Bromberg
Is a “vanishing tumor” always a lymphoma ?
Bromberg et al.
Data Supplement
Table (E) T-2. Previously published patients with a vanishing tumor
ref. / patientsex, age / presentation / site / diagnosis
(initial/recurr.) / treatment
(initial/recurr.) / recurrence
(mths) / survival
(mths)
1 / m 20 / seizure / mult. bilat. / hemangioma / - / nr / nr
2 / m 59 / cognitive changes / frontal / PCNL / steroids / 18
3 / f 58
f 49
f 54
f 57 / fatigue, cons
ataxia, vertigo
paresis, headache
dysarthria, sens / hypothal.
pons
int. caps
parietal / infl./PCNL
infl./PCNL
infl./PCNL
infl./PCNL / steroids
steroids
steroids
steroids / 7
11
8
9 / nr
nr
nr
nr
4 / f 30
f 47 / paresis
diplopia / cerebellum
cerebellum / -/ PCNL
-/ PCNL / none/ RTX
none / RTX / 48
21 / 72
nr
5 / f 20 / ataxia, diplopia, cogn. / wall 2nd+3rd ventricle / - / infl /PCNL / steroids/CTX+RTX / 60, 24, 12 / 96
6 / m 63 / speech, gait / frontal / - / PCNL / steroids / RTX / 30 / 46
7 / f 53 / pers.changes, cogn. / bifrontal / infl / PCNL / steroids / 1 / 2
8 / f 38 / menstr., headache, wt / hypoth,bas. / sarcoidosis / steroids / nr / nr
9 / m 58
f 54 / paresis, aphasia
paresis, aphasia / frontotemp
parietal / infl. / PCNL
infl. / PCNL / steroids / RTX
steroids / RTX / 0,5
2 / nr
nr
10 / f 58 / vision, headache / opt. chiasm / infl. / PCNL / steroids / RTX / 4 / >10
11 / m 75 / “dizzy”, cogn. / occipital / plex.papill. ?
PCNL ? / steroids / 2, 12 / 14
12 / f 55 / paresis / hemisfere / PCNL / steroids / none / 9, 3 / nr
13 / m 61 / gait dist, vertigo / cerebr ped. / - / PCNL / steroids / none/ RTX / 54, 15, 3, 1 / nr
14 / f 32 / paresis,dysarthria / frontopar,occ. / MS / none / nr / nr
15 / m 21 / polydipsia, polyuria / 3rd ventr. / germinoma / none / 4 / nr
16 / 27 pts aged
8 –77
f 57 / nr / hemisfere white matter
frontal / inflammatory
changes
PCNL / nr / 10 / nr
17 / f 51 / headache, diplopia / corp. call. / PCNL / steroids / RTX / nr / nr
18 / m 54 / paresis, cons / thalamus / PCNL / steroids / RTX / nr / nr
19 / f 46 / gait + speech dist / front, bas. / - / PCNL / none/steroids + RTX / 14 / 27
20 / f 44
m 10 / malaise, vomiting
headache, nausea, cons / frontal
frontopar / PCNL
PCNL / steroids
steroids / 1
mult / nr
> 24
21 / f 36 / gait, cran. nerves / brainstem / infl. (ADEM) / steroids / nr / > 18
22 / f 57 / hemiparesis / parietal / renal ca. metast / steroids / nr / nr
23 / f 70 / cogn dist, ataxia / frontal / PCNL / steroids / 2 / 5
24 / f 25 / headache, paresis / thal/int caps / infl. / PCNL / steroids/CTX + RTX / 48 / > 66
25 / f 73 / seizures, paresis / parietal / - / PCNL / steroids / RTX / 18 / > 42
26 / m 29 / seizures / temporal / sarcoidosis / steroids / - / nr
27 / m 38 / visual, cogn dist / pituitary / prolactinoma / - / nr / nr
28 / f 56 / paresis / frontal / PCNL / - / steroids / RTX / 13, 2 / nr
29 / m 50 / ataxia, nystagmus / 3+4 ventr. / PCNL (CSF) / steroids/RTX+CTX / 14,12,10,2 / 54
30 / f 52 / ataxia,fatigue,vomiting / multifoc / PCNL / steroids / 4, 3 / 8
31 / m 25 / diplopia, gait dist / vermis / infl. / PCNL / steroids / 29, 6, 3 / 39
32 / f 63 / seizures, paresis / front + par / PCNL / - / RTX + CTX / 5 / nr
33 / m 44 / extrapyramidal syndr / bas + front / PCNL / steroids / - / 3 / nr
34 / f 59 / vertigo, ataxia / peri 2+4 vent / PCNL / steroids / 14,7,6 / 28
35 / m 59 / paresis, cons / parietal / infl/PCNL(pm) / steroids / 4 / 6
36 / f 39
f 25 / menstrual dist, galact.
menstrual dist, galact / sella
pituitary / prolactinoma
prolactinoma / -
- / -
- / nr
nr
37 / f 69
f 69
f 60 / pers.changes, gait
paresis, cogn
cogn, cons,seizures / bifrontal
intcaps/caud
mult parietal / PCNL (pm)
PCNL (pm)
PCNL / -
-
- / steroids + RTX / 4
3
4 / 4
3
> 48
38 / m 34
m 55 / cogn, cran. nerve
cogn, paresis / suprasel,caud
thal, striatum / infl/PCNL(pm)
infl/PCNL / - / steroids
- / steroids/RTX / mult
7,1 / 84
nr
39 / m 19 / paresis / frontoparietal / MS / ADEM / steroids / 1 / nr
40 / m 76
f 56 / dysarthria, paresis
headache, vomiting / parietal
pons, parietal / PCNL
-/PCNL (CSF) / steroids / RTX
steroids+ RTX+CTX / -
38 / > 33
> 65
Legend: nr = not reported; cogn = cognitive symptoms; cons=decreased consciousness; sens = sensory symptoms or signs; infl = inflammatory changes; RTX = radiotherapy; CT:N= CT normal; CTX=chemotherapy; pers = personality changes; menstr=menstrual disturbances; wt=weightgain;
hypoth = hypothalamus; bas=basal ganglia; cerebr ped=cerebral peduncle; corp call=corpus callosum;
peri 2+4 ventr=periventricularly at 4th and lateral ventricles; (CSF)=diagnosis based on CSF analysis; (pm)=post mortem diagnosis; suprasel=suprasellar; caud=caudate nucleus.
References to Table (E) T-2
1. Abe M, Tabuchi K, Takagi M, Matsumoto S, Shimokama T, Kishikawa T. Spontaneous resolution of multiple hemangiomas of the brain. Case report. J Neurosurg 1990; 73(3):448-452.
2. Aki T, Nakamura T, Ichikizaki K, Iwata T, Toya S, Nakano S. [A case of primary malignant lymphoma of the brain which showed a remarkable response to prednisolone]. No To Shinkei 1982; 34(10):965-971.
3. Alderson L, Fetell MR, Sisti M, Hochberg F, Cohen M, Louis DN. Sentinel lesions of primary CNS lymphoma. J Neurol Neurosurg Psychiatry 1996; 60(1):102-105.
4. Al Yamany M, Lozano A, Nag S, Laperriere N, Bernstein M. Spontaneous remission of primary central nervous system lymphoma: report of 3 cases and discussion of pathophysiology. J Neurooncol 1999; 42(2):151-159.
5. Bender GP, Schapiro RT. Primary CNS lymphoma presenting as multiple sclerosis. A case study. Minn Med 1989; 72(3):157-160.
6. van den Bent MJ, Vanneste JA, Ansink BJ. Prolonged remission of primary central nervous system lymphoma after discontinuation of steroid therapy. J Neurooncol 1992; 13(3):257-259.
7. Coca A, Goday A, Font J, Ingelmo M, Balcells A. Primary cerebral lymphoma: the "ghost tumor". J Neurosurg 1984; 61(1):202-203.
8. Gizzi MS, Lidov M, Rosenbaum D. Neurosarcoidosis presenting as a tumour of the basal ganglia and brainstem: sequential MRI. Neurol Res 1993; 15(2):93-96.
9. Geppert M, Ostertag CB, Seitz G, Kiessling M. Glucocorticoid therapy obscures the diagnosis of cerebral lymphoma. Acta Neuropathol (Berl) 1990; 80(6):629-634.
10. Gray RS, Abrahams JJ, Hufnagel TJ, Kim JH, Lesser RL, Spencer DD. Ghost-cell tumor of the optic chiasm. Primary CNS lymphoma. J Clin Neuroophthalmol 1989; 9(2):98-104.
11. Heckmann JG, Bockhorn J, Stolte M, Druschky A, Neundorfer B. An instructive false diagnosis: steroid-induced complete remission of a CNS tumor--probably lymphoma. Neurosurg Rev 1998; 21(1):48-51.
12. Heinzlef O, Poisson M, Delattre JY. [Spontaneous regression of primary cerebral lymphoma]. Rev Neurol (Paris) 1996; 152(2):135-138.
13. Herrlinger U, Schabet M, Eichhorn M, Petersen D, Grote EH, Meyermann R et al. Prolonged corticosteroid-induced remission in primary central nervous system lymphoma: report of a case and review of the literature. Eur Neurol 1996; 36(4):241-243.
14. Hyman RA, Blankfein RJ, Pitman ER, Naidich JB, McGeachie RE. Computed tomography: regression of periventricular enhancing lesions in multiple sclerosis. Comput Tomogr 1979; 3(2):93-96.
15. Ide M, Jimbo M, Yamamoto M, Hagiwara S, Aiba M, Kubo O. Spontaneous regression of primary intracranial germinoma. A case report. Cancer 1997; 79(3):558-563.
16. Kepes JJ. Large focal tumor-like demyelinating lesions of the brain: intermediate entity between multiple sclerosis and acute disseminated encephalomyelitis? A study of 31 patients. Ann Neurol 1993; 33(1):18-27.
17. Kikuchi K, Watanabe K, Miura S, Kowada M. Steroid-induced regression of primary malignant lymphoma of the brain. Surg Neurol 1986; 26(3):291-296.
18. Kobayashi S, Kojo N, Yoshida M, Katayama M, Harada K, Watanabe M et al. [Primary malignant lymphoma of the brain with marked size reduction by administration of prednisolone. Case report]. Neurol Med Chir (Tokyo) 1985; 25(2):125-130.
19. Kojo N, Tokutomi T, Eguchi G, Takagi S, Matsumoto T, Sasaguri Y et al. [Spontaneous regression of intracranial malignant lymphoma. Case report]. Neurol Med Chir (Tokyo) 1988; 28(5):498-503.
20. McKinstry CS, Worthington BS, Lewis PD, Lowe J. Primary intracranial lymphoma. An important differential diagnosis in magnetic resonance imaging of the brain. Acta Radiol Suppl 1986; 369:147-150.
21. Miller DH, Scaravilli F, Thomas DC, Harvey P, Hirsch NP. Acute disseminated encephalomyelitis presenting as a solitary brainstem mass. J Neurol Neurosurg Psychiatry 1993; 56(8):920-922.
22. Omland H, Fossa SD. Spontaneous regression of cerebral and pulmonary metastases in renal cell carcinoma. Scand J Urol Nephrol 1989; 23(2):159-160.
23. Pamphlett R, Dunne JW. Familial visual loss and a vanishing brain tumour. Med J Aust 1985; 143(2):72-76.
24. Pirotte B, Levivier M, Goldman S, Brucher JM, Brotchi J, Hildebrand J. Glucocorticoid-induced long-term remission in primary cerebral lymphoma: case report and review of the literature. J Neurooncol 1997; 32(1):63-69.
25. Pohl P, Oberhuber G, Dietze O, Vogl G, Pallua AK, Plangger CA et al. Steroid-induced complete remission in a case of primary cerebral non-Hodgkin's lymphoma. Clin Neurol Neurosurg 1989; 91(3):247-250.
26. Powers WJ, Miller EM. Sarcoidosis mimicking glioma: case report and review of intracranial sarcoid mass lesions. Neurology 1981; 31(7):907-910.
27. Rainov NG, Burkert W. Spontaneous shrinking of a macroprolactinoma. Neurochirurgia (Stuttg) 1993; 36(1):17-19.
28. Rubin M, Libman I, Brisson ML, Goldenberg M, Brem S. Spontaneous temporary remission in primary CNS lymphoma. Can J Neurol Sci 1987; 14(2):175-177.
29. Ruff RL, Petito CK, Rawlinson DG. Primary cerebral lymphoma mimicking multiple sclerosis. Arch Neurol 1979; 36(9):598.
30. Scully RE, Mark EJ, McNeely WF, Ebeling SH, Phillips LD. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-1997. A 74-year-old man with progressive cough, dyspnea, and pleural thickening. N Engl J Med 1997; 336(26):1895-1903.
31. Singh A, Strobos RJ, Singh BM, Rothballer AB, Reddy V, Puljic S et al. Steroid-induced remissions in CNS lymphoma. Neurology 1982; 32(11):1267-1271.
32. Sugita Y, Shigemori M, Yuge T, Iryo O, Kuramoto S, Nakamura Y et al. Spontaneous regression of primary malignant intracranial lymphoma. Surg Neurol 1988; 30(2):148-152.
33. Suzuki T, Yamamoto M, Saitoh M, Aoki A, Imai H, Narabayashi H. [A case of intracranial malignant lymphoma with pure akinesia and repeated regression on CT scans]. No To Shinkei 1984; 36(7):689-696.
34. Todd FD, Miller CA, Yates AJ, Mervis LJ. Steroid-induced remission in primary malignant lymphoma of the central nervous system. Surg Neurol 1986; 26(1):79-84.
35. Vaquero J, Martinez R, Rossi E, Lopez R. Primary cerebral lymphoma: the "ghost tumor". Case report. J Neurosurg 1984; 60(1):174-176.
36. Vaughn TC, Haney AF, Wiebe RH, Kramer RS, Hammond CB. Spontaneous regression of prolactin-producing pituitary adenomas. Am J Obstet Gynecol 1980; 136(8):980-982.
37. Weingarten KL, Zimmerman RD, Leeds NE. Spontaneous regression of intracerebral lymphoma. Radiology 1983; 149(3):721-724.
38. Williams RS, Crowell RM, Fisher CM, Davis K, Lavyne MH, Ropper AH et al. Clinical and radiologic remission in reticulum cell sarcoma of the brain. Arch Neurol 1979; 36(4):206-210.
39. Youl BD, Kermode AG, Thompson AJ, Revesz T, Scaravilli F, Barnard RO et al. Destructive lesions in demyelinating disease. J Neurol Neurosurg Psychiatry 1991; 54(4):288-292.
40. Yamasaki T, Kikuchi H, Yamashita J, Moritake K, Shibamoto Y, Paine JT et al. Intracerebral malignant lymphoma with fluctuating regression and spatial evolution. Surg Neurol 1990; 34(4):235-244.
1