Supplementary Table 1: Comparisons of Clinical Activity Indices, Quality of life Scores, and Inflammatory Makers with Endoscopic Activity Indices According to Age of Diagnosis
Disease Type
Crohn’s Disease / Ulcerative Colitis
Age of Diagnosis / HBI / SIBDQ / ESR (mm/hr) / CRP (mg/L) / SCCAI / SIBDQ / ESR (mm/hr) / CRP (mg/L)
≥60, n / 10 / 8 / 2 / 3 / 16 / 10 / 10 / 10
Spearman* Correlation with SES or Mayo respectively, rho (p-value) / 0.32 (0.37) / -0.57 (0.14) / N/A / 0.50 (1.00) / 0.58 (0.02) / -0.64 (0.05) / -0.18 (0.61) / 0.003 (0.99)
40-59, n / 29 / 25 / 18 / 17 / 38 / 29 / 26 / 26
Spearman* Correlation with SES or Mayo respectively, rho (p-value) / 0.21 (0.27) / -0.11 (0.59) / -0.10 (0.69) / 0.05 (0.84) / 0.48 (0.002) / -0.48 (0.009) / 0.32 (0.11) / 0.36 (0.07)
18-39, n* / 208 / 174 / 130 / 128 / 145 / 122 / 85 / 88
Spearman* Correlation with SES or Mayo respectively, rho (p-value) / 0.15 (0.03) / -0.13 (0.08) / 0.34
(<0.001) / 0.41 (<0.001) / 0.57 (<0.0001) / -0.56 (<0.0001) / 0.36 (<0.001) / 0.52 (<0.001)

Legend:

HBI: Harvey-Bradshaw Index

SCCAI: Simple Colitis Clinical Activity Index

SIBDQ: Short IBD Questionnaire

CRP: C-reactive Protein

ESR: Erythrocyte Sedimentation Rate

Supplementary Table 2: Comparisons of Clinical Activity Indices, Quality of life Scores, and Inflammatory Makers with Endoscopic Activity Index According to History of Surgery
Crohn’s Disease
Surgery / HBI / SIBDQ / CRP / ESR
No / 135 / 115 / 90 / 89
Spearman* Correlation with SES, rho (p-value) / 0.12 (0.17) / -0.08 (0.41) / 0.38 (<0.001) / 0.35 (<0.001)
Yes / 112 / 92 / 58 / 61
Spearman* Correlation with SES, rho (p-value) / 0.27 (0.004) / -0.28 (0.007) / 0.34 (0.009) / 0.21 (0.11)

Legend:

HBI: Harvey-Bradshaw Index

SIBDQ: Short IBD Questionnaire

CRP: C-reactive Protein

ESR: Erythrocyte Sedimentation Rate

Supplementary Table 3: Comparisons of Clinical Activity Indices, Quality of life Scores, and Inflammatory Makers with Endoscopic Activity Indices According toDuration of Disease
Disease Type
Crohn’s Disease / Ulcerative Colitis
Disease Duration / HBI / SIBDQ / CRP / ESR / SCCAI / SIBDQ / CRP / ESR
<10 years / 147 / 119 / 88 / 90 / 131 / 107 / 87 / 86
Spearman* Correlation with SES or Mayo respectively, rho (p-value) / 0.28 (<0.001) / -0.29 (0.001) / 0.41 (<0.001) / 0.32 (0.002) / 0.61 (<0.001) / -0.54 (<0.001) / 0.54 (<0.001) / 0.36 (<0.001)
≥10 years / 100 / 88 / 60 / 60 / 68 / 54 / 37 / 35
Spearman* Correlation with SES or Mayo respectively, rho (p-value) / 0.09 (0.36) / -0.02 (0.82) / 0.32 (0.01) / 0.30 (0.02) / 0.37 (0.002) / -0.55 (<0.001) / 0.31 (0.06) / 0.35 (0.04)

Legend:

HBI: Harvey-Bradshaw Index

SCCAI: Simple Colitis Clinical Activity Index

SIBDQ: Short IBD Questionnaire

CRP: C-reactive Protein

ESR: Erythrocyte Sedimentation Rate