Karnataka college of pharmacy, bidar.

RAJIVGANDHIUNIVERSITY OF HEALTH SCIENCES,

BANGALORE, KARNATAKA

Annexure- II

Proforma for Registration of Subjects for Dissertation

1 / Name of The Candidate And
Address ( In Block Letters ) / Mr.K.BHARATH REDDY
KARNATAKACOLLEGE OF PHARMACY, MANHALLI ROAD, BIDAR – 585403
2 / Name of The Institution / KARNATAKACOLLEGE OF PHARMACY, BIDAR – 585403
3 / Course of study and subject / M. PHARM
(BULK DRUGS)
4 / Date of Admission to Course / 20-12-2010
5 / Title Of The Topic
SYNTHESIS AND ANTIMICROBIAL ACTIVITY SOME
NOVEL PYRAZOLINEDERIVATIVES
6 / Brief resume of the intended work:
6.1 Need For The Study Enclosure-I
6.2 Review Literature Enclosure-II
6.3 Objective Of The Study Enclosure-III 6.4 Methodology Enclosed- IV
7 / Materials And Methods :
7.1 Sources Of Data Enclosure-V
7.2 Methods Of Collection Of data Enclosure-VI
7.3 Does the study require any investigation or intervention to be conducted on patients
or humans and animals? If so please describe briefly:
…Yes ….
7.4 Has ethical clearance been obtained from yours institution? If so please describe
briefly: …Applied …
8 / List of References / Enclosure-VII
9 / Signature of the candidate / K.BHARATH REDDY
10 / Remarks of the guide / SATISFACTORY
11 / Name and Designation
(in block letter)
11.1 Guide
11.2 Signature
11.3 Co-guide (if any)
11.4 Signature
11.5 Head of Department
11.6 Signature / Dr. RAGA BASAWARAJ
M. Pharm. PhD.
PROFESSOR
DEPARTMENT OF BULK DRUG
--
--
Dr. KASHINATH NOUBADE
M. Pharm .PhD
HOD & PROFESSOR
KarnatakaCollege of Pharmacy, Bidar.
12 / 12.1 Remarks of the chairmen and
Principal
12.2 Signature with seal / Dr. KRANTIKUMAR SIRSE
M.Pharm.PhD
PRINCIPAL
KarnatakaCollege Of Pharmacy, Bidar.

ENCLOSURE- I

6. BRIEF RESUME OF THE INTENDED WORK

6.1 Need for the study

As basic objective of this study is to develop new drugs for better health.The pharmaceutical chemistry programmes in the country must be directed to solving the national health problems, the health requirement of country should thus form the basis of the starting of research priority.

The advances made in the synthesis of organic compounds, knowledge of enzymes and their structures and of other biochemical basis of the physiological processes helped in understanding the disease & consequently their cure by drugs.

Research and development of new drug molecule is continuously on going process. This particular trend in drug development has increased due to development of high standards of safety and therapeutic efficiency.

The drugs, which are active today, may become inactive after some period due to resistance developed gradually by the microorganisms against particular drugs. Some potent drugs may cause allergic reactions to some persons and may show toxic effect.

Therefore it is necessary to develop more potent drug molecule with safer side than existing one. Pharmaceutical chemist in order to optimize the development of a new drug.

An approach has been made to synthesize some novel pyrazoline derivatives of pharmacological interestin expectation for better biological and pharmacological properties.

ENCLOSURE- II

6.2 ReviewofLiterature:-

Literature survey suggests that extensive synthetic work on pyrazolines is going on in recent years because of their pronounced biological activity. Our main goal is to study the synthesis of some novel substituted pyrazoline compounds and screened for their biological and pharmacological activities.

Pyrazoles and its derivatives are the interesting class of compounds. Drugs having pyrazole and pyrazoline ring systems are well known for their antibacterial1, analgesic2,CNS depressants, anticonvulsant, anti-inflammatory3, anti-oxidant, hypoglycemic4, hypotensive, anti-carcinogenic activity.

Pyrazolines possess a wide spectrum of biological and pharmacological activities5-10.Based on these observations and in continuation of our research work on synthesis of biologically active heterocyclic compounds, we now report the synthesis of some new pyrazolines.

P.M. Gurubasavaraja Swamy et al11have synthesis and antimicrobial activity of 3-(3’-hydroxy benzofuranyl)-5-aryl – pyrazolines.

H.S.Joshi et al12 have synthesis and biological activity of some pyrazoline derivatives.

R. A. Shastriet al13studied the synthesis and antimicrobial activity of 1H-3(2’-hydroxy substituted) phenyl 5(6”-methoxy) napthyl pyrazolines.

Gurubasavaraj V. Pujar et al14have reported the synthesis, anticonvulsant and antibacterial activities of some novel pyrazolines derived from benzoxazole and benzimidazole.

T.M. Upadhyay et al15 have studied synthesis and biological evaluation of some new pyrazolines.

Raga Basawaraj et al16 synthesized some new pyrazolines, isoxazolines and pyrimidines as potential antimicrobial agents.

Sushma Drabu et al17 studied the synthesis, anti-inflammatory, ulcerogenic and antibacterial activities of 1,3,5-trisubstituted pyrazolines.

Artur M. S. Silva et al18 have synthesis of 3-benzoyl-4-styryl—2-pyrazolines and their oxidation to the corresponding pyrazoles.

Gulhan Turan-Zitouni et al19 synthesize some 1-[N, N-Disubstituted thiocarbamoylthio) acetyl]-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and investigation of their antibacterial and antifungal activities.

Zuha Ozdemir20 and coworkers reported synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-thieny) pyrazoliine derivatives.

Mohammad Amir et al21 have the studied the synthesis and pharmacological evaluation of pyrazolinederivatives as new anti-inflammatory and analgesic agents.

Amir Azam and coworker22 reported the synthesis and antiamoebic activities of 1-N-substituted cyclisedpyrazoline analogues of thiosemicarbazones.

Stan DAndrea, and coworkers23 studied the Synthesis and antibacterial activity of dihydro-1, 2-oxazine and2-pyrazoline oxazolidinones: novel analogs of linezolid.

Y. Rajendra Prasad, et al24 reported the Synthesis and antidepressant activity of some1, 3, 5-triphenyl-2-pyrazolines and 3-(200-hydroxynaphthalen-100-yl)-1, 5-diphenyl-2-pyrazolines.

ENCLOSURE- III

6.3 Objective of the Study:-

In view of the significance of naturally occurring and physiologically activepyrazolinestimulated our interest in the synthesis of several heterocyclic compounds containing pyrazolinederivatives.

In the present cource of study we planned to synthesize some new pyrazoline derivatives. The structure of newly synthesized molecules will be established on the basis of physical data, analytical data and spectral studies such as IR,1H NMR, 13CNMR and mass spectra.

The newly synthesized compounds were screened for their biological and pharmacological activities on the basis of literature survey

The results of biological and pharmacological activities of the newly synthesized compounds were compared with standard drug andalso discussed about their structural activity relationship.

6.4 Methodology:-

During the present investigation we proposed to synthesize some novel pyrazoline derivatives of pharmacological interest, by using a starting material such as some substituted acids and converted into corresponding carbohydrazides, these underwent cyclisation with chalcones resulting into the formation of substituted pyrazolines.

ENCLOSURE- IV

7. MATERIALS AND METHODS

7.1 Source of data:-

In the present investigation, we planned to synthesize some novel pyrazoline derivatives with different reagents. This synthetic work mainly a laboratory based work. All the basic facilities which required to carry out are available in our laboratory.

The literature survey pertaining to present investigation will carried out by referring chemical abstracts, internet, national and international journals.

The day to day development in the area will be updated by literature survey through e-publishing, internet and current periodicals in our library and else where.

ENCLOSURE- V

7.2 Method of collection of data:-

The chemical structure of synthesized compounds will be established on the basis of physical, chemical and analytical data. Melting point of new compounds will be determined in open capillary tube and is uncorrected; they are expressed in degree centigrade.

The compounds synthesized will be characterized by IR, 1HNMR and Mass Spectral data. This will be collected by sending the sample to other advanced research center.

The main objective of the present investigation is to explore newer molecule with potent biological and pharmacological activities.

7.3 Does the study require any investigation to be conducted on patients or other human or animals? If so, please describe briefly.

Yes, at the later stage, after successful synthesis of molecules. The compound will be screened for pharmacological actions on albino mice and rats.

7.4Has ethical clearance been obtained from your institution in case?

Yes ethical clearance committee had been obtained by our Institution.

ENCLOSURE- VI

8. List of References:-

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  10. Chem. Abstr., 126 (1997), 14421w.
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Indian J.Heterocyclic Chem. vol.18, 275(2009).

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Indian J. Heterocyclic chem. vol.17, 135(2007).

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Indian J.Heterocyclic chem. vol.17,387 (2008).

  1. T. M. Upadhyay and V. M. Barot, Indian J. Heterocyclic chem. vol.15,393(2006).
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Indian J. Heterocyclic chem. vol.16,399 (2007).

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Eur. J. Org. Chem. 2000, 259322599.

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