Preferences for oral anticoagulants in atrial fibrillation: a best-best discrete choice experiment
PharmacoEconomics
Peter Ghijben, Emily Lancsar, Silva Zavarsek
Centre for Health Economics, Monash University, Clayton 3800, Victoria, Australia
Peter Ghijben
Research Fellow
Centre for Health Economics, Monash University, Clayton 3800, Victoria, Australia
Emily Lancsar
Associate Professor
Centre for Health Economics, Monash University, Clayton 3800, Victoria, Australia
Silva Zavarsek
Senior Research Fellow
Correspondence to: Peter Ghijben

Electronic supplementary material 4 presents the qualitative interview guide and the comprehension test questions.

Electronic supplementary material 4, Table 1 Qualitative Interview Guide
PART I Comprehension Test:
1 / “Could you please answer these 10 short questions?”
(see Electronic supplementary material 4, Table 2)
PART II Choice-set related questions:
2 / “How did you find the choice task overall?”
(Probe: was it difficult/easy to make decisions?)
3 / “Were any parts of the choice task harder than other parts?”
(Probe: was it difficult choosing the best from the 3, and then choosing the best from the remaining 2 options?)
4 / [Show example choice-set]“Can you walk me through how you would go about making your choices with this choice-set?”
(Probe: What did you look at first? How did you weight up the options? Which option would/did you choose, and how do you make this decision? After your first choice, how would you then choose the next best option?)
5 / “Did you ever choose the ‘No treatment’ option? If not, why not?”
6 / “Could you please rank each of the following attributes from most important (1) to least important (7)?”
7 / “Did you ever ignore or disregard any of the characteristics because they didn’t seem important to you?
(Probe: If so, which ones?”)
8 / “Would you have liked any other information about the options that you think could help you make your choices?
(Probe: If so, what were they?”)
PART III Survey format, detail and wording related questions
9 / “At the start of the survey, you were presented with information to help your make your choices. Would you have liked more or less information?”
(Probe: If more, what type of extra information would you have liked? If less, which parts did you think were unnecessary?)
10 / “What did you think about the wording of the survey?”
(Probe: Was it clear? Was it difficult to follow and understand? Do you think any parts could be improved or better explained? Did you ever press the replay button?)
11 / “What did you think about the format and presentation of the survey?”
Probe: the survey was designed to mimic a medical consultation; do you think this helped you complete the survey?)
12 / What did you think of the avatar in the survey?
(Probe: Did the avatar help you understand the information presented? Was it too fast or slow?)
13 / “How could the survey be improved?”
14 / “Is there anything else you would like to discuss in relation to the survey?”
Electronic supplementary material 4, Table 2Comprehension Test
1 / The condition atrial fibrillation is a heart condition where blood does not flow properly through the heart? / TRUE / FALSE
2 / Atrial fibrillationincreases the risk of stroke occurring? / TRUE / FALSE
3 / If a stroke occurs, there is a 50:50 chance a stroke will be minor or major in severity? / TRUE / FALSE
4 / ‘Blood-thinning’ medications are prescribed to lower the risk of stroke? / TRUE / FALSE
5 / ‘Blood-thinning’ medications lower the risk of bleeding? / TRUE / FALSE
6 / ‘Bleeding from the stomach is the most common type of bleeding side effect associated with blood-thinning medications? / TRUE / FALSE
7 / Some, but not all, ‘blood-thinning’ medications require a blood test once a month on average / TRUE / FALSE
8 / What is the risk of stroke (per year) shown in this picture? / __ out of 100
Please refer to the picture below for questions 9 and 10.

9 / Which alternative has the lowest risk of stroke? / A / B
10 / Which alternative has the highest risk of bleeding? / A / B