science, 288(5471): pp.1660-3

2. Yoshihito Taniguchi*, Helena Karlström*, Johan Lundkvist, Tomohiko Mizutani, Akira Otaka, Monica Vestling, Alan Bernstein, Dorit Donoviel, Urban Lendahl and Tasuku Honjo.

Notch receptor cleavage depends on but is not directly executed by presenilins. (2002).

Proc. Natl. Acad. Sci. U S A 99, pp. 4014-4019

* shared first authorship.

3. Helena Karlström, Anna Bergman, Urban Lendahl, Jan Näslund and Johan Lundkvist. A sensitive and quantitative assay for measuring cleavage of presenilin substrates. (2002).

J. Biol. Chem. 277, pp. 6763-6766

4. Helena Karlström, Paul Beatus, Karin Dannaeus, Gavin Chapman, Urban Lendahl and Johan Lundkvist.

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. (2002)

Proc. Natl. Acad. Sci. U S A. 99(26), pp. 4014-4019

5. Anna Bergman, Dorota Religa, Helena Karlström, Hanna Laudon, Bengt Winblad, Lars Lannfelt, Johan Lundkvist and Jan Näslund.

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer’s disease mutations. (2003)

Exp. Cell Res. 287(1), pp. 1-9

6. Hanna Laudon, Paul M. Mathews, Helena Karlström, Anna Bergman, Mark R. Farmery, Ralph A. Nixon, Bengt Winblad, Samuel E. Gandy, Urban Lendahl, Johan Lunfkvist and Jan Näslund

Co-expressed presenilin 1 NTF and CTF form functional g-secretase complexes in cells devoid of full-length protein

J Neurochem. 2004 Apr;89 (1):44-53.

7. Laudon H, Karlstrom H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Naslund J

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

J Biol Chem. 2004 Jun 4;279(23):23925-32. Epub 2004 Mar 29

8. Lundkvist J, Zhu S, Hansson EM, Schweinhardt P, Miao Q, Beatus P, Dannaeus K, Karlstrom H, Johansson CB, Viitanen M, Rozell B, Spenger C, Mohammed A, Kalimo H, Lendahl U. Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

Genesis. 2005 Jan;41(1):13-22

9. Holmberg K, Kuteeva E, Brumovsky P, Kahl U, Karlström H, Lucas GA, Rodriguez J, Westerblad H, Hilke S, Theodorsson E, Berge OG, Lendahl U, Bartfai T, Hokfelt T. Generation and phenotypic characterization of a galanin overexpressing mouse.

Neuroscience. 2005;133(1):59-77.

10. Dehvari, N., Cedazo-Minguez, A., Isacsson, O., Nilsson, T., Winblad, B., Karlström, H., Benedikz, E. and Cowburn, R.F. (2007) Presenilin Dependence of Phospholipase C and Protein Kinase C Signalling.

J Neurochem. 2007 Aug;102(3):848-5

11. Karlstrom H, Kwok JB, Gregory GC, Hallupp M, Brooks WS, Schofield PR.

No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis.

Neuroreport. 2007 Aug 6;18(12):1267-9

12. Johanna Wanngren, Jenny Frånberg, Annelie I Svensson, Hanna Laudon, Bengt Winblad, Frank Liu, Jan Näslund, Johan Lundkvist and Helena Karlström. The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the Abeta profile without affecting Notch processing.

J. Biol. Chem. 2010 March 19;285(2): 8527-8536

13. Jenny Frånberg, Helena Karlström, Bengt Winblad, Lars O. Tjernberg, and Susanne Frykman. g-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes

PLoS ONE, Research Article, published 19 Mar 2010 doi:10.1371/journal.pone.0009772

14. Luty AA, Kwok JB, Dobson-Stone C, Loy CT, Coupland KG, Karlström H, Sobow T, Tchorzewska J, Maruszak A, Barcikowska M, Panegyres PK, Zekanowski C, Brooks WS, Williams KL, Blair IP, Mather KA, Sachdev PS, Halliday GM, Schofield PR. Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration - motor neuron disease

Annals of Neurology. 2010 Nov;68(5):639-49.

15. Louise Hedskog, Camilla A Hansson Petersen, Annelie I Svensson, Hedvig Welander, Lars O Tjernberg, Helena Karlström and Maria Ankarcrona. Gamma-secretase Complexes Containing Caspase-cleaved Presenilin-1 Increase Intracellular Aβ42/Aβ40 Ratio.

J Cell Mol Med. 2010 Nov 3. doi: 10.1111/j.1582-4934.2010.01208.x.

16. Jenny Frånberg, Annelie I. Svensson, Bengt Winblad, Helena Karlström*, Susanne Frykman. Minor contribution of presenilin 2 for g-secretase activity in mouse embryonic fibroblasts and adult mouse brain.

Biochem. Biophys. Res. Commun. 2010, doi:10.1016/j.bbrc.2010.12.029

* corresponding author

17. Pamrén AI, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Naslund J, Karlstrom H. Mutations in nicastrin differentially affect amyloid b-peptide production and notch processing.

J Biol Chem. 2011 Jul 18. [Epub ahead of print]

18. Hedskog L, Brohede J, Wiehager B, Pinho CM, Revathikumar P, Lilius L, Glaser E, Graff C, Karlström H, Ankarcrona M. Biochemical Studies of Poly-T Variants in the Alzheimer's Disease Associated TOMM40 Gene.

J Alzheimers Dis. 2012 May 16.

19. Wanngren J, Ottervald J, Parpal S, Portelius E, Strömberg K, Borgegård T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlström H. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.

J Biol Chem. 2012 Sep 21;287(39):32640-50

20. Tomas Borgegård, Susanne Gustavsson, Charlotte Nilsson, Santiago Parpal, Rebecka Klintenberg, Anna-Lena Berg, Susanne Rosqvist, Lutgarde Serneels, Samuel Svensson, Fredrik Olsson, Shaobo Jin, Hongmei Yan, Johanna Wanngren, Anders Jureus, Anna Ridderstad-Wollberg, Patrik Wollberg, Kenneth Stockling, Helena Karlström, Åsa Malmberg, Johan Lund, Per Arvidsson, Bart De Strooper, Urban Lendahl, and Johan Lundkvist. Alzheimer's disease: Presenilin 2-sparing gamma-secretase inhibition is a tolerable Ab peptide lowering strategy

Journal of Neuroscience, 2012 Nov 28;32(48):17297-17305.

21. Schedin-Weiss S, Inoue M, Teranishi Y, Yamamoto NG, Karlström H, et al. (2013) Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase. PLoS ONE, 2013 8(5): e63962. doi:10.1371/journal.pone.0063962

22. Johanna Wanngren; Patricia Lara; Karin Öjemalm; Silvia Maioli; Nasim Moradi; Lu Chen; Lars Tjernberg; Johan Lundkvist; IngMarie Nilsson; Helena Karlström. Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by Presenilin1 familial Alzheimer-linked mutations. FEBS Open Bio. 2014 Apr 24;4:393-406.

REVIEW

23. Karlstrom H, Brooks, WS, Kwok, JBJ, Broe GA, Kril JK, McCann H, Halliday GM, Schofield PR. Variable phenotype of Alzheimer’s disease with spastic paraparesis. Review. J Neurochem. 2008 104: 573-583

BOOK CHAPTER

Helena Karlstrom, William S Brooks, John BJ Kwok, Jillian J Kril, Glenda M Halliday, and Peter R Schofield. Variable phenotype of Alzheimer’s Disease with Spastic Paraparesis.

Genotype-Proteotype-Phenortype, Relationsship in Neurodegenerative Diseases, IPSEN FOUNDATION, Book chapter, 2005

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