Program
Tuesday-May 21, 20138:00-20:00 / Registration
Wednesday–May 22, 2013
8:00-8:40 / Opening Ceremony- Introductory Remarks (Yuan Xiang Hall)
8:40-9:00 / Group Photographing
Session 1
Yuan Xiang Hall
Chairs: Lianfu Deng, Xu Cao
9:00-9:25 / IS-1 / Biomaterials and osseointegration
Kerong Dai / The Ninth People’s Hospital, Shanghai Jiao Tong University, CHINA
9:25-9:45 / IS-2 / Loading independent interactions of muscle and bone: potential synergy
Lynda Bonewald / University of Missouri-Kansas City, USA
9:45-10:05 / IS-3 / Intracellular calcium signaling in osteocytes: a mechano-transduction- mechano paradigm
X. Edward Guo / Columbia University, USA
10:05-10:25 / IS-4 / Cell and material interactions in an innovative bone scaffold incorporating osteopromotive and anti-adipogenicphytomolecule developed for bone defect repair in steroid-associated osteonecrosis
Ling Qin / The Chinese University of Hong Kong, CHINA
10:25-10:40 / Coffee break
Session 2
Yuan Xiang Hall
Chairs: Dengshun Miao, X. Edward Guo
10:40-11:00 / IS-5 / Mesenchymal stem cells in bone remodeling and osteoarthritis
Xu Cao / Johns Hopkins University, USA
11:00-11:20 / IS-6 / Regulation of cortical modeling by osteoblast/osteocyte connexin43
Roberto Civitelli / Washington University at St. Louis, USA
11:20-11:40 / IS-7 / New insights into bone strength in primary hyperparathyroidism
John Bilezikian / Columbia University, USA
11:40-12:00 / IS-8 / The early chronic kidney disease-mineral bone disorder (CKD-MBD) stimulates vascular calcification
Keith Hruska / Washington University at St. Louis, USA
12:00-13:30 / Lunch/ Satellite meeting / Poster exhibition
Concurrent Session 3 —Orthopaedic Biomechanics and Mechanobiology
Yuan Xiang Hall
Chairs: John Bilezikian, ZongpingLuo
13:30-13:39 / FT-1 / Stress-induced premature senescence of nucleus pulposuschondrocytes in human intervertebral disc degeneration
Yuntao Wang / ZhongdaHospital, Southeast University, CHINA
13:39-13:48 / FT-2 / Osteocyte-specific connexin43 transgenic mice decreases bone mass and the response to tibia loading
HuiyunXu / Northwestern PolytechnicalUnversity, CHINA
13:48-13:57 / FT-3 / 3D osteoblasticmechanotransduction in response to oscillatory fluid flow
Jun You / The PennsylvaniaStateUniversityCollege of Medicine, USA
13:57-14:06 / FT-4 / Mechanotransduction via functional interplay of integrins, connexinhemichannels, and signaling in osteocytes.
Jean X. Jiang / University of Texas Health Science Center, USA
14:06-14:26 / IS-9 / Nanomechanics and ultrastructural origins of bone fragility
Xiaodu Wang / University of Texas at San Antonio, USA
14:26-14:46 / IS-10 / Advanced medical imaging of the musculoskeletal system for research
John A. Carrino / Johns Hopkins Hospital, USA
14:46-15:06 / IS-11 / Biomechanical applications in orthopaedic implants research and development
Cheng-Kung Cheng / 1National Yangming University; 2Beihang University, CHINA
Concurrent Session 4 —Stem Cells
Fu Cui Hall
Chairs: Jiang Peng, Qin Shi
13:30-13:50 / IS-12 / Tendon stem cell mechanobiology and tendon repair
James H-C. Wang / University of Pittsburgh, USA
13:50-14:10 / IS-13 / Promoting fracture healing through systematic or local administration of allogeneicmesenchymal stem cells
Gang Li / The Chinese University of Hong Kong, CHINA
14:10-14:30 / IS-14 / Mesenchymal stem cells contribute to the growth and metastasis of osteosarcoma
Tingting Tang / Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, CHINA
14:30-14:39 / FT-5 / Functionally replicated bioimprint scaffold promotes tenomodulin expression of mesenchymal stem cells
Kelvin W.K.Yeung / The University of Hong Kong, CHINA
14:39-14:48 / FT-6 / Cartilage tissue engineering using oriented cartilage extracellular matrix-derive scaffold combined with chondrogenic-induced bone mesenchymal stem cells in vivo
ShuaijunJia / Xijing Hospital, The Fourth Military Medical University, CHINA
14:48-14:57 / FT-7 / Adiponectin mobilizes mesenchymal stem cells through a novel mechanism
QishengTu / TuftsUniversitySchool of Dental Medicine, USA
14:57-15:06 / FT-8 / The role of bmpria in regulating the differentiation of mesenchymal stem cells into osteoblasts
ZhaowenZong / Daping Hospital, The Third Military Medical University, CHINA
15:06-15:25 / Coffee break
Concurrent Session 5 —Bone as an Endocrine Organ
Yuan Xiang Hall
Chairs: Hong Zhou, Lynda Bonewald
15:25-15:45 / IS-15 / Bone as an endocrine organ
Thomas Clemens / Johns Hopkins University, USA
15:45-16:05 / IS-16 / Osteocytes (Ocys) are the key to bone mineralization and maintenance
Jerry Feng / Texas A&M University, USA
16:05-16:14 / FT-9 / Potential functions of neurotrophic factors in growth plate cartilage bony repair and skeletal cell formation
Yuwen Su / University of South Australia, AUSTRALIA
16:14-16:23 / FT-10 / Insulin resistance regulation through adipokines induced by a bioactive peptide derived from bone
XiaoyongGuo / Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, CHINA
16:23-16:32 / FT-11 / Role of acidic non-collagenous proteins in bone regeneration
Yao Sun / Tongji University, CHINA
16:32-16:41 / FT-12 / Epimedium-derived flavonoids reduce incidence of steroid-associated osteonecorsis via their metabolite(s) in vivo
Xinluan Wang / Shenzhen Institute of Advanced Technology, Chinese Academy of Science, CHINA
16:41-16:50 / FT-13 / An essential role of Bmp receptor1A (Alk3) in postnatal skeleton formation
J. Jing / 1Texas A&MBaylorCollege of Dentistry, USA; 2West China Stomatology Hospital, Sichuan University, CHINA
16:50-16:59 / FT-14 / The changing clinical patterns and molecular pathogenesis of primary hyperparathyroidism in chinese patients
Lin Zhao / Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, CHINA
Concurrent Session 6 —Osteoporosis
Fu Cui Hall
Chairs: Ling Qin,William W. Lu
15:25-15:34 / FT-15 / Protection by salidroside against bone loss via inhibition of oxidative stress and bone-resorbing mediators
Jinkang Zhang / The Fourth Military Medical University, CHINA
15:34-15:43 / FT-16 / The influence of the genetic and non-genetic factors on bmd and osteoporotic fractures in Chinese women
Yanhua Deng / Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, CHINA
15:43-15:52 / FT-17 / Bone healing enhancement through inhibition of sclerostin by monoclonal antibody in rat osteotomy model
Pui Kit Suen / The Chinese University of Hong Kong, CHINA
15:52-16:01 / FT-18 / LLP2A-Ale, a novel compound that directs mesenchymal stem cells to bone to reverse bone loss
Min Guan / Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, CHINA
16:01-16:10 / FT-19 / Icariin reverses the phenotypes of osteoprotegerin-deficient mice through the activation of Wnt/β-catenin-Bmp signaling
Dezhi Tang / Shanghai University of Traditional Chinese Medicine, CHINA
16:10-16:19 / FT-20 / Reversing bone loss by directing mesenchymal stem cells to the bone
WeiYao / University of California at Davis, USA
16:19-16:39 / IS-17 / Attenuation of osteoporotic bone loss and enhancement of travecular integrity by dynamic acoustic radiation force
Yixian Qin / SUNY Stony Brook, USA
16:39-16:59 / IS-18 / Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation
Di Chen / Rush University Medical Center, USA
16:59-18:30 / Poster exhibition
18:30-20:30 / Banquet
Thursday–May 23, 2013
Concurrent Session 7 —Osteoarthritis
Yuan Xiang Hall
Chairs: Liao Cui, Yongjun Wang
8:00-8:20 / IS-19 / Subchondral bone micro structure and material properties change at early stage of osteoarthritis, an animal study
William W. Lu / The University of Hong Kong,CHINA
8:20-8:40 / IS-20 / Abnormal notch activation and inflammatory bone loss
LianpingXing / University of Rochester Medical Center, USA
8:40-9:00 / IS-21 / Glucocorticoid-induced diabetes is a bone disease
Hong Zhou / The University of Sydney, AUSTRALIA
9:00-9:09 / FT-21 / Role of osteocytes in osteoarthritis subchondral bone remodelling and mineral metabolism
Yin Xiao / Queensland University of Technology, AUSTRALIA
9:09-9:18 / FT-22 / The difference of animal models of femoral head osteonecrosis induced by alternating freezing-heating insult and local administration of alcohol in emu
Wenlong Gou / Institute of Orthopedics, Chinese PLA General Hospital, CHINA
9:18-9:27 / FT-23 / Mutations in the SLCO2A1 gene and primary hypertrophic osteoarthropathy: a clinical and biochemical characterization
Zeng Zhang / Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, CHINA
9:27-9:36 / FT-24 / K/Bxn mouse serum-induced arthritis is aggravated in mice with tamoxifen-induced chondrocyticglucocorticoid receptor knockout
JinwenTu / University of Sydney, AUSTRALIA
9:36-9:45 / FT-25 / Bmi-1 is a critical molecule for activation of the sonic hedgehog signal pathway
Jun Wu / Nanjing Medical University, CHINA
9:45-9:54 / FT-26 / Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis
Yanli Wang / The Fourth Military Medical University, CHINA
Concurrent Session 8 —Musculoskeletal Tissue Engineering
Fu Cui Hall
Chairs: Roberto Civitelli, Bin Li
8:00-8:09 / FT-27 / Hydrogels that mimic natural ECM and N-cadherin interactions enhance hMSCchondrogenesis
Liming Bian / The Chinese University of Hong Kong, CHINA
8:09-8:18 / FT-28 / PLGA/TCP scaffolds incorporating phytoestrogenic molecule icaritin developed for bone defect repair
Shihui Chen / The Chinese University of Hong Kong, CHINA
8:18-8:27 / FT-29 / The effect of insulation layer on the tissue-engineering osteochondral composite scaffold
HuDa / 1The 82nd Hospital of PLA；2The Fourth Military Medical University, CHINA
8:27-8:36 / FT-30 / A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin
Junjun Fan / Xi Jing Hospital, TheFourth Military Medical University, CHINA
8:36-8:45 / FT-31 / Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in the rat hemisected spinal cord injury model
Wei Gao / The First Affiliated Hospital of Soochow University, CHINA
8:45-8:54 / FT-32 / PEI600-B-Cyd: a promising nanopolymer for non-viral osteogenetic gene delivery of mesenchymal stem cells
XiaolingZhang / Shanghai Jiao Tong University, CHINA
8:54-9:14 / IS-22 / In situ bone regeneration: strategies andpractices
Changsheng Liu / East China University of Science and Engineering, CHINA
9:14-9:34 / IS-23 / Regulation of cartilage and bone formation by mechanically sensitive microRNAs
Qian Chen / Brown University, USA
9:34-9:54 / IS-24 / Decoupling physical factors of cell microenvironments in the biomaterials
ZigangGe / Peking University, CHINA
9:54-10:15 / Coffee break
Concurrent Session 9 —Musculoskeletal Systems in Development
Yuan Xiang Hall
Chairs: Keith Hruska, Lei Yang
10:15-10:24 / FT-33 / Role of Stat3 inosteoclasts in vivo
Jiliang Li / IndianaUniversityPurdueUniversityIndianapolis, USA
10:24-10:33 / FT-34 / Snp Rs6265 regulates protein phosphorylation and osteoblast differentiation and influences BMD in humans
Feiyan Deng / Soochow University, CHINA
10:33-10:42 / FT-35 / Akt is critical for myeloma promotion of osteoclast differentiation and osteolytic lesions
Huiling Cao / University of Pittsburgh, USA
10:42-10:51 / FT-36 / Regulation of migration of prostate cancer cells to bmsc conditioned medium by Wnt5A
Qiming Fan / Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, CHINA
10:51-11:00 / FT-37 / The pro-osteoclastic roles of Wnt5A-Ror2 signaling on the increased subchondral bone remodeling in tmjoa
Kai Jiao / The Fourth Military Medical University, CHINA
11:00-11:09 / FT-38 / Bmi1 plays a critical role in preventing bone aging by inhibiting oxidative stress
Qian Wang / Nanjing Medical University, CHINA
11:09-11:18 / FT-39 / Type I collagen gene mutations in Chinese osteogenesisimperfecta patients
Yanqin Lu / ShandongAcademy of Medical Sciences, CHINA
11:18-11:38 / IS-25 / The role of activating transcription factor 4 in bone
Guozhi Xiao / Rush University Medical Center, USA
11:38-11:58 / IS-26 / Mechanisms of WNT signaling in bone
Fanxin Long / WashingtonUniversitySchool of Medicine, USA
Concurrent Session 10 —Treatments for Osteoporosis and Bone Defects
Fu Cui Hall
Chairs:Xiaoling Zhang, Jian Liu
10:15-10:35 / IS-27 / The importance of human genetics for selecting targets for drug discovery
W. Scott Simonet / Amgen Discovery Research, USA
10:35-10:55 / IS-28 / FGF23: The bone-kidney-parathyroid axis
Suzanne Jan de Beur / Johns Hopkins University, USA
10:55-11:04 / FT-40 / Developing an “enhanced” bone tissue engineering therapeutic strategy for large bone defect treatment under diseased condition-- a pilot study in diabetic rabbit model
ZhiyongZhang / 1Shanghai Ninth People's Hospital, Shanghai Jiao Tong University;2National Tissue Engineering Center of China,CHINA
11:04-11:13 / FT-41 / Salvianolate stimulate bone formation and inhibit bone resorption in glucocorticoid treated sle mice
Yanzhi Liu / Guangdong Medical College, CHINA
11:13-11:22 / FT-42 / Evaluation of site-specific delivery system of small molecules for femoral fracture healing in mice
Wayne YW Lee / The Chinese University of Hong Kong,CHINA
11:22-11:31 / FT-43 / Glucagon-like peptide-1 receptor agonists improve bone defects in spontaneous type 2 diabetic GK rats and OVX rats
Nan Lu / Rui-JinHospital, ShanghaiJiaoTongUniversitySchool of Medicine, CHINA
11:31-11:40 / FT-44 / Knee joint kinematics following ACL reconstruction- a comparison between two surgical techniques
Nigel Zheng / University of North Carolina at Charlotte, USA
11:40-11:49 / FT-45 / Monocytechemotactic protein-1 (Mcp-1): a potential target to inhibit the progression of bone invasion by oral squamous cell carcinoma (Oscc)
JingjingQuan / Hospital of Stomatology, Sun Yat-sen University, CHINA
11:49-11:58 / FT-46 / The relationship betweenbiomaterials performance and their micro-pH
Weijia Lu / The University of Hong Kong, CHINA
11:58-13:30 / Lunch / Poster exhibition
Session 11 —Innovative Treatments for Spine and Bone Fractures(Optional Chinese presentation)
Yuan Xiang Hall
Chairs: David Ke, Liang Chen
13:30-13:50 / IS-29 / Kyphoplasty for Osteoporotic Vertebral Compression Fractures
Huilin Yang / 1The First Affiliated Hospital of Soochow University; 2Orthopedic Institute, Soochow University, CHINA
13:50-14:10 / IS-30 / Orthopaedic medical biomaterials in spinal fusion: an epigenetic mechanism in early bone regeneration
XuenongZou / 1Orthopaedic Research Institute; 2The First Affiliated Hospital of Sun Yat-sen University, CHINA
14:10-14:30 / IS-31 / Biomechanical research in percutaneousKyphoplasty
ZongpingLuo / 1The First Affiliated Hospital of Soochow University; 2Orthopedic Institute, Soochow University, CHINA
14:30-14:39 / FT-47 / Dramatic loss in trabecular plates and compromised bone stiffness in postmenopausal women with primary hyperparathyroidism
Bin Zhou / Columbia University, USA
14:39-14:48 / FT-48 / Correlation of MRI abnormalities and low back pain in a population study of 854 subjects
JiongjiongGuo / The First Affiliated Hospital of Soochow University, CHINA
14:48-14:57 / FT-49 / The effect of antiresorptive agents (elcatonin and alendronate) on bone microdamage and remodeling in cynomolgus monkeys vertebral bone
Yongping Cao / Peking University First Hospital, CHINA
14:57-15:06 / FT-50 / Inhibitory effects of strontium on titanium particle-induced osteoclastogenesis
Shijun Zhu / The First Affiliated Hospital of Soochow University, CHINA
15:06-15:25 / Coffee break
Session 12 —Bone Remodeling and Regeneration (Optional Chinese presentation)
Yuan Xiang Hall
Chairs: Shihe Li, Di Chen
15:25-15:45 / IS-32 / The only way that realizes regenerative medicine—"Four-Standard" mode
Guoxian Pei / XijingOrthopeadic Hospital, The Fourth Military Medical University, CHINA
15:45-16:05 / IS-33 / hPTH enhances bone healing in multiple preclinical animal models
Yanfei Linda Ma / Eli Lilly and Company, USA
16:05-16:25 / IS-34 / C/EBPα regulates osteoclast lineage commitment and is a unique therapeutic target for diseases of excessive bone resorption
Yiping Li / University of Alabama at Birmingham, USA
16:25-16:34 / FT-51 / Micro-CT evaluation of high-quality bone regeneration in rat femoral distraction osteogenesis treated with nell1
Aiyuan Wang / Institute of Orthopedics, Chinese PLA General Hospital, CHINA
16:34-16:43 / FT-52 / Plumbagin attenuates cancer cells growth and osteoclast formation in bone microenvironment
Wei Yan / Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, CHINA
16:43-16:52 / FT-53 / Tanshinol regulates Wnt/Foxo pathway to protect against hydrogen peroxide-induced oxidative stress in osteoblastic differentiation of pluripotent C2C12 cells
Yajun Yang / 1Guangdong Medical College; 2Southern Medical University, CHINA
16:52-17:01 / FT-54 / Andrographolide suppresses osteoclast formation and prevents bone loss through attenuating Nf-Κb signaling pathway
ZhanjingZhai / ShanghaiNinth People's Hospital, Shanghai Jiao Tong University School of Medicine, CHINA
17:01-17:30 / Award Ceremony & Closing Remarks(Yuan Xiang Hall)
Note:
IS: Invited Speeches. FT: Free Talks.
Exhibits and posters are open during the entire meeting.
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