INNATE IMMUNITY And

INNATE IMMUNITY and

INFECTIOUS DISEASES

INNATE IMMUNITYAND INFECTIOUS DISEASES

Course

(fromApril 10 to April 25, 2017)

This two and halfweek long course offers lectures on the players and on the mechanisms of the innate immune system and inflammation involved in the defense of the host againstpathogens. It alsooffers lectures on the new toolsallowing to study of the immune system.

After the discovery of phagocytosis, 135 yearsago by Elie Metchnikoff, innateimmunityunderwent a rebirthfollowing the discovery of the “pattern recognition receptors” awarded by the Nobel Prize in 2011.

The understanding of the mechanismsthat control infectiousinsults have been decipheredthese last years, and a preciserole of each of the playersisnowbetterunderstood.

Not onlyinnateimmunityiscommon to all animal species, but for thosewhichalso have at theirdisposal an adaptive immunity, the contribution of innateimmunityis a prerequisite for itsinvolvement.

Most recently, a memory in innate immune system has been described and contributes tobetterinnate and adaptive responses.

This course isaimed to offer the most up-dated information on the cellular and molecularplayers of innateimmunity, and on the mechanismsthat lead to the elimination of the pathogens, either of bacterial, viral, fungal or parasiticorigin.

Becauseinnateimmunityiscloselyintricatedwith inflammation, the involvement of innateimmunitywithdiseaseswillalsobeaddressed.

Finally, up-to date tools to study the innate immune system willbepresented

Co-directors

Jean-Marc CAVAILLON
Unit Cytokines & Inflammation
Institut Pasteur, Paris / Daniel SCOTT-ALGARA
Unit Cytokines & Inflammation
Institut Pasteur, Paris

Monday, 10 April

9:00 - 9:45WelcomeRegistrar’s office

General IntroductionJean-Marc Cavaillon & Daniel Scott-Algara

(Institut Pasteur, Paris)

Historical Background

9:45 - 10:30From miasma to bacteria & Once upon a time inflammationJean-Marc Cavaillon

(Institut Pasteur, Paris)

CELLULAR PLAYERS

10:45 - 12:00MacrophagesJean-Louis Mège

(Faculté de médecine Aix-Marseille)

13:45 - 15:00Neutrophils Margarita Hurtado

(Inserm, Faculté de Médecine, Bichat, Paris)

15:15 – 16:30NK cellsDaniel Scott-Algara

(Institut Pasteur, Paris)

16:45 – 18:00NKT cellsMaria Leite de Moraes

(Univ. Paris-Descartes, Paris)

Tuesday, 11April

9:00 - 10:15Innate lymphoid cellsGéraldEberl

(Institut Pasteur, Paris)

10:30 - 11:45T γ/δ cellsMarc Bonneville

(INserm, Université de Nantes)

13:45 - 15:00Th17 cellsXxxxXxxx

(xxx)

15:15 - 16:30Treg cellsLaurence Weiss

(AP-HP, Hôpital Pompidou, Paris)

16:45 - 18:00Dendritic cellsAnne Hosmalin

(Inserm, Paris)

Wednesday, 12 April

9:00 - 10:15Mast cellsSalah Mecheri

(Institut Pasteur, Paris)

MOLECULAR PLAYERS

10:30 - 12:00PAMPsJean-Marc Cavaillon

(Institut Pasteur, Paris)

14:00 - 15:30DAMPs (alarmins)Lionel Apetoh

(Inserm, UMR, Dijon)

15:45 - 17:15Innate Immunity in insectsBruno Lemaître

(Ecole polytechnique fédérale deLausanne)

Thursday, 13 April

9:00 - 10:30PRRs: TLRJean-Marc Cavaillon

(Institut Pasteur, Paris)

10:45 - 12:15PPRs: NLRCatherine Werts

(Institut Pasteur, Paris)

14:00 - 15:30PPRs: RLREliane Meurs

(Institut Pasteur, Paris)

15:45 - 17:15Scavenger receptorsFrancisco Lozano

(Hospital Clinic de Barcelona, Barcelone)

Friday, 14 April

9:00 - 10:30Complement system LoubkaRoumenina

(Inserm, Centre de recherche des Cordeliers, Paris)

10:45 - 12:15CytokinesJean-Marc Cavaillon

(Institut Pasteur, Paris)

14:00 - 15:30ChemokinesSofieStruyf

(University of Leuven, Leuven)

15:45 - 17:15Anti-microbial peptidesJean-Michel Sallenave

(Inserm, Hôpital Bichat, Paris)

Tuesday, 18 April

INTERACTIONS HOST - PATHOGENS

9:00 - 10:30Anti-infectious role of cytokines Jean-Marc Cavaillon

(Institut Pasteur, Paris)

10:45 - 12:15Mucosal innate immunityNadine Cerf-Bensussan

(Inserm, Institut Imagine, Paris)

14:00 - 15:30Innate immunity and viral infectionsDaniel Scott-Algara

(Institut Pasteur, Paris)

15:45 - 17:15Innate immunity and fungal infectionsOumaimaGranet

(Institut Pasteur, Paris)

Wednesday, 19 April

9:00 - 10:30Innate immunity and parasitic infectionsGerald Spaeth

(Institut Pasteur, Paris)

10:45 - 12:15Microbial strategies against the immune systemGeoffrey L. Smith

(University of Cambridge, Cambridge)

14:00 - 15:30Innate immunity and bacterial infectionsPhilippe Sansonetti

(Institut Pasteur, Paris)

REGULATION OF THE INNATE IMMUNE RESPONSE

15:45 - 17:15Epigenetic control of innate immune responseAlberto Mantovani

(IstitutoClinicoHumanitas, Milan)

Thursday, 20 April

9:00 - 10:30Nervous system regulation of immune responseMonique Lafon

(Institut Pasteur, Paris)

10:45 - 12:15Links between innate and adaptive immunityMatthew Albert

(Genentech / Institut Pasteur, Paris)

14:00 - 15:30Microbiota and immune systemIvo Bonneca

(Institut Pasteur, Paris)

15:45 - 17:15Resolution of inflammation by lipid mediatorsMauro Perretti

(Queen Mary University,London)

Friday, 21 April

9:00 - 10:30Evolutionary genetics of the human innate immune system Lluis Quintana-Murci

(Institut Pasteur, Paris)

10:45 - 12:15Innate immunity memoryJessica Quintin

(Institut Pasteur, Paris)

INNATE IMMUNITY, INFLAMMATION and DISEASES

14:00 - 15:30Sepsis & InflammationJean-Marc Cavaillon

(Institut Pasteur, Paris)

15:45 - 17:15Bowel diseasesMathias Chamaillard

(Institut Pasteur, Lille)

Monday, 24 April

9:00 - 10:30Lung inflammatory disorders LhousseineTouqui

(Institut Pasteur, Paris)

10:45 - 12:15Cancer: NK cells: from receptors to the cure of high riskLorenzo Moretta

leukemias(PediatricHospital Bambino Gesù, Rome)

STUDYING INNATE IMMUNE SYSTEM

14:00 - 15:30Parameters influencing the immune response and its study Jean-Marc Cavaillon

(Institut Pasteur, Paris)

15:45 - 17:15Visit of the Museum

Tuesday, 25 April

9:00 - 10:00Monitoring of immune cells in vivoPhilippe Bousso

(Institut Pasteur, Paris)

10:15 - 11:15Organs-on-chipsSamyGobaa

(Institut Pasteur, Paris)

11:30 - 12:30Single cell technology and High-throughput analysisFabrice Porcheray

andChristophe Vedrine

(Bioaster, Paris)

14:00 - 15:30EXAM

15:45 - 17:15EXAM

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INNATE IMMUNITYAND INFECTIOUS DISEASES Course

2016 - 2017

CO-DIRECTORS

Mr Jean-Marc CAVAILLON

Cytokines & Iflammation Unit,

Institut Pasteur Phone+33-(0)1 45 68 82 38

25-28, rue du Dr RouxEmail

75 724 Paris Cedex 15

France

Mr Daniel SCOTT-ALGARA

Cytokines & Iflammation Unit,

Institut Pasteur Phone+33-(0)1 45 68 82 13

25-28, rue du Dr RouxEmail

75 724 Paris Cedex 15

France

LECTURERS

Matthew Albert

Department of Cancer Immunology, Genentech

Immunobiology of Dendritic Cells Unit

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15FranceEmail

Lionel Apetoh

ERCTeam leader,

INSERM UMR866,

Centre Georges François Leclerc,

Université de Bourgogne, Dijon, FranceEmail

Ivo GompertsBonneca

UnitéBiologieetGénétique de la paroibactérienne

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15, FranceEmail

Marc Bonneville

INSERM U892
Centre de Recherche en Cancérologie Nantes - Angers
Institut de Biologie
9 quaiMoncousu
44035 Nantes Cedex 01, FranceEmail

Philippe Bousso

UnitéDynamique des réponses immunes

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Nadine Cerf-Bensussan

UMR_S1163 :Laboratoired'ImmunitéIntestinale

Unité de recherche : INSERM UMR_S1163

Institut Imagine - Université Paris Descartes

Laboratoired’ImmunitéIntestinale
24 boulevard du Montparnasse
75015 Paris, FranceEmail

Mathias Chamaillard

Nods-like receptors in infection and immunity

Center of Infection and Immunity of Lille

Institut Pasteur

1 Rue du Professeur Calmette,

59000Lille, FranceEmail

Mr Gerald Eberl

UnitéMicroenvironnementetImmunité

Départementd'Immunologie

Institut Pasteur,

25-28 rue du Docteur Roux

75724 Paris Cedex 15, FranceEmail

SamyGobaa

IRT Bioaster

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

OumaïmaGranet

Unit Cytokines & Inflammation

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Anne Hosmalin

Infection Immunity and Inflammation Department

and Antigen Presentation by Dendritic Cell Team

INSERM Unit 1016, UMR CNRS 8104, Paris-Descartes University
InstitutCochin
Bâtiment Gustave Roussy 8ème étage
27, rue du Faubourg Saint Jacques
75014 Paris,FranceEmail

Margarita Hurtado-Nedelec
Départementd'hématologieetd'immunologie

UF DysfonctionnementsImmunitaires

HUPNVS Bichat-Claude Bernard
48 rue Henri Huchard

75018 Paris, FranceEmail

Monique Lafon

UnitéNeuro-immunologievirale

DépartementVirologie

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Maria Leite-de-Moraes
INEM (Institut Necker EnfantsMalades) - INSERM U1151, CNRS UMR8253,

Univ. Paris Descartes
Necker Hospital
Hamburger Building – 5th Floor
149, rue de Sèvres
75015 Paris,FranceEmail

Bruno Lemaitre

Global Health Institute

EPFL-GHI-SV-UPLEM-Station 19

CH-1015 Lausanne,SwitzerlandEmail

Francesco Lozano

Institutd'InvestigacionsBiomèdiques August Pi iSunyer

Serveid'Immunologia, Hospital Clínic de Barcelona

Departament de Biologia Cellular, ImmunologiaiNeurociències,

Universitat de Barcelona,

08007 Barcelona,Spain Email

AlbertoMantovani,

Humanitas University

IstitutoClinicoHumanitas

Via Manzoni 56

20089 Rozzano, Milano, ItalyEmail

Salah Mécheri

Unit Biologie des Interactions Hôte-Parasite

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex, 15FranceEmail

Jean-Louis Mège

Laboratoired'Immunologie - Hôpital de la Conception

APHM Assistance PubliqueHôpitauxde Marseille,

Faculté de Médecine de Marseille, Aix-Marseille University,

Marseille, FranceEmail

Eliane F. Meurs

UnitéHépacivirus et ImmunitéInnée”

Institut Pasteur

28 rue du Docteur Roux

75724 Paris Cedex 15, FranceEmail

Lorenzo Moretta

Director, Immunology Area,

Director Dept Laboratories

Pediatric Hospital Bambino Gesù

Viale San Paolo, 15

00146 Rome,ItalyEmail

Mauro Perretti

Centre for Biochemical Pharmacology, The William Harvey Research Institute

Barts and The London School of Medicine and Dentistry

Queen Mary University of London

Charterhouse Square, London EC1M 6BQ, UKEmail

Fabrice Porcheray

IRT BIOASTER

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Lluis Quintana-Murci

Scientific Director Institut Pasteur

Head of Unit GénétiqueEvolutiveHumaine

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Jessica Quintin

UnitéImmunologie des infections fongiques

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

LoubkaRoumenina

Sorbonne Universités, Université Pierre et Marie Curie (UPMC)

Unité Mixte de Recherche en Santé (UMRS 1138),

Centre de Recherche des Cordeliers,

75006 Paris, FranceEmail

Jean-Michel Sallenave

Inserm, U1152, Hôpital Bichat,

andUniversité Paris-Diderot, Sorbonne Paris Cité,

46 Rue Henri Huchard,

75018 Paris, FranceEmail

Philippe Sansonetti

Collège de France &

UnitéPathogénieMicrobienneMoléculaire

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Geoffrey Smith

Department of Pathology,

University of Cambridge,

Tennis Court Road,

Cambridge CB2 1QP, UKEmail

Gerald Spaeth

UnitéParasitologiemoleculaireet Signalisation

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

SofieStruyf

Department of Microbiology and Immunology,

Rega Institute for Medical Research,

University of Leuven,

Minderbroedersstraat 10,

3000 Leuven, Belgium.Email

LhousseineTouqui

Département Infection etépidémiologie

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Christophe Vedrine

IRT Bioaster

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

Laurence Weiss

Unit of Clinical Immunology

HôpitalEuropéen Georges Pompidou
20rue Leblanc
75015Paris, FranceEmail

Catherine Werts

UnitéBiologieetGénétique de la paroibactérienne I

Institut Pasteur

25-28 rue du Docteur Roux

75724 Paris Cedex 15,FranceEmail

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