Electronic Supplementary Material s12

Electronic Supplementary Material:

- Figure S1. MEDLINE search strategy.

- Table S1. Quality assessment of studies included in the meta-analysis.

- Figure S2. Funnel plot of the standardized mean difference (SMD) between between the effect of exercise training in hypoxia versus normoxia on skeletal muscle capillarization.

- Figure S3. Funnel plot of the standardized mean difference (SMD) between the effect of exercise training in hypoxia versus normoxia on vascular dilator function.

- Figure S4. Funnel plot of the standardized mean difference (SMD) between the effect of exercise training in hypoxia versus normoxia on arterial stiffness.

Figure S1. MEDLINE search strategy (Filters activated: “Humans”)

(“hypox*” [All Fields] OR “altitude” [All Fields]) AND “exercise training” [All Fields]
AND
“vascular” [All Fields] OR “arterial” [All Fields] OR “cardi*” [All Fields]

Table S1. Quality assessment of studies included in the meta-analysis[1]

Study,
year of publication / Random allocation / Allocation concealed / Baseline similarity / Subject blinding / Therapist blinding / Assessor blinding / Adequate follow-up / ITT analysis / Between-group comparison / Point measures & variability
Desplanches et al [2], 2014 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Kon et al [3], 2014 / 1 / 0 / 1 / 0 / 0 / 0 / 0 / 1 / 1 / 1
Kong et al [4], 2014 / 1 / 0 / 1 / 0 / 0 / 0 / 0 / 1 / 1 / 1
Schreuder et al [5], 2014 / 1 / 0 / 1 / 0 / 0 / 1 / 1 / 1 / 1 / 1
Shi et al [6], 2014 / 1 / 0 / 1 / 0 / 0 / 1 / 1 / 1 / 1 / 1
Shi et al [7], 2013 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Nishiwaki et al [8], 2011 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Park et al A [9], 2010 / 0 / 0 / 1 / 0 / 0 / 0 / 0 / 0 / 0 / 1
Park et al B [9], 2010 / 0 / 0 / 1 / 0 / 0 / 0 / 0 / 0 / 0 / 1
Wang et al A [10], 2010 / 1 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Wang et al B [10], 2010 / 1 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Geiser et al A [11], 2001 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Geiser et al B [11], 2001 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Masuda et al [12], 2001 / 1 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Messonnier et al [13], 2001 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Vogt et al A [14], 2001 / 1 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Vogt et al B [14], 2001 / 1 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Melissa et al [15], 1997 / 1 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Desplanches et al [16], 1996 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Terrados et al [17], 1990 / 0 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1
Terrados et al [18], 1988 / 1 / 0 / 1 / 0 / 0 / 0 / 1 / 1 / 1 / 1

1 = yes (scored); 0 = no. ITT, intention-to-treat analysis

Figure S2. Funnel plot of the standardized mean difference (SMD) between the effect of exercise training performed in hypoxia versus normoxia on skeletal muscle capillarization

Figure S3. Funnel plot of the standardized mean difference (SMD) between the effect of exercise training performed in hypoxia versus normoxia on vascular dilator function

Figure S4. Funnel plot of the standardized mean difference (SMD) between the effect of exercise training performed in hypoxia versus normoxia on arterial stiffness

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