Supplemental Table II.Illustration of the variation in estimated glomerular filtration rate (eGFR) across different available GFR estimation equations.

Authors / GFR estimation equation / Example eGFR
Based on Cr 120 umol/L (or 1.25 mg/dL), Ht 156.3cm, Wt 37.9kg at 17.15 years.
Counahan et al,1976 [1] / eGFR = 0.43* height / serum Cr
Based on CKiD data [2] revised to: 0.413*(height in cm/Cr) / 53.8 mL/min/1.73m2
51.7 mL/min/1.73m2
Schwartz et al, 1987 [3] / eGFR = k * height / serum Cr
where k is a constant of proportionality
k values: infant (LBW, less than one year) 0.33, infant (term, less than 1 year) 0.45, child or adolescent girl 0.55 and adolescent boy 0.70. / 68.8 mL/min/1.73m2
Gonzales et al, 2007 [4] / Revised Schwartz based on a cohort of renal dysplasia children:
eGFR = k * height / serum Cr
k values: age 0-2 yrs 0.338, 2-13 yrs 0.333, males >13 yrs 0.347 and females >13 yrs 0.327 / 40.9 mL/min/1.73m2
Leger et al, 2002 [5] / eGFR = 0.641 * weight / serum Cr +16.063*height[m]2/ serum Cr
Based on CKiD data [2] revised to:
eGFR = 0.542*weight/serum Cr +9.948*height[m]2/serum Cr / 50.9 mL/min/1.73m2
35.9 mL/min/1.73m2
Revised Schwartz et al, 2009 [2] / based on CKiD cohort
eGFR = 39.1 (height [m]/Cr)*0.516 (1.8/ cystatin C [mg/L]) *0.294 (30/BUN [mg/dL]) * 0.169 (1.099 for men, 1 for women)*(height [m]/1.4)0.188 / Not calculated as Cystatin C level unknown
Modification of Diet in Renal Disease (MDRD) estimate [6] / eGFR = 186 * serumCr -1.154 * age-0.203 * 1.210 (if patient is black) * 0.742 (if female)
Note – May underestimate GFR by up to 29% in healthy subjects [7]. Not recommended for use in children in K/DOQI guidelines [6]. / 60.0 mL/min/1.73m2
Cystatin C based formula: Filler et al, 1999 [8] / eGFR = 91.62 (1/cystatin)1.123
Based on CKiD data [2] revised to:
66.22 (1/cystatin)0.777 / Not calculated as Cystatin C level unknown

Height in centimetres (cm) unless otherwise stated. Serum creatinine in mg/dL.

LBW – low birth weight

References

1.Counahan R, Chantler C, Ghazali S, Kirkwood B, Rose F, Barratt TM (1976) Estimation of glomerular filtration rate from plasma creatinine concentration in children. Arch Dis Child 51:875-878.

2.Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. Journal of the American Society of Nephrology : JASN 20:629-637.

3.Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 34:571-590.

4.Gonzalez Celedon C, Bitsori M, Tullus K (2007) Progression of chronic renal failure in children with dysplastic kidneys. Pediatr Nephrol 22:1014-1020.

5.Leger F, Bouissou F, Coulais Y, Tafani M, Chatelut E (2002) Estimation of glomerular filtration rate in children. Pediatr Nephrol 17:903-907.

6.National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Kidney Disease Outcome Quality Initiative. . Am J Kidney Dis 39:S1-246.

7.Rule AD, Larson TS, Bergstralh EJ, Slezak JM, Jacobsen SJ, Cosio FG (2004) Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease. Ann Intern Med 141:929-937.

8.Filler G, Priem F, Vollmer I, Gellermann J, Jung K (1999) Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate. Pediatr Nephrol 13:501-505.