RESUME
Joël, Raymond DREVET
Born, December 28th, 1960, Bayonne, France.
Citizenship: French
Married, two children.
Professionnal address:
Université Blaise Pascal, Clermont2
GReD laboratory
CNRS UMR 6247 – INSERM U931 - Clermont University
24, avenue des Landais
63171 Aubière, France
Tel: (33)4.73.40.74.13
Fax: (33)4.73.40.70.42
E-mail:
Academic background
1986: Master degree in Cellular Biology & Biochemistry
Université Claude Bernard, Lyon I, France
1989: Ph.D. in Molecular and Cellular Biology
Université Claude Bernard, Lyon I, France
1990: Postdoctoral fellow/Research and Teaching Associate
The University of Calgary, Faculty of Medicine, Department of Medical
Biochemistry, Health Science Center, Calgary, Alberta, Canada
1993: Assistant Professor in Cellular Biology
Université Blaise Pascal, Clermont2, France
1995: Associate Professor in Molecular and Cellular Biology
Université Blaise Pascal, Clermont2, France
1998 to date: Full Professor in Immunology and Cell Biology
Université Blaise Pascal, Clermont2, France
Teaching duties (Present)
125 hours/year of courses in Developmental Biology, Reproductive Biology and Immunology to graduate and undergraduate students.
Research activities
Adjunct-director of the laboratory GReD «Genetics, Reproduction & Development».
13 research groups -150 persons.Website:
Research group leader: «Mechanisms of post-testicular infertlity »
Research fields:Reproductive Biology, Post-testicular events of sperm maturation, infertilty,
male contraception, oxidative stress / free radicals / antioxidant enzymes/glutathione peroxidases, cholesterol homeostasis and fertility, inflammation and immunomodulation in the epididymis
Grants/Contracts
1986-1989: French Ministry of Higher Education. Ph.D. fellowship.
1990-1993: Teaching & Research fellowship grants, University of Calgary (Alberta, Canada).
1994-1996: Contract 2056, Cancer Research Association, France
1996-1998: Contract 5067, Cancer Research Association, France
2001-2002: Contract : Foundations Rockefeller & Ernst Schering Research: AMPPA1 «Applied Molecular Pharmacology for Post-testicular Activity»
2003-2005: Contract: Ernst Schering Research Foundation & CONRAD: AMPPA2.
2001-2005: French Ministry of Agriculture (15 KEuros/year)
2005-2007: Contract: Ernst Schering Research Foundation & CONRAD: AMPPA2extension.
1993- to date: CNRS/INSERM and French Ministry of higher education operating grants.
Administrative duties
Member of the French CNRS National Committee (Developmental Biology & Reproduction: committee 26) from 2000 to 2008.
General scientific secretary of the «Developmental Biology and Reproduction» committee (from 2005 to 2008)
Member of the CNRS hiring committee in «Developmental and Reproductive Biology» from 2000 to 2004.
President of a CNRS hiring Committes in «Developmental and Reproductive Biology» from 2005 to 2008.
Member of various University hiring committees from 1995 to 2011 in Cell Biology & Biochemistry.
President of University hiring committees from 2000 to 2008 in Cell Biology & Biochemistry.
Member of various evaluating committees (CNRS, AERES, INRA, FRSQ…)
General Secretary of the French Society of Andrology from 2004 to 2007.
Editorial duties
Associate-Editor of the French periodic «Andrologie» since 2006.
Member of the Editorial board of «ISRN Urology» since 2010.
Regular-occasional journal referee for:
On an average basis 20-25 papers per year.
Antioxidant Research Signaling, Asian Journal of Andrology, Biology of Reproduction, BBA (Biochemica & Biophysica Acta), BBA Molecular basis of diseases, Biochimie, Endocrinology, Experimental Gerontology, FASEB J., Food and Chemical Toxicology, Human Reproduction, International Journal of Andrology, ISRN Urology, Journal of Andrology, Journal of Clinical Investigation, Journal of Comparative Physiology, Journal of Endocrinology, Molecular Endocrinology, Molecular & Cellular Endocrinology, Molecular Human Reproduction, Physiologia Plantarum, Plant Science, Plos One, Proteomics, Reproduction, Reproductive Biology & Endocrinology, Toxicological Sciences
Congress/Workshop organizations
Member of the Scientific Committee for the «Third International Symposium on Epididymis», Charlotesville, Virginia, USA, 29-3/05-06/2002.
Co-organizer of the 21st Congress of the French Andrology Society with Dr. G. Grizard (SALF 2004), Clermont-Ferrand, France.9-11/12/2004.
Co-Organizer of the «Fourth International Symposium on Epididymis» with Dr. Trevor Cooper, Chatel-Guyon, France, 4-7/12/2006.
Member of the local organizing committee of the 4th International Congress of Andrology (ECA 2006), Toulouse, France, 7-9/12/2006.
Member of the Scientific committee of the 5th International Symposium on Epididymis, Sao Paulo (Brazil), 5-28th/10/2010.
Direction of studies
Ph.D thesis supervisor of 14 doctoral fellows to date.
Publications
1 -JR. Drevet and P. Couble.
"Tissue-specific expression of protein factors showing affinity for the promoter regions of silk protein genes in Bombyx mori".
(1990)Sericologia, 30, 171-183.
2 -JR. Drevet and P. Couble.
"Preparation and rapid fractionation of a silkgland cell-free protein extract: preliminary investigations of the protein-binding properties of the P25 gene 5’-flanking sequences".
(1991)Sericologia, 31, 636-656.
3 -B. Durand, JR. Drevet and P. Couble.
"P25 gene regulation in Bombyx mori silkgland: two promoter-binding factors have distinct tissue- and developmental-specificities".
(1992) Mol. Cell. Biol., 12, 5768-5777.
4 -P. Roeckel, M. Moloney and JR. Drevet.
"Plant transformation using the sexual route".
(1992) Int. Rev. Cytol., 140, 425-446.
5 -JR. Drevet, Y.A.W. Skeiky and K. Iatrou.
"GATA-type zinc finger motif-containing sequences and chorion gene transcription factors of the silkworm Bombyx mori".
(1994) J. Biol. Chem., 269 (14), 10660-10667.
6 -Y.A.W. Skeiky, JR. Drevet, L. Swevers and K. Iatrou.
"Protein phosphorylation and control of chorion gene activation through temporal mobilization of a promoter DNA binding factor from the cytoplasm into the nucleus".
(1994) J. Biol. Chem., 269 (16), 12196-12203.
7 -JR. Drevet, L. Swevers and K. Iatrou.
"Developmental regulation of a silkworm gene encoding multiple GATA-type transcription factors by alternative splicing".
(1995) J. Mol. Biol., 246, 43-53.
8 -L. Swevers, JR. Drevet, M. Lunke and K. Iatrou.
"The Silkmoth homolog-asterisk of the Drosophila ecdysone receptor (B1 isoform) : cloning and analysis of expression during follicular cell differentiation".
(1995) Ins. Biochem. Mol. Biol., 25, 857-866.
9 -V. Schwaab, E. Baud, N.B. Ghyselinck, J.P. Dufaure and JR. Drevet.
"Cloning of the mouse gene encoding plasma glutathione peroxidase : organization, sequence and chromosomal localization"
(1995) Gene , 167, 25-31.
10 -P. Vernet, N. Rigaudière, N. Ghyselinck, J.P. Dufaure and JR. Drevet.
"In vitro expression of a mouse tissue-specific glutathione peroxidase-like cDNA lacking the selenocysteine codon can protect stably transfected mammalian cells against oxidative damage".
(1996) Biochemistry and Cell Biology , 74 (1), 125-131.
11 -J.P. Dufaure, J.J. Lareyre, V. Schwaab, M.G. Mattei and JR. Drevet
"Structural organization, chromosomal localization, expression and phylogenetic evaluation of mouse glutathione peroxidase encoding genes."
(1996) C.R.A.S.III. 319, 559-568.
12 -P. Vernet, J. Faure, J.P. Dufaure and JR. Drevet.
Tissue- and developmental-distribution, dependance upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase.
(1997) Mol. Reprod. Dev., 47, 87-98.
13 -P. Roeckel, T. Oancia and JR. Drevet.
"Effects of seed-specific expression of a cytokinin biosynthetic gene on canola and tobacco phenotypes".
(1997) Transgenic Research , 5, 1-9.
14 -J.J. Lareyre, F. Claessens, W. Rombauts, J.P. Dufaure and JR. Drevet
"Characterization of an Androgen Response Element (ARE) within the promoter of the epididymis-specific murine glutathione peroxidase gene."
(1997) Molecular & Cellular Endocrinology , 129, 33-46.
15 -JR. Drevet, J.J. Lareyre, V. Schwaab, P. Vernet and J-P. Dufaure
"The PEA3 protein of the Ets oncogene family is a putative transcriptional modulator of the mouse epididymis-specific glutathione peroxidase gene, gpx5.
(1998) Mol. Reprod. Dev., 49, 131-140.
16 - P. Roeckel, T. Oancia and JR. Drevet
"Phenotypic alterations and seed yield component analysis in transgenic Brassica napus plants expressing the tzs gene under the control of the hsp70 promoter."
(1998) Physiologia Plantarum , 102, 243-249.
17 - N. Depège, JR. Drevet and N. Boyer.
"Molecular cloning and characterization of tomato cDNAs encoding glutathione peroxidase-like proteins.
(1998) E.J.B., 253, 445-451.
18 - P. Roeckel-Drevet, G. Gagne, D. Tourvieille de Labrouhe, P. Nicolas, J.P.
Dufaure and JR. Drevet.
"Molecular characterization, tissue-distribution and stress-mediated induction of two glutathione peroxidase-like encoding mRNAs in sunflower Helianthus annuus."
(1998) Physiologia Plantarum, 103, 385-394.
19 - V. Schwaab, J-J. Lareyre, P. Vernet, E. Pons, J. Faure, J-P. Dufaure and
JR. Drevet.
"Characterization, regulation of the expression and putative roles of two glutathione peroxidase proteins found in the murine epididymis. "
(1998) J. Reprod. Fertil. , 53S:157-162.
20- J-P. Dufaure and JR. Drevet
"La régulation de l’expression des gènes dans l’épididyme. "
(1998) Med. & Sci. 12, 1392-1398.
21- V. Schwaab, J. Faure, J-P. Dufaure and JR. Drevet.
"GPX3: the plasma-type glutathione peroxidase is expressed under androgenic
control in the mouse epididymis and vas deferens. "
(1998)Mol. Reprod. Dev. 51, 362-372.
22 - F. Mazeyrat, I. Salles, JR. Drevet, P. Roeckel-Drevet, D. Tourvieille and G. Ledoigt.
«Isolation of a complete PAL cDNA from sunflower»
(1998) Plant Physiol., 117, 719.
23 - P. Roeckel-Drevet, J. Tourvieille, JR. Drevet, V. Says-Lesage, P. Nicolas and D. Tourvieille de Labrouhe.
«Development of a PCR-diagnostic test for the detection of the biotrophic pathogen Plasmopara halstedii in sunflower.»
(1999) Can. J. Microbiol., 45, 797-803.
24 - P. Vernet, E. Rock, A. Mazur, Y. Rayssiguier, J-P. Dufaure and JR. Drevet.
"Selenium-independent epididymis-restricted glutathione peroxidase 5 protein (GPX5) can back-up failing Se-dependent GPXs in mice subjected to selenium-deficiency."
(1999) Mol. Reprod. Dev. 54, 362-370.
25 - JR. Drevet
«Glutathione peroxidase expression in the mammalian epididymis and vas deferens.»
(2000) Andrology, 1, 427-462.
26 - JR. Drevet.
«Regulation of the expression and approaches towards the understanding of the function of glutathione peroxidase in the mammalian epididymis.»
(2000). Andrologia, 32, 368-369.
27 - JR. Drevet
"Regulation of gene expression in epididymis. "
(2001) In: «Andrology in the 21st century». B. Robaire, H. Chemes and CR.
Morales (eds). pp199-214. Medimond Press, USA.
28 - P. Lahti, R. Shariatmadari, J.K. Penttinen, JR. Drevet, M. Vierula, I.
Huhtaniémi and M. Poutanen.
" Evaluation of the 5’-flanking regions of glutathione peroxidase five (GPX5) and
cysteine-rich protein-1 (CRISP-1) genes for targeting epididymis in transgenic
mice. "
(2001) Biol. Reprod. 64, 1115-1121.
29 - H. Rejraji, P. Vernet and JR. Drevet
" GPX5 is present in the mouse caput and cauda epididymidis lumen at three different
locations"
(2002). Mol. Reprod. Dev., 63, 96-103.
30 - F. Norre, C. Peyrot, C. Garcia, I. Rance, JR. Drevet, M. Thiesen and V. Gruber
" Powerful effect of an atypical bifactorial endosperm box from wheat HMWG-Dx5
promoter in maize endosperm ".
(2002) Plant Mol. Biol., 50:699-712.
31 * S. Herbette, C. Lenne, N. Leblanc, J-L. Julien, JR. Drevet and P. Roeckel-
Drevet
"Two GPX-like proteins from Lycopersicum esculentum and Helianthus annuus
are enzymes with phospholipid hydroperoxide glutathione peroxidase and thioredoxin
peroxidase activities "
(2002) E.J.B., 269:2414-2420.
32 * P. Sipilä, TG Cooper, CH Yeung, M. Mustonen, J. Penttinen, JR. Drevet, I.
Huhtaniemi and M. Poutanen.
" Epididymal dysfunction initiated by the expression of Simian Virus 40 T-antigen
leads to angulated sperm flagella and infertility in transgenic mice" .
(2002) Mol. Endocrinol., 16:2603-2617.
33 * E. Pons, P. Sipilä, A. Britan, P. Vernet, M. Poutanen, I. Huhtaniemi and JR.
Drevet
"Epididymal expression of the mouse GPX5 protein: analysis of the mechanisms of its
tissue- and region-specific expression through in vitro and in vivo approaches"
(2003) in BT. Hinton & T. Turner (Eds)
34* S. Herbette, C. Lenne, D. Tourvieille de Labrouhe, JR. Drevet and P. Roeckel-
Drevet
"Transcripts of sunflower antioxidant scavengers of the SOD and GPX families
accumulate differentially in response to downy mildew infection, phytohormones,
reactive oxygen species, nitric oxide, protein kinase and phosphatase inhibitors."
(2003) Physiologia Plantarum., 119:418-428.
35 * T.G. Cooper, A. Wagenfeld, G. Cornwall, N. Hsia, S.T. Chu, M-C. Orgebin-
Crist, P. Vernet, JR. Drevet, C. Avram, E. Nieschlag and C-H. Yeung.
"Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice."
(2003). Biol.Reprod., 69(5):1750-1762.
36* P. Vernet, J. Aitken and JR. Drevet.
"Antioxidant strategies in the epididymis"
(2004) Mol. Cell. Endocrinol., 216:31-39.
37*K. Suzuki, JR. Drevet, B.T. Hinton, I. Huhtaniemi, J-J.Lareyre, R.J. Matusik,
E. Pons, M. Poutanen, P. Sipilä and M-C. Orgebin-Crist1,3*
"Epididymis-specific promoter driven gene targeting:a new approach to control
epididymal function. "
(2004) Mol. Cell. Endocrinol., 216:15-22.
38 *H. Rejraji and JR. Drevet.
"Sécrétions apocrines dans le tractus génital mâle: rôles potentiels dans la maturation
des gamètes. "
(2004). Andrologie, 14, 22-33.
39 * S. Herbette, N. Brunel, G. Prensier, JL. Julien, JR. Drevet and P. Roeckel-
Drevet.
Immunolocalization of a plant glutathione peroxidase-like protein.
(2004), Planta,219:784-789.
40 * JR. Drevet
Contraception épididymaire : états des recherches et perspectives.
(2004), Andrologie , 14(2):171-185.
41* A. Britan, J-J. Lareyre, A.M. Lefrançois-Martinez, M. Manin, V. Schwaab, V.
Greifeuille and JR. Drevet.
Spontaneously immortalized epithelial cells from mouse caput epididymidis.
(2004) Mol. Cell.Endocr., 224:41-53.
42 * J-M. Frenoux* P. Vernet*, A. Britan, D. Volle, F. Saez, A. Kocer, J. Henry-
Berger , D. Mangelsdorf, J-M. Lobacarro and JR. Drevet
"Nuclear oxysterol receptors, LXR, are involved in the maintenance of caput
epididymidis structure and functions.
(2004) J. Mol. Endocr, , 33:361-375.
43* P. Vernet, A. Britan, A. Mazur, E. Gueux and JR. Drevet
"Dietary magnesium depletion does not promote oxidative stress but targets apical cells
within the mouse caput epididymidis."
(2004) Biochemica Biophysica Acta, 1675:32-45.
44* DH. Volle, JM. Frenoux, K. Mouzat, P. Vernet, M. Prodhomme, A. Britan, F.
Saez, J. Henry-Berger, A. Kocer, F. Caira, G. Veyssiere, JR. Drevet* & JM.
Lobaccaro*.
*contributions égales
"Rôle des récepteurs nucléaires des oxystérols LXR dans la régulation de l’homéostasie du cholestérol au niveau de l’appareil reproducteur mâle"
(2005) Andrologie, 15: 10-21.
45* P. Vernet & JR. Drevet
"Stratégies antioxydantes dans l’épididyme des mammifères"
(2005) Andrologie, 15:22-30.
46 * E. Grignard, J. Morin, P. Vernet & JR. Drevet .
GPX5 orthologs of the mouse epididymis-restricted and sperm-bound selenium-
independent glutathione peroxidase are not expressed with the same quantitative and
spatial characteristics in large domestic animals.
(2005) Theriogenology, 64:1016-1033..
47 * S. Herbette, A. Le Menn, T. Ameglio, Z. Faltin, G. Branlard, Y. Eshdat, JL.
Julien, JR. Drevet and P. Roeckel-Drevet
«Modification of photosynthetic regulation in tomato overexpressing glutathione
peroxidase.»
(2005) B.B.A., 1724:108-118.
48 * JR. Drevet
«The antioxidant glutathione peroxidase family and spermatozoa: a complex story.»
(2006) Mol. Cell. Endocrinol., .250:70-79.
49 * A. Britan and J.R. Drevet.
«Régulation des fonctions de l’épithélium épididymaire: état des lieux.»
(2006) Andrologie, 17: 197-217.
50 * A. Britan, V. Maffre, S. Tone and JR. Drevet.
“Quantitative and spatial differences in the expression of tryptophan-metabolizing
enzymes in mouse epididymis.
(2006) Cell Tissue Res., 324:301-310.
51. A. Kocer, F. Saez, K. Mouzat, P. Vernet, JMA Lobaccaro, JR. Drevet.
Criblage de nouveaux genes cibles des récepteurs aux oxystérols LXRs impliqués dans le
maintien de l’épithélium épididymaire et la maturation des spermatozoids dans
l’épididyme.
(2006) Andrologie 17:11-23.
52. H. Rejraji, B. Sion, G. prensier, M. Carreras, C. Motta, JM. Frenoux, E. Vericel, G.
Grizard, P. Vernet, and JR. Drevet.
Lipid remodeling of murine epididymosomes and spermatozoa during epididymal
maturation.
(2006) Biology of Reproduction, 74:1104-1113.
53 * S. Herbette, P. Roeckel-Drevet and J.R. Drevet.
“Seleno-independent glutathione peroxidases: more than simple antioxidant scavengers”.
(2007) FEBS J., 274:2163-2180.
54 * E. Grignard, R. Cadet, F. Saez, J.R. Drevet and P. Vernet.
“Identification of sperm antigens as a first step towards the generation of a contraceptive
vaccine to decrease fossorial water vole Arvicola terrestris Scherman proliferations”
(2007) Theriogenology, 68:779-795.
55 * F. Saez, E. Chabory, R. Cadet, P. Vernet, S. Baron, J.M.A. Lobaccaro and J.R.
Drevet.
“Liver X receptors and epididymal epithelium physiology”
(2007) Asian Journal of Andrology., 9:574-582.
56 * F. Saez, A. Ouvrier, B. Laillet, R. Cadet, P. Vernet, B. Sion, J.M.A. Lobaccaroand
J.R. Drevet.
“Les «Liver X receptors» (LXRs) et le métabolisme lipidique dans l’épididyme murin”
(2007) Andrologie,17: 201-211.
57 *S. Tone, A. Britan, A. Jrad, V. Maffre and JR. Drevet
“The mouse epididymis : a site of strong and constitutive expression of the tryptophan
indoleamine 2,3-dioxygenase (IDO).”
(2007) Int. Cong. Series.,.in press
58 * T. Zhang, E. Chabory, A. Britan, E. Grignard, O. Pitiot, F. Saez, R. Cadet, J. Henry-
Berger, P. Vernet, J.R. Drevet.
GPX5, the selenium-independent glutathione peroxidase encoding single copy gene is differentially expressed in the mouse epididymis.
(2008) Reprod. Fertil. Dev., 20:615-625.
59 * J. Drevet, E. Chabory and P. Vernet.
Epididymal glutathione peroxydase 5 contributes to the maintenance of sperm DNA integrity and to embryo viability.
(2009) Systems Biology in Reproductive Medicine, 55:38.
60 * H. Rejraji, Saez F. and Drevet JR.
Evolution de la composante lipidique de la membrane plasmique des spermatozoides durant la maturation épididymaire.
(2009) Andrologie, 1:1-12.
61 * E. Chabory, C. Damon, A. Lenoir, G. Kauzelmann, H. Kern, B. Zevnik, C. Garrel, F.
Saez, R. Cadet, J. Henry-Berger, M. Schoor, U. Gottwald, U. Habenicht, JR. Drevet*,
P. Vernet. .*corresponding author.
Epididymis seleno-independent glutathione peroxidase 5 (GPx5) contributes to the maintenance of sperm DNA integrity
(2009)J. Clin. Invest.,119: 2074-2085.
62* A. Ouvrier, R. Cadet, P. Vernet, B. Laillet, J.M. Chardigny, J.M.A. Lobaccaro, J.R. Drevet*, F. Saez. .*corresponding author
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell specific manner.
(2009) J. Lipid. Res., 50:1766-1775.
63 * Ouvrier A., Cadet R., Lobaccaro JM., Drevet JR*, F. Saez.*corresponding author.
LXR regulate cholesterol homeostasis in the proximal mouse epididymis.
(2009)Folia Histochemica et Cytobiologica,47(5):75-79.
64 * E. Chabory, C. Damon, A. Lenoir, J. Henry-Berger, P. Vernet, R. Cadet, F. Saez, JR. Drevet.
Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity.
(2010).J. Anim. Sci., 88(4):1321-1331.
65 * F. Saez, A. Ouvrier, JR. Drevet.
Epididymis cholesterol homeostasis and sperm fertilizing ability.
(2011).As. J. Androl., 13(1):11-17.
66 * S. Herbette, Denis Tourvieille de Labrouhe, JR. Drevet, P. Roeckel-Drevet.Transgenic tomatoes showing higher glutathione peroxydase antioxidant activity are more resistant to an abiotic stress but more susceptible to biotic stresses.
(2011).Plant Science, 180:548-553.
67 * A. Jrad-Lamine, J. Henry-Berger, P. Gourbeyre, C. Damon-Soubeyrand, A. Lenoir, L. Combaret, F. Saez, A. Kocer, S. Tone, D. Fuchs, W. Zhu, P.J. Oefner, D.H. Munn, A.L. Mellor, N. Gharbi, R. Cadet,R.J. Aitken, J.R. Drevet.
Deficient-tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.
(2011). J. Biol. Chem.,286(10):8030-8042.
68 * F. El-Hajjaji, A. Oumeddour, AJC. Pommier, A. Ouvrier, E. Viennois, J. Dufour, F. Caira, JR. Drevet, D.H. Volle, S. Baron, F. Saez, JMA. Lobaccaro.
Lipid, liver X receptors and male disorders.
(2011).B.B.A. Molecular Basis of diseases,doi:10.1016/j.bbadis.2011.02.004.
69 * A. Noblanc, A. Kocer, E. Chabory, P. Vernet, F. Saez, R. Cadet, M. Conrad, J.R. Drevet.
Glutathione peroxidases (GPx) at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.
(2011).J. Androl.,in press.