Key words in STN retrieval language Messenger for Literature and Patent Search for the ESTO study “Nanobiotechnology in the medical sector - Drivers for development and possible impacts”

Drug Delivery:

1) Liposomes

(LIPOSOM? AND (DRUG(2A)DELIVER? OR GENE(2A)DELIVER? OR PROTEIN(2A)DELIVER? OR DRUG(2A)CARRIER? OR DRUG(2A)TARGET? OR DRUG(2A)CONTAIN? OR DRUG(2A)RELEAS? OR PROTEIN(2A)DELIVER? OR GENE(2A)DELIVER?)) OR LIPOSOMAL DRUG# OR LIPOSOMAL PROTEIN# OR (LIPOSOM? FORMULATION# AND DRUG#)

2) Polymer therapeutics

(POLYMER##(W)CONJUGATE# AND DRUG#) OR POLYMERIC DRUG# OR (DRUG(W)POLYMER# AND CONJUGATE#)OR POLYMER(W)BASED PRODRUG# OR MACROMOLECULAR(A)THERAPEUTIC# OR POLYMER##(A)THERAPEUTIC#

OR

[PEGYLAT?(2A)PROTEIN# OR PEGYLAT?(2A)PEPTIDE OR PEGYLAT?(2W)DRUG OR ((POLYETHYLENE GLYCOL)(W)CONJUGAT? AND (PROTEIN? OR PEPTIDE?)) OR (POLYMER?(2A)MICELL? AND (DRUG# OR PROTEIN# OR PEPTIDE#))

AND

DRUG(2A)DELIVER? OR DRUG(2A)CARRIER# OR DRUG(2A)TARGET? OR DRUG(2A)CONTAIN? OR DRUG(2A)RELEAS? OR PROTEIN(2A)DELIVER? OR GENE(2A)DELIVER?]

3) Polymer nanoparticles

POLYMER? AND (NANOPARTICLE# OR NANOCAPSULE# OR NANOSPHER?)

AND

DRUG(2A)DELIVER? OR DRUG(2A)CARRIER# OR DRUG(2A)TARGET? OR DRUG(2A)CONTAIN? OR DRUG(2A)RELEAS? OR PROTEIN(2A)DELIVER? OR GENE(2A)DELIVER?

4) Nanosuspensions

((NANOCRYSTAL? OR NANOSUSPENSION#) AND DRUG#) OR DRUG NANOPARTICL?

5) Solid Lipid Nanoparticles

SLN# OR SOLID LIPID NANOPARTICLE#

AND

DRUG(2A)DELIVER? OR DRUG(2A)CARRIER# OR DRUG(2A)TARGET? OR DRUG(2A)CONTAIN? OR DRUG(2A)RELEAS? OR PROTEIN(2A)DELIVER? OR GENE(2A)DELIVER?

6) Dendrimers

DENDRIMER?

AND

DRUG(2A)DELIVER? OR DRUG(2A)CARRIER# OR DRUG(2A)TARGET? OR DRUG(2A)CONTAIN? OR DRUG(2A)RELEAS? OR PROTEIN(2A)DELIVER? OR GENE(2A)DELIVER?

7) Inorganic Nanoparticles

GOLD(2A)NANOPARTICLE# OR COLLOIDAL GOLD OR SILICATE(2A)NANOPARTICLE? OR (CALCIUM PHOSPHATE AND NANOPARTICL?) OR (BIOSILICON AND NANO?) OR (LANTHANUM AND NANO?) OR (TITANIUM DIOXIDE AND NANO?)

AND

DRUG(2A)DELIVER? OR DRUG(2A)CARRIER# OR DRUG(2A)TARGET? OR DRUG(2A)CONTAIN? OR DRUG(2A)RELEAS? OR PROTEIN(2A)DELIVER? OR GENE(2A)DELIVER?

Drugs AND Therapy

1) Fullerenes

FULLEREN?(S)DRUG# OR FULLEREN?(S)THERAPEUT? OR FULLEREN?(3A)MEDIC?

2) Dendrimers

(DENDRIMER#(S)DRUG# NOT DRUG DELIVERY) OR (DENDRIMER#(S)ANTIMICROBIAL AND

DRUG# NOT DRUG DELIVERY)

3) Nanoshells

NANOSHEL? AND (HYPOTHERM? OR PHOTOTHERAP? OR PHOTODYNAMIC(2A)THERAP?)

4) Magnetic Nanoparticles

MAGNETI?(S)NANOPARTICL? AND (HYPERTHERM? OR THERM?(S)CANCER OR THERM?(S)TUMOR)

In vivo Imaging

1) Magnetic Resonance Imaging

superparamagnetic iron oxide# OR SPIO# OR USPIO# OR nanoparticle# or MION# OR CLIO# OR nanoparticu? OR dendrim? OR gadom?

AND

((magnetic resonance and imaging) OR MR#(2A)imaging)

2) Ultrasound Imaging

ultrasound and imaging and (medic? or clinic?)

AND

liposome? or (nano? not (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?))

3) Nuclear medicine imaging methods

(nuclear(3a)imaging and medic?) OR (PET OR SPECT and medic?) OR positron emission tomography or Single photon emission computerized tomography

AND

nano? not (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)

AND

CONTRAST(3A)AGENT# OR IMAGING(3A)AGENT

4) Optical Imaging Methods

((optical imaging OR OCT) and (medic? or clinic?)) OR optical coherence tomography

AND

nanopartic? or liposom? or nanoshell? or quantum dot# or nanotech? or nanobiotech? or dendrim? or gadomer?

Medical Biosensors

1) Surface plasmon resonance

(SPR OR SURFACE PLASMON RESONANCE)(s)(sensor? or biosensor?)and(diagnostic? or medic? or clinic? or disease? or biological detection or cancer?)

2) Cantilever Chips

((CANTILEVER# OR Nanocantilever# or Microcantilever# Or nanomechanic?)(s)(sensor? or biosensor? Or bioassay# or assay#))

AND

[s disease# or cancer? Or tumor# or Alzheimer# or cardi? Or myocard? or Arthrit? or arthro? or allerg? or cardi? Or myocard? or HIV or AIDs or pregnancy or HIV or AIDs or virus# or viral or malaria or hepat? or SARS or bacteria? or pathogen? or E(w)coli or escherichia coli

OR

s biomedic? or biopharma? or biodiagnos? or biologic? or nucleotide# or oligonucleotide# or polynuclotide# or SNP# or DNA or RNA or Protein? or cell(2A)imaging or microorganism? Or enzyme# or immune?

OR

s clinic? or diagnost? or medic? or disease# or bioanalytic?]

NOT

OPTIC?

3) DNA Chips, Electrical Detection

[(ELECTRic? Or electrod? OR Microelectrod? Or ELECTROCHEMICAL? OR CONDUCTIV? OR IMPEDANCE OR Transistor# Or amperomet? OR redox?)(s)(DNA chip OR biochip OR MICROARRAY# OR NANOARRAY#)

OR

(nanotube? or CNT? OR nanowire?)and(biosensor or sensor)]

AND

[s disease# or cancer? Or tumor# or Alzheimer# or cardi? Or myocard? or Arthrit? or arthro? or allerg? or cardi? Or myocard? or HIV or AIDs or pregnancy or HIV or AIDs or virus# or viral or malaria or hepat? or SARS or bacteria? or pathogen? or E(w)coli or escherichia coli

OR

s clinic? or diagnost? or medic? or disease# or bioanalytic?]

4) Quantum Dots

(quantum dot# OR qdot# OR semiconduct?(4A)(nanoparticle# or nanocryst?)) and (medic?(4A)diagnost? or clinical or biodiag? or biomed? or cell(s)imaging or diseas?)

5)Gold Nanoparticles

gold(2a)nanoparticle? OR colloidal gold or ((RLS or plasmon resonant)(4A)(nanopartic? or particle#))

AND

rapid test# or lateral(w)flow(2A)(test# or diagnostic?) or (DNA(2A)CHIP# OR protein#(2A)chip# OR biochip# OR MICROARRAY#)

6)Magnetic Nanoparticles

magnetic?(4A)nanoparticle# or magnetic?(4A) colloid or (superparamagnetic iron oxide(s)(particle# or nanoparticle#))OR (superparamagnetic iron(s)(particle# or nanoparticle#))

AND

DNA(2A)CHIP# OR PROTEIN#(2A)CHIP# OR BIOCHIP# OR MICROARRAY# OR SENSOR# OR BIOSENSOR# OR DETECTION OR SEPARATION# OR BIOSEPARATION# OR SENSING OR BIOANALYTICAL

AND

clinic? or diagnost? or medic? or disease# or bioanalytic?

Medical Implants

1)Bone Restoratives

BONE#(s)CEMENT# OR Bone(s)SUBSTIUT? OR Bone(s)FILLER# Or Bone(s)RESTORATIVE#

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)

2) Dental Implants

[DENTAL(4A)IMPLANT# OR DENTAL(4A)Composite# OR DENTAL(4A)Filler# OR Dental(4A)material# OR Dental(4A)ceramic#

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)]

OR

Dental(s)Nanocomposite# OR Dental(s)nanofiller# OR Dental(s)nanotechnolog? OR dental(s)nanobiotechnolog?

3) Orthopedic Implants

Orthopedic(s)Implant# OR Orthopedic(2A)application# Or bone#(2A)replacement#

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)

4) Cardiovascular Implants

Cardiovascular(2A)Implant# OR Stent#

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)

5)Tissue Engineering

s Tissue Engineering OR cell#(A)encapsulat? OR cell#(A)microencapsulat? OR cell#(A)Microcapsule# Or bioartific?(A)organ#

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)

6)Silver Nanoparticles for implants and wound dressings

s silver? and (antimicro? OR biocid? OR antibacter?) and (implant# OR medical(2A)device? OR wound(2A)dressing# OR medical(s)application# OR medical(s)instrument# OR catheter#)

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)

Intelligent Implants/ Neural Prothesis

1) Electronic Drug Delivery Systems

(controlled(w)release and microchip#) OR (drug(2A)delivery and (microchip# OR MEMS OR BIOMEMS OR micro(2A)system# OR microfabri? or microsystem?))

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)

2) Neural Prothesis

NEURAL(2W)PROSTHES? OR Neural(2W)implant# OR RETINA#(2W)implant# OR COCHLEA#(2W)implant# OR BLADDER(2W)implant# OR AUDITORY(2W)implant# OR RETINA#(2W)prosthes? OR COCHLEA#(2W)prosthes? OR BLADDER(2W)prosthes? OR

AUDITORY(2W)prosthes? OR HEART PACEMAKER# OR NERV?(2W)STIMULAT? OR neuroprosthes? OR vision chip OR retina#(2W)interface#

AND

nano? NOT (nano(w)s OR nano2 OR nano3 or nanolit? or nanogram? or nanomol? or nanosec?)