ESM Table 3 Expression of secreted proteins commonly dysregulated in adipose cells after 24 h and 48 h in culture, and of secreted proteins in adipose cells isolated from Zucker fa/fa rats

Accession / Description / Geometric mean of ratios / Geometric mean of ratios / Geometric mean of ratios / Gene ontology annotations
Values
at 24 h : 0 h / Values
at 48 h : 0 h / Zucker
obese/lean
NM_007729 / Procollagen, type XI, alpha 1 / −1.76 / −1.43 / −1.75 / Extracellular matrix organization and biogenesis; proteoglycan metabolism; extracellular space
NM_008610 / Matrix metalloproteinase 2 / 2.31 / 2.35 / 1.55 / Proteolysis; metalloendopeptidase activity; extracellular space
NM_011593 / Tissue inhibitor of metalloproteinase / 5.7 / 7.94 / 4.59 / Cell proliferation; cAMP metabolism; regulation of MAPKKK cascade; neuron differentiation; metalloendopeptidase inhibitor activity; extracellular space
NP_035305 / Legumain / 3.01 / 1.77 / 2.2 / Proteolysis; regulation of body size; late endosome
X54966 / Cathepsin B / 1.45 / 1.38 / 2.28 / Regulation of apoptosis, proteolysis; response to oxidative stress, peroxidase activity; lysosome; extracellular region
NM_013693 / LPS-induced TNF-alpha factor / 1.94 / 1.63 / 1.62 / Inflammatory response; apoptosis; glucose metabolism; regulation of cell proliferation; extracellular space; secretory granule
NM_008357 / Interleukin 15 / −1.74 / −1.53 / −1.56 / Immune response; angiogenesis; positive regulation of cell proliferation; extracellular space
P07141 / Colony stimulating factor 1 / 1.47 / 2.24 / 1.79 / Macrophage differentiation; positive regulation of osteoclast differentiation; neural crest cell migration; pigmentation during development; cell proliferation; extracellular space
NP_001771 / CD63 antigen / 2.66 / 3.52 / 1.52 / Positive regulation of endocytosis; lysosome; late endosome
NP_031683 / CD9 antigen / 5.11 / 3.05 / 2.09 / Cell adhesion; cell motility; platelet activation; protein binding; integral to plasma membrane
NM_011255 / Retinol binding protein 4 / −2.95 / −2.52 / −1.28 / Retinol binding; transporter activity; glucose metabolism; insulin resistance; extracellular space
NP_032506 / Laminin, alpha 1 / −2.34 / −1.37 / −1.45 / Cell surface receptor linked signal transduction; development; blood vessel morphogenesis; neuron migration; extracellular matrix
NM_010683 / Laminin, gamma 1 / 1.76 / 1.32 / 1.91 / Cell adhesion; cell proliferation; protein complex assembly; endoderm development; extracellular space
NM_009368 / Transforming growth factor, beta 3 / −1.67 / −1.8 / −1.54 / Activation of MAPK activity; embryonic development; negative regulation of cell proliferation; organ morphogenesis; positive
regulation of apoptosis; extracellular space
NM_010512 / Insulin-like growth factor 1 / −8.3 / −2.83 / −1.49 / Cell development; body growth; anti-apoptosis; glycolate metabolism; extracellular space; phosphoinositide
3-kinase binding; extracellular space
NP_034019 / Glycoprotein hormones, alpha / −2.13 / −1.53 / −1.82 / Hormone activity; extracellular space
NM_007428 / Angiotensinogen / −1.83 / −1.44 / −1.49 / Blood pressure regulation; blood vessel development; extracellular matrix organization and biogenesis; hormone metabolism; negative regulation of neuron apoptosis; negative regulation of cell proliferation; cell–matrix adhesion; positive regulation of fatty acid biosynthesis; extracellular space
NP_033404 / Thrombomodulin / −2.13 / −1.56 / −1.56 / Blood coagulation; embryonic development; pregnancy; extracellular space
NM_007752 / Ceruloplasmin / 3.66 / 1.37 / 1.67 / Copper ion homeostasis; iron ion homeostasis; ferroxidase activity; extracellular space
NM_007833 / Decorin / 3.72 / 3.97 / 1.69 / Extracellular matrix organization and biogenesis; collagen binding; organ morphogenesis; extracellular matrix; extracellular space
NM_009735 / Beta-2 microglobulin / −1.63 / 1.86 / 2.45 / Cellular defence response; protein binding; extracellular space

MAPK mitogen-activated protein kinase, MAPKKK mitogen-activated protein kinase kinase kinase