Evangelista et al. BCS-S102 pilot study

Table 1S. Agreements among Sentinella 102, SMM and histological findings in all study population

N patients / Age / Sentinella
102 findings / Histological
response to NT / Agreement
S-H / SMM / Agreement
SMM-H / Agreement
SMM-S
1 / 45 / BL / ypTxN3a / NO / Negative / NO / NO
2 / 65 / BL / ypT2N1a / YES / BL / NO / YES
3 / 67 / Negative / ypT1cN3a / NO / LN / NO / NO
4 / 56 / Negative / ypT0N0 / YES / Negative / YES / YES
5 / 43 / Negative / ypT0N0 / YES / Negative / YES / YES
6 / 35 / Negative / ypT0N0 / YES / Negative / YES / YES
7 / 47 / BL / ypTxN1a / YES / Negative / NO / NO
8 / 63 / LN / ypT0N1a / YES / LN / YES / YES
9 / 46 / Negative / ypT0N0 / YES / Negative / YES / YES
10 / 73 / BL / ypT2N1a / YES / BL / NO / YES
11 / 66 / Negative / ypT0N1c / NO / Negative / NO / YES
12 / 51 / Negative / ypT2N0 / NO / Negative / NO / YES
13 / 56 / BL+LN / ypT2N3 / YES / BL / NO / NO
14 / 45 / Negative / ypTxN1a / NO / Negative / NO / YES
15 / 38 / LN / yT1b N1a / YES / Negative / NO / NO
16 / 40 / BL+LN / ypT3N3b / YES / Negative / NO / NO
17 / 32 / LN / ypTisN0 / NO / Negative / NO / NO
18 / 62 / BL / ypT1cN1a / YES / BL / NO / YES

NT: neoadjuvant therapy; S=Sentinella 102; H=histology; BL: breast lesion; LN: lymph nodes

Table 2S. Response to therapy results by Sentinella 102, histological data and conventional scintimammography

N patients / Age / Sentinella 102
findings / Histological
response to NT / SMM
1 / 45 / PR / PR / CR
2 / 65 / PR / PR / PR
3 / 67 / CR / PR / PR
4 / 56 / CR / CR / CR
5 / 43 / CR / CR / CR
6 / 35 / CR / CR / CR
7 / 47 / PR / PR / CR
8 / 63 / PR / PR / PR
9 / 46 / CR / CR / CR
10 / 73 / PR / PR / PR
11 / 66 / CR / PR / CR
12 / 51 / CR / PR / CR
13 / 56 / PR / PR / PR
14 / 45 / CR / PR / CR
15 / 38 / PR / PR / CR
16 / 40 / PR / PR / CR
17 / 32 / PR / PR / CR
18 / 62 / PR / PR / PR

NT: neoadjuvant therapy; SMM: scintimammography;

PR: partial response; CR: complete response

Table 3s. Diagnostic accuracies for SMM and Sentinella 102 based on complete/partial response therapy

TP / TN / FP / FN / Sens %
(CI 95%) / Spec %
(CI 95%) / PPV %
(CI 95%) / NPV %
(CI 95%) / Acc %
(CI 95%)
SMM / 6 / 4 / 0 / 8 / 60
(29.6-90.4) / 100 / 100 / 66.7
(34-99.3) / 77.8
(58.5-96.9)
Sentinella 102 / 10 / 4 / 0 / 4 / 71.4
(47.8-95.1) / 100 / 100 / 50
(1-99) / 77.8
(58.6-96.9)

SMM: scintimammography; TP: true positive; TN: true negative; Sens: sensitivity; Spec: specificity; PPV: positive predictive value; NPV: negative predictive value; Acc: accuracy; CI: confidence interval;

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