Gomathi Ramanoudjame

SUMMARY

Over ten years of experience in research with experience in teaching for first year and second year masters students.

EDUCATION AND CREDENTIALS

Ph.D. in Organic Chemistry, from Annamalai University, India, May 2004

M.Phil. in Chemistry, from Annamalai University, India, Nov 2000

M.Sc. in Organic Chemistry, from Annamalai University, India, May 1999

B.Sc. in Chemistry, from Anna Adharsh College, University of Madras, India, May 1997

EXPERIENCE

  • Teaching Chemistry for first year and second year College students.
  • Total 10 years’ Experience in Research and Developmentin the field ofOrganic Chemistry.

EMPLOYMENT HISTORY

Organic Chemist, Department Of Biochemistry and Molecular Biology, The University Of Texas Medical Branch, Galveston, Texas - Jun 2008 - Mar 2012

  • Actively worked in a project of synthesis of novel polymers (to be patented) for use in two dimensional electrophoresis.
  • Extensive experience in organic synthesis in finding out a novel organic compound to be used in polymerization.
  • Accomplished monopolymer synthesis and identification through spectroscopic methods.
  • Application of the polymer onto glass plates to create a surface bonded initiator. Optimized the chemistry and the coating processes
  • Foundation coating procedures were established in capillaries to produce plates without endo-osmotic flow
  • The capping of the foundation coating eliminated the endo-osmotic flow and protein-foundation coating interaction.

Postdoctoral Fellow, Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston , Texas - May 2005 – July 2007

  • Worked on a class of membrane protein called glutamate receptors, which are the main excitatory neurotransmitter in the central nervous system.
  • FRET based probe was designed and developed in our lab to study the degree of cleft closure in the ligand-binding core of the glutamate receptors.
  • Have experience in Fourier transform infrared spectroscopy to monitor the changes in the ligand: protein interactions.
  • A set of mutants that exhibit a wide spectrum of activation were expressed in the bacterial cells and the contributions of specific ligand: protein interactions towards mediating conformational changes in the isolated LBD of the glutamate receptors were studied.
  • Worked on organic synthesisof fluorophores to be used in fluorescence resonance energy experiments.
  • Gained experience in making mutations, protein expression, western blot analysis, and gel analysis.

TeachingAssistant,Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India. - Jan 2001 – Oct 2003

  • Taught introduction to classes for first-year college students.
  • Conducted conferences with students for each major paper assignment.
  • Emphasized research as an on-going process of discovery and growth, encouraging students to see research and inquiry as activities central to daily life.
  • Teach students to conduct research and to critically evaluate the quality of sources.
  • Worked with a diverse population of students, including many international students.

PUBLICATIONS

Biochemistry.2008, Volume 47, Issue 37, Pages 9803-9810.Overexpression and functional characterization of the extracellular domain of the human alpha 1 glycine receptor.

Zhenyu Liu, Gomathi Ramanoudjame, Deqian Liu, Robert Fox, Vasanthi Jayaraman, Maria Kurnikova and Michael Cascio.

Biochemistry.2007, Volume 46, Issue 5, Pages 1343-1349.Role of the Chemical Interactions of the Agonist in Controlling -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Activation.

Kimberly A. Mankiewicz, Anu Rambhadran, Mei Du, Gomathi Ramanoudjame, and Vasanthi Jayaraman.

Proceedings of the National Academy of Sciences of the United States of America.2006, Volume 103, Number 27, Pages 10473-10478.Allosteric mechanism in AMPA receptors: a FRET-based investigation of conformational changes.Gomathi Ramanoudjame, Mei Du, Kimberly.A. Mankiewicz, and Vasanthi Jayaraman

Nature Chemical Biology.2005,Volume 1, Number 6, Pages 329-332.Evolution of glutamate interactions during binding to a glutamate receptor.Qing Cheng, Mei Du, Gomathi Ramanoudjame, and Vasanthi Jayaraman.

Magnetic Resonance in Chemistry.2005, Volume 43, Issue 5, Pages 430-434.Synthesis and NMR spectral study of some t (3)-aryl-r (2), c (4)-bisethoxycarbonyl-t (5)-hydroxy-c (5)-methylcyclohexanones.K. Pandiarajan, R. T. Sabapathy Mohan, R. Gomathi, and G. Muthukumaran.

PRESENTATIONS

  • Investigation of the mutant Y450F in glutamate receptor ligand binding site
  • Presentation at the Cell and Regulatory Biology meeting, Camp Allen, Texas, May 2005
  • Extend of cleft closure versus activation in AMPA receptors. ​
  • Poster presentation at 50th Biophysical Society Annual Meeting at Salt Lake city, Utah, Feb 2006.
  • Fluorescence resonance energy transfer to probe cleft closure in the ligand binding domain of the Glutamate receptors.
  • Presentation at the Cell and Regulatory Biology meeting, Texas, April 2006
  • Overexpression and functional characterization of a mutated form of the extracellular domain of human glycine α 1 subunit.
  • Poster presentation at 51st Biophysical Society Annual Meeting at Baltimore, Maryland, March 2007.

CERTIFICATIONS

Basic Safety in the Research and Clinical Laboratory Environment.

COMPUTER SKILLS

MS office Word, Excel and PowerPoint

TRAINING

Indira Gandhi Center for Atomic Research