Figure S1. Forest plot for UPDRS-II, UPDRS-III and adverse effect.
Figure S2. Results of direct, indirect and network comparisons according to UPDRS-II, UPDRS-III and Adverse Effect.
Table S1. Searching strategy of PubMed database
PubMedType / Searching Strategy
Disease / "Parkinson Disease"[Mesh] OR "Parkinson Disease"[tiab] OR "Idiopathic Parkinson's Disease"[tiab] OR "Lewy Body Parkinson Disease"[tiab] OR "Lewy Body Parkinson's Disease"[tiab] OR "Primary Parkinsonism"[tiab] OR "Parkinson's Disease"[tiab] OR "Idiopathic Parkinson Disease"[tiab] OR "Paralysis Agitans"[tiab]
Treatments / "Antidepressive Agents"[Mesh] OR "Antidepressive Agents"[tiab] OR "Antidepressant Drugs"[tiab] OR "Antidepressants"[tiab] OR "Thymoanaleptics"[tiab] OR "Thymoleptics"[tiab] OR Antidepressive treatments[tiab] OR depression[tiab]
"Antidepressive Agents, Tricyclic"[Mesh] OR Tricyclic Antidepressive Agents[tiab] OR “TCA”[tiab] OR “TCAs”[tiab] OR "Nortriptyline"[Mesh] OR “nortriptyline”[tiab] OR “sensoval”[tiab] OR “aventyl”[tiab] OR “pamelor”[tiab] OR “norpress”[tiab] OR “allegron”[tiab] OR “noritren”[tiab] OR “nortrilen”[tiab] OR “chlorpromazine”[tiab] OR “thorazine”[tiab] OR “largactil”[tiab] OR “G22355”[tiab] OR "Amitriptyline"[Mesh] OR “amitriptyline”[tiab] OR “elavil”[tiab] OR “butriptyline”[tiab] OR “clomipramine”[tiab] OR "Desipramine"[Mesh] OR “desipramine”[tiab] OR “dosulepin”[tiab] OR "Doxepin"[Mesh] OR “doxepin”[tiab] OR “imipramine”[tiab] OR “iprindole”[tiab] OR “lofepramine”[tiab] OR “protriptyline”[tiab] OR “trimipramine”[tiab]
"Serotonin Uptake Inhibitors"[Mesh] OR “selective serotonin reuptake inhibitors”[tiab] OR “SSRI” [tiab] OR “SSRIs”[tiab] OR "Fluoxetine"[Mesh] OR “fluoxetine”[tiab] OR "Paroxetine"[Mesh] OR “paroxetine”[tiab] OR "Citalopram"[Mesh] OR “citalopram”[tiab] OR "Sertraline"[Mesh] OR “sertraline”[tiab] OR “escitalopram”[tiab] OR “fluvoxamine”[tiab]
"Serotonin and Noradrenaline Reuptake Inhibitors"[Mesh] OR “SNRI”[tiab] OR “SNRIs”[tiab] OR “milnacipran”[tiab] OR “duloxetine”[tiab] OR “levomilnacipran”[tiab] OR “desvenlafaxine”[tiab] OR "Venlafaxine Hydrochloride"[Mesh] OR “venlafaxine”[tiab] OR "Atomoxetine Hydrochloride"[Mesh] OR “atomoxetine”[tiab] OR “nefazodone”[tiab]
"Dopamine Agonists"[Mesh] OR “DA”[tiab] OR “DAs”[tiab] OR "pramipexole" [Supplementary Concept] OR “pramipexole”[tiab] OR "Memantine"[Mesh] OR “memantine”[tiab] OR "Pergolide"[Mesh] OR “pergolide”[tiab] OR "ropinirole" [Supplementary Concept] OR “ropinirole”[tiab] OR "pardoprunox" [Supplementary Concept] OR “pardoprunox”[tiab] OR “aripiprazole”[tiab] OR “abilify”[tiab] OR “phencyclidine”[tiab] OR “quinpirole”[tiab] OR “salvinorin A”[tiab] OR “apomorphine”[tiab] OR "Bromocriptine"[Mesh] OR “bromocriptine”[tiab] OR “cabergoline”[tiab] OR “ciladopa”[tiab] OR “dihydrexidine”[tiab] OR “dinapsoline”[tiab] OR “doxanthrine”[tiab] OR "Lisuride"[Mesh] OR “lisuride”[tiab] OR "Piribedil"[Mesh] OR “piribedil”[tiab] OR “propylnorapomorphine”[tiab] OR “quinagolide”[tiab] OR "rotigotine" [Supplementary Concept] OR “rotigotine”[tiab] OR “roxindole”[tiab] OR “sumanirole”[tiab] OR "Levodopa"[Mesh] OR "Levodopa"[tiab]
"Monoamine Oxidase Inhibitors"[Mesh] OR “MAOI”[tiab] OR “MAOIs”[tiab] OR “MAOI-A”[tiab] OR “MAOI-B”[tiab] OR "Selegiline"[Mesh] OR “selegiline”[tiab] OR "rasagiline" [Supplementary Concept] OR “rasagiline”[tiab] OR “isocarboxazid”[tiab] OR “nialamide”[tiab] OR “phenelzine”[tiab] OR “hydracarbazine”[tiab] OR “tranylcypromine”[tiab] OR “bifemelane”[tiab] OR “m oclobemide”[tiab] OR “pirlindole”[tiab] OR “toloxatone”[tiab] OR “deprenyl”[tiab] OR "lazabemide" [Supplementary Concept] OR "lazabemide" [tiab]
Design / ((double* [tw] OR trebl* [tw] OR tripl* [tw]) AND (mask* [tw] OR blind* [tw])) OR randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized controlled trial[mh] OR randomized[tiab] OR placebo[tiab] OR clinical trials as topic[mh] OR controlled clinical trials as topic[mh] OR random allocation[mh] OR randomization[tiab] OR randomly allocated[tiab]