Stefano Campaner, Curriculum Vitae

Stefano Campaner, Curriculum Vitae

CURRICULUM VITAE

NAME:Stefano Campaner

DATE AND PLACE OF BIRTH:3 March 1968, Milano, Italy

CITIZENSHIP:Italian

MARITAL STATUS:Married

E-MAIL ADDRESS:

PRESENT EMPLOYMENT:Istituto Italiano di Tecnologia

Center for Genomic Science

via Adamello 16, 20139 Milano, Italy

Phone: +390294372407

LANGUAGES: Italian, English.

EDUCATION

1997: PhD Degree in Biochemistry, University of Milan, Italy

1994: Board exam for Biologist

1992: Master Degree in Biological Sciences, Magna cum Laude, University of Milan, Italy

CAREER PATH AND SCIENTIFIC ACTIVITY

2012-present : Researcher (independent PI),Center for Genomic Science ofIIT@SEMM,Istituto Italiano di Tecnologia (IIT) Italy.

2008-present: Professor (external collaborator) of Molecular and Cellular Oncology, University of Milano-Bicocca, Milan, Italy

2009-2011: Staff Scientist, European Institute of Oncology, Milan Italy.

2003-2009: Post-doctoral Fellow, European Institute of Oncology. PI: Dr. Bruno Amati

1998-2003: Post-doctoral Fogarty fellowship, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, USA. PI: Dr. I.R. Kirsch

1997-1998: Research assistant, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, USA. PI: Dr. I.R. Kirsch

1994-1997: Ph.D. student, Department of General Physiology and Biochemistry, University of Milan, Italy. PI: Prof. Mirella S. Pilone

1993-1994: Social service.

1992-1993: post-graduate student at the Department of General Biochemistry and Physiology, University of Milan, Italy. PI: Prof. Mirella S. Pilone

1990-1992: Internship at the Department of General Biochemistry and Physiology, University of Milan, Italy. PI: Prof. Mirella S. Pilone

PATENTS

PHARMACEUTICAL COMPOSITION AND METHOD FOR REGULATING ABNORMAL CELLULAR PROLIFERATION, PCT Patent Application No. PCT IL2006-001324.

AWARDS

2008: Keystone Symposia scholarship, travel Award funded by the International Society of Differentiation

1998-2003: Fogarty Fellowship, the National Institute of Health (NIH), Bethesda, USA.

2002:Recipient of the 2002 Fellow Award for Research Excellence at the National Institute of Health (NIH), Bethesda, USA.

GRANTS

“The Myc induced DNA damage response: dual roles in tumor suppression and progression”. Investigator Grant, AIRC (Associazione Italiana Ricerca sul Cancro), 2013-2016(360.000 Eu).

REFEREEING

Reviewer for scientific journals (Nature Medicine, PNAS, Oncogene and Molecular and Cellular Biology) and grants (AIRC).

TEACHING ACTIVITY

2012-present: teacher for the PhD course on Cancer Genetics, European School of Molecular Medicine, Milan, Italy.

2008-present: Professor (external collaborator) of Molecular and Cellular Oncology, University of Milano-Bicocca, Milan, Italy

INVITED SPEAKER AT SCIENTIFIC CONFERENCES

Assessing Therapeutic targets in a pre-clinical model of Myc induced Lymphoma

56° National Meeting of the Italian Society of Biochemistry and Molecular Biology, Chieti, 26-29 September 2012

Cdk2 suppresses cellular senescence induced by myc or wnt oncogenes

SFB 684 "MOLECULAR MECHANISMS OF NORMAL AND MALIGNANT HEMATOPOIESIS" Symposium , Munich April 2-4,2009.

Cdk2 is required to suppress oncogene and stress-induced senescence

TRR 54-Meeting, Lymphoma Conference, Wachstum und berleben, Plastizit und zellulre Interaktivitt lymphatischer Neoplasienì, 13-14 February 2009 Charité Universitaetsmedizin Berlin, Germany.

CDK2 PROTECTS FROM MYC INDUCED CELLULAR SENESCENCE

Selezionato per presentazione orale, The Cell Cycle meeting, Cold Spring Harbour Laboratory, May14-May 18, 2008

Function of Cyclin E1 and CDK2 in Hematopoietic Stem Cells

International Workshop on Cancer Stem Cells, IFOM-IEO Campus, Milan, Italy

The SIL protein is implicated in the mitotic checkpoint

3rd ANNUAL RCGL-RPFL Retreat, September 23-25, 2002, Historic Inns of Annapolis, MD, US

A mitotic role for SIL suggested by cell cycle regulation and interaction with PIN1

Center for Cancer Research Festival, June 2001, Frederick , MD, US.

PUBLICATIONS

Campaner S*, Amati B. Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance. Cell Div. 2012 Feb 28;7(1).6.

*Corresponding Author

Murga M*, Campaner S*, Lopez-Contreras AJ, Toledo LI, Soria R, Montana MF, D'Artista L, Schleker T, Guerra C, Garcia E, Barbacid M, Hidalgo M, Amati B, Fernandez-Capetillo O. Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol. 2011 Nov 27;18(12).1331-5. *: co-first authors

Campaner S*, Spreafico F*, Burgold T, Doni M, Rosato U, Amati B, Testa G. The

methyltransferase Set7/9 (Setd7) is dispensable for the p53-mediated DNA damage response in vivo. Mol Cell. 2011 Aug 19;43(4).681-8. *:co-first authors

Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, Amati B, de Marco A, Biffo S. Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. Cancer Cell. 2011 Jun 14;19(6):765-75.

Campaner S, Doni M, Verrecchia A, Fag‡ G, Bianchi L and Amati B. Myc, Cdk2 and cellular senescence: Old players, new game. Cell Cycle. 2010 Sep;9(18):3655-61.

Campaner S, Doni M, Hydbring P, Verrecchia A, Bianchi L, Sardella D, Schleker T, Perna D, Tronnersjˆ S, Murga M, Fernandez-Capetillo O, Barbacid M, Larsson LG and Amati B. Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol. 2010 Jan;12(1):54-9; sup pp 1-14.

Magnifico A, Albano L, Campaner S, Delia D, Castiglioni F, Gasparini P, Sozzi G, Fontanella E, Menard S, Tagliabue E. Tumor-initiating cells of HER2-positive carcinoma cell lines express the highest oncoprotein levels and are sensitive to trastuzumab. Clin Cancer Res. 2009 Mar 15;15(6):2010-21. Epub 2009

Magnifico A., Albano L., Campaner S., Campiglio M., Pilotti S., Menard S., and Tagliabue, E. (2007). Proteinkinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification. Cancer Res 67, 5308-5317.

Erez, A., Castiel, A., Trakhtenbrot, L., Perelman, M., Rosenthal, E., Goldstein, I., Stettner, N., Harmelin, A., Eldar-Finkelman, H., Campaner S., et al. (2007). The SIL gene is essential for mitotic entry and survival of cancer cells. Cancer Res 67, 4022-4027.

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