Online Supplement

TABLE A1
Sibship structure of 164 Japanese families
Number in sibship / Number of such sibships / Number of people / Possible pairs per sibship / Total possible pairs
2 / 134 / 268 / 1 / 134
3 / 22 / 66 / 3 / 66
4 / 6 / 24 / 6 / 36
5 / 2 / 10 / 10 / 20
Total / 164 / 368 / - / 256
TABLE A2
Clinical characteristics of 368 Japanese subjects with type 2 diabetes
Men/Women / 180/188
Age at time of study (years) / 58.8 ± 10.1
Age at diagnosis (years) / 45.2 ± 10.9
Current BMI (kg/m2) / 23.0 ± 3.0
Maximum BMI (kg/m2) / 26.4 ± 3.8
HbA1c (%) / 7.7 ±1.7
Fasting plasma glucose (mg/dl) (n=248) / 151.5 ± 46.8
Fasting insulin (µU/ml) (n=161) / 8.0 ± 4.1
Fasting C-peptide (ng/ml) (n=61) / 1.4 ± 1.6

We have no information on the prevalence of smoking in these subjects or its possible effect on current or maximum BMI.

Data are mean ± SD

TABLE A3
Regions showing nominal evidence of linkage (P<0.05) with type 2 diabetes in other studies
Chr. / Location (cM) / Study (Reference)
2 / 169.9 / Indigenous Australians (1)
236.8 / Asian (Han Chinese) (2)
Asian (Japanese) (3)
4 / 104.9 / Asian (Han Chinese) (2)
Asian (Japanese American) (4)
5 / 114.8 / Asian (Japanese American) (4)
6 / 42.3 / Asian (Han Chinese) (2)
Asian (Japanese) (3)
8 / 15.3 / Oji-Cree Indians (5)
Caucasian (British) (6)
Caucasian (Askenzai Jewish) (7)
Asian (Japanese American) (4)
17 / 36.1 / Caucasian (British) (6)
Caucasian (Finnish, Botnia) (8)
21 / 48.0 / Caucasian (USA) (4)
TABLE A4
Multipoint linkage results of three genome wide scans for type 2 diabetes susceptibility genes in Japanese and regions showing nominal evidence of linkage (P<0.05)
Iwasaki et al. (this study)
(168 families, 256 ASPs) / Mori et al. (Ref. 3)
(159 families, 224 ASPs) / Ehm et al. (Ref. 4)
(18 families, 45 ASPs)
Chr. / Location
(cM) / LOD / Location
(cM) / LOD / Location
(cM) / LOD
1 / 29.9 / 0.77
57.1 / 1.53 / 67.9 / 0.80
141.4 / 1.01
2 / 29.3 / 0.66
64.6 / 0.99
143.7 / 1.58
169.6 / 0.99
236.8 / 0.81 / 233.9 / 1.68
3 / 102.0 / 1.03
216.7 / 1.38
4 / 104.9 / 0.79 / 120.0 / 0.93
5 / 52.9 / 0.82
114.1 / 0.67 / 102.5 / 0.98
179.6 / 1.61
6 / 42.2 / 0.69 / 23.8 / 1.52
7 / 10.3 / 1.80
1.77 / 0.97
8 / 15.3 / 0.73 / 16.6 / 1.75
93.3 / 0.62
127.2 / 0.64
9 / 5.6 / 1.01
136.5 / 1.40
10 / 46.6 / 1.28
133.1 / 1.06
11 / 54.2 / 3.08
131.6 / 0.71
12 / 0.0 / 0.68
13 / 16.9 / 0.79
71.0 / 0.60
15 / 7.0 / 0.62
42.7 / 2.19
17 / 36.1 / 0.67
1.20 / 0.95
20 / 66.2 / 1.67
97.3 / 0.70
21 / 48.0 / 1.92
X / 9.5 / 2.82
56.8 / 0.61
150.6 / 1.45

Iwasaki et al. and Mori et al. did not examine the X-chromosome for linkage with T2DM.

TABLE A5
Regions showing nominal evidence of linkage (P<0.05) with BMI and BMI-related traits in other studies
Chr. / Location (cM) / Study (Reference)
2 / 167.9 / Pima Indian/% Fat (9)
210.5 / Caucasian (USA)/visceral fat (10)
3 / 185.7 / Pima Indian/waist-to-thigh ratio (9)
Caucasian (USA)/BMI (11)
African-American/BMI (12)
5 / 131.9 / Caucasian (USA)/BMI (13)
7 / 7.4 / Asian/BMI (14)
Asian (Japanese)/BMI (3)
Caucasian (French)/BMI (15)
16 / 30.0 / Pima Indian/BMI (16)
17 / 47.8 / Mexican-American/BMI (14)
Caucasian (USA)/waist-to-hip ratio (11)

References for online supplement

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