Table S2. Turnover rates of multiprotein complexes. For each multiprotein complex identified (Fig. 6), each protein subunit is listed along with its turnover rate (in parentheses, log d-1). The ordering of the list is based on Figure 6.
Brain: intermediate filament
P14733 lamin B1 (-2.3)
P08551 neurofilament, light polypeptide (-2)
P08553 neurofilament, medium polypeptide (-2)
P46660 internexin neuronal intermediate filament protein, alpha (-1.9)
P19246 neurofilament, heavy polypeptide (-1.7)
P03995 glial fibrillary acidic protein (-1.6)
Q99104 myosin VA (-0.9)
Brain: proton-transporting ATP synthase complex
Q91VR2 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (-1.9)
Q9CQQ7 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 (-1.8)
P56480 ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit (-1.8)
Q9CPQ8 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g (-1.7)
Q9DB20 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (-1.7)
Q03265 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 (-1.7)
Q9DCX2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d (-1.5)
P50516 ATPase, H+ transporting, lysosomal V1 subunit A (-1.2)
P62814 ATPase, H+ transporting, lysosomal V1 subunit B2 (-1.1)
Brain: mitochondrial respiratory chain complex I
Q9DCJ5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 (-1.8)
Q9DCT2 NADH dehydrogenase (ubiquinone) Fe-S protein 3 (-1.6)
Q9Z1P6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) (-1.5)
Q91VD9 NADH dehydrogenase (ubiquinone) Fe-S protein 1 (-1.5)
Q91YT0 NADH dehydrogenase (ubiquinone) flavoprotein 1 (-1.5)
Brain: clathrin coat
O08585 clathrin, light polypeptide (Lca) (-1.6)
Q68FD5 clathrin, heavy polypeptide (Hc) (-1.5)
Q61548 synaptosomal-associated protein 91 (-1.5)
P17427 adaptor protein complex AP-2, alpha 2 subunit (-1.3)
Q6IRU5 clathrin, light polypeptide (Lcb) (-1.3)
Q9DBG3 adaptor-related protein complex 2, beta 1 subunit (-1.3)
P17426 adaptor protein complex AP-2, alpha 1 subunit (-1.3)
P84091 adaptor protein complex AP-2, mu1 (-1.3)
P22892 adaptor protein complex AP-1, gamma 1 subunit (-1.2)
O35643 adaptor protein complex AP-1, beta 1 subunit (-1.1)
Q8CHC4 synaptojanin 1 (-1.1)
Q91X97 neurocalcin delta (-0.9)
Q8BMI3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 (-0.9)
P62743 adaptor-related protein complex 2, sigma 1 subunit (-0.5)
Brain: Arp2/3 protein complex
P59999 actin related protein 2/3 complex, subunit 4 (-1.4)
Q9CVB6 actin related protein 2/3 complex, subunit 2 (-1.3)
Q9R0Q6 actin related protein 2/3 complex, subunit 1A (-1.2)
P61161 ARP2 actin-related protein 2 homolog (yeast) (-1.2)
Q9JM76 actin related protein 2/3 complex, subunit 3 (-1.2)
Brain: small ribosomal subunit
P62702 ribosomal protein S4, X-linked (-1.4)
P25444 ribosomal protein S2 (-1.3)
P62849 ribosomal protein S24 (-1.3)
P14131 ribosomal protein S16 (-1.3)
Q9CZX8 ribosomal protein S19 (-1.3)
P62908 ribosomal protein S3 (-1.3)
Q6ZWN5 ribosomal protein S9 (-1.2)
P62264 ribosomal protein S14 (-1.2)
P97461 ribosomal protein S5 (-1.2)
P62301 ribosomal protein S13 (-1.2)
P14206 ribosomal protein SA (-1.2)
P62082 ribosomal protein S7 (-1.1)
P62843 ribosomal protein S15 (-1.1)
Brain: proteasome core complex
Q9R1P4 proteasome (prosome, macropain) subunit, alpha type 1 (-1.2)
Q9R1P0 proteasome (prosome, macropain) subunit, alpha type 4 (-1.1)
Q9Z2U0 proteasome (prosome, macropain) subunit, alpha type 7 (-1.1)
O55234 proteasome (prosome, macropain) subunit, beta type 5 (-1.1)
Q60692 proteasome (prosome, macropain) subunit, beta type 6 (-1.1)
Q9Z2U1 proteasome (prosome, macropain) subunit, alpha type 5 (-1)
P99026 proteasome (prosome, macropain) subunit, beta type 4 (-1)
P49722 proteasome (prosome, macropain) subunit, alpha type 2 (-1)
O09061 proteasome (prosome, macropain) subunit, beta type 1 (-1)
O70435 proteasome (prosome, macropain) subunit, alpha type 3 (-1)
Q9R1P3 proteasome (prosome, macropain) subunit, beta type 2 (-1)
P70195 proteasome (prosome, macropain) subunit, beta type 7 (-1)
Brain: chaperonin-containing T-complex
P80315 chaperonin containing Tcp1, subunit 4 (delta) (-1.1)
P80317 chaperonin containing Tcp1, subunit 6a (zeta) (-1)
P80313 chaperonin containing Tcp1, subunit 7 (eta) (-1)
P11983 (-1)
P80316 chaperonin containing Tcp1, subunit 5 (epsilon) (-0.9)
Brain: myosin complex
Q64331 myosin VI (-2.1)
Q9JMH9 myosin XVIIIA (-1.2)
Q61879 myosin, heavy polypeptide 10, non-muscle (-1)
Q8VDD5 myosin, heavy polypeptide 9, non-muscle (-1)
Q3THE2 myosin, light chain 12B, regulatory (-0.9)
Q99104 myosin VA (-0.9)
Q60605 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle (-0.9)
Q5SYD0 myosin ID (-0.5)
Brain: signalosome
Q8VBV7 COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana) (-1.1)
P14685 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 (-0.9)
O88544 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) (-0.5)
O88545 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) (-0.2)
Q2PFD7 pleckstrin and Sec7 domain containing 3 (-0.1)
Brain: kinesin complex
P28740 kinesin family member 2A (-1.1)
Q9QXL2 kinesin family member 21A (-0.9)
P33173 kinesin family member 1A (-0.5)
P28738 kinesin family member 5C (-0.2)
Q9QXL1 kinesin family member 21B (-0.1)
Liver: small ribosomal subunit
P62267 ribosomal protein S23 (-1.2)
P63323 ribosomal protein S12 (-1.2)
Q9CZX8 ribosomal protein S19 (-1.1)
P14206 ribosomal protein SA (-1)
P62858 ribosomal protein S28 (-1)
P14131 ribosomal protein S16 (-1)
P62754 ribosomal protein S6 (-1)
P62274 ribosomal protein S29 (-1)
P62843 ribosomal protein S15 (-1)
P62301 ribosomal protein S13 (-1)
Q6ZWN5 ribosomal protein S9 (-1)
P63276 ribosomal protein S17 (-1)
P62855 ribosomal protein S26 (-1)
P62908 ribosomal protein S3 (-1)
P62849 ribosomal protein S24 (-1)
P62264 ribosomal protein S14 (-0.9)
P62702 ribosomal protein S4, X-linked (-0.5)
Q6ZWU9 ribosomal protein S27 (-0.5)
Liver: large ribosomal subunit
P62911 ribosomal protein L32 (-1)
P61255 (-1)
P41105 ribosomal protein L28 (-0.9)
P14148 ribosomal protein L7 (-0.9)
Q9CXW4 ribosomal protein L11 (-0.9)
P19253 ribosomal protein L13A (-0.9)
Q9CPR4 ribosomal protein L17 (-0.8)
P84099 ribosomal protein L19 (-0.8)
P62918 ribosomal protein L8 (-0.5)
Liver: intermediate filament
P05784 keratin 18 (-0.9)
P48678 lamin A (-0.9)
P11679 keratin 8 (-0.9)
P14733 lamin B1 (-0.5)
O55135 eukaryotic translation initiation factor 6 (-0.2)
Liver: proton-transporting ATP synthase complex
Q91VR2 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (-1)
Q9D3D9 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (-0.9)
Q9CQQ7 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1 (-0.9)
Q9DB20 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (-0.9)
Q03265 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1 (-0.9)
P56480 ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit (-0.8)
Q06185 ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e (-0.8)
Q9CPQ8 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g (-0.8)
Q9DCX2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d (-0.8)
P56135 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 (-0.8)
P03930 (-0.7)
P97450 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F (-0.7)
Liver: mitochondrial respiratory chain complex I
Q9DCJ5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 (-0.9)
Q91VD9 NADH dehydrogenase (ubiquinone) Fe-S protein 1 (-0.8)
Q9CQ75 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (-0.7)
Q91YT0 NADH dehydrogenase (ubiquinone) flavoprotein 1 (-0.7)
Q9CXZ1 NADH dehydrogenase (ubiquinone) Fe-S protein 4 (-0.7)
Q9DCT2 NADH dehydrogenase (ubiquinone) Fe-S protein 3 (-0.5)
Liver: clathrin coat
Q9DBG3 adaptor-related protein complex 2, beta 1 subunit (-0.8)
Q68FD5 clathrin, heavy polypeptide (Hc) (-0.8)
O35643 adaptor protein complex AP-1, beta 1 subunit (-0.7)
P17427 adaptor protein complex AP-2, alpha 2 subunit (-0.7)
P17426 adaptor protein complex AP-2, alpha 1 subunit (-0.6)
P61967 adaptor protein complex AP-1, sigma 1 (-0.6)
P61924 coatomer protein complex, subunit zeta 1 (-0.5)
P22892 adaptor protein complex AP-1, gamma 1 subunit (-0.3)
Liver: proteasome core complex
Q9QUM9 proteasome (prosome, macropain) subunit, alpha type 6 (-1.3)
Q9R1P4 proteasome (prosome, macropain) subunit, alpha type 1 (-0.7)
Q9R1P0 proteasome (prosome, macropain) subunit, alpha type 4 (-0.7)
Q60692 proteasome (prosome, macropain) subunit, beta type 6 (-0.7)
Q9Z2U1 proteasome (prosome, macropain) subunit, alpha type 5 (-0.6)
O55234 proteasome (prosome, macropain) subunit, beta type 5 (-0.6)
P99026 proteasome (prosome, macropain) subunit, beta type 4 (-0.6)
P49722 proteasome (prosome, macropain) subunit, alpha type 2 (-0.6)
Q9R1P1 proteasome (prosome, macropain) subunit, beta type 3 (-0.6)
Q9R1P3 proteasome (prosome, macropain) subunit, beta type 2 (-0.6)
P70195 proteasome (prosome, macropain) subunit, beta type 7 (-0.5)
O09061 proteasome (prosome, macropain) subunit, beta type 1 (-0.5)
Liver: chaperonin-containing T-complex
P11983 (-0.9)
P80313 chaperonin containing Tcp1, subunit 7 (eta) (-0.8)
P80317 chaperonin containing Tcp1, subunit 6a (zeta) (-0.6)
P80318 chaperonin containing Tcp1, subunit 3 (gamma) (-0.5)
P80314 chaperonin containing Tcp1, subunit 2 (beta) (-0.4)
Liver: myosin complex
Q6URW6 myosin, heavy polypeptide 14 (-0.8)
P46735 myosin IB (-0.5)
Q8VDD5 myosin, heavy polypeptide 9, non-muscle (-0.5)
Q3THE2 myosin, light chain 12B, regulatory (-0.5)
O08638 myosin, heavy polypeptide 11, smooth muscle (-0.4)
Q60605 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle (-0.3)
Q9JMH9 myosin XVIIIA (-0.2)
Liver: COPI vesicle coat
Q8CIE6 coatomer protein complex subunit alpha (-0.6)
P61924 coatomer protein complex, subunit zeta 1 (-0.5)
O89079 coatomer protein complex, subunit epsilon (-0.5)
Q9QZE5 coatomer protein complex, subunit gamma (-0.4)
O55029 coatomer protein complex, subunit beta 2 (beta prime) (-0.4)
Q9JIF7 coatomer protein complex, subunit beta 1 (-0.4)
Blood: proteasome core complex
O55234 proteasome (prosome, macropain) subunit, beta type 5 (-1.2)
Q9R1P3 proteasome (prosome, macropain) subunit, beta type 2 (-1.1)
Q9R1P0 proteasome (prosome, macropain) subunit, alpha type 4 (-1.1)
O09061 proteasome (prosome, macropain) subunit, beta type 1 (-1.1)
Q9Z2U0 proteasome (prosome, macropain) subunit, alpha type 7 (-1)
Q9R1P1 proteasome (prosome, macropain) subunit, beta type 3 (-0.8)
Q9Z2U1 proteasome (prosome, macropain) subunit, alpha type 5 (-0.3)
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