Ernesto L. SCHIFFRIN

CURRICULUM VITAE

Ernesto L. Schiffrin, CM, MD, PhD, FRSC, FRCPC, FACP, FAHA

Physician-in-Chief, Sir Mortimer B. Davis-Jewish General Hospital

Canada Research Chair and Director, Hypertension and Vascular Research Unit, Lady Davis Institute

Professor and Vice-Chair (Research), Department of Medicine, McGill University

DATE OF BIRTH: August 8, 1946

1969 University of Buenos Aires, School of Medicine, M.D. degree

1970-1974 Resident in Internal Medicine, Instituto de Investigaciones Médicas, University of Buenos Aires

1974-1975 Fellow, Hypertension and Hemodynamics Research, Instituto de Investigaciones Médicas, University of Buenos Aires

1974-1976 Internal Medicine Ward Chief, Instituto de Investigaciones Médicas, University of Buenos Aires

1976-1980 Research Fellow, Hypertension Group, Clinical Research Institute of Montreal

1979-1980 Clinical Fellow, Division of Nephrology, Hotel Dieu Hospital, University of Montreal

1980 McGill University, Ph.D. degree

APPOINTMENTS

1980-1982 Senior Investigator, Hypertension Group, Clinical Research Institute of Montreal

1981-1986 Assistant Professor of Medicine, Department of Medicine, School of Medicine, University of Montreal

1981-2005 Attending physician, Division of Internal Medicine, Hotel Dieu Hospital, University of Montreal

1982-1983 Associate Director, Experimental Hypertension Laboratory, Clinical Research Institute of Montreal

1983-2005 Director, Experimental Hypertension Laboratory, Clinical Research Institute of Montreal

1986-1991 Associate Professor of Medicine, Department of Medicine, School of Medicine, University of Montreal

1986-2005 Adjunct Professor, Department of Medicine, Division of Experimental Medicine, McGill University

1990-1992 Acting Director, Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal

1991-1992 President, Canadian Hypertension Society

1991-2005 Professor of Medicine, Department of Medicine, University of Montreal

1991-2005 Director of the Hypertension Clinic, Clinical Research Institute of Montreal

1992-2005 Director, Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal

2000-2002 Vice-Chair, High Blood Pressure Research Council, American Heart Association

2002-2004 Chair, High Blood Pressure Research Council, American Heart Association

2003- Associate Editor of Hypertension, journal of the American Heart Association (Editor-in-Chief John E. Hall)

2004-2006 Past-Chair, High Blood Pressure Research Council, American Heart Association

2005-2007 President, InterAmerican Society of Hypertension

2006- Physician-in-Chief and Chair, Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital

2006-2013 Tier 1 Canada Research Chair in Vascular and Hypertension Research

2006- Director, Vascular and Hypertension Research Unit, Lady Davis Institute for Biomedical Research

2006- Professor and Vice-Chair (Research), Department of Medicine, McGill University

2006-2009 Member, Regional Committee of Chiefs of Departments of Specialized Medicine for the Island of Montreal region

2007-2009 President-Elect, Québec Hypertension Society

2009-2011 President, Québec Hypertension Society

2009-2012 President, Regional Committee of Chiefs of Departments of Specialized Medicine for the Island of Montreal region

2010-2012 Vice-President, International Society of Hypertension

2011-2012 President-Elect, International Society of Hypertension

2012-2015 Member, Board of the Health and Social Services Authority [Agence de santé et services sociaux (ASSS)] for the Island of Montreal

2012-2014 President, International Society of Hypertension

2013-2020 Tier 1 Canada Research Chair in Vascular and Hypertension Research

DEGREES AND DIPLOMAS

M.D. University of Buenos Aires, School of Medicine, 1969

Ph.D. McGill University, 1980

Licence to practice medicine in the Province of Quebec, Canada, 1981

C.S.P.Q. Specialist in Internal Medicine, Province of Quebec, Canada, 1981

FRCPC Specialist in Internal Medicine, Fellow of the Royal College of Physicians and Surgeons of Canada, 1982

FACP Fellow of the American College of Physicians, 1984

Fellow High Blood Pressure Council, American Heart Association, 1984

Specialist in Diploma of the Specialist Program of the American Society of Hypertension, 1999

Hypertension

FAHA Fellow American Heart Association, 2000

HONORS AND PRIZES

1969 "Diploma de honor", University of Buenos Aires, School of Medicine

1974-1975 Research Fellowship, Merck, Sharp & Dohme, Argentina

1978-1980 Research Fellowship, Conseil de recherches médicales du Québec

1980 Dean's Honors List, McGill University

1985 Astra Young Investigator Award, Canadian Hypertension Society

1991 Prix Marcel-Piché, IRCM

1998 1997 Merck Science Award for one of 10 best abstracts of the year on angiotensin II receptors (awarded to first author, Dr. J.S. Li, research assistant in the laboratory, and first author in the abstract).

2000 2000 Merck Angiotensin Receptor Research Award, European Hypertension Society.

2003 Elected Member of Honor, Spanish Society of Hypertension (3rd person to be so honored in the history of the Society).

2003 Senior Investigator Award, Canadian Society of Internal Medicine.

2003 R. Douglas Wright Lecturer and Honorary Member, High Blood Pressure Research Council of Australia

2004 John Foerster Distinguished Lecture Award, Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba

2004 Distinguished Service Award of the Canadian Society of Hypertension

2005 Member, Canadian Academy of Health Sciences

2006 Fellow, Royal Society of Canada, Academy of Sciences, Division of Life Sciences.

2007 Irvine Page-Alva Bradley Lifetime Achievement Award, Council for High Blood Pressure Research, American Heart Association.

2010 Bjorn Folkow Award, European Society of Hypertension.

2010 Appointed Member of the Order of Canada (C.M.)

2010 Award of Excellence in Basic Research, Jewish General Hospital.

2011 American Heart Association 2011 Excellence Award for Hypertension Research, sponsored by Novartis (previously known as the Stouffer, then the Ciba, and later until recently the Novartis Award for Hypertension Research).

CLINICAL ACTIVITIES

1981-2005 Hypertension Out-Patient Clinic at the Clinical Research Institute of Montreal: Two half days per week.

1981-2005 Staff, Division of Internal Medicine, Hôtel-Dieu Hospital of Montreal. One half day at the Internal Medicine out-patient clinic. Two months attending in the Internal Medicine. Clinical Teaching Unit and/or in-patient consultation service in Internal Medicine.

1991-2005 Director of the Hypertension Clinic, Clinical Research Institute of Montreal.

2006- Physician-in-Chief, SMBD-Jewish General Hospital.

2006- Director, Cardiovascular Prevention Centre, SMBD-Jewish General Hospital.

2006- Two-four weeks attending in one of the McGill Internal Medicine Clinical Teaching Units at the Jewish General Hospital.

TEACHING

1981-2005

Undergraduate: Courses to 4th year medical students at Hôtel-Dieu Hospital, 1 hour per month. During the 2 months as attending at CTU, rounds with 4th year medical students 9-12 hours per week.

Graduate: At the lab in the Clinical Research Institute of Montreal, teaching to Graduate students (Ph.D. students). Teaching during weekly 1 hour lab meetings and 1 hour seminars of the Hypertension Group.

Postgraduate: For 15 years was during 2 months as attending at the CTU at Hôtel-Dieu Hospital, and when on Consultation service, still currently do rounds with R1, R2 and R3s in Internal Medicine 9-12 hours per week. At the out-patient clinic in Internal Medicine at Hôtel-Dieu Hospital, 2 hours/week of supervision of R3s.

At the Clinical Research Institute, occasionally 2 hours/week of supervision of R3s in the Hypertension Clinic. Teaching to postdocs (post Ph.D. and M.D.) as described for Graduate students.

Numerous seminars nationally and internationally (see below), some part of postgraduate medical education programs.

Member of the pedagogical commitee in Internal Medicine at the University of Montreal 1989-1992.

2006-

Professor, Department of Medicine, SMBD-Jewish General Hospital, Senior Physician rounds with medical students, Professor rounds with residents and students in CTUs; 4 weeks of service and teaching in CTU. Chair of Medical Grand Rounds.

RESEARCH

1981-2005

Director of the Experimental Hypertension Laboratory, of the Hypertension Clinic and of the Multidisciplinary Research Group on Hypertension at the Clinical Research Institute. This research activity occupies together with travel to give research seminars or present results of research at national or international meetings, or other research-related travel, 70-80% of time.

2006-

Canada Research Chair and Director, Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research; Vice-Chair (Research), Department of Medicine, McGill University.

RESEARCH INTERESTS

Clinical and experimental hypertension, role and receptors for vasoactive peptides (angiotensin, endothelin, vasopressin) and their intracellular signal transduction, resistance arteries in cardiovascular disease and more specifically in clinical and experimental hypertension, role of endothelium, cardiovascular hypertrophy and vascular remodeling, clinical pharmacology of hypertension, genetic determinants of hypertension.

ADMINISTRATION

· Director of Experimental Hypertension Laboratory at the Clinical Research Institute, 1983-2005.

· Director of the Multidisciplinary Research Group on Hypertension funded by the Canadian Institutes of Health Research (formerly Medical Research Council of Canada), 1990-2005.

· Director of the Hypertension Clinic at the Clinical Research Institute, 1991-2005.

·  Member, Scientific Advisory Committee, British Heart Foundation, Glasgow Cardiovascular Research Centre, 2004- .

·  Member, Management Committee, Clinical Research Institute, 2003-2005.

·  Physician-in-Chief, Sir Mortimer B. Davis-Jewish General Hospital, 2006-

·  Director, Cardiovascular Prevention Centre, SMBD-Jewish General Hospital, 2006-.

·  Director, Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, 2006-.

·  Vice-Chair (Research), Department of Medicine, McGill University, 2006-.

·  Member, Promotions and Tenure Committee, Department of Medicine, McGill University, 2006-.

·  Member, Promotions and Tenure Committee, Faculty of Medicine, McGill University, 2006-2008.

·  Member, Medical Advisory Committee, SMBD-Jewish General Hospital, 2007-.

·  Elected member, Medical Executive Committee, SMBD-Jewish General Hospital, 2007-.

·  Chair, site visit committee, Meakins-Christie Laboratories, Department of Medicine, McGill University, 2007.

·  Chair, Search and Selection Committee for Chief of Department of Neurosciences, SMBD-Jewish General Hospital, 2008.

·  Member, Search and Selection Committee for Director of the Meakins-Christie Laboratories, Department of Medicine, McGill University, 2008.

·  Chair, Search and Selection Committee for Chief of McGill and SMBD-Jewish General Hospital Division of Geriatrics, 2008.

·  Member, Senior Management Committee, SMBD-Jewish General Hospital, 2008-.

·  Chair, Ad-hoc Research Integrity Committee, McGill University, 2009-2010.

·  Member, Honors and Awards Committee, Faculty of Medicine, McGill University, 2010-

·  Member, Board of Hypertension Canada (2011-)

·  Member, Board of North America Artery (2011-)

MEMBERSHIP IN SOCIETIES

·  Association des médecins chercheurs du Québec

· American Federation for Clinical Research

· Canadian Hypertension Society

· Canadian Society for Clinical Investigation

·  Canadian Society for Clinical Pharmacology

· Canadian Society of Internal Medicine

· Club de recherches cliniques du Québec

· Fellow, American College of Physicians

· Fellow, Council for High Blood Pressure Research, American Heart Association

· Fellow, Royal College of Physicians of Canada

·  Fellow, Royal Society of Canada

·  InterAmerican Society of Hypertension

· International Society of Hypertension

· Society for Experimental Biology and Medicine

·  Canadian Institute of Academic Medicine

·  Canadian Academy of Health Sciences

·  Intl. Soc. Vascular Health (Paris)

COMMITTEES AND ROLE IN SCIENTIFIC SOCIETIES

1982-2005 Scientific Committee, Clinical Research Institute of Montreal

1982-1983 Cardiovascular Grants Committee, Medical Research Council of Canada

1984-1987 Canadian Heart Foundation Grants Committee

1985-1987 Membership Committee, Interamerican Society of Hypertension

1986-1990 Comité de rédaction, Hypertension Canada

1986-1989 Program Committee, Council for High Blood Pressure Research, American Heart Association

1987- Member, Board of Trustees, InterAmerican Society of Hypertension

1987-1993 Member, Board of Trustees, Canadian Hypertension Society

1988-1991 Secretary-Treasurer, Canadian Hypertension Society

1988-1992 Member, Promotions Committee, Department of Medicine, University of Montreal, School of Medicine

1989-1991 Member, Medical Research Council CardiovascularB Grants Committee

1989-1992 Member, Internal Medicine Pedagogical Committee, University of Montreal Medical School

1991-1994 Program Committee, American Heart Association National Meeting

1991-1992 President, Canadian Hypertension Society

1991-1994 Chairman, Cardiovascular B Committee, Medical Research Council of Canada

1992 Chairman, Working Group on Hypertension and Stroke of the Canadian Task Force on Cardiovascular Science

1992 Member, Organizing Committee of the Canadian Hypertension Society Consensus Conference on the treatment of hypertension.

1992-1996 Member, Scientific Advisory Committee, Heart and Stroke Foundation of Quebec

1992-1993 Past President, Canadian Hypertension Society

1993 Chairman, Symposium on Nitric oxide and regulation of the circulation, Canadian Hypertension Society, Canadian Society of Clinical Investigation and Royal College of Physicians of Canada, Vancouver, September 10, 1993

1993 Chairman, Postgraduate Symposium on Natriuretic Peptides, National Meeting of the American Heart Association, Atlanta, November 10, 1993

1993-1994 Member, Organizing Committee, Symposium on Neuroeffector Mechanisms in Hypertension Satellite of IUPHAR, Banff, August, 1994

1993-1995 Member, Executive Committee and Scientific Policy Committee, InterAmerican Society of Hypertension

1993-1995 Chairman, Organizing Committee, XIth Scientific Meeting, InterAmerican Society of Hypertension, Montreal, June 18-21, 1995

1995 Member, International Advisory Board, World Hypertension League Conference on Hypertension Control, Ottawa, June 22-24, 1995

1995-1996 Member, International Advisory Board, 5th International Symposium on Resistance Arteries, Cambridge, September 1996

1995-1997 Secretary, Executive Committee, InterAmerican Society of Hypertension

1996-1997 Member, International Advisory Board, Seventh International Symposium on Cardiovascular Pharmacotherapy, Jerusalem, Israel, June 1997

1996-1997 Member, Organizing Committee, Symposium on Spontaneously Hypertensive Rats and Genetics of Hypertension, Montreal, November 1997.

1996-2006 Member, Nominating/Membership Committee, Council for High Blood Pressure Research, American Heart Association

1997 Member, International Advisory Board, Fifth International Symposium on Endothelin, Kyoto, Japan, September 1997

1997-1999 Member, Publications and Communications Committee, American Society of Hypertension

1997-1999 Member ad hoc, Executive Committee, InterAmerican Society of Hypertension

1997-2000 Member ad hoc, Executive Committee, Council for High Blood Pressure Research, American Heart Association

1997-2000 Member, Program Committee, Council for High Blood Pressure Research, American Heart Association National Meeting

1997-2001 Chair, Personnel Support Committee, Canadian Hypertension Society

1997-2001 Member, Comité de promotions, Département de médecine, Université de Montréal

1997-2000 Member, Standing Committee on Science and Research, Medical Research Council of Canada

1997-1998 Member, International Scientific Committee, 6th. International Symposium on Resistance Arteries (6 ISRA). Moll, Belgium, June 3-6, 1998

1997-2002  President-Elect, Council for High Blood Pressure Research, American Heart Association

1998 Member, International Scientific Committee, Second International Symposium on Endothelin Antagonists, Zurich, March 1998

1998-1999 Member, International Scientific Advisory Committee, 8th. Symposium of the International Society of Cardiovascular Pharmacotherapy, Amsterdam, March 1999

1998-1999 Member, Organizing Committee, Sixth International Symposium on Endothelin, Montreal, October 1999

1998-2000 Member, Program Committee, Scientific Meeting of the American Society of Hypertension

1998-2000 Chair, Program Committee, Council for High Blood Pressure Research, American Heart Association National Meeting

1998-2002 Member, Executive Council, American Society of Hypertension

1999-2000 Member, Program Committee, International Society of Hypertension Meeting, Chicago, August 20-24, 2000.

1999-2002 Secretary, American Society of Hypertension (ASH)

1999-2003 Treasurer, InterAmerican Society of Hypertension (IASH)

1999-  Member, Board of the International Society of Cardiovascular Pharmacotherapy

2000-2002 Vice-Chair, Awards Committee, Council for High Blood Pressure Research, American Heart Association

2000-2002  Vice-Chair and Chair Elect, Council for High Blood Pressure Research, American Heart Association.

2000  Chair, Organizing Committee, 7th. International Symposium on Resistance Arteries (7 ISRA), Muskoka Sands, ON.

2001 Member, Organizing Committee, Satellite Symposium on "The Cardiovascular System and Inflammatory Mediators" of the XVII World Congress of the International Society for Heart Research, Montreal, July 13-14, 2001.