Endoplasmic Reticulum Stress, the Unfolded Protein Response and the Development of Colon

Nicolas Piton

ADDITIONAL DATA

Table 1: Pairwise correlations between BiP, CHOP, Ki67, E-cadherin and HIF-1 alpha in normal colon epithelium.

The Spearman correlation coefficient rhô was calculated for each pair of proteins from each normal epithelium core included in the TMA. Cores with at least one missing value were excluded. For each coefficient, the p-value is indicated below. The highlighted cell indicates a degree of significance inferior to the alpha risk after a Bonferroni correction calculated at 0.0001. For this coefficient, the number of cores (n) included in the calculation is indicated.

Table 2: Pairwise correlations between BiP, CHOP, Ki67, E-cadherin and HIF-1 alpha in low-grade dysplasia.

The Spearman correlation coefficient rhô was calculated for each pair of proteins from each low-grade dysplasia core included in the TMA. Cores with at least one missing value were excluded. For each coefficient, the p-value is indicated below. The highlighted cells indicate a degree of significance inferior to the alpha risk after a Bonferroni correction calculated at 0.0001. For these coefficients, the number of cores (n) included in the calculation is indicated.

Table 3: Pairwise correlations between BiP, CHOP, Ki67, E-cadherin and HIF-1 alpha in high-grade dysplasia.

The Spearman correlation coefficient rhô was calculated for each pair of proteins from each high-grade dysplasia core included in the TMA. Cores with at least one missing value were excluded. For each coefficient, the p-value is indicated below. No significant coefficient was obtained after a Bonferroni correction (0.000666).

Table 4: Pairwise correlations between BiP, CHOP, Ki67, E-cadherin and HIF-1 alpha in adenocarcinoma.

The Spearman correlation coefficient rhô was calculated for each pair of proteins from each adenocarcinoma core included in the TMA. Cores with at least one missing value were excluded. For each coefficient, the p-value is indicated below. The highlighted cells indicate a degree of significance inferior to the alpha risk after a Bonferroni correction calculated at 0.0001. For these coefficients, the number of cores (n) included in the calculation is indicated.

Table 5: Pairwise correlations between BiP, CHOP, Ki67, E-cadherin and HIF-1 alpha, regardless of histological nature.

The Spearman correlation coefficient rhô was calculated for each pair of proteins from each core included in the TMA, regardless of histological nature. Cores with at least one missing value were excluded. For each coefficient, the p-value is indicated below. The highlighted cells indicate a degree of significance inferior to the alpha risk after a Bonferroni correction calculated at 0.0001. For these coefficients, the number of cores (n) included in the calculation is indicated.

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