from Erin Rumpke (internal) to Everyone:
hi all
from Jessica Mullen to Everyone:
hierin!
from Jessica Mullen to Everyone:
i have a question on the assignment when you get the chance
from Erin Rumpke (internal) to Everyone:
hi there, sorry i was multitasking
from Erin Rumpke (internal) to Everyone:
i wish it made a noise when someone entered the chat!
from Jessica Mullen to Everyone:
its ok no worries
from Jessica Mullen to Everyone:
yes that would be nice lol
from Erin Rumpke (internal) to Everyone:
what can i do for you jessica?
from Jessica Mullen to Everyone:
i am having trouble with part one question one
from Jessica Mullen to Everyone:
are u asking for characteristics like they penerate the skin, sexual contact and mother to fetus type deal
from Erin Rumpke (internal) to Everyone:
okay - ask yourself the question in a different way - why are normal infections cleared?
from Erin Rumpke (internal) to Everyone:
or HOW are normal infections cleared?
from Jessica Mullen to Everyone:
by draining out
from Jessica Mullen to Everyone:
or leaving the host
from Erin Rumpke (internal) to Everyone:
how about the immune system?
from Erin Rumpke (internal) to Everyone:
what properties of spirochetes allow them to evade immunity?
from Erin Rumpke (internal) to Everyone:
also, there is a specific characteristic of spirtochetal infection (stages of infection) that allows for persistance
from Jessica Mullen to Everyone:
hmmmim getting lost with this
from Erin Rumpke (internal) to Everyone:
the immune system clears infections normally, agreed?
from Jessica Mullen to Everyone:
yes
from Erin Rumpke (internal) to Everyone:
how?
from Jessica Mullen to Everyone:
imtryinmg to find that
from Erin Rumpke (internal) to Everyone:
you took immunology, so i know you know this :)
from Erin Rumpke (internal) to Everyone:
don't overthink it..
from Erin Rumpke (internal) to Everyone:
i'm just walking you through it.
from Erin Rumpke (internal) to Everyone:
what tools does the immune system use to clear infection?
from Jessica Mullen to Everyone:
antigens and antibodies?
from Erin Rumpke (internal) to Everyone:
yes! so to make antibodies that work they have to be directed against antigens that are reliably present, correct?
from Jessica Mullen to Everyone:
yes
from Erin Rumpke (internal) to Everyone:
When you examine relapsing fever, why does the fever reappear and disease restablish?
from Jessica Mullen to Everyone:
a new antigenic form appears
from Erin Rumpke (internal) to Everyone:
yes. there is also info in the lectures about how treponema and borrelia evade immunity.
from Erin Rumpke (internal) to Everyone:
these organisms also establish latent infection which allows them to persist
from Jessica Mullen to Everyone:
so the antibody response system reduces symptoms in the 3rd phase following a relaspse of the infection
from Erin Rumpke (internal) to Everyone:
What are you referring to specifically - relapsing fever? or all spirochetal infection?
from Jessica Mullen to Everyone:
spirochetal infection
from Jessica Mullen to Everyone:
is there a specific page in the book for this i am confusing myself
from Erin Rumpke (internal) to Everyone:
Did you look for the info on Treponema or Borrelia? Organisms exist differently during latency. they regulate protein expression during latency. It's in the lectures, look for it there.
from Erin Rumpke (internal) to Everyone:
Some down regulate protein expression, some change their surface antigens, etc.
from Erin Rumpke (internal) to Everyone:
the question is just looking for a very general response, nothing too specific
from Jessica Mullen to Everyone:
i thought this had to do with the phases
from Erin Rumpke (internal) to Everyone:
The question asks: . What key characteristics allow spirochetes to persist in their infected host for years, effectively evading the immune response? "
from Erin Rumpke (internal) to Everyone:
all of the ways that we've discussed are ways that they do this.
from Jessica Mullen to Everyone:
so antibodies and antigens are one?
from Erin Rumpke (internal) to Everyone:
antibodies and antigens are one way the immune system would try to clear them. You need to say why it can't.
from Jessica Mullen to Everyone:
okay thank you for your help i will reread again
from Erin Rumpke (internal) to Everyone:
Have you listened to the lectures?
from Jessica Mullen to Everyone:
yes
from Erin Rumpke (internal) to Everyone:
they are more helpful than the book:)
from Jessica Mullen to Everyone:
i have listened a few times and for some reason this question is confusing me
from Erin Rumpke (internal) to Everyone:
maybe step away from it for a bit and come back, i'll repost our chat notes too so that you can review them.
from Jessica Mullen to Everyone:
okay thanks again for the help have a good day!
from Erin Rumpke (internal) to Everyone:
you too Jessica, thanks for stopping in!