2011 Successful Grant Applications
Kids Research Institute at The Children’s Hospital at Westmead
NHMRC Grants
Project Grants
Chief Investigators: D Little, J Cooper‐White, A Ruys, A Schindeler
Project Title: Pre‐clinical validation of a novel implant for bone tissue engineering
Total awarded: $421,175
Chief Investigators: K North, N Laing, K Nowak, N Clarke, M Buckley
Project Title: Neuromuscular disorders: Gene discovery and disease mechanism
Total awarded: $772,350
Chief Investigators: E Elliott, J Latimer, C Bower, J Fitzpatrick, A Martiniuk
Project Title: The Lililwan Project: Prevalence of Fetal Alcohol Spectrum Disorders in the Fitzroy Valley
Total awarded: $1,024,474
Chief Investigators: R Skinner, S Cooper, K McCaffery, G Zimet, K McGeehan, P Whyte, D Regan
Project Title: Randomised Controlled Evaluation of a Complex Intervention to Promote Uptake of School‐based HPV Vaccination
Total awarded: $723,634
Chief Investigators: C Jones, S Alexander
Project Title: Defining the contribution of skin gamma delta T cells to cutaneous
immunosurveillance, immunity and disease after HSV infection.
Total awarded: $581,010
Chief Investigators: J Christodoulou, S Cooper
Project Title: Gene Discovery and Functional Studies to Reveal Mechanisms Underlying Mitochondrial Respiratory Chain Disorders.
Total awarded: $368,510
Chief Investigators: S Alexander, K Dwyer, Y M Wang
Project Title: Role of Purines in renal and transplant injury
Total awarded: $539,610
Chief Investigators: I Alexander, P Tam, G Yeoh, D Russell
Project Title: Cellular therapy for genetic liver disease exploiting induced pluripotent stem cells
and liver progenitor cells
Total awarded: $770,175
Chief Investigators: I Alexander, S Ranganathan, M Cavazzana‐Calvo
Project Title: Analysis and manipulation of the genome‐wide integration signatures of gammaretroviral
and lentiviral vectors in human haematopoietic stem cells
Total awarded: $591,125
Chief Investigators: N Laing, K North, N Clarke
Project Title: Approaches to therapy for the skeletal muscle actin diseases.
Total awarded: $881,175
Chief Investigators: K A O’Grady, A Chang, K Grimwood, P Morris, H Smith‐Vaughan, E Mulholland,
Paul Torzillo, A Cripps, N Wood, A Revell
Project Title: A multi‐centre, double blind randomised controlled trial to evaluate the efficacy of 10 valent pneumococcal –Protein D conjugate vaccine in reducing respiratory exacerbations in children aged 18 months with suppuratives lung disease
Total awarded: $1,122,492
Chief Investigators: R Andrews, K A O’Grady, T Nolan, P Richmond, N Wood, S Lambert, M Chatfield
Project Title: FluMuM: a prospective cohort study of mother‐infant pairs assessing the effectiveness of maternal influenza vaccination in prevention of influenza in early infancy
Total awarded: $2,481,063
Chief Investigators: C Semsarian, D Winlaw (CIC) full list of Chief investigators to be confirmed
Project Title: Genetic Basis of Valvular Heart Disease
Total awarded: $434,255
Chief Investigators: E Banks, S Eades, C D’Este, S Bailey, S Redman, A Williamson, A Purcell, H
Gunasekera, P McIntyre, K Clapham
Project Title: Longitudinal investigation of health outcomes in urban Aboriginal children: SEARCH follow‐up
Total awarded: $1,727,460
Chief Investigators: AL Ponsonby, F Cameron, M Craig, A Kemp
Project Title: Enterovirus, vitamin D status and inflammation at the clinical onset of type 1 diabetes in childhood
Total awarded: $398,047.50
Chief Investigators: J Couper, M Craig, P Colman, P Baghurst, W Rawlinson, T Jones, A Cotterill
Project Title: Early environmental determinants of pancreatic islet autoimmunity: a pregnancy to early life cohort study in children at risk of type 1 diabetes
Total awarded: $1,083,720
Chief Investigators: S Chadban, H Wu, S Alexander
Project Title: Tolerance or rejection: The role of innate immunity in determining the fate of a kidney allograft.
Total awarded: $489,255
Chief Investigators: R Heine, A Kakakios (full list of Chief Investigator to be confirmed)
Project Title: Effect of a four‐food elimination diet in children with eosinophilic oesophagitis a multi‐centre, randomised controlled trial and investigation of disease mechanisms.
Total awarded: $520,448
Chief Investigators: L Askie, L Baur, K Campbell, L Daniels, B Taylor, LM Wen, K Hesketh, A Magarey, R Taylor, A Martin
Generating evidence of reduced rates of overweight/obesity in children: value adding to four established Australasian early intervention trials
Total awarded: $187,018
Chief Investigators: AChang, P Morris, KA O’Grady, K Grimwood, T Sloots, PVan Asperen, A Wilson, C Robertson
Project Title: Multicentre Randomised Controlled Trial To Improve The Management Of Exacerbations In Children With Bronchiectasis.
Total awarded: $1,148,522.00 (2012-2014)
2012 Centre of Research Excellence
Chief Investigators: K North, N Laing, A Kornberg, J Burns, M Ryan, N Clarke, A Corbett, K Refshauge, M Buckley, C McLean
Project Title: Centre for Research Excellence in neuromuscular disorders
Total awarded: $2,496,650
Chief Investigators: R MacIntyre, P McIntyre, R Booy, J Leask, N Wood, C Jones, R Menzies, J Kaldor, P Beutels, D Dwyer
Project Title: Immunisation in understudied and special risk populations
Total awarded: $2,499,969
2012 Partnership Projects
Chief Investigators: J Craig, E Banks, S Eades, C D'Este, S Bailey, S Redman, A Williamson, SPope, C Parter, H Gunasekera
Project Title: SEARCH: better evidence, better health for urban Aboriginal children
Total awarded: $1,395,760
2012 Practitioner Fellowships
Chief Investigators: E Elliott
Total awarded: $448,908
2012 Career Development Fellowships
Chief Investigators: N Clarke
Project Title: Advancing the diagnosis and treatment of inherited muscle disorders
Total awarded: $391,076
2012 Early Career Fellowships
Chief Investigators: A Tong
Project Title: Consumer preferences in chronic kidney disease
Total awarded: $294,892
Chief Investigators: G Wong
Project Title: Cancer and chronic kidney disease
Total awarded: $248,424
Chief Investigators: T Snelling
Project Title: Monitoring the effectiveness and safety of vaccination in Australia
Total awarded: $248,424
2011 Postgraduate Scholarships
Chief Investigators: N Pride
Project Title: The Identification and treatment of cognitive and social deficits in neurofibromatosis
Total awarded: $78,625
Chief Investigators: R McGee
Project Title: Trials and outcomes in Paediatric surgery
Total awarded: $80,938
Chief Investigators: M Menzes
Project Title: Peripheral Neuropathy in Children with Mitochondrial Disease
Total awarded: $45,188
Chief Investigators: D Campbell
Project Title: To investigate rates of peritonitis in incident peritoneal dialysis patients in Australia and perform a pilot study aimed at reducing these rates
Total awarded: $74,750
Chief Investigators: P Lopez‐Vargas
Project Title: A multi‐component education program for patients with early stage chronic kidney disease
Total awarded: $63,000
Chief Investigators: M Ho
Project Title: Obesity and insulin resistance in adolescents
Total awarded: $74,750
Chief Investigators: E Palmer
Project Title: Finding a Drug Treatment for Rett Syndrome
Total awarded: $74,750
Sydney Children’s Hospital, Randwick
NHMRC Grants
2012 Project Grants
Chief Investigators: E Sullivan (full list of Chief Investigator to be confirmed)
Project Title: A national population‐based study of rheumatic heart disease in pregnancy
Total awarded: $841,035
Kids Research Institute at The Children’s Hospital at Westmead
Grants from other funding bodies
Australian Paediatric Endocrine Group
Chief Investigators: M Poon, M Craig, K Donaghue
Project Title: The role of environmental factors in the development of microvascular and macrovascular complications in type 1 diabetes ‐ a 14 year follow up of an incident cohort
Total awarded: $25,000
Australian Primary Health Care Research Institute Centre of Research Excellence
Chief Investigators: E Banks, J Craig, S Bailey, S Redman, C D’Este, D Fernando, A Williamson, H Gunasekera, D Thiele, A Purcell, S Woolfenden , D Wright, S Lyons, B Raphael , D Barwick, T Senior, K Howard
Project Title: Centre for Research Excellence for Urban Aboriginal Child Health
Total awarded: $2,500,000
Australian Research Council – Linkage Project
Chief Investigators: Y Zurynski, E Elliott, H Leonard, J Christodoulou
Project Title: Psychosocial and economic impacts of rare diseases on Australian children, families and health professionals
Total awarded: $316,780
Australian Research Council – Discovery Early Career Researcher Award (DECRA)
Chief Investigators: A Tong
Project Title: Protecting equity and ethics in organ donation: patient, public and professional perspectives
Total awarded: $375,000
Australian Research Council – Discovery Project
Chief Investigators: K North
Project Title: Molecular dissection of the functional regions of genes that encode actinins (ACTN2 and ACTN3) and their contribution to normal variation in skeletal muscle function
Total awarded: $300,000
Australian Orthopaedic Association Research Foundation
Chief Investigators: D Little
Project Title: BMP‐2 and Bisphosphonate treatment of Avascular Necrosis in Piglet model
Total awarded: $32,725
Cancer Institute NSW – AYA Fellowship
Chief Investigators: A Fernando
Project Title: Bridging the Gap ‐ Developing a Palliative Care Service Specific to Adolescents and
Young Adults with Cancer
Total awarded: $156,742
Children’s Tumor Foundation
Chief Investigators: D Little
Project Title: The use of MEK ibhibitors in Nf1 pseudarthrosis
Total awarded: $30,000
Chief Investigators: J Payne
Project Title: The Neural Basis and Treatment of reading disability in children with
Neurofibromatosis Type 1
Total awarded: $100,000
Clive and Vera Ramaciotti Foundation – Establishment Award
Chief Investigators: L Lau
Project Title: MYCN/c‐MYC‐medicated regulation of the telomerase complex in neuroblastoma
Total awarded: $74,800
Chief Investigators: J Ayer
Project Title: Defining the role of T‐Cadherin (T‐CAD) in Adiponectin (APN) mediated protection against vascular injury and angiogenesis
Total awarded: $75,000
Diabetes Australia Research Trust
Chief Investigators: M Poon, M Craig, K Donaghue
Project Title: The role of environmental factors in the development of microvascular and macrovascular complications in type 1 diabetes – a 14 year follow up of an incident cohort
Total awarded: $60,000
Foundation for Children
Chief Investigators: P Caldwell
Project Title: Randomised controlled trial of timed voiding using an alarm watch vs. standard watch for treatment of daytime urinary incontinence in children
Total awarded: $163,920
Ian Potter Foundation – Travel Grant
Chief Investigators: S Cooper
Project Title: To attend conference in Berlin
Total awarded: $2,100
IRSF Research grant
Chief Investigators: J Christodoulou
Project Title: IRSF MECP2 Vation Database (RettBASE)
Total awarded: $35,165
Multiple Sclerosis Research Australia
Chief Investigators: F Brilot, R Dale
Project Title: Autoantibody in first episode of demyelination, and risk of progression to MS in Australian children
Total awarded: $50,000
Pablove Foundation
Chief Investigators: L Lau
Project Title: Alternative Lengthening of Telomeres (ALT) in Neuroblastoma
Total awarded: $49,500
Perpetual Foundation
Chief Investigators: K North
Project Title: Purchase Mobile Spectral Domain OCT System
Total awarded: $23,000
The University of Sydney – Equipment Grant
Chief Investigators: K North, I Alexander, S Alexander, J Christodoulou, D Catchpoole, N Clarke
Project Title: Ion Torrent Personal Genome Machine (PGM)
Total awarded: $75,000
Sydney Children’s Hospital, Randwick: Grants from other funding bodies
Clive and Vera Ramaciotti Foundations Establishment Award
Chief Investigator: T Roscioli
Title: Next Generation Sequencing
Total awarded: $76,000
NSW Cancer Council Infrastructure Grant
Chief Investigators: M Buckley, R Ward, M Field, T Roscioli (associate)
Title: Next Generation Sequencing
Total awarded: $600,000
Royal Australasian College of Physicans Award ‐ Jacquot Research Establishment Awards
Chief Investigator: S Kennedy
Title: Acute Kidney Injury after Hematopoietic Stem Cell Transplant in Children
Total awarded: $90,000
Chief Investigator: K Ooi
Total awarded: $10,000
Chief Investigator: D Ziegler
Title: New treatments for diffuse pontine glioma
Total awarded: $50,000
KRI bridging grants for 2012
Chief investigator: D Little
Project title: Modulation of Wnt Pathway in Skeletal Loading Response and Skeletal Repair
Total awarded:$35K
Chief investigators:N Clarke, K North, N Laing, B Ilkovski
Project title: Tropomyosin myopathies: Investigating the causes of muscle weakness and potential pharmacological therapies
Total awarded:$35K
Additional new grants and government funding for 2012
Foster K, Morris J, Jeffrey H, Elliott EJ, Adams C, Hirst J, Lahra M, Glasson R. Educational Initiative to Improve Maternal, Neonatal and Childhood Health Outcomes in Dien Bien Province, Viêt Nam. AusAid Public Sector Linkages Program. $242,000. 2012-2013.
Peadon E, Elliott E. Development of the first screening and diagnostic and service for Fetal Alcohol Spectrum Disorders in Australia. Foundation for Alcohol Research and Education. $108,000. 2012-2013.
Latimer J, Elliott EJ. Marulu: Tristan’s Story and Educational Film. Foundation for Alcohol Research and Education. $40,000. 2012-2013.
Elliott EJ for the Lililwan Collaboration. FASD prevalence in the Fitzroy Valley. Save the Children Australia. $60,000. 2012-13.
Elliott EJ, Bower C, Kaldor J, Booy R. Australian Paediatric Surveillance Unit: A collaborative network for child health research. Additional funding from NHMRC for Enabling Grant (402784). $100,000. January 1 to September 30th, 2012.
Elliott EJ, Zurynski Y. Australian Paediatric Surveillance Unit. Commonwealth Department of Health and Ageing. $177,014. July 2011 to June 2012.
Latimer J, Elliott EJ, Fitzpatrick J, Oscar J, Carter M. The Lililwan Project. Commonwealth Department of Health and Ageing and Department of Families Housing Community Services and Indigenous Affairs. $945,000.2012-2013.
McIntyre P,Elliott EJ, Zurynski Y, Booy R, Wood N, Macarteney KThe Paediatric Active Enhanced Disease Surveillance (PAEDS)Collaboration. Commonwealth Department of Health and Ageing. $454,260. 2012-2014.
C Jones, M Fernandez - TLR2 Agonist – HIV Peptide Induction of TH17 responses: A new immunotherapuetic and vaccine strategy? – CIs on grant totaling $113,000 for 12 months.
A Holland, Kate Curtis, Rebecca Ivers. 2012 International Program Development Fund,University of Sydney.