Physiology and Cell Biology Research Day

The 7th Annual

Physiology and Cell Biology Research Day

OSU Biomedical Research Tower

March 29, 2013

Organizing committee: B. Biesiadecki, V. Fedorov, M. Treon,

N. Weisleder and M. Ziolo

Schedule of Events

10:30-10:45 Opening Remarks BRT Rm 115

10:45-12:00 Emil Bozler Lecture BRT Rm 115

Lynda F. Bonewald, Ph.D.

12:00-12:45 Light lunch BRT Rm 115

12:45-1:30 Oral Session BRT Rm 115

1:30-3:30 Poster Session BRT Lobby

3:30-4:30 Nishikawara Scholars BRT Rm 115

Oral presentations

4:30-4:45 Awards presentation BRT Rm 115

(Nishikawara Scholars and Poster awards)

5:00 Off-campus social

Eddie George’s restaurant (South Campus Gateway)

Poster Presentations

1:30-3:30 P.M.

* Poster Presenters:

- Please mount your posters from 10:00-10:30 A.M.

- Poster presentation and judging will be at 1:30-3:30 P.M.

Odd numbered posters will be presented at 1:30-2:30.

Even numbered posters will be presented at 2:30-3:30.

Presenters should be at their poster during this time.

P1. Endogenous Capsaicin-Like Lipids in Guinea Pig and Human Small Intestine.

X.-Y. Wang, G-D Wang and JD Wood

P2. Purinergic Inhibitory Neuromuscular Transmission in Human Jejunum and Guinea Pig Colon.

X.-Y. Wang, JD Wood and G-D Wang

P3. Sarcolipin Increases Energy Expenditure and Provides Resistance Against Diet-induced Obesity.

Santosh K. Maurya, N.C. Bal, D.H. Sopariwala, S.A. Shaikh, L.A. Rowland and M. Periasamy

P4. Synchronization of Ca2+ Release in Multicellular Cardiac Preparations.

Jessica L. Slabaugh, L. Brunello, S. Gyorke and P.M.L. Janssen

P5. Myosin 9b Regulates Osteoclast Function Through Rho and Src.

Brooke McMichael, K. Scherer, N. Franklin and B. Lee

P6. Mechanisms of Junctional Membrane Uncoupling in the Progression of Heart Failure.

Sayak Bhattacharya, J. Alloush, E. Beck and N. Weisleder

P7. Evaluation of the Therapeutic Effects of Tripartite Motif Family Proteins on Muscular Dystophy.

Heather Manring, Z. Xu, J. Alloush, E. Beck, L. Gushchina and N. Weisleder

P8. Developing Novel TRIM Family Proteins as Therapeutic Agents for Chronic Diseases.

Liubov Gushchina, J. Alloush, E. Beck, H. Manring, Z. Xu and N. Weisleder

P9. Myocardial Rac1 Exhibits Partial Involvement in Thyroxin-Induced Cardiomyocyte Hypertrophy and its Inhibition is Not Sufficient to Improve Cardiac Dysfunction or Contractile Abnormalities in Mouse Papillary Muscles.

Mohammad T. Elnakish, L. Moldovan, H.H. Hassanain and P.M.L. Janssen

P10. Restoring Nitroso-redox Equilibrium After Myocardial Infarction Limits Contractile Dysfunction and Adverse Remodeling.

Bo Zhang, H. Wang, X. Huang, C. Heymes, E. Villamena, R.J. Gumina and M.T. Ziolo

P11. NOS1 Orchestrates a Localized Nitroso-redox Signaling Network in Ventricular Myocytes.

Honglan Wang, L. Tang, B. Zhang, S.R. Roof, X. Huang, L.S. Kirschner, F. Villamena, B.J. Biesiadecki and M.T. Ziolo

P12. Spinal Cord Contusion Induces Extracellular Signal-Regulated Kinase (ERK)1/2 Activation Early After Injury.

Kent E. Williams and L.B. Jakeman

P13. Targeted Delivery of NIS-­‐Specific Knockdown Agents to the Mouse Salivary Gland.

Brynn Hollingsworth, K.M.D. La Perle, M.P. Brandt and S.M. Jhiang

P14. Dynamic Interplay of Smooth Muscle α-Actin Gene-Regulatory Proteins Reflects the Biological Complexity of Myofibroblast Differentiation.

Bill Willis, S. Hariharan and A.R. Strauch

P15. HuR mRNA Isoform Expression in Cellular Energy Depletion.

Suman S. Govindaraju and B.S. Lee

P16. Contribution of the NOS1/CaMKII/RyR Axis in the Positive Inotropic Response to Beta-adrenergic Stimulation in Ventricular Myocytes.

Lifei Tang, S.R. Roof, X. Huang, P.J. Mohler, X.H. Wehrens and M.T. Ziolo

P17. The Role of Increased Sarcolipin Expression in Neonatal Development and in Muscle Disease.

Meghna Pant, N.C. Bal, D. Delfin, J. Rafael-Fortney and M. Periasamy

P18. Sarcolipin and Ucp1 Play Distinct Roles in Diet- Versus Cold-induced Thermogenesis.

Leslie Rowland, N.C. Bal and M. Periasamy

P19. Development of a Striated Muscle Contractile Function Assay in Developing Zebrafish.

Neha Rastogi, J.P. Davis, S.L. Amacher, C.E. Beattie and P.M.L. Janssen

P20. Adenosine A1 Receptors Overexpression in the Pacemaker Complex Aggravate Atrial Tachy-Brady Arrhythmias in Canine and Human Chronic Heart Failure.

Lori Hage, O. Fedorenko, B. Hansen, Q. Lou, A. Kalyanasundaram, A.V. Glukhov, I.M. Bonilla Mercado, R.S.D. Higgins, A. Kilic, D. Van Wagoner, S. Gyorke, P.M.L. Janssen, P.J. Mohler, R. Weiss, B.J. Biesiadecki, C.A. Carnes and V.V. Fedorov

P21. Characterization of CD200 and CD200R Expression After Spinal Cord Injury.

Bryan Brautigam and L.B. Jakeman

P22. Adapting Stress Responses in Plants to the Mammal: Step One.

Shane D. Walton, V. Shettigar, C.W. Wilson, P.D. Conley, A.J. O’Neil and J.P. Davis

P23. Calcium and Magnesium Binding Properties of Soybean Calmodulin 1 and 4.

Vikram Shettigar J. Zhang, A.J. O’Neil, S.D. Walton, H. Chakravarthy, and J.P. Davis

P24. The Roles of Kindlin 3 in Osteoclast Function.

(Nishikawara 2012 Summer Undergraduate Fellow)

Jordan Brauner and B.S. Lee

P25. The Role of Myoferlin in the Differentiation and Multinucleation of Osteoclasts.

(Nishikawara 2012 Summer Undergraduate Fellow)

Lauren Savage, B. McMichael and B.S. Lee

Oral Presentations

12:45-1:30 P.M.

1. Enhanced Sensitivity to Adenosine in Chronic Heart Failure Aggravate Atrial Tachy-Brady Arrhythmias.

(Nishikawara 2012 Summer Undergraduate Fellow)

Brian Hansen, Q. Lou, L. Hage, O. Fedorenko, A. Kalyanasundaram, A.V. Glukhov, I.M. Bonilla, S. Györke, P.M.L. Janssen, D.R. Van Wagoner, P.J. Mohler, R. Weiss, B.J. Biesiadecki, C.A. Carnes, V.V. Fedorov

2. Apigenin enhances Akti1/2-induced Radioactive Iodine Uptake (RAIU) in Thyroid Cells in p38 MAPK Activity-dependent Manner.

Aparna Lakshmanan, S.M. Jhiang

3. Sarcolipin Interaction With SERCA is Distinct from Phospholamban; Only Sarcolipin Can Promote Uncoupling of the SERCA Pump.

Sanjaya K. Sahoo, S.A. Shaikh, D.H. Sopariwala, N.C. Bal and M. Periasamy

4. Targeting Membrane Repair as a Therapeutic Approach for Myocardial Ischemic Injury.

Zhaobin Xu, J. Alloush, E. Beck, H. Manring, L. Gushchina, N. Weisleder

Nishikawara Presentations

3:30-4:30 P.M.

Margaret T. Nishikawara (1975)

Nima Milani-Nejad

“Effect of Muscle Length on Cross-bridge Cycling Kinetics in Intact Cardiac Trabeculae Under Near-physiological Conditions: Studies from Rodents to Humans Using a Novel Approach”

Benjamin Nixon

“Troponin I Serine 150 Phosphorylation Imparts Protection From pH-Induced Troponin Ca2+ Desensitization”

Hsiang-Ting Ho

“RyR Phosphorylation by Oxidized CAMKII Contributes to the Cardiotoxic Effects of Cardiac Glycosides”

Emil Bozler Distinguished Lecture

Department of Physiology and Cell Biology

Lynda F. Bonewald, Ph.D.

Lefkowitz Professor of Oral Physiology

Vice Chancellor for Translational Clinical Research

Director, UMKC Center of Excellence

in the Study of Dental and Musculoskeletal Tissues

University of Missouri at Kansas City

“Muscle and Bone Interactions”

Friday, March 29, 2013 - 10:45 A.M.

BRT Room 115