CURRICULUM VITAE
Dr Mark Jeremy Dayer MBBS (Hons) BSc (Hons) PhD FRCP
Current Position and Roles
- I qualified from Guy’s and St Thomas’ Hospitals in 1995 with honours; my intercalated degree was in psychology. I obtained my MRCP in 1998, my CCST in 2007 and obtained my PhD from Imperial College in 2008. I am a certified cardiac device specialist and have level II cardiac CT accreditation. The majority of my specialist training was in London at the Royal Brompton and Harefield hospitals.
- I am currently a general cardiologist at Taunton and Somerset NHS Trust, a medium sized hospital in the West of the country, where I have worked for over 8 years. I am the lead clinician. My principal sub-specialty interest is cardiac devices, and I implant over 200 each year, including ICDs and CRT devices. I see and manage an increasing number of patients with inherited cardiac conditions, which is a fascinating and rapidly evolving area. I undertake cardiac CT scanning and a regular general cardiology clinic.I have in-patient responsibilities for both cardiology and general medical patients. Aside from this,I am the Caldicott Guardian and the lead for the Electronic Prescribing and Medicines Administration Project.
- I am active in research, and focus in particular on the use of large datasets to answer interesting research questions. For the last 10 years, my focus has principally been the epidemiology of infective endocarditis.
Personal Details
NameMark Jeremy Dayer
StatusMarried
Date of Birth27th August 1970
NationalityBritish
GMCFull Registration, 4206635
Revalidation Due06/05/2018
Defence Org.Medical Protection Society, 205556
CCST DateFebruary 12th 2008, Cardiology and General Internal Medicine
AddressWestbrook Cottage
Croford
Wiveliscombe
Taunton TA4 2TS
Home01984 624265
Mobile07428 690564
Web
Current PositionConsultant Cardiologist
Musgrove Park Hospital
Taunton
Somerset TA1 5DA
Tel. (Work)01823 342154 (Direct line)
Tel. (Work)01823 343824 (Secretary, Natalie Shedden)
Fax. (Work)01823 344916
Appointed 1st November 2007
Private PracticeNuffield Health Taunton Hospital
Staplegrove Elm
Taunton
Somerset
TA2 6AN
Main Reception 01823 286991
Appointments01823 250611
Consulting rooms01823 250609
Qualifications
April 2013 Level II Cardiac CT Accreditation
August 2011FRCP (UK)
May 2008PhD
February 2008CCST in Cardiology and General Internal Medicine
September 2007Certified Cardiac Device Specialist – Physician
June 1998MRCP (UK)
June 1995MB BS (Hons), Distinction in Surgery
June 1992BSc (Hons) in Psychology with Basic Medical Sciences, First Class Honours
Education
2001-2004PhD, Imperial College London
1989-1995United Medical and Dental Schools of Guy’s and St Thomas’s
1981-1988Bristol Grammar School
Previous Positions
Cardiology Specialist Registrar Rotation
1st October 2007 – 31st October 2007
Harefield Hospital, Royal Brompton and Harefield NHS Trust
Dr N Banner, Dr E Birks
Transplant Cardiology
1st October 2006 –30th September 2007
Harefield Hospital, Royal Brompton and Harefield NHS Trust
Dr M Mason, Dr V Markides, Dr T Wong, Dr A Mitchell
General Cardiology, Devices & Electrophysiology
2nd October 2005 – 31st September 2005
Royal Brompton Hospital, Royal Brompton and Harefield NHS Trust
Dr J Clague, Professor R Sutton, Dr V Markides, Dr T Wong
General Cardiology, Devices & Electrophysiology
April 2005 – 1st October 2005
Harefield Hospital, Royal Brompton and Harefield NHS Trust
Dr A Mitchell
General Cardiology
3rd October 2004 – April 2005
Harefield Hospital, Royal Brompton and Harefield NHS Trust
Dr N Banner, Dr E Birks
Transplant Cardiology
3rd October 2001 – 2nd October 2004
Imperial College, London & Royal Brompton Hospital
Dr M Polkey, Professor J Moxham, Professor P Poole-Wilson
Clinical Research Fellow
June 2001 – 2nd October 2001
Royal Brompton Hospital, Royal Brompton and Harefield NHS Trust
Dr M Gatzoulis, Dr M Mullen
Grown-up Congenital Heart Disease
31st January 2001 – June 2001
Royal Brompton Hospital, Royal Brompton and Harefield NHS Trust
Professor A Coats, Professor P Poole-Wilson, Professor P Collins, Dr D Gibson
Academic Heart Failure
4th October 2000 – 30th January 2001
The Whittington Hospital
Dr D Patterson, Dr S Hardman
LAT in Cardiology/General Internal Medicine
6th October 1999 – 3rd October 2000
Kent and Canterbury Hospital
Dr D A Lythall, Dr A J Johnson
LAT in Cardiology/Respiratory Medicine/General Internal Medicine
General Medical Training
9th August 1999 – 5th October 1999
Frimley Park Hospital
Dr R K Knight
LAS, General Internal Medicine/Chest Medicine
February 1999 – August 1999
St Thomas’s Hospital
Dr C Bucknall, Dr M Webb-Peploe, Dr J Gill, Dr J Chambers, Dr J Coltart
Senior House Officer, Cardiology
August 1998 – February 1999
Guy’s Hospital
Dr I Abbs, Dr J Pattison, Dr D Goldsmith, Dr S Scoble
Senior House Officer, Renal Medicine
February 1997 - August 1998
Worthing Hospital
Senior House Officer Rotation in General Medicine:
Dr G Caldwell – Endocrinology/General Medicine
Dr A Roques, Dr C Rist – Haematology
Dr P Carr – Renal/General Medicine
Dr J Bull – Gastroenterology/General Medicine
Dr M Signy – Cardiology/General Medicine
Dr J Evans – Chest/General Medicine
August 1996 – February 1997
Kent and Canterbury Hospital
Dr S Brooks
Senior House Officer, Accident and Emergency Medicine
February 1996 – August 1996
Kent and Canterbury Hospital
Mr RM Heddle
Pre-registration House Officer, General Surgery
August 1995 – February 1996
St Thomas’s Hospital
Dr F C Martin – Elderly Care/General Medicine
Dr D Russell-Jones, Professor P Sonksen, Dr C Lowy – Endocrinology/General Medicine
Pre-registration House Officer, General Medicine
Management / Leadership Training
Leadership Matters Trust run leadership programme
LEAD programmeTrust run leadership programme
Positions of Responsibility
Since my arrival at the trust I have taken on leadership roles. I am currently the Cardiology Clinical Service Lead and until recently was the Clinical Safety Officer for the Trust. I have held roles whose primary responsibility is to my department, and also roles that are trust wide and regional.
Clinical Lead for Heart Failure – November 2007 – June 2013
- Oversight of the community heart failure service.
- Participated in developing a service specification enabling commissioning of the hospital-based heart failure service.
Clinical Lead for Cardiac Devices – November 2008, On-going role
- Reduced length of stay from 3 days to less than 1 day.
- Maintained clinical waiting times and outcomes in the context of changes in personnel and changes in demand.
- Won MAFTA for work to reduce the rate of device infections.
- Introduced new procedures and practices (e.g. operating on warfarin).
Cardiology Network Lead (AGWSCS) for Arrhythmias, January 2009 – May 2012
- Introduced new regional guidelines and pathways for management of arrhythmias and ICCs.
- Introduction of remote monitoring of devices.
- Promoted the introduction of new oral anticoagulants and the GRASP-AF tool, which is starting to reduce stroke rates in the region.
Clinical Lead for Research – Cardiology, 2011, On-going role
- Creation of a cardiology research team, currently 2 full-time nurses, one part-time nurse and an administrator.
- 2014, lead trust for cardiology clinical trials recruitment within South West Peninsula NIHR Clinical Research Network.
- Income used to support education of nursing staff and partially funding of the rotablation service.
- Invited speaker at national and international conferences.
Clinical Lead for Cardiology – January 2014 – April 2017
- Maintained a dialogue with management at times of significant tension.
- Maintained performance at a time of increasing demand and expectations.
- Fully implemented CG95 despite considerable resistance, to enable the CCG to continue to commission chest pain services.
- Current transitioning of cardiology job plans onto Zircadian.
- Ensured that Trust cardiology guidelines are reviewed and up to date.
- Ensured compliance with all cardiology NICE guidelines.
- Ensured that the department continues to provide data to all relevant national audits.
Clinical Safety Officer – September 2014, On-going role
- Implementation of Cerner and IMS.
- No significant patient safety episodes with either implementation.
Caldicott Guardian
- Senior person responsible for protecting the confidentiality of patient and service-user information and enabling appropriate information-sharing at Musgrove Park Hospital.
Lead for Electronic Prescribing and Medicines Administration (EPMA) implementation
- Musgrove park is a “Global Digital Exemplar”, and it is currently being supported to transform its IT systems.
- As part of this we plan to implement an EPMA by April 2020 across the trust.
Research
I have a particular interest in infective endocarditis. Over the past 7 years I have been part of an international group that has had a successful track record of publishing at the highest level. At the end of 2014 I presented data at the AHA in a late breaking clinical trials session and the Lancet published the paper simultaneously. I am recognized as an expert in the field internationally. I was appointed as a topic expert for NICE in their review of the endocarditis guidelines and I am an author for an upcoming Cochrane review of endocarditis treatment. I have been invited to be part of a core group designing an international randomized controlled clinical trial. Professor Thornhill and myself are currently putting together a program of work to answer some of the questions raised by our Lancet paper and will be seeking further funding once our current studies are completed. I am preparing a chapter on Endocarditis in patients with congenital heart disease for the next edition of Adult Congenital Heart Disease: a Practical Guide, by Braunwald, Gatzoulis and Swan. I have presented at the British Cardiac Society and European Society of Cardiology this year.
In addition to this I am working with NICOR and their device database. I am currently writing software to clean their dataset and transform it into a more usable format with the long-term aim of providing real time analytical data to inform the device community. This work may have real importance with regards to the cost effectiveness of these expensive devices.
My final area of work, which is just developing, is looking at the MINAP database to examine the impact of primary angioplasty. I have investigated the impact locally, looking at around 1200 cases over the past 10 years. Locally we have transitioned from pre-hospital thrombolysis to primary angioplasty. Rather than see a clear and convincing improvement in outcomes (as assessed by 1-year mortality) as might be expected, we have instead seen a non-significant increase in mortality, driven, possibly by a reluctance to undertake angioplasty on some patients and manage them conservatively, and also by prolonged transfer times; the times to reperfusion have increased significantly. A paper is in preparation.
I have detailed my PhD research below.
I chose psychology for my intercalated BSc in 2001, and during that time worked at the Kobler centre at Chelsea and Westminster studying quality of life in patients with HIV and AIDS. A number of abstracts were presented as a result of the work, and a paper was published in AIDS.
My first publication resulted from work I performed in my gap year in 1988-89 at ICI, where I studied potential theoretical high temperature superconductors.
My publications to date are listed below.
I am PI for a number of commercial studies and was the lead recruiter to cardiology studies in the South West in 2014.
Commercial Trials
The following is a list of commercial trials for which I have been Principal Investigator:
Name / Target / Recruited / Status (Closing Date)Dal-GenE (Dalcor) / 8 / 3 / Open (06/2018)
NOAH/AFNET / 10 / 3 / Open (08/2018)
ETTAA / 10 / 13 / Open (06/2018)
Post 4 / 3 / 2 / Open
ARIADNE / 20 / 16 / Open (11/2017)
GALACTIC / 3 / 0 / Open (01/2019)
ASSESS / 30 / 33 / Closed
PARADIGM Open Label / 5 / 5 / Closed
PARADIGM / 6 / 11 / Closed
PARAGON / 6 / 5 / Closed
CANTOS Ext / 8 / 6 / Closed
CANTOS / 8 / 16 / Closed
GLORIA / 30 / 34 / Closed
MATRIX / 12 / 17 / Closed
AEGEAN / 3 / 1 / Closed
EMMACE 3 / 10 / 20 / Closed
EMMACE 4 / 20 / 20 / Closed
UKAGS / 800 / 1275 / Closed
Clinical Research Fellow Post (PhD)
SupervisorsDr Michael Polkey
Professor John Moxham
Professor Andrew Coats, later Professor Poole-Wilson
TitleLimitations to Exercise in Congestive Heart Failure: Insights from Peripheral and Transcranial Magnetic Stimulation
BackgroundIn patients with congestive heart failure (CHF) there is a mismatch between objective exercise tolerance and measures of ventricular function. The final limits to exercise tolerance and symptoms are centrally driven. A number of studies have documented structural and functional changes in the central nervous system (CNS) in patients with CHF.
ObjectivesTo compare the behaviour of the CNS in patients with CHF and age-matched healthy controls.
TechniquesA number of techniques were employed including: volitional and non-volitional invasive and non-invasive respiratory and peripheral muscle studies, lung function testing, cardiopulmonary exercise testing, transcranial magnetic stimulation and cortical evoked potentials in response to respiratory occlusion.
ResultsThere is evidence of mild peripheral respiratory and quadriceps muscle weakness at rest in patients with CHF. Cycle exercise induces quadriceps, but not diaphragm fatigue in both healthy subjects and patients, but at lower workloads in patients. In healthy subjects there is a fall in cortical reactivity after exercise, but not in patients with CHF. Evoked potentials can be elicited in patients.
ConclusionsThere is some evidence of change in central nervous system performance in patients with heart failure. Changes in peripheral muscle function are also noted at lower workloads.
ProgressPhD awarded 31st May 2008.
Publications
Scientific Papers
Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model.Pufulete M, Maishman R, Dabner L, Mohiuddin S, Hollingworth W, Rogers CA, Higgins J, Dayer M, Macleod J, Purdy S, McDonagh T, Nightingale A, Williams R, Reeves BC.Health Technol Assess. 2017 Aug;21(40):1-150. doi: 10.3310/hta21400.
Model-based cost-effectiveness analysis of B-type natriuretic peptide-guided care in patients with heart failure.Mohiuddin S, Reeves B, Pufulete M, Maishman R, Dayer M, Macleod J, McDonagh T, Purdy S, Rogers C, Hollingworth W.BMJ Open. 2016 Dec 28;6(12):e014010. doi: 10.1136/bmjopen-2016-014010.
The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis.Franklin M, Wailoo A, Dayer MJ, Jones S, Prendergast B, Baddour LM, Lockhart PB, Thornhill MH.Circulation. 2016 Nov 15;134(20):1568-1578.
The healthcare costs of heart failure during the last five years of life: A retrospective cohort study.Hollingworth W, Biswas M, Maishman RL, Dayer MJ, McDonagh T, Purdy S, Reeves BC, Rogers CA, Williams R, Pufulete M.Int J Cardiol. 2016 Dec 1;224:132-138. doi: 10.1016/j.ijcard.2016.09.021.
Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial. Appelboam A, Reuben A, Mann C, Gagg J, Ewings P, Barton A, Lobban T, Dayer M, Vickery J, Benger J; REVERT trial collaborators. Lancet. 2015 Oct 31;386(10005):1747-53. doi: 10.1016/S0140-6736(15)61485-4. Epub 2015 Aug 24.
Latest NICE guidelines on the use of cardiac resynchronisation therapy and implantable cardioverter defibrillator devices in heart failure may significantly increase implant rates. Mahendiran T, Gosling OE, Newton J, Giblett D, McKenzie D, Dayer M. British Journal of Cardiology. 2015. In Press.
Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis. Thornhill MT, Dayer MJ, Prendergast B, Baddour LM, Jones S, Lockhart PB. J AntimicrobChemother. 2015. In Press. Doi: 10.1093/jac/dkv115.
Incidence of infective endocarditis in England, 2000-13: a secular trend, interrupted time-series analysis. Dayer MJ, Jones S, Prendergast B, Baddour LM, Lockhart PB, Thornhill MH. Lancet. 2014 Nov 18. pii: S0140-6736(14)62007-9. doi: 10.1016/S0140-6736(14)62007-9. [Epub ahead of print].
Protocol for a systematic review and individual participant data meta-analysis of B-type natriuretic peptide-guided therapy for heart failure. Pufulete M, Higgins JP, Rogers CA, Dreyer L, Hollingworth W, Dayer M, Nightingale A, McDonagh T, Reeves BC. Syst Rev. 2014 May 2;3:41. doi: 10.1186/2046-4053-3-41.
NICE guidance on antibiotic prophylaxis to prevent infective endocarditis: a survey of clinicians' attitudes. Dayer MJ, Chambers JB, Prendergast B, Sandoe JA, Thornhill MH.QJM. 2013 Mar;106(3):237-43. doi: 10.1093/qjmed/hcs235. Epub 2013 Jan 3.
Hopkinson NS, Dayer M, Antoine-Jonville S, Swallow EB, Porcher R, Vazir A, Poole-Wilson P, Polkey MI. Central and peripheral quadriceps fatigue in congestive heart failure. Int J Cardiol. 2012 Jul 12. [Epub ahead of print]
Hopkinson NS, Sharshar T, Dayer MJ, Lofaso F, Moxham J, Polkey MI. The effect of acute non-invasive ventilation on corticospinal pathways to the respiratory muscles in chronic obstructive pulmonary disease. RespirPhysiolNeurobiol. 2012 Jul 31;183(1):41-7. doi: 10.1016/j.resp.2012.05.018. Epub 2012 May 29.
Bond R, Augustine D, Dayer M. Pacemaker complications in a district general hospital. Br J Cardiol. Br J Cardiol 2012;19:90-4. Doi: 10.5837/bjc.2012.018.
Oxygen uptake efficiency slope, aerobic fitness, and V(E)-VCO2 slope in heart failure.Antoine-Jonville S, Pichon A, Vazir A, Polkey MI, Dayer MJ. Med Sci Sports Exerc. 2012 Mar;44(3):428-34. doi: 10.1249/MSS.0b013e31822f8427.
Martin H Thornhill, Mark J Dayer, Jamie M Forde, G Ralph Corey, Vivian H Chu, David J Couper, Peter B Lockhart. Impact of the NICE guideline recommending cessation of antibiotic prophylaxis for prevention of infective endocarditis: before and after study BMJ 2011;342:doi:10.1136/bmj.d2392 (Published 3 May 2011).
Hastings PC, Vazir A, Meadows GE, Dayer M, Poole-Wilson PA, McIntyre HF, Morrell MJ, Cowie MR, Simonds AK. Adaptive servo-ventilation in heart failure patients with sleep apnea: A real world study. Int J Cardiol. 2010; 139: 17-24.
Hopkinson NS, Dayer MJ, Moxham J, Polkey MI. Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease. Respir Res 2010; 11: 15-22.
Jaye J, Chatwin M, Dayer M, Morrell MJ, Simonds AK. Autotitrating versus standard noninvasive ventilation: a randomised crossover trial. EurRespir J 2009; 33: 566-71.
Swallow EB, Gosker HR, Ward KA, Moore AJ, Dayer MJ, Hopkinson NS, Schols AMWJ, Moxham J, Polkey MI. A novel technique for non-volitional assessment of quadriceps muscle endurance in man. J ApplPhysiol 2007; 103: 739-46.
Hopkinson NS, Tennant RC, Dayer MJ, Swallow EB, Hansel TT, Moxham J, Polkey MI. A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary disease. Respiratory Research 2007; 8: 25.
Dayer M, Jonville S, Chatwin M, Swallow E, Porcher R, Sharshar T, Ross E, Moxham J, Similowski T, Hopkinson N, Polkey M. Exercise-induced depression of the diaphragm motor evoked potential is not affected by non-invasive ventilation. RespirPhysiolNeurobiol 2007; 155: 243-254.
Vazir A, Hastings PC, Dayer M, McIntyre HF, Henein MY, Poole-Wilson PA, Cowie MR, Morrell MJ, Simonds AK. A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction. Eur J Heart Fail 2007; 9: 243-50.
Szollosi I, O’Driscoll DM, Dayer MJ, Coats AJ, Morrell MJ, Simonds AK. Adaptive servo-ventilation and deadspace: effects on central sleep apnoea. J Sleep Res 2006; 15: 199-205
Vazir A, Dayer M, Hastings P, McIntyre H, Henein M, Poole-Wilson P, Cowie M, Morrell M, Simonds A. Can heart rate variation rule out sleep disordered breathing in heart failure? EurResp J 2006; 27: 571-7.
Dayer MJ, Hopkinson NS, Ross ET, Jonville S, Sharshar T, Kearney M, Moxham J, Polkey MI. Does symptom limited cycle exercise cause low frequency diaphragm fatigue in patients with heart failure. Eur J Heart Fail. 2006; 8: 68-73.
Sharshar T, Hopkinson NS, Ross ET, Jonville S, Dayer MJ, Nickol AH, Lofaso F, Moxham J, Polkey MI. Motor control of the costal and crural diaphragm – insights from transcranial magnetic stimulation in man. Resp Phys Neurobiol 2005; 146: 5-19.
Hopkinson NS, Man WD, Dayer MJ, Ross ET, Nickol AH, Hart N, Moxham J, Polkey MI. Acute effect of oral steroids on muscle function in chronic obstructive pulmonary disease. EurResp J 2004; 24: 137-42.