DESIGN OF MEDICATED DERMASTICKS FOR TOPICAL APPLICATION
M.PHARM DISSERTATION PROTOCOL
SUBMITTED TO
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
BANGALORE, KARNATAKA.
By
MOHD. MUNTASIB ALI KHAN
Under the Guidance of
Dr.K.PURUSHOTHAM RAO
M.Pharm., Ph.D.
DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
H.K.E.S’s MATOSHREE TARADEVI RAMPURE INSTITUTE OF PHARMACEUTICAL SCIENCES
SEDAM ROAD GULBARGA – 585105
2011-2012
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA
BANGALORE
ANNEXURE-II
PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION
1. / Name of the candidate(In block letters) / MOHD. MUNTASIB ALI KHAN
Permanent address / WARD NO.21, WEST KAKRALA
DISTRICT,BUDAUN-243637
UTTAR PRADESH
2. / Name of the institution / H.K.E.S’s MATOSHREE TARADEVI RAMPURE INSTITUTE OF PHARMACEUTICAL SCIENCES
SEDAM ROAD
GULBARGA – 585105
3. / Course of study and subjects / M.PHARM
(PHARMACEUTICAL TECHNOLOGY)
4. / Date of admission to the course / 23-12-2011
5. / Title of the topic / DESIGN OF MEDICATED DERMA STICKS FOR TOPICAL APPLICATION
6. / Brief resume of the intended work
/ 6.1 / Need for the study:
Ø The topical drug delivery systems available for the treatment have several disadvantages like greasiness, inconvenient to store and require applicator or use of fingertip, which may lead to contamination1.
Ø Therefore, it was found essential to find an alternative to counter all the above disadvantages effectively and hence in the present work, design of medicated derma sticks for topical application to act effectively.
Ø A few common examples of fungal and bacterial infections such like ringworm, erythema multiforme, contact dermatitis, furuncle, impetigo2.
/ 6.2 / Review of Literature :
A through literature survey has been carried out on the proposed topic and most prominent
Reference found are:
Ø Ketoconazole Derma Sticks For Topical Application3.
Ø Formulation and evaluation of topical drug delivery system of fluconazole4.
Ø Medicated dermasticks for the treatment of warts5.
Ø Derma Sticks Thickened Ointment, United State Patent Publication6.
Ø Medicated sticks, United State Patent 3,856,9317.
Ø Antifungal activity of Clotrimazole Derma Sticks for Topical Infection8.
6.3 / Objectives of the study :
Ø Design of new dosage form model.
Ø To provide better patient compliance.
Ø Convenience and comfortless.
Ø To provide economical dosage form.
Ø Self medication is possible.
Ø To avoid contamination while applying.
Ø Easy to store and transport.
7. / Materials and Methods1,3,8
7.1 / Materials:
Ø It is planned to prepare and use around five water in oil ointment bases reported in textbook of pharmaceutics.
Ø In the present work it is planned to study some selected topical antibacterial and antifungal drugs like: Miconazole, Fluconazole etc..
7.2 / Method:
It is planned to follow the present methodology with minor modifications in reported
oil in water bases.
Phase –I : Preparation of medicated sticks:
It is planned to prepare medicated sticks by following heating and congealing process, by varying concentrations of waxes present in the bases.
Phase -II : Charatecterization of prepared medicated sticks:
The prepared formulation will be subjected for various evaluation parameters like;
a) Drug content estimation.
b) Penetrometer test.
c) Thickness.
d) Weight variation.
e) IR & DTA.
f) TLC etc.
Phase –III: In vitro drug diffusion:
All the formulations prepared will be subjected for in-vitro drug release studies by diffusion method for a period of 3 hours using pre-hydrated cellophane membrane as drug barrier.
At various time intervals a 10 ml sample will be withdrawn and subjected for
amount of drug diffused using UV spectrophotometer.
Stability studies:
It is planned to study for 6 months by estimation of drug content in the prepared formulations for every 15 days time intervals.
7.3 / Does the study require any investigation or invervention to be conducted on patients or other humans or animals? If so please describe briefly
------Not under the plan of our work------
7.4 / Has ethical clearance have been obtained from your institution in case of 7.4?
------Not applicable------
8
8. / List of References:
1. Cooper and Gunn’s. Dispensing for pharmaceutical students. 12th ed. Chapter No. 13. Ointment, paste and Jellies. New Delhi: CBS. Publisher and Distributors; 2002: 192-211.
2. Harsh Mohan. Text book of pathology. 4th edition. Topic III, Inflammation, Healing and Infection, 2000: 167-176.
3. Rao Purushotham K, Venkateshwarlu P, Shashikala P, Saran SV, Ravindranath A, Sagare P, Ashok Kumar C, Anand C, Ketoconazole dermasticks for topical application. International journal of research in chemistry and environment. Vol.2, 2012; 255-259.
4. Purushotham Rao K, Prabhakar V, Ravindranath R, Prashant Sagare, and Venkateshwarlu. Design of medicated dermasticks for the treatment of warts. International journal of research in pharmacy and chemistry. 2011; 1(3): 637-640.
5. Kavitha K, Sivaramakrishnan M, Nalini CN and Nappinnai M. Formulation and evaluation of topical drug delivery systems of Fluconazole. Indian Drugs 2003; 40 (12): 720-23.
6. Lindahl A. Dermastick Thikened Ointment. United State Patent Application Publication. 2008/0089939 A1.
7. Fuchs P, Schopflin G. Medicated sticks, United State Patent 3,856,931; Berlin: (1974)
8. Purushotham Rao K, Ravinranath A, Ashok Kumar C, Saran SV, Shashikala P, Anand C. Design of clotrimazole derma sticks for the treatment of topical applications. International Journal of Science Innovations and Discoveries. 2011, 1(3), 327-334.
9. / Signature of candidate /
MOHD.MUNTASIB ALI KHAN
10. / Remarks of Guide /
The necessary facilities are available for this work.
11. / Name and designation of
(in block letters)
11.1 Guide /
Dr. K.PURUSHOTHAM RAO
M. Pharm., Ph.D
PROFESSOR
DEPT.OF PHARMCEUTICAL TECHNOLOGY
H.K.E.S’s COLLEGE OF PHARMACY
GULBARGA – 585105
11.2 Signature
12 / 12.1 Remarks of Chairman and Principal
12.2 Signature
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