Supplementary data

Table 1. Key genes involved in lactation that are differentially expressed in murine mammary explants cultured with IFP.

Gene symbol / Gene description / Fold change NH→IFP / Reference
Milk protein synthesis
Elf5 / E74-like factor 5 (ets domain transcription factor) / 10 / Oaks et al., 2006
Csns1 / casein alpha S1 / 10 / Rudolph et al., 2003; Naylor et al., 2005
Csn3 / casein kappa / 10 / Rudolph et al., 2003; Naylor et al., 2005
Csn2 / casein beta / 10 / Rudolph et al., 2003; Naylor et al., 2005
Csn1s2a / casein alpha S2-like A / 10 / Rudolph et al., 2003; Naylor et al., 2005
Lalba / lactalbumin, alpha- / 10 / Rudolph et al., 2003; Naylor et al., 2005
Wap / whey acidic protein / 10 / Rudolph et al., 2003; Naylor et al., 2005
Ltf / lactoferrin / 10 / Kirkpatrick et al., 1971
Stat5a / signal transducer and activator of transcription 5A / 2 / Wakao et a., 1992
Lipid synthesis and secretion
Spot14 / thyroid hormone responsive SPOT14 / 10 / Zhu et al., 2005
Btn1a1 / Butyrophilin, subfamily 1, member A1 / 10 / Ogg et al., 1996
Fabp3 / fatty acid binding protein 3, muscle and heart / 10 / Bansal and Medina, 1993
Aldoc / aldolase C, fructose-biphosphate / 3 / Naylor et al., 2005; Rudolph et al., 2003
Fasn / fatty acid synthase / 3 / Naylor et al., 2005
Mod1 / malic enzyme 1 / 3 / Ramanathan et al., 2007; Naylor et al., 2005
Acsl1 / acyl-CoA synthetase long-chain family member 1 / 3 / Rudolph et al,. 2007
Xdh / xanthene dehydrogenase / 2 / Mather and Keenan, 1998
Acly / ATP citrate lysate / 2 / Naylor et al., 2005, Ballard and Hanson, 1967
Scd1 / stearoyl-Coenzyme A desaturase 1 / 2 / Ramanathan et al., 2007
Mfge8 / milk fat globule-EGF factor 8 protein / 2 / Stubbs et al., 1990
Carbohydrate synthesis
Lalba / lactalbumin, alpha- / 10 / Naylor et al., 2005; Soulier et al., 1997; Brodbeck et al., 1967
St6gal (Siat1) / sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase) / 3 / Naylor et al., 2005: Dalziel, 2001
Gale / galactose-4-epimerase, UDP / 2 / Prestoz et al., 1998
Defense factors
Muc 1 / mucin 1, transmembrane / 10 / McAuley et al., 2007; McGuckin et al., 2007
Ltf / lactoferrin / 10 / Kirkpatrick et al., 1971
Saa1 / serum amyloid A 1 / 10 / Benditt et al., 1979
Lbp / lipopolysaccharide binding protein / 5 / Fierer et al., 2002; Jack et al., 1997
Extracellular matrix
Col9a1 / procollagen, type IX, alpha 1 / 10 / Rudolph et al., 2003
Expi / extracellular proteinase inhibitor / 10
Itga7 / integrin alpha 7 / 3
Lamb3 / laminin, beta 3 / 3 / Delcommenne and Streuli, 1995
Lama2 / laminin, alpha 2 / 2 / Delcommenne and Streuli, 1995
Spint2 / serine protease inhibitor, Kunitz type 2 / 3
Spint1 / serine protease inhibitor, Kunitz type 1 / 2
Mmp9 / matrix metallopeptidase 9 / -5
Mmp13 / matrix metallopeptidase 13 / -5
Mmp10 / matrix metallopeptidase 10 / -3
Mmp11 / matrix metallopeptidase 11 / -2
Mmp3 / matrix metallopeptidase 3 / -2
Tight junction closure
Cldn7 / claudin 7 / 5
Cldn3 / claudin 3 / 3 / Blanchard et al,. 2006; Ormandy et al., 2003
Cldn4 / claudin 4 / 2 / Blanchard et al,. 2006
Gene symbol / Gene description / Fold change NH→IFP / Reference
Molecular transporters
Kcnk1 / potassium channel, subfamily K, member 1 / 5 / Naylor et al., 2005
Slc39a8 / solute carrier family 39 (metal ion transporter), member 8 / 3 / Naylor et al., 2005
Slc34A2 / solute carrier family 34 (sodium phosphate), member 2 / 3 / Naylor et al., 2005; Ramanathan et al., 2007
Slc25a10 / solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 / 2 / Ramanathan et al., 2007
Signal transduction
Folr1 / folate receptor 1 / 10 / Naylor et al., 2005; Ramanathan et al., 1993
Col9a1 / procollagen, type IX, alpha 1 / 10 / Rudolph et al., 2003
Cidea / cell death-inducing DNA fragmentation factor, alpha subunit-like effector A / 10 / Naylor et al., 2005
Vdr / vitamin D (1,25- dihydroxyvitamin D3) receptor / 3 / Rudolph et al., 2003
GOs2 / G0/G1switch 2 / 2 / Naylor et al., 2005
Egln3 / EGl nine homolg 3 / 2 / Ramanathan et al., 2007
Sox4 / SRY-box containing gene 4 / -2 / Rudolph et al., 2003, Naylor et al., 2005
Smad1 / MAD homolog 1 / -2 / Rudolph et al., 2003
Tgfb1 / transforming growth factor beta 1 / -2 / Rudolph et al., 2003