Supplementary data

Caveat emptor: limitations of the automated reconstruction of metabolic pathways in Plasmodium

Hagai Ginsburg

Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmund J. Safra Campus, Jerusalem 91904, Israel

Corresponding author: Ginsburg, H. ().

Supplement 1: Enzyme holes in MPMP

Pathway / Enzyme / EC / URL
1 / Lysine metabolism / 4-acetamidobutyrate deacetylase / 3.5.1.63 /
2 / Glutamate metabolism / Glutamate-tRNA(Gln) ligase / 6.1.1.24 / http://sites.huji.ac.il/malaria/maps/glutamatemetpath.html
3 / Glycine and Serine metabolism / Glycine dehydrogenase / 1.4.4.2 / http://sites.huji.ac.il/malaria/maps/glycineSerinemetpath.html
4 / Leucine, Isoleucine and Valine metabolism / Acyl-CoA dehydrogenase / 1.3.99.2/3 / http://sites.huji.ac.il/malaria/maps/LeuIsoVal.gif
5 / Methionine and polyamine metabolism / Methionine synthase / 2.1.1.13 / http://sites.huji.ac.il/malaria/maps/methioninemetpath.html
6 / Pentose Phosphate Cycle / Transaldolase / 2.2.1.2 / http://sites.huji.ac.il/malaria/maps/ppcpath.html
7 / Nicotinate and nicotinamide metabolism / NAD+ kinase / 2.7.1.23 / http://sites.huji.ac.il/malaria/maps/nicotinatemetpath.html
8 / Porphyrin metabolism / Uroporphyrinogen-III synthase / 4.2.1.75 / http://sites.huji.ac.il/malaria/maps/porphyrinmetpath.html
9 / Shikimate biosynthesis / 3-deoxy-7-phosphoheptulonate synthase / 2.5.1.54 / http://sites.huji.ac.il/malaria/maps/shikimatebiopath.html
10 / 3-Dehydroquinate synthase / 4.2.3.4
11 / 3-Dehydroquinate dehydratase / 4.2.1.10
12 / Shikimate 5-dehydrogenase / 1.1.1.25
13 / Ubiquinone metabolism / 3-octaprenyl-4-hydroxybenzoate carboxy-lyase / 4.1.1.- / http://sites.huji.ac.il/malaria/maps/ubiquinonemetpath.html
14 / SHAMT and GCV / Glycine dehydrogenase / 1.4.4.2 / http://sites.huji.ac.il/malaria/maps/SHAMTandGCV.html
15 / Thiamine metabolism / Thiamine-phosphate kinase / 2.7.4.16 / http://sites.huji.ac.il/malaria/maps/thiaminemetpath.html
16 / Phosphatidylethanolamine and phosphatidylserine metabolism / Phosphatidylglycerophosphatase / 3.1.3.27 / http://sites.huji.ac.il/malaria/maps/phserine.html
17 / Inositol phosphate metabolism / Inositol 1-phosphatase / 3.1.3.25 / http://sites.huji.ac.il/malaria/maps/inosiPhosphmetpath.html
18 / Inositol-1,4-bisphosphate phosphatase / 3.1.3.57