Supplementary Table 1: Top 20 MEF2C Ingenuity Conical Pathways at 5, 50, 100 and 500Kb

Supplementary Table 1:Top 20 MEF2C Ingenuity Conical pathways at 5, 50, 100 and 500kb plus all binding sites

Canonical Pathways (MEF2C: 5kb Genes) / P-value / B-H Multiple testing correction p-value / Molecules
EIF2 Signaling / 5.01187E-26 / 2.51189E-23 / RAF1,RPL27A,PIK3R1,MAPK3,KRAS,EIF4A2,EIF2A,RPS11,EIF4G2,PIK3CG,RPL12,RPL8,ATM,PABPC1,PIK3C2B,RPL3,RPL27,RPL37,RPL7L1,RPLP0,RPS29,RPS6,RPS4X,RPS15,RPS25,PIK3CD,RPL41,RPLP1,EIF3K,RPL24,PIK3CA,EIF2B4,RPL26,EIF4E,RPS9,SOS1,EIF3A,RPL35,RPLP2,PIK3R2,RPL13,RPL4,RPL34,RPS2,RPL17,RPS19,EIF2C2,PPP1R15A,RPL21,EIF3G,RPL5,RPS5,UBA52,EIF4A1,EIF2C3,EIF2B1,RPL38,RPL11,RPL22,MAPK1,EIF1,RPS7,RPS24,RPS3A,RPL7A,EIF3D,EIF5,RPL19,RPL36,RPS20,GSK3B,EIF2C1,RPS10,PPP1CA,EIF2B3,RPL23A,EIF3E,RPL15,PIK3R3,RPL26L1,RPL10,EIF2B5,RPS15A,INSR,RPSA,PPP1CC,RPL22L1,PPP1CB,RPS8,RPS13,RPL10A,RPS27,RPS16,EIF2S3,RPS3,MAP2K1,RPL29,NRAS,RPL37A,EIF3F,RPL23,RPS27L,RPS12,RPS26,RPL39L,EIF2AK3
Regulation of eIF4 and p70S6K Signaling / 1.25893E-11 / 3.71535E-09 / RAF1,MAPK1,MAPK3,EIF1,PIK3R1,PPP2R5B,EIF4A2,KRAS,EIF2A,RPS11,RPS7,RPS24,RPS3A,EIF4G2,EIF4EBP3,EIF3D,PIK3CG,RPS20,RPS10,EIF2C1,ATM,ITGA4,PABPC1,PIK3C2B,EIF2B3,EIF3E,PIK3R3,RPS29,RPS6,PPP2CB,PPP2R1A,RPS4X,EIF2B5,RPS15,PIK3CD,RPS25,RPS15A,RPSA,EIF3K,PIK3CA,EIF2B4,RPS8,RPS13,EIF4E,RPS27,MTOR,RPS16,MKNK1,RPS9,SOS1,EIF2S3,EIF3A,PIK3R2,RPS3,MAP2K1,ITGB1,NRAS,EIF3F,RPS2,RPS19,EIF2C2,RPS27L,PPP2R5A,RPS12,EIF3G,MAPK14,RPS5,RPS26,EIF2C3,EIF4A1,EIF2B1
Molecular Mechanisms of Cancer / 1.69824E-10 / 3.0903E-08 / RAP2B,RAF1,SHH,RAPGEF1,PIK3R1,MAPK3,ADCY4,TAB2,CDKN2C,KRAS,ARHGEF1,GSK3A,RBL1,ZBTB17,RB1,GNA15,PIK3CG,PLCB1,GNA13,PRKD3,ATM,TP53,PIK3C2B,PTCH1,ARHGEF17,NFKB2,TCF3,RAP1A,CCND2,MAX,CCND3,APH1A,PIK3CD,CFLAR,NOTCH1,ARHGEF9,WNT1,RAP2A,FYN,TCF4,PIK3CA,ARHGEF7,LRP6,RHOT2,CRK,JAK2,MAP3K5,CHEK1,CASP6,JUN,HHAT,BBC3,SOS1,PRKCE,BID,ARHGEF3,PIK3R2,CTNNB1,CASP8,PAK2,MDM2,SIN3A,FADD,FOS,RASGRP1,CDKN1A,RASGRF1,RBPJ,ATR,CASP7,FZD7,PSEN1,BIRC2,JAK1,MAPK1,SMAD3,MYC,PTK2,E2F6,CAMK2D,RHOG,RHOB,GSK3B,BRCA1,RASA1,BIRC3,TAB1,E2F2,RALGDS,E2F4,TYK2,CDK6,RAC3,PIK3R3,CBL,RHOQ,PTPN11,RABIF,CDK4,CYCS,DIABLO,FNBP1,RELA,PA2G4,HIF1A,SMAD5,E2F3,NFKB1,RHOH,FAS,BCL2,BRAF,NLK,NFKBIA,FANCD2,MAP3K7,PRKAR1B,ARHGEF2,RHOF,MAP2K1,CHEK2,NRAS,ARHGEF12,BAX,NBN,GNAI2,MAPK14,FOXO1,PRKAG2,CDKN1B,GLI1,BCL2L11
PI3K/AKT Signaling / 2.39883E-10 / 3.31131E-08 / RAF1,JAK1,YWHAH,MAPK1,MAPK3,PIK3R1,PPP2R5B,GSK3A,KRAS,PTEN,YWHAQ,PIK3CG,GSK3B,THEM4,MCL1,ITGA4,TP53,CDC37,RHEB,YWHAG,YWHAE,TYK2,YWHAZ,NFKB2,PIK3R3,PPP2CB,PPP2R1A,HSP90AA1,PIK3CD,INPP5K,TSC1,RELA,PIK3CA,GDF15,INPPL1,MAP3K5,JAK2,NFKB1,EIF4E,BCL2,HSP90B1,MTOR,NFKBIA,HSP90AB1,SOS1,FOXO3,RPS6KB2,PIK3R2,CTNNB1,MAP2K1,ITGB1,NRAS,MDM2,INPP5D,PPP2R5A,FOXO1,LIMS1,CDKN1A,MAP3K8,CDKN1B,SFN
Protein Ubiquitination Pathway / 1.23027E-09 / 1.38038E-07 / UBE2H,DNAJB4,PSMA7,USP48,PAN2,PSMC2,ANAPC11,DNAJC16,UBE2J1,DNAJB12,DNAJC9,UBE2Q1,USP9X,UBE2S,SKP2,TRAF6,HSPA8,PSMB7,PSMD12,ANAPC5,PSMB1,PSMA4,ANAPC2,HSPA6,CDC23,USP39,UBE4A,USO1,USP3,HSP90AB1,PSMD14,AMFR,CRYAA,UBE2M,MED20,PSMD13,USP30,MDM2,PSMD5,HSPA2,PSMD8,DNAJC11,USP4,USP22,BTRC,BIRC2,PSMA3,USP5,DNAJC6,UBE2D2,UBE2V2,FBXW7,DNAJB2,TCEB1,HSPA4,UBE2B,SUGT1,NEDD4L,BRCA1,BIRC3,USP28,PSMA6,USP36,BIRC6,PSMC4,PSMD6,DNAJC25,DNAJC2,PSMD3,PSMD11,CBL,UBE2G1,RBX1,DNAJC18,BAP1,HSP90AA1,VHL,HSPB1,UBE2J2,PSMB3,B2M,USP12,UBE2N,USP11,UBR1,ANAPC10,USP2,UBE2F,HSP90B1,USP13,DNAJC1,HSPA4L,PSMB4,UBB,USP15,HSPH1,PSMA1,UBE3A,UBE2E2,UBA1,UBC,PSMC3,DNAJB5,UBE2D3
mTOR Signaling / 2.13796E-09 / 1.99526E-07 / MAPK1,PRKAB2,PRKAB1,MAPK3,PIK3R1,PPP2R5B,EIF4A2,KRAS,RICTOR,RPS11,RPS7,VEGFA,RPS24,RHOG,RPS3A,EIF4G2,RHOB,EIF3D,PIK3CG,RPS20,RPS10,PRKD3,ATM,PIK3C2B,RHEB,DDIT4,STK11,EIF3E,MLST8,PIK3R3,RPS6,ATG13,RPS29,PPP2CB,PPP2R1A,RPS4X,RHOQ,RPS15,PIK3CD,RPS25,RPS15A,RPS6KA1,INSR,PLD6,FNBP1,RPSA,EIF3K,TSC1,PIK3CA,RHOT2,RPS13,RPS8,HIF1A,RHOH,EIF4E,MTOR,RPS27,RPS16,RPS9,RPS6KB2,EIF3A,RPTOR,PRKCE,PIK3R2,RHOF,RPS3,NRAS,EIF3F,RPS2,RPS19,RPS27L,PPP2R5A,RPS12,PLD4,EIF3G,DGKZ,RPS5,RPS26,EIF4A1,PRKAG2
Hypoxia Signaling in the Cardiovascular System / 7.07946E-08 / 5.49541E-06 / UBE2H,UBE2N,UBE2D2,UBE2V2,HIF1A,CREB5,UBE2F,PTEN,VEGFA,HSP90B1,JUN,NFKBIA,HSP90AB1,UBE2B,CREB1,ATF4,UBE2J1,ATM,TP53,P4HB,UBE2M,UBE2Q1,CREB3,BIRC6,MDM2,UBE2S,SLC2A4,UBE2G1,HIF1AN,UBE2E2,HSP90AA1,UBE2D3,VHL,LDHA,UBE2J2
PI3K Signaling in B Lymphocytes / 1.25893E-07 / 8.70964E-06 / RAF1,MAPK1,NFATC3,MAPK3,PIK3R1,KRAS,PLEKHA4,PTEN,PTPRC,CAMK2D,PPP3R1,PIK3CG,ATF4,PLCB1,IL4R,ATF3,ITPR1,NFKB2,MALT1,PLCL2,PPP3CC,CBL,CD40,SYK,PIK3CD,PIK3AP1,BLNK,FYN,RELA,PIK3CA,ATF7,ATF5,PDIA3,ATF6,NFKB1,CD79A,BLK,NFKBIA,JUN,NFAT5,PPP3CB,CREB1,FOXO3,PIK3R2,MAP2K1,NRAS,CHP1,PLCG1,NFATC1,INPP5D,FOS,CALM1 (includes others),DAPP1,LYN,PLEKHA2,PLEKHA1
Prostate Cancer Signaling / 3.80189E-07 / 2.13796E-05 / RAF1,RELA,PIK3CA,MAPK1,PA2G4,PIK3R1,MAPK3,KRAS,CREB5,NFKB1,BCL2,PTEN,RB1,HSP90B1,MTOR,NFKBIA,HSP90AB1,PIK3CG,CREB1,SOS1,ATF4,GSK3B,PIK3R2,CTNNB1,MAP2K1,ATM,TP53,PIK3C2B,NRAS,CREB3,MDM2,NFKB2,SIN3A,PIK3R3,FOXO1,CDKN1A,HSP90AA1,PIK3CD,CDKN1B,GSTP1
IL-15 Signaling / 3.80189E-07 / 2.13796E-05 / RAF1,RELA,PIK3CA,IL15RA,JAK1,MAPK1,PIK3R1,MAPK3,KRAS,JAK2,NFKB1,IL2RB,BCL2,PTK2,LCK,PIK3CG,PIK3R2,MAP2K1,ATM,STAT6,PIK3C2B,NRAS,TYK2,IL15,PLCG1,STAT3,NFKB2,RAC3,IL17A,PIK3R3,MAPK14,SYK,PIK3CD
Hereditary Breast Cancer Signaling / 1.20226E-06 / 6.16595E-05 / PIK3R1,SMARCD2,KRAS,DDB2,PTEN,RB1,PIK3CG,POLR2H,PMS2,BRCA1,ATM,TP53,PIK3C2B,HDAC2,WEE1,CDK6,HDAC5,PIK3R3,PALB2,RFC4,POLR2E,SMARCA2,CDK4,H2AFX,C19orf40,PIK3CD,RFC3,POLR2K,PIK3CA,GADD45B,BARD1,MRE11A,CHEK1,POLR2A,POLR2C,FANCD2,RFC2,PIK3R2,CHEK2,HDAC9,UBB,NRAS,HDAC1,NBN,CDKN1A,MSH6,UBC,SFN,ATR,HLTF
B Cell Receptor Signaling / 1.65959E-06 / 7.58578E-05 / RAF1,MAP3K11,MAPK1,NFATC3,MAPK3,PIK3R1,GSK3A,KRAS,CREB5,PTEN,PTPRC,MAP3K10,CAMK2D,PIK3CG,PPP3R1,ATF4,GSK3B,ATM,PIK3C2B,PTPN6,CREB3,NFKB2,MALT1,PPP3CC,TCF3,PIK3R3,PTPN11,SYK,PIK3CD,PIK3AP1,INPP5K,BCL2A1,BLNK,RELA,PIK3CA,POU2F2,INPPL1,MAP3K5,NFKB1,CD79A,MTOR,NFKBIA,JUN,NFAT5,PPP3CB,MAP3K7,CREB1,SOS1,CD22,RPS6KB2,PIK3R2,MAP2K1,NRAS,EGR1,CSK,NFATC1,INPP5D,CALM1 (includes others),MAPK14,FOXO1,DAPP1,PAG1,LYN,MAP3K8
p53 Signaling / 2.13796E-06 / 9.12011E-05 / PIK3CA,GADD45B,TP73,PIK3R1,RRM2B,C12orf5,FAS,BCL2,PTEN,BIRC5,CHEK1,SCO2,RB1,CASP6,JUN,STAG1,BBC3,PIK3CG,ADCK3,GSK3B,PIK3R2,CTNNB1,BRCA1,CHEK2,ATM,TP53,PIK3C2B,TP53INP1,TP63,HDAC1,MDM2,BAX,PIK3R3,MDM4,CCND2,MAPK14,CDK4,CDKN1A,PIK3CD,SFN,ATR,DRAM1,SIRT1
T Cell Receptor Signaling / 5.88844E-06 / 0.000234423 / RAF1,FYN,RELA,PIK3CA,MAPK1,NFATC3,PIK3R1,MAPK3,KRAS,NFKB1,CTLA4,PTPRC,CD28,LCK,NFKBIA,NFAT5,JUN,PPP3CB,PPP3R1,PIK3CG,SOS1,PIK3R2,RASA1,MAP2K1,ATM,PIK3C2B,PTPN7,NRAS,CSK,PLCG1,NFATC1,PPP3CC,MALT1,NFKB2,PIK3R3,CALM1 (includes others),FOS,PTPRH,CBL,GRAP2,PAG1,RASGRP1,PIK3CD
Cell Cycle: G1/S Checkpoint Regulation / 6.91831E-06 / 0.00025704 / RPL11,PA2G4,SMAD3,E2F3,RBL1,MYC,E2F6,RB1,GSK3B,E2F2,ATM,TP53,HDAC9,E2F4,HDAC2,HDAC1,CDK6,MDM2,SIN3A,HDAC5,SKP2,CCND2,CCND3,MAX,RPL5,CDK4,CDKN1A,BTRC,CDKN1B,ATR
Glucocorticoid Receptor Signaling / 7.76247E-06 / 0.000269153 / TAF4B,RAF1,TAF11,JAK1,YWHAH,MAPK1,PRKAB1,PRKAB2,SGK1,NFATC3,MAPK3,SMAD3,PIK3R1,SMARCD2,KRAS,GTF2E2,MNAT1,FGG,TSC22D3,HSPA4,HMGB1,PIK3CG,PPP3R1,POLR2H,TAB1,ATM,PIK3C2B,PPP3CC,STAT3,NCOA3,HSPA8,PIK3R3,TRAF6,POU2F1,POLR2E,SMARCA2,IL1RN,HSP90AA1,PIK3CD,ESR1,POLR2K,RELA,PIK3CA,ICAM1,POU2F2,HSPA6,TAF7,CCL5,JAK2,CCL3,NFKB1,GTF2A1,NR3C1,PTGES3,BCL2,GTF2A2,HSP90B1,GTF2B,JUN,NFAT5,POLR2A,POLR2C,NFKBIA,PPP3CB,NCOA2,HSP90AB1,IL2,VIPR1,MAP3K7,ANXA1,CREB1,SOS1,FOXO3,CEBPA,PIK3R2,STAT1,FKBP5,MAP2K1,TAF12,SRA1,NRAS,TAF6,IL10,CHP1,NFATC1,HSPA2,TSG101,FOS,MAPK14,CDKN1A,PRKAG2,HLTF,TAF15
Integrin Signaling / 1.34896E-05 / 0.000436516 / RAP2B,RAPGEF1,RAF1,MAP3K11,MPRIP,MAPK1,MAPK3,PIK3R1,MYL5,KRAS,PTEN,PTK2,PARVB,RHOG,RHOB,PIK3CG,ARF4,ARPC4,ITGAV,ARPC1A,GSK3B,TSPAN4,ATM,ITGA4,ACTR2,PIK3C2B,TSPAN5,CAPN10,BCAR3,TNK2,RAP1A,RAC3,PIK3R3,MYL12A,RHOQ,CAPN1,ARPC2,PIK3CD,ACTN4,FNBP1,RAP2A,FYN,PIK3CA,ARHGEF7,RHOT2,MYLK3,PPP1CB,CRK,RHOH,ITGB7,BRAF,ITGAE,WASL,ACTR3,SOS1,ARPC3,PIK3R2,RHOF,MAP2K1,ITGB1,NRAS,PAK2,ARPC5L,PLCG1,ACTG1,ITGAL,ROCK1,ITGB2,LIMS1,TSPAN1,NEDD9,ACTN3,ITGAX
Apoptosis Signaling / 2.13796E-05 / 0.000660693 / GAS2,RAF1,RELA,MAPK1,MAPK3,KRAS,MAP3K5,NFKB1,FAS,DFFA,BCL2,CASP6,NFKBIA,BID,PRKCE,CASP8,MAP2K1,BIRC3,MCL1,TP53,ENDOG,NRAS,BIRC6,LMNA,BCL2L10,PLCG1,BAX,NFKB2,CAPN10,PARP1,ROCK1,CAPN1,RPS6KA1,CYCS,DIABLO,BCL2A1,BCL2L11,CASP7,BIRC2
CD40 Signaling / 2.39883E-05 / 0.000707946 / RELA,TRAF3,PIK3CA,ICAM1,MAPK1,PIK3R1,MAPK3,TNFAIP3,NFKB1,TANK,JUN,NFKBIA,MAP3K7,PIK3CG,PIK3R2,MAPKAPK2,MAP2K1,TRAF1,FCER2,ATM,PIK3C2B,STAT3,NFKB2,PIK3R3,TRAF6,FOS,MAPK14,CD40,PIK3CD,MAP2K5
PDGF Signaling / 2.88403E-05 / 0.000776247 / RAF1,PIK3CA,JAK1,MAPK1,PDGFA,PIK3R1,MAPK3,SRF,INPPL1,KRAS,CRK,JAK2,MYC,JUN,SPHK2,PIK3CG,SOS1,SPHK1,PIK3R2,STAT1,RASA1,MAP2K1,ATM,PIK3C2B,NRAS,TYK2,PLCG1,STAT3,INPP5D,PDGFB,PIK3R3,FOS,ACP1,PIK3CD,INPP5K
Canonical Pathways (MEF2C: 50kb Genes) / P-value / B-H Multiple testing correction p-value / Molecules
EIF2 Signaling / 6.30957E-19 / 3.16228E-16 / RAF1,RPL27A,PIK3R1,MAPK3,KRAS,EIF4A2,EIF2A,RPS11,EIF4G2,PIK3CG,RPL12,RPL8,ATM,PABPC1,PIK3C2B,RPL3,RPL27,RPL37,RPL7L1,RPLP0,RPS29,RPS6,RPS4X,PIK3R6,RPS15,RPS25,PIK3CD,RPLP1,RPL41,EIF3K,RPL24,PIK3CA,EIF2B4,RPL26,RPS17/RPS17L,EIF4E,SOS1,RPS9,EIF3A,RPL35,RPLP2,PIK3R2,RPL31,RPL13,RPL4,EIF3H,GRB2,RPL34,RPS2,RPL17,RPS19,EIF2C2,PPP1R15A,RPL21,EIF3G,RPL5,RPS5,UBA52,EIF4A1,EIF2C3,EIF2B1,RPL38,RPS14,RPL11,RPL22,MAPK1,EIF1,PIK3R4,RPS7,RPS24,RPS3A,MAP2K2,RPL7A,EIF3D,EIF5,MRAS,RPL19,RPL36,RPS20,GSK3B,PPP1CA,RPS10,EIF2C1,EIF2AK1,EIF2B3,RPL23A,EIF3E,EIF2AK4,RPL15,PIK3R3,RPL26L1,RPL10,EIF2B5,RPS15A,INSR,RPSA,PPP1CC,PIK3R5,RPL22L1,RPS13,RPS8,PPP1CB,RPL10A,RPS27,RPS16,EIF2S3,RPS3,MAP2K1,RPL29,NRAS,RPL37A,PIK3C2A,EIF3F,EIF3J,RPL23,RPS27L,RPS12,RPS26,RPL39L,EIF2AK3
Molecular Mechanisms of Cancer / 1.99526E-15 / 5.01187E-13 / RAP2B,RAC2,RAF1,SHH,RAPGEF1,TGFBR1,PIK3R1,ADCY4,MAPK3,TAB2,CDKN2C,GSK3A,KRAS,ARHGEF1,MAPK13,RBL1,RB1,ZBTB17,PAK1,BMP8A,GNA15,PIK3CG,PLCB1,GNA13,PRKD3,BMP8B,ATM,TP53,PIK3C2B,TFDP1,PTCH1,RALB,ARHGEF17,NFKB2,TCF3,RAP1A,CDH1,MAX,CCND3,CCND2,GAB1,IRS1,APH1A,PIK3R6,MAP2K3,ARHGEF18,PIK3CD,CFLAR,NOTCH1,ARHGEF9,WNT1,CAMK2G,FYN,RAP2A,TCF4,PIK3CA,ARHGEF7,LRP6,RHOT2,CTNNA1,CRK,PSEN2,MAP3K5,FZD1,JAK2,EP300,CHEK1,CASP6,HHAT,JUN,RHOD,BBC3,SOS1,E2F5,BID,PRKCE,ARHGEF3,PIK3R2,CTNNB1,CASP8,PMAIP1,PAK2,RHOC,GRB2,GNA12,MDM2,SIN3A,BAK1,FADD,FOS,CCNE1,RASGRP1,CDKN1A,RASGRF1,RBPJ,ATR,CASP7,PRKCB,BIRC2,FZD7,CTNND1,PSEN1,PRKACB,GAB2,JAK1,MAPK1,SMAD3,PIK3R4,PTK2,TGFBR2,MYC,E2F6,CAMK2D,RHOG,MAP2K2,RHOB,MRAS,GSK3B,BRCA1,FZD2,BIRC3,SMAD1,RASA1,RALGDS,E2F2,TAB1,E2F4,TYK2,CDK6,GNAZ,RAC3,RALBP1,PIK3R3,BCL2L1,CBL,RHOQ,RABIF,PTPN11,CDK4,PRKCD,PRKACG,LEF1,PRKCH,CYCS,ADCY10,DIABLO,FNBP1,RELA,PA2G4,BMP3,PIK3R5,HIF1A,SMAD5,E2F3,NFKB1,MAPK11,RHOH,FAS,BCL2,BRAF,NFKBIA,NLK,FANCD2,MAP3K7,BMPR1A,SMO,PRKAR1B,ARHGEF2,RHOF,MAP2K1,CHEK2,SRC,NRAS,ARHGEF12,GNAS,PIK3C2A,ADCY3,SMAD7,BAX,BMP5,XIAP,NBN,GNAI2,PRKCI,MAPK14,FOXO1,NF1,PRKAG2,CDKN1B,ADCY7,GLI1,BCL2L11,PRKAR1A
B Cell Receptor Signaling / 5.01187E-15 / 7.94328E-13 / RAC2,RAF1,PIK3R1,MAPK3,GSK3A,KRAS,MAP3K4,MAPK13,CREB5,PTPRC,MAP3K10,PIK3CG,ATF4,ATM,ETS1,MAP3K9,PIK3C2B,CREB3,NFKB2,TCF3,ATF2,SYNJ2,MAP3K12,GAB1,INPP5F,PLCG2,SYK,PIK3R6,MAP2K3,PIK3CD,BCL2A1,CAMK2G,PIK3CA,POU2F2,MAP3K5,EP300,MTOR,JUN,INPP5B,SOS1,CREB1,PIK3R2,PPP3CA,GRB2,EGR1,CSK,INPP5D,CALM1 (includes others),DAPP1,BCL10,LYN,MAP3K8,PRKCB,GAB2,MAP3K11,MAPK1,NFATC3,BCL6,PIK3R4,PTEN,PAX5,IKBKB,IKBKG,CAMK2D,MAP2K2,PPP3R1,MRAS,GSK3B,MAP3K14,PTPN6,PPP3CC,MALT1,PIK3R3,BCL2L1,PTPN11,PIK3AP1,INPP5K,BLNK,RELA,CAMK4,PIK3R5,INPPL1,NFKB1,MAPK11,CD79A,NFAT5,NFKBIA,PPP3CB,MAP3K7,CD22,RPS6KB2,MAP2K1,VAV2,NRAS,PIK3C2A,MAP3K1,NFATC1,IKBKE,EBF1,MAPK14,SYNJ1,FOXO1,PAG1,VAV3,NFATC2
T Cell Receptor Signaling / 7.94328E-12 / 1.1749E-09 / RAF1,MAPK1,CD3E,NFATC3,MAPK3,PIK3R1,KRAS,PIK3R4,PTPRC,CD28,IKBKB,IKBKG,LCK,TXK,MAP2K2,PIK3CG,PPP3R1,MRAS,RASA1,ATM,ITK,PIK3C2B,PPP3CC,MALT1,NFKB2,PIK3R3,PTPRH,CBL,ZAP70,PIK3R6,PIK3CD,LCP2,RELA,FYN,PIK3CA,CAMK4,PIK3R5,NFKB1,CTLA4,NFKBIA,JUN,NFAT5,PPP3CB,SOS1,PIK3R2,MAP2K1,PPP3CA,VAV2,PTPN7,NRAS,PIK3C2A,GRB2,CSK,MAP3K1,PLCG1,IKBKE,NFATC1,TEC,CALM1 (includes others),SHB,FOS,GRAP2,BCL10,VAV3,PAG1,RASGRP1,NFATC2,CARD11
Regulation of eIF4 and p70S6K Signaling / 6.30957E-11 / 7.58578E-09 / RAF1,MAPK1,PIK3R1,MAPK3,EIF1,PPP2R5B,EIF4A2,KRAS,MAPK13,PIK3R4,RPS11,EIF2A,RPS7,RPS24,RPS3A,EIF4EBP3,EIF4G2,MAP2K2,EIF3D,PIK3CG,PPM1L,MRAS,RPS20,RPS10,EIF2C1,ITGA4,ATM,PABPC1,PIK3C2B,EIF2B3,EIF3E,PIK3R3,RPS6,RPS29,PPP2CB,PPP2R1A,RPS4X,PPP2R4,IRS1,RPS15,PIK3R6,EIF2B5,PIK3CD,RPS25,RPS15A,EIF3K,RPSA,PIK3CA,EIF2B4,PIK3R5,RPS13,RPS8,RPS17/RPS17L,MAPK11,EIF4E,MTOR,RPS27,RPS16,MKNK1,SOS1,RPS9,EIF2S3,EIF3A,PPP2R5C,PIK3R2,RPS3,MAP2K1,ITGB1,NRAS,EIF3H,PIK3C2A,EIF3F,GRB2,RPS2,ITGA2,RPS19,EIF3J,EIF2C2,RPS27L,PPP2R5A,RPS12,EIF3G,MAPK14,RPS5,RPS26,EIF2C3,EIF4A1,EIF2B1,PPP2R5E,RPS14
PI3K/AKT Signaling / 1.12202E-10 / 1.09648E-08 / GAB2,RAF1,JAK1,YWHAH,MAPK1,MAPK3,PIK3R1,PPP2R5B,GSK3A,KRAS,PTEN,YWHAQ,IKBKB,IKBKG,MAP2K2,PIK3CG,PPM1L,MRAS,GSK3B,MCL1,ITGA4,THEM4,TP53,CDC37,RHEB,YWHAG,YWHAE,TYK2,YWHAZ,NFKB2,PIK3R3,SYNJ2,PPP2CB,BCL2L1,PPP2R1A,GAB1,INPP5F,PPP2R4,HSP90AA1,PIK3CD,INPP5K,RELA,TSC1,PIK3CA,GDF15,INPPL1,JAK2,MAP3K5,NFKB1,EIF4E,BCL2,HSP90B1,MTOR,NFKBIA,HSP90AB1,INPP5B,SOS1,FOXO3,RPS6KB2,PPP2R5C,PIK3R2,CTNNB1,MAP2K1,ITGB1,NRAS,GRB2,ITGA2,MDM2,IKBKE,INPP5D,PPP2R5A,FOXO1,SYNJ1,LIMS1,CDKN1A,MAP3K8,CDKN1B,PPP2R5E,SFN
RANK Signaling in Osteoclasts / 3.63078E-10 / 3.01995E-08 / RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,TAB2,MAPK13,MAP3K4,PIK3R4,IKBKB,MAP3K10,IKBKG,MAP2K2,PIK3CG,PPP3R1,TRAF5,BIRC3,ATM,PIK3C2B,MAP3K14,MAP3K9,NFKB2,PPP3CC,TRAF6,PIK3R3,MAP3K12,CBL,PIK3R6,PIK3CD,RELA,PIK3CA,CAMK4,PTK2B,PIK3R5,MAP3K5,NFKB1,MAPK11,NFKBIA,JUN,PPP3CB,MAP3K7,PIK3R2,MAP2K1,PPP3CA,SRC,TNFSF11,PIK3C2A,MAP3K1,CHP1,NFATC1,IKBKE,TNFRSF11A,XIAP,CALM1 (includes others),FOS,TRAF2,MAPK14,NFATC2,MAP3K8,BIRC2
mTOR Signaling / 7.07946E-10 / 5.24807E-08 / PRKAB1,PRKAB2,PIK3R1,MAPK3,EIF4A2,KRAS,RICTOR,RPS11,VEGFA,EIF4G2,PIK3CG,PRKD3,ATM,PIK3C2B,RHEB,DDIT4,PLD1,RPS29,RPS6,RPS4X,PPP2R4,IRS1,PIK3R6,RPS15,RPS25,PIK3CD,RPS6KA1,EIF3K,TSC1,PIK3CA,RHOT2,RPS17/RPS17L,EIF4E,MTOR,RHOD,RPS9,EIF3A,PRKCE,RPS6KA2,PIK3R2,MAPKAP1,EIF3H,RHOC,RPS2,RPS19,PPP2R5A,EIF3G,DGKZ,RPS5,EIF4A1,PPP2R5E,RPS14,PRKCB,MAPK1,PPP2R5B,PIK3R4,RPS7,RPS24,RHOG,RPS3A,RHOB,EIF3D,PPM1L,MRAS,RPS20,RPS10,STK11,EIF3E,MLST8,ATG13,PIK3R3,PPP2CB,PPP2R1A,RHOQ,PRKCD,PRKCH,RPS15A,INSR,PLD6,FNBP1,RPSA,PIK3R5,RPS8,RPS13,HIF1A,PRR5L,RHOH,HMOX1,RPS27,RPS16,RPS6KB2,RPTOR,PPP2R5C,RHOF,RPS3,NRAS,PIK3C2A,EIF3F,EIF3J,RPS27L,RPS12,PLD4,PRKCI,RPS26,PRKAG2,PRR5,RPS6KA5
PI3K Signaling in B Lymphocytes / 1.14815E-09 / 7.4131E-08 / RAF1,MAPK1,NFATC3,MAPK3,PIK3R1,KRAS,PLEKHA4,PTEN,PTPRC,IKBKB,IKBKG,CAMK2D,MAP2K2,PIK3CG,PPP3R1,MRAS,ATF4,PLCB1,CR2,IL4R,ATF3,ITPR2,NFKB2,ITPR1,MALT1,PPP3CC,PLCL2,ATF2,CBL,CD40,CD180,IRS1,PLCG2,SYK,PIK3CD,PIK3AP1,CAMK2G,BLNK,RELA,FYN,PIK3CA,CAMK4,ATF7,ATF5,PDIA3,ATF6,NFKB1,CD79A,BLK,NFAT5,JUN,NFKBIA,PPP3CB,CREB1,FOXO3,PIK3R2,MAP2K1,PPP3CA,VAV2,NRAS,CHP1,PLCG1,IKBKE,NFATC1,INPP5D,CALM1 (includes others),TLR4,FOS,PRKCI,DAPP1,BCL10,VAV3,SH2B2,LYN,NFATC2,PLEKHA1,PLEKHA2,PRKCB
Chronic Myeloid Leukemia Signaling / 1.65959E-09 / 9.77237E-08 / GAB2,RAF1,TGFBR1,MAPK1,MAPK3,PIK3R1,SMAD3,KRAS,CBLC,PIK3R4,RBL1,TGFBR2,MYC,E2F6,RB1,IKBKB,IKBKG,MAP2K2,PIK3CG,HDAC7,MRAS,E2F2,ATM,TP53,STAT5A,PIK3C2B,RBL2,E2F4,HDAC4,TFDP1,HDAC2,CDK6,NFKB2,HDAC5,PIK3R3,BCL2L1,PTPN11,CDK4,PIK3R6,PIK3CD,RELA,PIK3CA,PA2G4,PIK3R5,CRK,E2F3,NFKB1,SOS1,CTBP2,E2F5,PIK3R2,MAP2K1,HDAC9,NRAS,PIK3C2A,GRB2,HDAC1,IKBKE,MDM2,SIN3A,CDKN1A,CDKN1B
IL-15 Signaling / 3.38844E-09 / 1.8197E-07 / RAF1,RELA,PIK3CA,IL15RA,JAK1,MAPK1,MAPK3,PIK3R1,PIK3R5,KRAS,MAPK13,JAK2,PIK3R4,NFKB1,IL2RB,MAPK11,BCL2,PTK2,LCK,MAP2K2,PIK3CG,MRAS,PIK3R2,MAP2K1,ATM,STAT6,PIK3C2B,STAT5A,NRAS,PIK3C2A,IL15,TYK2,PLCG1,STAT3,NFKB2,RAC3,IL17A,PIK3R3,BCL2L1,TRAF2,MAPK14,SYK,PIK3R6,PIK3CD,CSF2
Prolactin Signaling / 6.91831E-09 / 3.31131E-07 / FYN,RAF1,SOCS1,PIK3CA,MAPK1,PRL,PIK3R1,MAPK3,SOCS2,PIK3R5,KRAS,JAK2,PIK3R4,NR3C1,TCF7,EP300,MYC,JUN,SP1,MAP2K2,PIK3CG,SOS1,MRAS,PRKCE,PIK3R2,PRLR,STAT1,MAP2K1,PRKD3,ATM,PIK3C2B,STAT5A,NRAS,PIK3C2A,GRB2,PLCG1,SOCS4,STAT3,IRF1,PIK3R3,FOS,PRKCI,PTPN11,PLCG2,PRKCD,IRS1,PIK3R6,PRKCH,PIK3CD,SOCS7,PRKCB
Integrin Signaling / 7.24436E-09 / 3.31131E-07 / RAP2B,RAC2,RAF1,RAPGEF1,PIK3R1,MAPK3,MYL5,KRAS,NCK2,PAK1,PIK3CG,ARF4,ARPC4,ARPC1A,ITGA4,ATM,PIK3C2B,ACTR2,RALB,TSPAN2,CAPN10,TNK2,RAP1A,MYL12A,ARPC2,PLCG2,CAPN1,PIK3R6,PIK3CD,TSPAN6,RAP2A,FYN,PIK3CA,ITGA2B,ARPC1B,ARHGEF7,RHOT2,MYLK3,CRK,ITGB8,ITGB7,ARF6,ACTR3,RHOD,SOS1,ARPC3,PIK3R2,VCL,ITGB1,PAK2,RHOC,GRB2,ACTB,ITGA2,PLCG1,ITGB2,WIPF1,LIMS1,NEDD9,MAP3K11,MPRIP,MYL2,MAPK1,PIK3R4,PTEN,PTK2,PARVB,RHOG,RHOB,MAP2K2,GRB7,MRAS,ITGAV,GSK3B,TSPAN4,ACTA1,TSPAN5,BCAR3,RAC3,PIK3R3,ITGAM,RHOQ,MYL12B,CAPN2,ACTN4,CTTN,FNBP1,ACTA2,PIK3R5,PPP1CB,RHOH,BRAF,ITGAE,WASL,RHOF,MAP2K1,VASP,SRC,NRAS,PIK3C2A,ASAP1,ARPC5L,ITGAL,ACTG1,ITGB3,ROCK1,CAPNS1,TSPAN1,ACTN3,ITGAX
CD40 Signaling / 7.94328E-09 / 3.38844E-07 / RELA,CD40LG,PIK3CA,TRAF3,ICAM1,MAPK1,PIK3R1,MAPK3,PIK3R5,TNFAIP3,MAPK13,PIK3R4,NFKB1,MAPK11,TANK,IKBKB,IKBKG,NFKBIA,JUN,MAP2K2,MAP3K7,PIK3CG,TRAF5,PIK3R2,MAPKAPK2,MAP2K1,FCER2,ATM,TRAF1,MAP3K14,PIK3C2B,PIK3C2A,IKBKE,STAT3,NFKB2,TRAF6,PIK3R3,FOS,TRAF2,MAPK14,CD40,PIK3R6,MAP2K3,PIK3CD,MAP2K5
Rac Signaling / 3.63078E-08 / 1.41254E-06 / RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,PIKFYVE,LIMK2,KRAS,PIK3R4,CDK5R1,LIMK1,ANK1,PTK2,PAK1,CYFIP2,MAP2K2,CFL2,PIK3CG,ARPC4,CYBB,MRAS,ARPC1A,ITGA4,ATM,ACTR2,PIK3C2B,NFKB2,PLD1,PIK3R3,PIP5K1C,ARPC2,NCF2,PIK3R6,PIK3CD,PARD3,PIP4K2A,PIP4K2C,ELK4,RELA,ABI2,PIK3CA,PTK2B,ARPC1B,NOX3,PIK3R5,IQGAP1,NFKB1,IQGAP2,ACTR3,JUN,ARPC3,PIK3R2,MAP2K1,PI4KA,ITGB1,NRAS,PAK2,PIK3C2A,ARPC5L,MAP3K1,ITGA2,BRK1,PRKCI,CD44,SH3RF1
NGF Signaling / 6.0256E-08 / 2.13796E-06 / RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,KRAS,MAP3K4,PIK3R4,CREB5,ROCK2,IKBKB,MAP3K10,IKBKG,RHOG,MAP2K2,PIK3CG,TRAF4,MRAS,ATF4,ATM,TP53,PIK3C2B,MAP3K14,MAP3K9,CREB3,NFKB2,RAP1A,ATF2,TRAF6,PIK3R3,MAP3K12,GAB1,PTPN11,PRKCD,PLCG2,PIK3R6,PIK3CD,RPS6KA1,RELA,PIK3CA,PIK3R5,SMPD1,CRK,MAP3K5,NFKB1,EP300,MAP3K7,NGFR,SOS1,CREB1,RPS6KB2,RPS6KA2,PIK3R2,MAP2K1,SMPD3,NRAS,PIK3C2A,GRB2,MAP3K1,PLCG1,IKBKE,BAX,ROCK1,TRIO,MAP3K8,RPS6KA5
Prostate Cancer Signaling / 6.16595E-08 / 2.13796E-06 / RELA,RAF1,PIK3CA,PA2G4,MAPK1,SRD5A1,PIK3R1,MAPK3,PIK3R5,KRAS,NFKB1,PIK3R4,CREB5,EP300,BCL2,PTEN,RB1,MTOR,HSP90B1,NFKBIA,HSP90AB1,MAP2K2,PIK3CG,SOS1,CREB1,MRAS,ATF4,PIK3R2,GSK3B,CTNNB1,MAP2K1,ATM,TP53,PIK3C2B,NRAS,PIK3C2A,TFDP1,GRB2,CREB3,MDM2,NFKB2,SIN3A,ATF2,PIK3R3,CCNE1,FOXO1,CDKN1A,PIK3R6,HSP90AA1,LEF1,PIK3CD,CDKN1B,GSTP1
Glucocorticoid Receptor Signaling / 6.76083E-08 / 2.18776E-06 / RAF1,TAF11,TGFBR1,PRKAB1,PRKAB2,SGK1,PIK3R1,MAPK3,SMARCD2,KRAS,GTF2E2,POMC,MAPK13,MNAT1,FGG,HMGB1,PIK3CG,SERPINE1,ATM,STAT5A,PIK3C2B,STAT3,HSPA8,TRAF6,POU2F1,TAF5,ERCC3,PIK3R6,PIK3CD,POLR2K,PIK3CA,ICAM1,PRL,POU2F2,HSPA6,CCL5,JAK2,EP300,GTF2A2,JUN,NCOA2,HSP90AB1,VIPR1,SOS1,CREB1,CEBPA,GTF2H5,PIK3R2,FKBP5,PPP3CA,IFNG,SRA1,IL10,GRB2,IL13,HSPA2,TSG101,FOS,TRAF2,GTF2E1,CDKN1A,NCOR2,CSF2,TAF15,PRKACB,TAF4B,JAK1,YWHAH,MAPK1,CD3E,NFATC3,SMAD3,PIK3R4,TSC22D3,TGFBR2,IKBKB,HSPA4,IKBKG,MAP2K2,PPP3R1,MRAS,POLR2H,TAB1,IL8,MAP3K14,PPP3CC,NCOA3,PIK3R3,BCL2L1,IL1RN,SMARCA2,POLR2E,PRKACG,NCOA1,HSP90AA1,ESR1,RELA,IL5,PIK3R5,TAF7,CCL3,NFKB1,GTF2A1,MAPK11,NR3C1,PTGES3,BCL2,GTF2B,HSP90B1,POLR2A,NFAT5,POLR2C,NFKBIA,PPP3CB,MAP3K7,IL2,ANXA1,FOXO3,STAT1,NOS2,MAP2K1,ADRB2,TAF12,VCAM1,NRAS,TAF6,PIK3C2A,MAP3K1,CHP1,IKBKE,NFATC1,MAPK14,PRKAG2,NFATC2,IL1B,HLTF
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis / 7.76247E-08 / 2.34423E-06 / RAF1,SOCS1,IL18RAP,PIK3R1,MAPK3,KRAS,CREB5,VEGFA,TLR10,PIK3CG,TRAF4,PLCB1,ATF4,TRAF5,PRKD3,ATM,PIK3C2B,CREB3,PLCL2,STAT3,TCF3,ATF2,TRAF6,PLCG2,PIK3R6,MAP2K3,PIK3CD,WNT1,CAMK2G,PIK3CA,TCF4,ICAM1,FGF2,PDIA3,IL1RL1,LRP6,CCL5,JAK2,FZD1,EP300,TRADD,JUN,C5AR1,NGFR,CREB1,TLR7,CEBPA,PRKCE,PIK3R2,CTNNB1,TNFRSF1B,PPP3CA,FCGR3A,TRAF1,TNFSF11,TNFRSF1A,IL10,IL15,DAAM1,PLCG1,IRAK3,CEBPE,IL16,FOS,CALM1 (includes others),TRAF2,CSF2,SOST,TCF7L2,IRAK4,IRAK2,PRKCB,FZD7,RYK,TLR1,TRAF3,MAPK1,NFATC3,IL32,PRSS2,CSNK1A1,TLR8,WNT16,WNT6,PIK3R4,TCF7,CEBPG,IL18R1,MYC,ROCK2,IKBKB,IKBKG,CAMK2D,MAP2K2,PPP3R1,MRAS,GSK3B,FZD2,MAP3K14,IL8,MIF,IL6R,PPP3CC,IL37,PDGFB,IL33,PIK3R3,IL1RN,PRKCD,LEF1,PRKCH,IL6ST,RELA,IL1A,CAMK4,PDGFA,PIK3R5,NFKB1,HNF1A,IRAK1,NFAT5,NLK,NFKBIA,PPP3CB,MAP3K7,SMO,MAPKAPK2,NOS2,MAP2K1,SRC,VCAM1,NRAS,PIK3C2A,WNT2B,CHP1,IKBKE,NFATC1,IL17A,ROCK1,TLR4,MAPK14,PRKCI,RIPK1,WNT10A,TLR5,APC2,NFATC2,IL1B,WNT11
Protein Ubiquitination Pathway / 7.94328E-08 / 2.34423E-06 / UBE2H,DNAJB4,PSMA7,UBR2,UBE2L3,USP48,PAN2,USP10,PSMC2,ANAPC11,PSMA2,DNAJC16,UBE2J1,DNAJB12,DNAJC9,UBE2Q1,USP9X,UBE2S,SKP2,HSPA8,TRAF6,PSMB7,ODF1,PSMD12,PSMA5,PSMB1,PSMA4,ANAPC5,DNAJC5B,HSPB7,SMURF2,ANAPC2,USP24,HSPA6,DNAJC13,CDC23,DNAJA1,USP39,UBE4A,DNAJB13,USO1,USP3,HSP90AB1,PSMD14,AMFR,UCHL3,IFNG,CRYAA,UBE2M,MED20,PSMD13,USP30,MDM2,PSMD5,HSPA2,PSMD8,DNAJC11,USP4,USP22,USP46,BTRC,USP49,BIRC2,PSMA3,USP5,DNAJC6,UBE2D2,UBE2V2,FBXW7,DNAJB2,TCEB1,USP7,HSPA4,USP8,UBE2B,SUGT1,USP40,NEDD4L,BRCA1,BIRC3,USP28,PSMA6,USP36,BIRC6,PSMC4,PSMD6,DNAJC2,DNAJC25,PSMD3,USP50,PSMD11,CBL,UBE2G1,RBX1,BAP1,DNAJB7,DNAJC18,HSP90AA1,DNAJB6,VHL,UBE2E1,UBE2J2,HSPB1,B2M,PSMB3,SACS,USP12,USP35,UBE2N,USP11,DNAJC12,UBR1,ANAPC10,USP2,UBE2F,HSP90B1,USP13,DNAJC1,HSPA4L,PSMB4,UBB,USP15,HSPH1,UBE2R2,PSMA1,USP1,UBE3A,XIAP,UBE2E2,UBA1,UBC,PSMC3,DNAJB5,UBE2D3
Canonical Pathways (MEF2C: 100kb Genes) / P-value / B-H Multiple testing correction p-value / Molecules
EIF2 Signaling / 7.94328E-19 / 5.01187E-16 / RAF1,RPL27A,PIK3R1,MAPK3,KRAS,EIF4A2,EIF2A,RPS11,EIF4G2,PIK3CG,RPL12,RPL8,ATM,PABPC1,PIK3C2B,RPL3,RPL27,RPL37,RPL7L1,RPLP0,RPS29,RPS6,RPS4X,PIK3R6,RPS15,RPS25,PIK3CD,RPLP1,RPL41,EIF3K,RPL24,PIK3CA,EIF2B4,RPL26,RPS17/RPS17L,EIF4E,PIK3C3,SOS1,RPS9,EIF3A,RPL35,RPLP2,PIK3R2,RPL31,RPL13,RPL4,EIF3H,RPL34,GRB2,RPS2,RPL17,RPS19,EIF2C2,PPP1R15A,RPL21,EIF3G,RPL5,RPS5,UBA52,EIF4A1,EIF2C3,EIF2B1,RPL38,RPS14,RPL11,RPL22,MAPK1,EIF1,PDPK1,PIK3R4,RPS23,RPS7,RPS24,RPS3A,RPL7A,MAP2K2,EIF3D,EIF5,RPL19,MRAS,RPL36,RPS20,GSK3B,PPP1CA,RPS10,EIF2C1,EIF2AK1,EIF4G3,EIF2B3,RPL23A,EIF3E,EIF3M,PIK3R3,EIF2AK4,RPL15,RPL26L1,RPL10,EIF2B5,RPS15A,INSR,RPSA,PPP1CC,PIK3R5,RPL22L1,RPS13,RPS8,PPP1CB,RPL10A,RPS27,RPS16,EIF2S3,RPS3,MAP2K1,RPL29,NRAS,RPL37A,PIK3C2A,EIF3F,EIF3J,RPL23,RPS27L,RPS12,RPS26,RPL39L,EIF2AK3
Molecular Mechanisms of Cancer / 1.99526E-16 / 6.30957E-14 / RAPGEF1,SHH,RAF1,RAC2,TGFBR1,ADCY4,PIK3R1,TAB2,KRAS,GSK3A,RB1,GNA15,GNA13,TP53,NFKB2,TCF3,RAP1A,RASGRF2,CDH1,APH1A,PIK3R6,ARHGEF18,PIK3CD,CFLAR,ARHGEF9,RAP2A,RHOT2,PSEN2,JAK2,CASP6,BBC3,PIK3C3,SOS1,PIK3R2,CASP8,PRKDC,PMAIP1,PAK2,RHOC,GRB2,GNA12,BAK1,FOS,CCNE1,CDKN1A,CASP7,PSEN1,PRKACB,JAK1,SMAD3,PIK3R4,TGFBR2,MYC,E2F6,RHOG,MAP2K2,RHOB,RASA1,SMAD1,BIRC3,TAB1,E2F2,TYK2,GNAZ,PIK3R3,BCL2L1,RHOQ,RND3,PTPN11,PRKACG,PRKCH,DIABLO,FNBP1,RELA,PIK3R5,SMAD5,NFKB1,E2F3,RHOH,BRAF,FANCD2,BMPR1A,PRKAR1B,SRC,GNAS,PIK3C2A,GNAI1,APAF1,NBN,MAPK14,PRKCI,NF1,FOXO1,CDKN1B,RAP2B,BMP4,MAPK3,CDKN2C,ARHGEF1,MAPK13,RBL1,ZBTB17,PAK1,BMP8A,PIK3CG,PLCB1,PRKD3,BMP8B,FASLG,ATM,PIK3C2B,TFDP1,RALB,PTCH1,ARHGEF17,CCND2,CCND3,MAX,GAB1,IRS1,MAP2K3,NOTCH1,WNT1,CAMK2G,MAP2K6,FYN,PIK3CA,TCF4,ARHGEF7,LRP6,CTNNA1,CRK,FZD1,MAP3K5,CHEK1,EP300,JUN,HHAT,RHOD,E2F5,PRKCE,BID,ARHGEF3,CTNNB1,MDM2,SIN3A,FADD,RASGRP1,RASGRF1,RBPJ,ATR,CTNND1,FZD7,BIRC2,PRKCB,MAP2K4,GAB2,MAPK1,PTK2,CAMK2D,MRAS,GSK3B,BRCA1,FZD2,RALGDS,E2F4,CDK6,RALBP1,RAC3,CBL,RABIF,PRKCD,CDK4,LEF1,ADCY10,CYCS,PA2G4,BMP3,ABL1,HIF1A,CDKN2B,MAPK11,FAS,BCL2,NLK,NFKBIA,MAP3K7,SMO,SMAD4,ARHGEF2,RHOF,MAP2K1,CHEK2,NRAS,ARHGEF12,ADCY3,SMAD7,BAX,BMP5,XIAP,GNAI2,PRKAG2,ADCY7,GLI1,BCL2L11,PRKAR1A
B Cell Receptor Signaling / 3.98107E-15 / 7.94328E-13 / RAC2,RAF1,PIK3R1,MAPK3,GSK3A,KRAS,MAP3K4,MAPK13,CREB5,PTPRC,MAP3K10,PIK3CG,ATF4,ATM,ETS1,MAP3K9,PIK3C2B,CREB3,NFKB2,TCF3,ATF2,SYNJ2,MAP3K12,INPP5F,GAB1,PLCG2,SYK,PIK3R6,MAP2K3,PIK3CD,BCL2A1,CAMK2G,MAP2K6,PIK3CA,POU2F2,MAP3K5,EP300,MTOR,JUN,PIK3C3,INPP5B,SOS1,CREB1,PIK3R2,PPP3CA,GRB2,EGR1,CSK,INPP5D,CALM1 (includes others),DAPP1,BCL10,LYN,MAP3K8,PRKCB,MAP2K4,GAB2,MAP3K11,MAPK1,NFATC3,PDPK1,BCL6,PIK3R4,PTEN,PAX5,IKBKB,IKBKG,CAMK2D,MAP2K2,PPP3R1,MRAS,GSK3B,MAP3K14,PTPN6,PPP3CC,MALT1,PIK3R3,BCL2L1,PTPN11,PIK3AP1,INPP5K,BLNK,RELA,CAMK4,PIK3R5,ABL1,INPPL1,NFKB1,MAPK11,CD79A,NFKBIA,NFAT5,PPP3CB,MAP3K7,RPS6KB2,CD22,MAP2K1,VAV2,NRAS,PIK3C2A,MAP3K1,NFATC1,IKBKE,EBF1,MAPK14,SYNJ1,FOXO1,PAG1,VAV3,NFATC2
T Cell Receptor Signaling / 3.16228E-11 / 4.0738E-09 / MAP2K4,RAF1,MAPK1,CD3E,NFATC3,MAPK3,PIK3R1,KRAS,PIK3R4,PTPRC,CD28,IKBKB,IKBKG,LCK,TXK,MAP2K2,PIK3CG,PPP3R1,MRAS,RASA1,ATM,ITK,PIK3C2B,MALT1,PPP3CC,NFKB2,PIK3R3,PTPRH,CBL,ZAP70,PIK3R6,PIK3CD,LCP2,RELA,FYN,PIK3CA,CAMK4,PIK3R5,NFKB1,CTLA4,NFKBIA,JUN,NFAT5,PPP3CB,PIK3C3,SOS1,PIK3R2,MAP2K1,PPP3CA,VAV2,PTPN7,NRAS,PIK3C2A,GRB2,CSK,MAP3K1,PLCG1,IKBKE,NFATC1,TEC,CALM1 (includes others),SHB,FOS,GRAP2,BCL10,VAV3,PAG1,RASGRP1,NFATC2,CARD11
Regulation of eIF4 and p70S6K Signaling / 3.16228E-11 / 4.0738E-09 / RAF1,MAPK1,PIK3R1,MAPK3,EIF1,PPP2R5B,PDPK1,EIF4A2,KRAS,MAPK13,PIK3R4,RPS23,EIF2A,RPS11,RPS7,RPS24,RPS3A,EIF4EBP3,EIF4G2,MAP2K2,EIF3D,PIK3CG,PPM1L,MRAS,RPS20,RPS10,EIF2C1,ITGA4,ATM,PABPC1,PIK3C2B,EIF2B3,EIF4G3,EIF3E,EIF3M,PIK3R3,RPS6,RPS29,PPP2CB,PPP2R1A,RPS4X,PPP2R4,IRS1,RPS15,PIK3R6,EIF2B5,RPS15A,PIK3CD,RPS25,RPSA,EIF3K,PIK3CA,EIF2B4,PIK3R5,RPS13,RPS8,RPS17/RPS17L,MAPK11,EIF4E,MTOR,RPS27,PIK3C3,RPS16,MKNK1,SOS1,RPS9,EIF2S3,EIF3A,PPP2R5C,PIK3R2,RPS3,MAP2K1,ITGB1,NRAS,EIF3H,PIK3C2A,EIF3F,GRB2,RPS2,ITGA2,RPS19,EIF3J,EIF2C2,RPS27L,PPP2R5A,RPS12,EIF3G,MAPK14,RPS5,RPS26,EIF2C3,EIF4A1,EIF2B1,PPP2R5E,RPS14
Integrin Signaling / 1E-10 / 8.91251E-09 / RAP2B,RAC2,RAF1,RAPGEF1,PIK3R1,MAPK3,MYL5,KRAS,NCK2,PAK1,PIK3CG,ARF4,ARPC4,CAV1,ARPC1A,ITGB5,ITGA4,ATM,PIK3C2B,ACTR2,RALB,TSPAN2,CAPN10,TNK2,RAP1A,MYL12A,ARPC2,PLCG2,CAPN1,PIK3R6,PIK3CD,CAPN7,TSPAN6,FYN,RAP2A,ITGA2B,PIK3CA,TSPAN7,ARPC1B,ARHGEF7,RHOT2,MYLK3,CRK,ITGB8,ITGB7,ARF6,ACTR3,RHOD,PIK3C3,SOS1,ARPC3,VCL,PIK3R2,ITGB1,PAK2,RHOC,GRB2,ACTB,ITGA2,PLCG1,ITGB2,WIPF1,LIMS1,NEDD9,MAP2K4,MAP3K11,MPRIP,MAPK1,MYL2,PIK3R4,PTEN,PTK2,PARVB,RHOG,RHOB,MAP2K2,GRB7,MRAS,ITGAV,GSK3B,TSPAN4,ACTA1,TSPAN5,BCAR3,RAC3,PIK3R3,TLN2,ITGAM,RHOQ,RND3,MYL12B,PPP1R12A,CAPN2,ACTN4,CTTN,FNBP1,ACTA2,PIK3R5,ABL1,PPP1CB,RHOH,BRAF,ITGAE,WASL,RHOF,MAP2K1,ACTN1,VASP,SRC,NRAS,PIK3C2A,ASAP1,ARPC5L,ITGAL,ACTG1,ITGB3,ROCK1,CAPNS1,TSPAN1,ACTN3,ITGAX
RANK Signaling in Osteoclasts / 2.13796E-10 / 1.58489E-08 / MAP2K4,RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,TAB2,MAPK13,MAP3K4,PIK3R4,IKBKB,MAP3K10,IKBKG,MAP2K2,PIK3CG,PPP3R1,TRAF5,BIRC3,ATM,PIK3C2B,MAP3K14,MAP3K9,NFKB2,PPP3CC,TRAF6,PIK3R3,MAP3K12,CBL,PIK3R6,PIK3CD,MAP2K6,RELA,PIK3CA,CAMK4,PTK2B,PIK3R5,MAP3K5,NFKB1,MAPK11,NFKBIA,JUN,PPP3CB,MAP3K7,PIK3C3,PIK3R2,MAP2K1,PPP3CA,SRC,TNFSF11,PIK3C2A,MAP3K1,CHP1,NFATC1,IKBKE,TNFRSF11A,XIAP,CALM1 (includes others),FOS,TRAF2,MAPK14,NFATC2,MAP3K8,BIRC2
mTOR Signaling / 2.13796E-10 / 1.58489E-08 / PRKAB1,PRKAB2,PIK3R1,MAPK3,KRAS,EIF4A2,RICTOR,RPS11,VEGFA,EIF4G2,PIK3CG,PRKD3,ATM,PIK3C2B,RHEB,DDIT4,PLD1,RPS29,RPS6,RPS4X,PPP2R4,IRS1,PIK3R6,RPS15,RPS25,PIK3CD,RPS6KA1,EIF3K,TSC1,PIK3CA,RHOT2,RPS17/RPS17L,EIF4E,MTOR,RHOD,PIK3C3,RPS9,EIF3A,PRKCE,RPS6KA2,PIK3R2,MAPKAP1,EIF3H,RHOC,RPS2,RPS19,PPP2R5A,EIF3G,DGKZ,RPS5,EIF4A1,PPP2R5E,RPS14,PRKCB,MAPK1,PPP2R5B,PDPK1,PIK3R4,RPS23,RPS7,RPS24,RHOG,RPS3A,RHOB,EIF3D,PPM1L,MRAS,RPS20,RPS10,STK11,EIF4G3,EIF3E,MLST8,EIF3M,ATG13,PIK3R3,PPP2CB,PPP2R1A,RHOQ,RND3,PRKCD,PRKCH,RPS15A,INSR,PLD6,FNBP1,RPSA,PIK3R5,RPS6KA3,RPS8,RPS13,HIF1A,PRR5L,RHOH,HMOX1,RPS27,RPS16,RPTOR,RPS6KB2,PPP2R5C,RPS3,RHOF,NRAS,PIK3C2A,EIF3F,EIF3J,RPS27L,RPS12,PLD4,PRKCI,RPS26,PRKAG2,PRR5,RPS6KA5
CD40 Signaling / 2.39883E-10 / 1.58489E-08 / MAP2K6,MAP2K4,RELA,PIK3CA,TRAF3,CD40LG,ICAM1,MAPK1,PIK3R1,MAPK3,PIK3R5,TNFAIP3,MAPK13,NFKB1,PIK3R4,MAPK11,TANK,IKBKB,IKBKG,NFKBIA,JUN,MAP2K2,MAP3K7,PIK3C3,PIK3CG,PIK3R2,TRAF5,MAPKAPK2,MAP2K1,TRAF1,FCER2,ATM,MAP3K14,PIK3C2B,PIK3C2A,ATF1,IKBKE,STAT3,NFKB2,TRAF6,PIK3R3,FOS,TRAF2,MAPK14,CD40,PIK3R6,MAP2K3,PIK3CD,MAP2K5
PI3K/AKT Signaling / 9.12011E-10 / 5.24807E-08 / GAB2,RAF1,JAK1,YWHAH,MAPK1,MAPK3,PIK3R1,PPP2R5B,PDPK1,GSK3A,KRAS,PTEN,YWHAQ,IKBKB,IKBKG,MAP2K2,PIK3CG,PPM1L,MRAS,GSK3B,MCL1,ITGA4,THEM4,TP53,CDC37,RHEB,YWHAG,YWHAE,TYK2,YWHAZ,NFKB2,PIK3R3,SYNJ2,PPP2CB,BCL2L1,PPP2R1A,GAB1,INPP5F,PPP2R4,HSP90AA1,PIK3CD,INPP5K,RELA,TSC1,PIK3CA,GDF15,INPPL1,MAP3K5,JAK2,NFKB1,EIF4E,BCL2,HSP90B1,MTOR,NFKBIA,HSP90AB1,INPP5B,SOS1,FOXO3,RPS6KB2,PPP2R5C,PIK3R2,CTNNB1,MAP2K1,ITGB1,NRAS,GRB2,ITGA2,MDM2,IKBKE,INPP5D,PPP2R5A,FOXO1,SYNJ1,LIMS1,CDKN1A,MAP3K8,PTGS2,CDKN1B,PPP2R5E,SFN
PI3K Signaling in B Lymphocytes / 9.77237E-10 / 5.24807E-08 / RAF1,MAPK1,NFATC3,MAPK3,PIK3R1,PDPK1,KRAS,PLEKHA4,PLEKHA3,PTEN,PTPRC,IKBKB,IKBKG,CAMK2D,MAP2K2,PIK3CG,PPP3R1,MRAS,ATF4,PLCB1,CR2,IL4R,ATF3,ITPR2,ITPR1,NFKB2,MALT1,PPP3CC,PLCL2,ATF2,CBL,CD40,CD180,PLCG2,IRS1,SYK,PIK3CD,PIK3AP1,CAMK2G,BLNK,RELA,FYN,PIK3CA,CAMK4,ATF7,ATF5,PDIA3,ABL1,ATF6,NFKB1,CD79A,BLK,JUN,NFAT5,NFKBIA,PPP3CB,CREB1,FOXO3,PIK3R2,MAP2K1,PPP3CA,VAV2,NRAS,ATF1,CHP1,PLCG1,IKBKE,NFATC1,INPP5D,CALM1 (includes others),TLR4,FOS,PRKCI,DAPP1,BCL10,VAV3,SH2B2,LYN,NFATC2,PLEKHA1,PLEKHA2,PRKCB
Chronic Myeloid Leukemia Signaling / 1.38038E-09 / 6.76083E-08 / GAB2,RAF1,TGFBR1,MAPK1,MAPK3,PIK3R1,SMAD3,KRAS,CBLC,PIK3R4,RBL1,TGFBR2,MYC,E2F6,RB1,IKBKB,IKBKG,MAP2K2,PIK3CG,HDAC7,MRAS,E2F2,ATM,TP53,STAT5A,PIK3C2B,RBL2,E2F4,HDAC4,TFDP1,HDAC2,CDK6,NFKB2,HDAC5,PIK3R3,BCL2L1,PTPN11,CDK4,PIK3R6,PIK3CD,RELA,PIK3CA,PA2G4,ABL1,PIK3R5,CRK,NFKB1,E2F3,PIK3C3,SOS1,CTBP2,E2F5,SMAD4,PIK3R2,MAP2K1,HDAC9,NRAS,PIK3C2A,GRB2,HDAC1,IKBKE,MDM2,SIN3A,CDKN1A,CDKN1B
Rac Signaling / 4.67735E-09 / 2.13796E-07 / MAP2K4,RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,PIKFYVE,LIMK2,KRAS,PIP5K1B,PIK3R4,CDK5R1,LIMK1,ANK1,PTK2,PAK1,CYFIP2,MAP2K2,CFL2,PIK3CG,ARPC4,CYBB,MRAS,ARPC1A,ITGA4,ATM,ACTR2,PIK3C2B,TIAM1,WASF1,NFKB2,PLD1,PIK3R3,PIP5K1C,ARPC2,NCF2,PIK3R6,PIK3CD,PARD3,PIP4K2A,PIP4K2C,ELK4,RELA,ABI2,PIK3CA,PTK2B,ARPC1B,NOX3,PIK3R5,NFKB1,IQGAP1,IQGAP2,ACTR3,JUN,PIK3C3,ARPC3,PIK3R2,MAP2K1,PI4KA,ITGB1,NRAS,PAK2,PIK3C2A,ARPC5L,MAP3K1,ITGA2,BRK1,PRKCI,CD44,SH3RF1
Small Cell Lung Cancer Signaling / 8.31764E-09 / 3.46737E-07 / TRAF3,PIK3R1,PIK3R4,PTEN,MYC,PTK2,IKBKB,RB1,IKBKG,PIK3CG,TRAF4,TRAF5,ATM,TP53,PIK3C2B,TFDP1,CDK6,NFKB2,SKP2,PIK3R3,TRAF6,BCL2L1,MAX,CDK4,PIK3R6,PIK3CD,RXRA,CYCS,NOS1,RELA,PIK3CA,PA2G4,PIK3R5,ABL1,NFKB1,CDKN2B,BCL2,NFKBIA,PIK3C3,BID,PIK3R2,TRAF1,FHIT,PIK3C2A,APAF1,IKBKE,SIN3A,CCNE1,TRAF2,CDKN1B,PTGS2,BIRC2
Prolactin Signaling / 9.77237E-09 / 3.89045E-07 / FYN,RAF1,SOCS1,PIK3CA,MAPK1,PRL,PIK3R1,MAPK3,SOCS2,PIK3R5,PDPK1,KRAS,JAK2,PIK3R4,NR3C1,TCF7,EP300,MYC,JUN,SP1,MAP2K2,PIK3C3,PIK3CG,SOS1,MRAS,PRKCE,PIK3R2,PRLR,STAT1,MAP2K1,PRKD3,ATM,PIK3C2B,STAT5A,NRAS,PIK3C2A,GRB2,PLCG1,SOCS4,STAT3,IRF1,PIK3R3,FOS,PRKCI,PTPN11,IRS1,PLCG2,PRKCD,PIK3R6,PRKCH,PIK3CD,SOCS7,PRKCB
IL-15 Signaling / 1.28825E-08 / 4.7863E-07 / RAF1,RELA,PIK3CA,IL15RA,JAK1,MAPK1,MAPK3,PIK3R1,PIK3R5,KRAS,MAPK13,JAK2,PIK3R4,NFKB1,IL2RB,MAPK11,BCL2,PTK2,LCK,MAP2K2,PIK3C3,PIK3CG,MRAS,PIK3R2,MAP2K1,ATM,STAT6,PIK3C2B,STAT5A,NRAS,PIK3C2A,IL15,TYK2,PLCG1,STAT3,NFKB2,RAC3,IL17A,PIK3R3,BCL2L1,TRAF2,MAPK14,SYK,PIK3R6,PIK3CD,CSF2
NGF Signaling / 2.95121E-08 / 1.02329E-06 / MAP2K4,RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,PDPK1,KRAS,MAP3K4,PIK3R4,CREB5,ROCK2,IKBKB,MAP3K10,IKBKG,RHOG,MAP2K2,PIK3CG,TRAF4,MRAS,ATF4,ATM,TP53,MAP3K9,MAP3K14,PIK3C2B,CREB3,NFKB2,RAP1A,ATF2,PIK3R3,TRAF6,MAP3K12,GAB1,PTPN11,PRKCD,PLCG2,PIK3R6,PIK3CD,RPS6KA1,RELA,PIK3CA,RPS6KA3,PIK3R5,SMPD1,CRK,MAP3K5,NFKB1,EP300,MAP3K7,PIK3C3,NGFR,SOS1,CREB1,RPS6KB2,RPS6KA2,PIK3R2,MAP2K1,SMPD3,NRAS,PIK3C2A,GRB2,MAP3K1,PLCG1,IKBKE,BAX,ROCK1,TRIO,MAP3K8,RPS6KA5
Prostate Cancer Signaling / 3.23594E-08 / 1.04713E-06 / RAF1,MAPK1,MAPK3,PIK3R1,PDPK1,KRAS,CREB5,PIK3R4,PTEN,RB1,MAP2K2,PIK3CG,MRAS,ATF4,GSK3B,ATM,TP53,PIK3C2B,TFDP1,CREB3,NFKB2,ATF2,PIK3R3,PIK3R6,HSP90AA1,PIK3CD,LEF1,GSTP1,RELA,PIK3CA,PA2G4,SRD5A1,PIK3R5,ABL1,NFKB1,BCL2,EP300,HSP90B1,MTOR,NFKBIA,HSP90AB1,PIK3C3,CREB1,SOS1,PIK3R2,CTNNB1,MAP2K1,NRAS,PIK3C2A,GRB2,MDM2,SIN3A,CCNE1,FOXO1,CDKN1A,CDKN1B
PDGF Signaling / 5.12861E-08 / 1.58489E-06 / MAP2K4,RAF1,JAK1,MAPK1,MAPK3,PIK3R1,SRF,KRAS,PIK3R4,MYC,SPHK2,MAP2K2,PIK3CG,CAV1,MRAS,RASA1,ATM,PIK3C2B,TYK2,STAT3,PDGFB,PIK3R3,SYNJ2,INPP5F,PLCG2,ACP1,PIK3R6,PIK3CD,INPP5K,PIK3CA,PDGFA,PIK3R5,ABL1,CRK,INPPL1,JAK2,JUN,INPP5B,PIK3C3,SOS1,SPHK1,PIK3R2,STAT1,MAP2K1,SRC,NRAS,PIK3C2A,GRB2,MAP3K1,PLCG1,INPP5D,FOS,SYNJ1,PRKCB
Glioma Signaling / 6.16595E-08 / 1.8197E-06 / RAF1,MAPK1,CAMK1D,MAPK3,PIK3R1,CDKN2C,KRAS,PIK3R4,RBL1,PTEN,RB1,E2F6,CAMK2D,MAP2K2,PIK3CG,MRAS,PRKD3,E2F2,ATM,TP53,PIK3C2B,E2F4,RBL2,TFDP1,CDK6,PDGFB,PIK3R3,PLCG2,PRKCD,CDK4,PIK3R6,PIK3CD,PRKCH,CAMK2G,PIK3CA,CAMK4,PA2G4,PDGFA,ABL1,PIK3R5,EGF,E2F3,CDKN2B,MTOR,IGF1,PIK3C3,SOS1,E2F5,PRKCE,PIK3R2,MAP2K1,EGFR,NRAS,PIK3C2A,GRB2,PLCG1,MDM2,IGF2R,SIN3A,CALM1 (includes others),PRKCI,CDKN1A,PRKCB
Canonical Pathways (MEF2C: 500kb Genes) / P-value / B-H Multiple testing correction p-value / Molecules
Molecular Mechanisms of Cancer / 3.98107E-19 / 2.51189E-16 / RAPGEF1,SHH,RAF1,RAC2,TGFBR1,ADCY4,PIK3R1,TAB2,KRAS,GSK3A,RB1,GNA15,GNA13,HIPK2,PRKD1,TP53,SMAD2,PRKCQ,NFKB2,TCF3,RAP1A,RASGRF2,CDH1,APH1A,PIK3R6,PIK3CD,ARHGEF18,CFLAR,ARHGEF9,RAP2A,RHOT2,PSEN2,JAK2,CASP6,BBC3,PIK3C3,SOS1,PIK3R2,CASP8,PRKDC,PMAIP1,PAK2,RHOC,GRB2,GNA12,BAK1,FOS,CCNE1,CDKN1A,BMP7,CASP7,PSEN1,PRKACB,JAK1,SMAD3,PIK3R4,TGFBR2,MYC,E2F6,RHOG,MAP2K2,RHOB,SMAD1,BIRC3,RASA1,E2F2,TAB1,TYK2,GNAZ,PIK3R3,BCL2L1,RHOQ,RND3,PTPN11,PRKACG,PRKCH,DIABLO,FNBP1,RELA,PIK3R5,SMAD5,NFKB1,E2F3,RHOH,BRAF,FANCD2,BMPR1A,PRKAR1B,PRKCA,SRC,GNAS,PIK3C2A,GNAI1,APAF1,NBN,PRKCI,MAPK14,FOXO1,NF1,CDKN1B,RAP2B,BMP4,MAPK3,CDKN2C,ARHGEF1,MAPK13,RBL1,ZBTB17,PAK1,BMP8A,PIK3CG,PLCB1,PRKD3,FASLG,BMP8B,ATM,PIK3C2B,TFDP1,RALB,PTCH1,ARHGEF17,CCND3,MAX,CCND2,GAB1,IRS1,PAK7,MAP2K3,NOTCH1,WNT1,GNAL,CAMK2G,RAP1B,MAP2K6,FYN,PIK3CA,TCF4,RALA,ARHGEF7,LRP6,CTNNA1,CRK,FZD1,GNA14,MAP3K5,CHEK1,EP300,JUN,HHAT,RHOD,E2F5,RHOU,PRKCE,BID,ARHGEF3,CTNNB1,MDM2,SIN3A,FADD,RASGRP1,RASGRF1,RBPJ,ATR,CTNND1,FZD7,BIRC2,PRKCB,MAP2K4,GAB2,MAPK1,PTK2,CAMK2D,MRAS,GSK3B,BRCA1,FZD2,RALGDS,E2F4,CDK6,RALBP1,RAC3,CBL,RABIF,PRKCD,CDK4,LEF1,ADCY10,CYCS,PA2G4,BMP3,ABL1,HIF1A,CDKN2B,MAPK11,FAS,BCL2,NLK,NFKBIA,MAP3K7,SMO,SMAD4,AKT3,ARHGEF2,RHOF,MAP2K1,CHEK2,NRAS,ARHGEF12,ADCY3,SMAD7,BAX,BMP5,XIAP,GNAI2,FZD8,PLCB4,PRKAG2,ADCY7,GLI1,BCL2L11,PRKAR1A,WNT5A
EIF2 Signaling / 1.58489E-16 / 5.01187E-14 / RAF1,RPL27A,PIK3R1,MAPK3,KRAS,EIF4A2,EIF2A,RPS11,EIF4G2,PIK3CG,RPL12,RPL8,ATM,PABPC1,PIK3C2B,RPL3,RPL27,RPL37,RPL7L1,RPLP0,RPS29,RPS6,RPS4X,PIK3R6,RPS15,RPS25,PIK3CD,RPLP1,RPL41,EIF3K,RPL24,PIK3CA,EIF2B4,RPL26,RPS17/RPS17L,EIF4E,PIK3C3,SOS1,RPS9,EIF3A,RPL35,RPLP2,PIK3R2,RPL31,RPL13,RPL4,EIF3H,RPL34,GRB2,RPS2,RPL17,RPS19,EIF2C2,PPP1R15A,RPL21,EIF3G,RPL5,RPS5,UBA52,EIF4A1,EIF2C3,EIF2B1,RPL38,RPS14,RPL11,RPL22,MAPK1,EIF1,PDPK1,PIK3R4,RPS23,RPS7,RPS24,RPS3A,RPL7A,MAP2K2,EIF3D,EIF5,RPL19,MRAS,RPL36,RPS20,GSK3B,PPP1CA,RPS10,EIF2C1,EIF2AK1,EIF4G3,EIF2B3,RPL23A,EIF3E,EIF3M,PIK3R3,EIF2AK4,RPL15,RPL26L1,RPL10,EIF2B5,RPS15A,INSR,RPSA,PPP1CC,PIK3R5,RPL22L1,RPS13,RPS8,PPP1CB,RPL10A,RPS27,RPS16,EIF2S3,AKT3,RPS3,MAP2K1,RPL29,NRAS,RPL37A,PIK3C2A,EIF3F,EIF3J,RPL23,RPS27L,RPS12,RPS26,RPL39L,EIF2AK3
B Cell Receptor Signaling / 7.94328E-14 / 1.58489E-11 / RAC2,RAF1,PIK3R1,MAPK3,GSK3A,KRAS,MAP3K4,MAPK13,CREB5,PTPRC,MAP3K10,PIK3CG,ATF4,ATM,ETS1,MAP3K9,PIK3C2B,PRKCQ,CREB3,NFKB2,TCF3,ATF2,SYNJ2,MAP3K12,INPP5F,GAB1,PLCG2,SYK,PIK3R6,MAP2K3,PIK3CD,BCL2A1,CAMK2G,MAP2K6,PIK3CA,POU2F2,MAP3K5,EP300,MTOR,JUN,PIK3C3,INPP5B,SOS1,CREB1,PIK3R2,PPP3CA,GRB2,CSK,EGR1,INPP5D,CALM1 (includes others),DAPP1,BCL10,LYN,MAP3K8,PRKCB,MAP2K4,GAB2,MAP3K11,MAPK1,NFATC3,PDPK1,BCL6,PIK3R4,PTEN,PAX5,IKBKB,IKBKG,CAMK2D,MAP2K2,PPP3R1,MRAS,GSK3B,MAP3K14,PTPN6,PPP3CC,MALT1,PIK3R3,BCL2L1,PTPN11,PIK3AP1,INPP5K,BLNK,RELA,CAMK4,PIK3R5,ABL1,INPPL1,NFKB1,MAPK11,CD79A,NFKBIA,NFAT5,PPP3CB,MAP3K7,CD22,RPS6KB2,AKT3,MAP2K1,VAV2,NRAS,PIK3C2A,MAP3K1,NFATC1,IKBKE,EBF1,MAPK14,SYNJ1,FOXO1,VAV3,PAG1,NFATC2
Integrin Signaling / 3.16228E-12 / 4.36516E-10 / RAP2B,RAC2,RAF1,RAPGEF1,PIK3R1,MAPK3,MYL5,KRAS,NCK2,TSPAN3,PAK1,ARF4,PIK3CG,ARPC4,CAV1,ARPC1A,ITGB5,ITGA4,ATM,PIK3C2B,ACTR2,RALB,TSPAN2,TNK2,CAPN10,RAP1A,ARHGAP5,MYL12A,ARPC2,PLCG2,CAPN1,PIK3R6,PAK7,PIK3CD,CAPN7,TSPAN6,RAP1B,FYN,RAP2A,ITGA2B,PIK3CA,RALA,TSPAN7,ARPC1B,ARHGEF7,RHOT2,MYLK3,CRK,ITGB8,ITGB7,ARF6,ACTR3,RHOD,PIK3C3,SOS1,RHOU,ARPC3,VCL,PIK3R2,ITGB1,PAK2,RHOC,GRB2,ACTB,ITGA2,PLCG1,ITGB2,WIPF1,LIMS1,NEDD9,MAP2K4,MAP3K11,ARHGAP26,MPRIP,MAPK1,MYL2,PIK3R4,PTEN,PTK2,PARVB,RHOG,RHOB,MAP2K2,GRB7,ITGAV,MRAS,GSK3B,TSPAN4,ACTA1,TSPAN5,BCAR3,TTN,RAC3,PIK3R3,RHOQ,TLN2,ITGAM,RND3,MYL12B,PPP1R12A,CAPN2,ACTN4,CTTN,FNBP1,ACTA2,PIK3R5,ABL1,PPP1CB,RHOH,BRAF,ITGAE,WASL,AKT3,RHOF,MAP2K1,ACTN1,VASP,SRC,NRAS,PIK3C2A,ASAP1,ARPC5L,ITGAL,ACTG1,ITGB3,ROCK1,CAPNS1,TSPAN1,ACTN3,ITGAX
T Cell Receptor Signaling / 7.94328E-11 / 8.51138E-09 / MAP2K4,RAF1,MAPK1,CD3E,NFATC3,MAPK3,PIK3R1,KRAS,PIK3R4,PTPRC,CD28,IKBKB,IKBKG,LCK,TXK,MAP2K2,PIK3CG,PPP3R1,MRAS,RASA1,ATM,ITK,PIK3C2B,PRKCQ,NFKB2,MALT1,PPP3CC,PIK3R3,PTPRH,CBL,ZAP70,LAT,PIK3R6,PIK3CD,LCP2,RELA,FYN,PIK3CA,CAMK4,PIK3R5,NFKB1,CTLA4,NFKBIA,NFAT5,JUN,PPP3CB,PIK3C3,SOS1,PIK3R2,MAP2K1,PPP3CA,VAV2,PTPN7,NRAS,PIK3C2A,GRB2,CSK,MAP3K1,PLCG1,IKBKE,NFATC1,TEC,CALM1 (includes others),SHB,FOS,GRAP2,BCL10,VAV3,PAG1,RASGRP1,NFATC2,CARD11
Prolactin Signaling / 1E-10 / 8.51138E-09 / SOCS1,RAF1,MAPK1,MAPK3,PIK3R1,SOCS6,PDPK1,KRAS,PIK3R4,TCF7,MYC,MAP2K2,PIK3CG,MRAS,PRLR,PRKD3,PRKD1,ATM,PIK3C2B,STAT5A,PRKCQ,STAT3,IRF1,PIK3R3,PTPN11,PLCG2,PRKCD,IRS1,PIK3R6,PIK3CD,PRKCH,FYN,PIK3CA,PRL,SOCS2,PIK3R5,JAK2,NR3C1,EP300,JUN,SP1,PIK3C3,SOS1,PRKCE,PIK3R2,STAT1,MAP2K1,PRKCA,NRAS,PIK3C2A,GRB2,PLCG1,SOCS4,CEBPB,FOS,PRKCI,SOCS7,PRKCB
mTOR Signaling / 1E-10 / 8.51138E-09 / PRKAB1,PRKAB2,PIK3R1,MAPK3,KRAS,EIF4A2,RICTOR,RPS11,VEGFA,EIF4G2,PIK3CG,PRKD3,PRKD1,ATM,PIK3C2B,RHEB,PRKCQ,DDIT4,PLD1,RPS29,RPS6,RPS4X,PPP2R4,IRS1,RPS15,PIK3R6,RPS25,PIK3CD,RPS6KA1,EIF3K,TSC1,PIK3CA,RHOT2,RPS17/RPS17L,EIF4E,MTOR,RHOD,PIK3C3,RPS9,RHOU,EIF3A,PRKCE,RPS6KA2,PIK3R2,MAPKAP1,EIF3H,RHOC,RPS2,RPS19,PPP2R5A,EIF3G,DGKZ,RPS5,EIF4A1,PPP2R5E,RPS14,PRKCB,MAPK1,PPP2R5B,PDPK1,PIK3R4,RPS23,RPS7,RPS24,RHOG,RPS3A,RHOB,EIF3D,PPM1L,MRAS,RPS20,RPS10,STK11,EIF4G3,VEGFC,EIF3E,MLST8,EIF3M,ATG13,PIK3R3,PPP2CB,PPP2R1A,RHOQ,RND3,PRKCD,PRKCH,RPS15A,INSR,PLD6,FNBP1,RPSA,RPS6KA3,PIK3R5,RPS8,RPS13,HIF1A,PRR5L,RHOH,HMOX1,RPS27,RPS16,RPTOR,RPS6KB2,AKT3,PPP2R5C,RPS3,RHOF,PRKCA,NRAS,PIK3C2A,EIF3F,EIF3J,RPS27L,RPS12,PLD4,PRKCI,RPS26,PRKAG2,PRR5,RPS6KA5
RANK Signaling in Osteoclasts / 3.63078E-10 / 2.75423E-08 / MAP2K4,RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,TAB2,MAP3K4,MAPK13,PIK3R4,IKBKB,MAP3K10,IKBKG,MAP2K2,PIK3CG,PPP3R1,TRAF5,BIRC3,ATM,PIK3C2B,MAP3K14,MAP3K9,MITF,PPP3CC,NFKB2,TRAF6,PIK3R3,MAP3K12,CBL,PIK3R6,PIK3CD,MAP2K6,RELA,PIK3CA,CAMK4,PTK2B,PIK3R5,MAP3K5,NFKB1,MAPK11,NFKBIA,JUN,PPP3CB,MAP3K7,PIK3C3,AKT3,PIK3R2,MAP2K1,PPP3CA,SRC,TNFSF11,PIK3C2A,MAP3K1,CHP1,NFATC1,IKBKE,TNFRSF11A,XIAP,CALM1 (includes others),FOS,TRAF2,MAPK14,NFATC2,MAP3K8,BIRC2
Regulation of eIF4 and p70S6K Signaling / 9.77237E-10 / 6.60693E-08 / RAF1,MAPK1,PIK3R1,MAPK3,EIF1,PPP2R5B,PDPK1,EIF4A2,KRAS,MAPK13,PIK3R4,RPS23,EIF2A,RPS11,RPS7,RPS24,RPS3A,EIF4EBP3,EIF4G2,MAP2K2,EIF3D,PIK3CG,PPM1L,MRAS,RPS20,RPS10,EIF2C1,ITGA4,ATM,PABPC1,PIK3C2B,EIF2B3,EIF4G3,EIF3E,EIF3M,PIK3R3,RPS6,RPS29,PPP2CB,PPP2R1A,RPS4X,PPP2R4,IRS1,RPS15,PIK3R6,EIF2B5,RPS15A,PIK3CD,RPS25,RPSA,EIF3K,PIK3CA,EIF2B4,PIK3R5,RPS8,RPS13,RPS17/RPS17L,MAPK11,EIF4E,MTOR,RPS27,PIK3C3,RPS16,MKNK1,SOS1,RPS9,EIF2S3,EIF3A,AKT3,PPP2R5C,PIK3R2,RPS3,MAP2K1,ITGB1,NRAS,EIF3H,PIK3C2A,EIF3F,GRB2,RPS2,ITGA2,RPS19,EIF3J,EIF2C2,RPS27L,PPP2R5A,RPS12,EIF3G,MAPK14,RPS5,RPS26,EIF2C3,EIF4A1,EIF2B1,PPP2R5E,RPS14
PI3K Signaling in B Lymphocytes / 1.69824E-09 / 1.02329E-07 / RAF1,MAPK1,NFATC3,MAPK3,PIK3R1,PDPK1,KRAS,PLEKHA4,PLEKHA3,PTEN,PTPRC,IKBKB,IKBKG,CAMK2D,MAP2K2,PIK3CG,PPP3R1,MRAS,PLCB1,ATF4,PLCL1,CR2,IL4R,ATF3,ITPR2,ITPR1,NFKB2,MALT1,PPP3CC,PLCL2,ATF2,CBL,CD40,CD180,PLCG2,IRS1,SYK,PIK3CD,PIK3AP1,CAMK2G,BLNK,RELA,FYN,PIK3CA,CAMK4,ATF7,ATF5,PDIA3,ABL1,ATF6,NFKB1,CD79A,BLK,JUN,NFAT5,NFKBIA,PPP3CB,CREB1,FOXO3,AKT3,PIK3R2,MAP2K1,PPP3CA,VAV2,NRAS,ATF1,CHP1,PLCG1,IKBKE,NFATC1,INPP5D,CALM1 (includes others),TLR4,FOS,PLCB4,PRKCI,DAPP1,BCL10,VAV3,SH2B2,LYN,NFATC2,PLEKHA1,PLEKHA2,PRKCB
CD40 Signaling / 3.98107E-09 / 2.13796E-07 / MAP2K6,MAP2K4,RELA,PIK3CA,TRAF3,CD40LG,ICAM1,MAPK1,PIK3R1,MAPK3,PIK3R5,TNFAIP3,MAPK13,NFKB1,PIK3R4,MAPK11,TANK,IKBKB,IKBKG,NFKBIA,JUN,MAP2K2,MAP3K7,PIK3C3,PIK3CG,PIK3R2,TRAF5,MAPKAPK2,MAP2K1,TRAF1,FCER2,ATM,MAP3K14,PIK3C2B,PIK3C2A,ATF1,IKBKE,STAT3,NFKB2,TRAF6,PIK3R3,FOS,TRAF2,MAPK14,CD40,PIK3R6,MAP2K3,PIK3CD,MAP2K5
Chronic Myeloid Leukemia Signaling / 1.04713E-08 / 5.24807E-07 / GAB2,RAF1,TGFBR1,MAPK1,MAPK3,PIK3R1,SMAD3,KRAS,CBLC,PIK3R4,RBL1,TGFBR2,MYC,E2F6,RB1,IKBKB,IKBKG,MAP2K2,PIK3CG,HDAC7,MRAS,E2F2,ATM,TP53,STAT5A,PIK3C2B,RBL2,E2F4,HDAC4,TFDP1,HDAC2,CDK6,NFKB2,HDAC5,PIK3R3,BCL2L1,PTPN11,CDK4,PIK3R6,PIK3CD,RELA,PIK3CA,PA2G4,ABL1,PIK3R5,CRK,NFKB1,E2F3,PIK3C3,SOS1,CTBP2,E2F5,SMAD4,AKT3,PIK3R2,MAP2K1,HDAC9,NRAS,PIK3C2A,GRB2,HDAC1,IKBKE,MDM2,SIN3A,CDKN1A,CDKN1B
Glioma Signaling / 1.23027E-08 / 5.62341E-07 / RAF1,MAPK1,CAMK1D,MAPK3,PIK3R1,CDKN2C,KRAS,PIK3R4,RBL1,PTEN,E2F6,RB1,CAMK2D,MAP2K2,PIK3CG,MRAS,PRKD3,PRKD1,E2F2,ATM,TP53,PIK3C2B,E2F4,RBL2,PRKCQ,TFDP1,CDK6,PDGFB,PIK3R3,PLCG2,PRKCD,CDK4,PIK3R6,PIK3CD,PRKCH,CAMK2G,PIK3CA,CAMK4,PA2G4,PDGFA,ABL1,PIK3R5,EGF,E2F3,CDKN2B,MTOR,IGF1,PIK3C3,SOS1,E2F5,PRKCE,AKT3,PIK3R2,MAP2K1,EGFR,PRKCA,NRAS,PIK3C2A,GRB2,PLCG1,MDM2,IGF2R,SIN3A,CALM1 (includes others),PRKCI,CDKN1A,PRKCB
PI3K/AKT Signaling / 1.34896E-08 / 5.62341E-07 / GAB2,RAF1,JAK1,YWHAH,MAPK1,MAPK3,PIK3R1,PPP2R5B,PDPK1,GSK3A,KRAS,PTEN,YWHAQ,IKBKB,IKBKG,MAP2K2,PIK3CG,PPM1L,MRAS,GSK3B,MCL1,ITGA4,THEM4,TP53,CDC37,RHEB,YWHAG,YWHAE,TYK2,YWHAZ,NFKB2,PIK3R3,SYNJ2,PPP2CB,BCL2L1,PPP2R1A,GAB1,INPP5F,PPP2R4,HSP90AA1,PIK3CD,INPP5K,RELA,TSC1,PIK3CA,GDF15,INPPL1,MAP3K5,JAK2,NFKB1,EIF4E,BCL2,HSP90B1,MTOR,NFKBIA,HSP90AB1,INPP5B,SOS1,FOXO3,RPS6KB2,AKT3,PPP2R5C,PIK3R2,CTNNB1,MAP2K1,ITGB1,NRAS,GRB2,ITGA2,MDM2,IKBKE,INPP5D,PPP2R5A,FOXO1,SYNJ1,LIMS1,CDKN1A,MAP3K8,PTGS2,CDKN1B,PPP2R5E,SFN
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis / 1.41254E-08 / 5.62341E-07 / RAF1,SOCS1,IL18RAP,PIK3R1,MAPK3,KRAS,IL6,CREB5,VEGFA,TLR10,PIK3CG,TRAF4,ATF4,PLCB1,TRAF5,PLCL1,PRKD3,PRKD1,ATM,PIK3C2B,PRKCQ,CREB3,PLCL2,STAT3,TCF3,ATF2,TRAF6,PLCG2,PIK3R6,MAP2K3,PIK3CD,WNT1,CAMK2G,MAP2K6,PIK3CA,TCF4,ICAM1,PDIA3,FGF2,IL1RL1,LRP6,FZD1,JAK2,CCL5,EP300,TRADD,JUN,C5AR1,NGFR,PIK3C3,CREB1,CEBPA,TLR7,PRKCE,PIK3R2,CTNNB1,TNFRSF1B,PPP3CA,FCGR3A,TRAF1,TNFSF11,TNFRSF1A,IL10,IL15,DAAM1,PLCG1,IRAK3,CEBPE,IL16,FOS,CALM1 (includes others),TRAF2,CSF2,SOST,TCF7L2,IRAK4,IRAK2,PRKCB,FZD7,RYK,MAP2K4,TLR1,TRAF3,MAPK1,NFATC3,IL32,PRSS2,CSNK1A1,TLR8,WNT16,WNT6,PIK3R4,CEBPG,TCF7,IL18R1,IL1R2,ROCK2,MYC,IKBKB,IKBKG,CAMK2D,MAP2K2,PPP3R1,MRAS,GSK3B,FZD2,MAP3K14,IL8,MIF,IL6R,VEGFC,PPP3CC,IL37,PDGFB,IL33,PIK3R3,IL1RN,PRKCD,CEBPD,LEF1,PRKCH,IL6ST,RELA,IL1A,SFRP2,CAMK4,PDGFA,PIK3R5,NFKB1,HNF1A,WNT2,IRAK1,ROR2,NFAT5,NLK,NFKBIA,PPP3CB,MAP3K7,SMO,AKT3,MAPKAPK2,NOS2,MAP2K1,PRKCA,SRC,VCAM1,NRAS,PIK3C2A,WNT2B,CHP1,IKBKE,NFATC1,CEBPB,IL1R1,IL17A,ROCK1,FZD8,TLR4,PLCB4,PRKCI,MAPK14,RIPK1,TLR5,WNT10A,APC2,NFATC2,IL1B,WNT11,WNT5A
Small Cell Lung Cancer Signaling / 3.23594E-08 / 1.20226E-06 / TRAF3,PIK3R1,PIK3R4,PTEN,MYC,PTK2,IKBKB,RB1,IKBKG,PIK3CG,TRAF4,TRAF5,ATM,TP53,PIK3C2B,TFDP1,CDK6,NFKB2,SKP2,PIK3R3,TRAF6,BCL2L1,MAX,CDK4,PIK3R6,PIK3CD,RXRA,CYCS,NOS1,RELA,PIK3CA,PA2G4,PIK3R5,ABL1,NFKB1,CDKN2B,BCL2,NFKBIA,PIK3C3,AKT3,BID,PIK3R2,TRAF1,FHIT,PIK3C2A,APAF1,IKBKE,SIN3A,CCNE1,TRAF2,CDKN1B,PTGS2,BIRC2
IL-15 Signaling / 3.54813E-08 / 1.25893E-06 / RAF1,RELA,PIK3CA,IL15RA,JAK1,MAPK1,MAPK3,PIK3R1,PIK3R5,KRAS,MAPK13,JAK2,PIK3R4,NFKB1,IL2RB,MAPK11,BCL2,PTK2,LCK,MAP2K2,PIK3C3,PIK3CG,MRAS,AKT3,PIK3R2,MAP2K1,ATM,STAT6,PIK3C2B,STAT5A,NRAS,PIK3C2A,IL15,TYK2,PLCG1,STAT3,NFKB2,RAC3,IL17A,PIK3R3,BCL2L1,TRAF2,MAPK14,SYK,PIK3R6,PIK3CD,CSF2
LPS-stimulated MAPK Signaling / 4.0738E-08 / 1.34896E-06 / MAP2K4,RAF1,MAPK1,MAPK3,PIK3R1,SRF,KRAS,MAPK13,PIK3R4,IKBKB,IKBKG,PAK1,MAP2K2,PIK3CG,MRAS,PRKD3,PRKD1,ATM,PIK3C2B,MAP3K14,PRKCQ,NFKB2,ATF2,PIK3R3,PRKCD,PIK3R6,PIK3CD,PRKCH,MAP2K3,MAP2K6,RELA,PIK3CA,PIK3R5,MAP3K5,NFKB1,MAPK11,NFKBIA,JUN,MAP3K7,PIK3C3,CREB1,PRKCE,PIK3R2,MAP2K1,PRKCA,NRAS,PIK3C2A,ATF1,IKBKE,FOS,TLR4,MAPK14,PRKCI,PRKCB
Rac Signaling / 4.2658E-08 / 1.34896E-06 / MAP2K4,RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,PIKFYVE,LIMK2,KRAS,PIP5K1B,PIK3R4,CDK5R1,LIMK1,ANK1,PTK2,PAK1,CYFIP2,MAP2K2,CFL2,PIK3CG,ARPC4,CYBB,MRAS,ARPC1A,ITGA4,ATM,ACTR2,PIK3C2B,TIAM1,WASF1,NFKB2,PLD1,PIK3R3,PIP5K1C,ARPC2,NCF2,PIK3R6,PIK3CD,PAK7,PARD3,PIP4K2A,PIP4K2C,ELK4,RELA,ABI2,PIK3CA,PTK2B,ARPC1B,NOX3,PIK3R5,NFKB1,IQGAP1,IQGAP2,ACTR3,JUN,PIK3C3,ARPC3,PIK3R2,MAP2K1,PI4KA,ITGB1,NRAS,PAK2,PIK3C2A,ARPC5L,MAP3K1,ITGA2,BRK1,PRKCI,CD44,SH3RF1
Growth Hormone Signaling / 4.46684E-08 / 1.34896E-06 / SOCS1,MAPK1,MAPK3,PIK3R1,SOCS6,SRF,PDPK1,PIK3R4,PIK3CG,PRKD3,PRKD1,ATM,STAT5A,PIK3C2B,PTPN6,PRKCQ,STAT3,SLC2A4,ONECUT1,PIK3R3,PLCG2,IRS1,PRKCD,IGFBP3,PIK3R6,PIK3CD,PRKCH,RPS6KA1,PIK3CA,SOCS2,PIK3R5,RPS6KA3,JAK2,IGF1,PIK3C3,RPS6KB2,CEBPA,PRKCE,PIK3R2,RPS6KA2,STAT1,PRKCA,PIK3C2A,PLCG1,SOCS4,GH1,FOS,PRKCI,RPS6KA5,SOCS7,PRKCB
Canonical Pathways (MEF2C: All Genes) / P-value / B-H Multiple testing correction p-value / Molecules
Molecular Mechanisms of Cancer / 6.30957E-18 / 3.98107E-15 / RAPGEF1,SHH,RAF1,RAC2,TGFBR1,ADCY4,PIK3R1,TAB2,KRAS,GSK3A,RB1,GNA15,GNA13,HIPK2,PRKD1,TP53,SMAD2,PRKCQ,NFKB2,TCF3,RAP1A,RASGRF2,CDH1,APH1A,PIK3R6,PIK3CD,ARHGEF18,CFLAR,ARHGEF9,RAP2A,RHOT2,PSEN2,JAK2,CASP6,BBC3,PIK3C3,SOS1,PIK3R2,CASP8,PRKDC,PMAIP1,PAK2,RHOC,GRB2,GNA12,BAK1,FOS,CCNE1,CDKN1A,BMP7,CASP7,PSEN1,PRKACB,JAK1,SMAD3,PIK3R4,TGFBR2,MYC,E2F6,RHOG,MAP2K2,RHOB,SMAD1,BIRC3,RASA1,E2F2,TAB1,TYK2,GNAZ,PIK3R3,BCL2L1,RHOQ,RND3,PTPN11,PRKACG,PRKCH,DIABLO,FNBP1,RELA,PIK3R5,SMAD5,NFKB1,E2F3,RHOH,BRAF,FANCD2,BMPR1A,PRKAR1B,PRKCA,SRC,GNAS,PIK3C2A,GNAI1,APAF1,NBN,PRKCI,MAPK14,FOXO1,NF1,CDKN1B,RAP2B,BMP4,MAPK3,CDKN2C,ARHGEF1,MAPK13,RBL1,ZBTB17,PAK1,BMP8A,PIK3CG,PLCB1,PRKD3,FASLG,BMP8B,ATM,PIK3C2B,TFDP1,RALB,PTCH1,ARHGEF17,CCND3,MAX,CCND2,GAB1,IRS1,PAK7,MAP2K3,NOTCH1,WNT1,GNAL,CAMK2G,RAP1B,MAP2K6,FYN,PIK3CA,TCF4,RALA,ARHGEF7,LRP6,CTNNA1,CRK,FZD1,GNA14,MAP3K5,CHEK1,EP300,JUN,HHAT,RHOD,E2F5,RHOU,PRKCE,BID,ARHGEF3,CTNNB1,MDM2,SIN3A,FADD,RASGRP1,RASGRF1,RBPJ,ATR,CTNND1,FZD7,BIRC2,PRKCB,MAP2K4,GAB2,MAPK1,PTK2,CAMK2D,MRAS,GSK3B,BRCA1,FZD2,RALGDS,E2F4,Cycs,CDK6,RALBP1,RAC3,CBL,RABIF,PRKCD,CDK4,LEF1,ADCY10,PA2G4,BMP3,ABL1,HIF1A,CDKN2B,MAPK11,FAS,BCL2,NLK,NFKBIA,MAP3K7,SMO,SMAD4,AKT3,ARHGEF2,RHOF,MAP2K1,CHEK2,NRAS,ARHGEF12,ADCY3,SMAD7,BAX,BMP5,XIAP,GNAI2,FZD8,PLCB4,PRKAG2,ADCY7,GLI1,BCL2L11,PRKAR1A,WNT5A
EIF2 Signaling / 7.94328E-16 / 2.51189E-13 / RAF1,RPL27A,PIK3R1,MAPK3,KRAS,EIF4A2,EIF2A,RPS11,EIF4G2,PIK3CG,RPL12,RPL8,ATM,PABPC1,PIK3C2B,RPL3,RPL27,RPL37,RPL7L1,RPLP0,RPS29,RPS4X,RPS15,PIK3R6,RPS25,PIK3CD,RPLP1,RPL41,EIF3K,null,RPL24,PIK3CA,EIF2B4,RPL26,RPS17/RPS17L,null,EIF4E,PIK3C3,SOS1,RPS9,EIF3A,RPL35,RPLP2,LOC100360290,PIK3R2,RPL13,RPL4,EIF3H,RPL34,GRB2,null,RPS2,RPS19,EIF2C2,PPP1R15A,RPL21,EIF3G,RPL5,RPS5,UBA52,EIF4A1,EIF2C3,EIF2B1,RPL38,RPS14,RPL11,RPL22,MAPK1,EIF1,PDPK1,PIK3R4,RPS23,RPS7,RPS24,RPS3A,RPL7A,MAP2K2,EIF3D,EIF5,RPL19,MRAS,GSK3B,PPP1CA,EIF2C1,EIF2AK1,EIF4G3,EIF2B3,RPL23A,EIF3E,EIF3M,EIF2AK4,RPL15,PIK3R3,RPL26L1,RPL10,EIF2B5,RPS15A,INSR,RPSA,PPP1CC,LOC681338,PIK3R5,RPL22L1,RPS13,RPS8,null,PPP1CB,RPL10A,RPS27,RPS16,AKT3,RPS3,MAP2K1,RPL29,NRAS,PIK3C2A,EIF3F,EIF3J,RPL23,null,null,RPS27L,RPS12,null,RPS26,EIF2AK3
B Cell Receptor Signaling / 3.16228E-13 / 6.30957E-11 / RAC2,RAF1,PIK3R1,MAPK3,GSK3A,KRAS,MAP3K4,MAPK13,CREB5,PTPRC,MAP3K10,PIK3CG,ATF4,ATM,ETS1,MAP3K9,PIK3C2B,PRKCQ,CREB3,NFKB2,TCF3,ATF2,SYNJ2,MAP3K12,INPP5F,GAB1,PLCG2,SYK,PIK3R6,MAP2K3,PIK3CD,BCL2A1,CAMK2G,MAP2K6,PIK3CA,POU2F2,MAP3K5,EP300,MTOR,JUN,PIK3C3,INPP5B,SOS1,CREB1,PIK3R2,PPP3CA,GRB2,CSK,EGR1,INPP5D,CALM1 (includes others),DAPP1,BCL10,LYN,MAP3K8,PRKCB,MAP2K4,GAB2,MAP3K11,MAPK1,NFATC3,PDPK1,BCL6,PIK3R4,PTEN,PAX5,IKBKB,IKBKG,CAMK2D,MAP2K2,PPP3R1,MRAS,GSK3B,MAP3K14,PTPN6,PPP3CC,MALT1,PIK3R3,BCL2L1,PTPN11,PIK3AP1,INPP5K,BLNK,RELA,CAMK4,PIK3R5,ABL1,INPPL1,NFKB1,MAPK11,CD79A,NFKBIA,NFAT5,PPP3CB,MAP3K7,CD22,RPS6KB2,AKT3,MAP2K1,VAV2,NRAS,PIK3C2A,MAP3K1,NFATC1,IKBKE,EBF1,MAPK14,SYNJ1,FOXO1,VAV3,PAG1,NFATC2
Integrin Signaling / 1.25893E-11 / 2.0893E-09 / RAP2B,RAC2,RAF1,RAPGEF1,PIK3R1,MAPK3,MYL5,KRAS,NCK2,TSPAN3,PAK1,ARF4,PIK3CG,ARPC4,CAV1,ARPC1A,ITGB5,ITGA4,ATM,PIK3C2B,ACTR2,RALB,TSPAN2,TNK2,CAPN10,RAP1A,ARHGAP5,MYL12A,ARPC2,PLCG2,CAPN1,PIK3R6,PAK7,PIK3CD,CAPN7,TSPAN6,RAP1B,FYN,RAP2A,ITGA2B,PIK3CA,RALA,TSPAN7,ARPC1B,ARHGEF7,RHOT2,MYLK3,CRK,ITGB8,ITGB7,ARF6,ACTR3,RHOD,PIK3C3,SOS1,RHOU,ARPC3,VCL,PIK3R2,ITGB1,PAK2,RHOC,GRB2,ACTB,ITGA2,PLCG1,ITGB2,WIPF1,LIMS1,NEDD9,MAP2K4,MAP3K11,ARHGAP26,MPRIP,MAPK1,MYL2,PIK3R4,PTEN,PTK2,PARVB,RHOG,RHOB,MAP2K2,GRB7,ITGAV,MRAS,GSK3B,TSPAN4,ACTA1,TSPAN5,BCAR3,TTN,RAC3,PIK3R3,RHOQ,TLN2,ITGAM,RND3,MYL12B,PPP1R12A,CAPN2,ACTN4,CTTN,FNBP1,ACTA2,PIK3R5,ABL1,PPP1CB,RHOH,BRAF,ITGAE,WASL,AKT3,RHOF,MAP2K1,ACTN1,VASP,SRC,NRAS,PIK3C2A,ASAP1,ARPC5L,ITGAL,ACTG1,ITGB3,ROCK1,CAPNS1,TSPAN1,ACTN3,ITGAX
T Cell Receptor Signaling / 2.13796E-10 / 2.34423E-08 / MAP2K4,RAF1,MAPK1,CD3E,NFATC3,MAPK3,PIK3R1,KRAS,PIK3R4,PTPRC,CD28,IKBKB,IKBKG,LCK,TXK,MAP2K2,PIK3CG,PPP3R1,MRAS,RASA1,ATM,ITK,PIK3C2B,PRKCQ,NFKB2,MALT1,PPP3CC,PIK3R3,PTPRH,CBL,ZAP70,LAT,PIK3R6,PIK3CD,LCP2,RELA,FYN,PIK3CA,CAMK4,PIK3R5,NFKB1,CTLA4,NFKBIA,NFAT5,JUN,PPP3CB,PIK3C3,SOS1,PIK3R2,MAP2K1,PPP3CA,VAV2,PTPN7,NRAS,PIK3C2A,GRB2,CSK,MAP3K1,PLCG1,IKBKE,NFATC1,TEC,CALM1 (includes others),SHB,FOS,GRAP2,BCL10,VAV3,PAG1,RASGRP1,NFATC2,CARD11
Prolactin Signaling / 2.39883E-10 / 2.34423E-08 / SOCS1,RAF1,MAPK1,MAPK3,PIK3R1,SOCS6,PDPK1,KRAS,PIK3R4,TCF7,MYC,MAP2K2,PIK3CG,MRAS,PRLR,PRKD3,PRKD1,ATM,PIK3C2B,STAT5A,PRKCQ,STAT3,IRF1,PIK3R3,PTPN11,PLCG2,PRKCD,IRS1,PIK3R6,PIK3CD,PRKCH,FYN,PIK3CA,PRL,SOCS2,PIK3R5,JAK2,NR3C1,EP300,JUN,SP1,PIK3C3,SOS1,PRKCE,PIK3R2,STAT1,MAP2K1,PRKCA,NRAS,PIK3C2A,GRB2,PLCG1,SOCS4,CEBPB,FOS,PRKCI,SOCS7,PRKCB
mTOR Signaling / 4.0738E-10 / 3.46737E-08 / PRKAB1,PRKAB2,PIK3R1,MAPK3,KRAS,EIF4A2,RICTOR,RPS11,VEGFA,EIF4G2,PIK3CG,PRKD3,PRKD1,ATM,PIK3C2B,RHEB,PRKCQ,DDIT4,PLD1,RPS29,RPS4X,PPP2R4,IRS1,RPS15,PIK3R6,RPS25,PIK3CD,RPS6KA1,EIF3K,TSC1,PIK3CA,RHOT2,RPS17/RPS17L,EIF4E,MTOR,RHOD,PIK3C3,RPS9,RHOU,EIF3A,PRKCE,LOC100360290,RPS6KA2,PIK3R2,MAPKAP1,EIF3H,RHOC,RPS2,RPS19,PPP2R5A,EIF3G,DGKZ,RPS5,EIF4A1,PPP2R5E,RPS14,PRKCB,MAPK1,PPP2R5B,PDPK1,PIK3R4,RPS23,RPS7,RPS24,RHOG,RPS3A,RHOB,EIF3D,PPM1L,MRAS,STK11,EIF4G3,VEGFC,EIF3E,MLST8,EIF3M,ATG13,PIK3R3,PPP2CB,PPP2R1A,RHOQ,RND3,PRKCD,PRKCH,RPS15A,INSR,PLD6,FNBP1,RPSA,PIK3R5,RPS6KA3,null,RPS8,RPS13,HIF1A,PRR5L,RHOH,HMOX1,RPS27,RPS16,RPTOR,RPS6KB2,AKT3,PPP2R5C,RPS3,RHOF,PRKCA,NRAS,PIK3C2A,EIF3F,EIF3J,RPS27L,RPS12,PLD4,PRKCI,null,RPS26,PRKAG2,PRR5,RPS6KA5
RANK Signaling in Osteoclasts / 9.33254E-10 / 6.91831E-08 / MAP2K4,RAF1,MAP3K11,MAPK1,MAPK3,PIK3R1,TAB2,MAP3K4,MAPK13,PIK3R4,IKBKB,MAP3K10,IKBKG,MAP2K2,PIK3CG,PPP3R1,TRAF5,BIRC3,ATM,PIK3C2B,MAP3K14,MAP3K9,MITF,PPP3CC,NFKB2,TRAF6,PIK3R3,MAP3K12,CBL,PIK3R6,PIK3CD,MAP2K6,RELA,PIK3CA,CAMK4,PTK2B,PIK3R5,MAP3K5,NFKB1,MAPK11,NFKBIA,JUN,PPP3CB,MAP3K7,PIK3C3,AKT3,PIK3R2,MAP2K1,PPP3CA,SRC,TNFSF11,PIK3C2A,MAP3K1,CHP1,NFATC1,IKBKE,TNFRSF11A,XIAP,CALM1 (includes others),FOS,TRAF2,MAPK14,NFATC2,MAP3K8,BIRC2
PI3K Signaling in B Lymphocytes / 1.62181E-09 / 1.07152E-07 / RAF1,MAPK1,NFATC3,MAPK3,PIK3R1,PDPK1,KRAS,PLEKHA4,PLEKHA3,PTEN,PTPRC,IKBKB,IKBKG,CAMK2D,MAP2K2,PIK3CG,PPP3R1,MRAS,PLCB1,ATF4,IRS2,PLCL1,CR2,IL4R,ATF3,ITPR2,ITPR1,NFKB2,MALT1,PPP3CC,PLCL2,ATF2,CBL,CD40,CD180,PLCG2,IRS1,SYK,PIK3CD,PIK3AP1,CAMK2G,BLNK,RELA,FYN,PIK3CA,CAMK4,ATF7,PDIA3,ATF5,ABL1,ATF6,NFKB1,CD79A,BLK,JUN,NFAT5,NFKBIA,PPP3CB,CREB1,FOXO3,AKT3,PIK3R2,MAP2K1,PPP3CA,VAV2,NRAS,ATF1,CHP1,PLCG1,IKBKE,NFATC1,INPP5D,CALM1 (includes others),TLR4,FOS,PLCB4,PRKCI,DAPP1,BCL10,VAV3,SH2B2,LYN,NFATC2,PLEKHA1,PLEKHA2,PRKCB
Regulation of eIF4 and p70S6K Signaling / 3.16228E-09 / 1.86209E-07 / RAF1,MAPK1,PIK3R1,MAPK3,EIF1,PPP2R5B,PDPK1,EIF4A2,KRAS,MAPK13,PIK3R4,RPS23,EIF2A,RPS11,RPS7,RPS24,RPS3A,EIF4EBP3,EIF4G2,MAP2K2,EIF3D,PIK3CG,PPM1L,MRAS,EIF2C1,ITGA4,ATM,PABPC1,PIK3C2B,EIF2B3,EIF4G3,EIF3E,EIF3M,PIK3R3,RPS29,PPP2CB,PPP2R1A,RPS4X,PPP2R4,IRS1,RPS15,PIK3R6,EIF2B5,PIK3CD,RPS25,RPS15A,EIF3K,RPSA,null,PIK3CA,EIF2B4,PIK3R5,RPS13,RPS8,null,RPS17/RPS17L,MAPK11,EIF4E,MTOR,RPS27,PIK3C3,RPS16,MKNK1,SOS1,RPS9,EIF3A,AKT3,LOC100360290,PPP2R5C,PIK3R2,RPS3,MAP2K1,ITGB1,NRAS,EIF3H,PIK3C2A,EIF3F,GRB2,RPS2,ITGA2,RPS19,EIF3J,EIF2C2,RPS27L,PPP2R5A,RPS12,EIF3G,MAPK14,null,RPS5,RPS26,EIF2C3,EIF4A1,EIF2B1,PPP2R5E,RPS14
CD40 Signaling / 8.31764E-09 / 4.46684E-07 / MAP2K6,MAP2K4,RELA,PIK3CA,TRAF3,CD40LG,ICAM1,MAPK1,PIK3R1,MAPK3,PIK3R5,TNFAIP3,MAPK13,NFKB1,PIK3R4,MAPK11,TANK,IKBKB,IKBKG,NFKBIA,JUN,MAP2K2,MAP3K7,PIK3C3,PIK3CG,PIK3R2,TRAF5,MAPKAPK2,MAP2K1,TRAF1,FCER2,ATM,MAP3K14,PIK3C2B,PIK3C2A,ATF1,IKBKE,STAT3,NFKB2,TRAF6,PIK3R3,FOS,TRAF2,MAPK14,CD40,PIK3R6,MAP2K3,PIK3CD,MAP2K5
Thrombopoietin Signaling / 2.45471E-08 / 1.14815E-06 / RAF1,GAB2,PIK3CA,MAPK1,MAPK3,PIK3R1,PIK3R5,KRAS,JAK2,PIK3R4,MYC,JUN,MAP2K2,PIK3C3,PIK3CG,SOS1,MRAS,PRKCE,IRS2,PIK3R2,STAT1,MAP2K1,PRKD3,PRKD1,ATM,PRKCA,PIK3C2B,STAT5A,PRKCQ,NRAS,PIK3C2A,GRB2,PLCG1,STAT3,PIK3R3,FOS,PRKCI,PTPN11,PRKCD,PLCG2,PIK3R6,PRKCH,PIK3CD,PRKCB
Chronic Myeloid Leukemia Signaling / 2.5704E-08 / 1.14815E-06 / GAB2,RAF1,TGFBR1,MAPK1,MAPK3,PIK3R1,SMAD3,KRAS,CBLC,PIK3R4,RBL1,TGFBR2,MYC,E2F6,RB1,IKBKB,IKBKG,MAP2K2,PIK3CG,HDAC7,MRAS,E2F2,ATM,TP53,STAT5A,PIK3C2B,RBL2,E2F4,HDAC4,TFDP1,HDAC2,CDK6,NFKB2,HDAC5,PIK3R3,BCL2L1,PTPN11,CDK4,PIK3R6,PIK3CD,RELA,PIK3CA,PA2G4,ABL1,PIK3R5,CRK,NFKB1,E2F3,PIK3C3,SOS1,CTBP2,E2F5,SMAD4,AKT3,PIK3R2,MAP2K1,HDAC9,NRAS,PIK3C2A,GRB2,HDAC1,IKBKE,MDM2,SIN3A,CDKN1A,CDKN1B
Glioma Signaling / 3.01995E-08 / 1.28825E-06 / RAF1,MAPK1,CAMK1D,MAPK3,PIK3R1,CDKN2C,KRAS,PIK3R4,RBL1,PTEN,E2F6,RB1,CAMK2D,MAP2K2,PIK3CG,MRAS,PRKD3,PRKD1,E2F2,ATM,TP53,PIK3C2B,E2F4,RBL2,PRKCQ,TFDP1,CDK6,PDGFB,PIK3R3,PLCG2,PRKCD,CDK4,PIK3R6,PIK3CD,PRKCH,CAMK2G,PIK3CA,CAMK4,PA2G4,PDGFA,ABL1,PIK3R5,EGF,E2F3,CDKN2B,MTOR,IGF1,PIK3C3,SOS1,E2F5,PRKCE,AKT3,PIK3R2,MAP2K1,EGFR,PRKCA,NRAS,PIK3C2A,GRB2,PLCG1,MDM2,IGF2R,SIN3A,CALM1 (includes others),PRKCI,CDKN1A,PRKCB
PI3K/AKT Signaling / 3.71535E-08 / 1.47911E-06 / GAB2,RAF1,JAK1,YWHAH,MAPK1,MAPK3,PIK3R1,PPP2R5B,PDPK1,GSK3A,KRAS,PTEN,YWHAQ,IKBKB,IKBKG,MAP2K2,PIK3CG,PPM1L,MRAS,GSK3B,MCL1,ITGA4,THEM4,TP53,CDC37,RHEB,YWHAG,YWHAE,TYK2,YWHAZ,NFKB2,PIK3R3,SYNJ2,PPP2CB,BCL2L1,PPP2R1A,GAB1,INPP5F,PPP2R4,HSP90AA1,PIK3CD,INPP5K,RELA,TSC1,PIK3CA,GDF15,INPPL1,MAP3K5,JAK2,NFKB1,EIF4E,BCL2,HSP90B1,MTOR,NFKBIA,HSP90AB1,INPP5B,SOS1,FOXO3,RPS6KB2,AKT3,PPP2R5C,PIK3R2,CTNNB1,MAP2K1,ITGB1,NRAS,GRB2,ITGA2,MDM2,IKBKE,INPP5D,PPP2R5A,FOXO1,SYNJ1,LIMS1,CDKN1A,MAP3K8,PTGS2,CDKN1B,PPP2R5E,SFN
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis / 6.76083E-08 / 2.34423E-06 / RAF1,SOCS1,IL18RAP,PIK3R1,MAPK3,KRAS,IL6,CREB5,VEGFA,TLR10,PIK3CG,TRAF4,ATF4,PLCB1,TRAF5,PLCL1,PRKD3,PRKD1,ATM,PIK3C2B,PRKCQ,CREB3,PLCL2,STAT3,TCF3,ATF2,TRAF6,PLCG2,PIK3R6,MAP2K3,PIK3CD,WNT1,CAMK2G,MAP2K6,PIK3CA,TCF4,ICAM1,PDIA3,FGF2,IL1RL1,LRP6,FZD1,JAK2,CCL5,EP300,TRADD,JUN,C5AR1,NGFR,PIK3C3,CREB1,CEBPA,TLR7,PRKCE,PIK3R2,CTNNB1,TNFRSF1B,PPP3CA,FCGR3A,TRAF1,TNFSF11,TNFRSF1A,IL10,IL15,DAAM1,PLCG1,IRAK3,CEBPE,IL16,FOS,CALM1 (includes others),TRAF2,CSF2,SOST,TCF7L2,IRAK4,IRAK2,PRKCB,FZD7,RYK,MAP2K4,TLR1,TRAF3,MAPK1,NFATC3,IL32,PRSS2,CSNK1A1,TLR8,WNT16,WNT6,PIK3R4,CEBPG,TCF7,IL18R1,IL1R2,ROCK2,MYC,IKBKB,IKBKG,CAMK2D,MAP2K2,PPP3R1,MRAS,GSK3B,FZD2,MAP3K14,IL8,MIF,IL6R,VEGFC,PPP3CC,IL37,PDGFB,IL33,PIK3R3,IL1RN,PRKCD,CEBPD,LEF1,PRKCH,IL6ST,RELA,IL1A,SFRP2,CAMK4,PDGFA,PIK3R5,NFKB1,HNF1A,WNT2,IRAK1,ROR2,NFAT5,NLK,NFKBIA,PPP3CB,MAP3K7,SMO,AKT3,MAPKAPK2,NOS2,MAP2K1,PRKCA,SRC,VCAM1,NRAS,PIK3C2A,WNT2B,CHP1,IKBKE,NFATC1,CEBPB,IL1R1,IL17A,ROCK1,FZD8,TLR4,PLCB4,PRKCI,MAPK14,RIPK1,TLR5,WNT10A,APC2,NFATC2,IL1B,WNT11,WNT5A
Small Cell Lung Cancer Signaling / 6.91831E-08 / 2.34423E-06 / TRAF3,PIK3R1,PIK3R4,PTEN,MYC,PTK2,IKBKB,RB1,IKBKG,PIK3CG,TRAF4,TRAF5,ATM,TP53,PIK3C2B,TFDP1,Cycs,CDK6,NFKB2,SKP2,PIK3R3,TRAF6,BCL2L1,MAX,CDK4,PIK3R6,PIK3CD,RXRA,NOS1,RELA,PIK3CA,PA2G4,PIK3R5,ABL1,NFKB1,CDKN2B,BCL2,NFKBIA,PIK3C3,AKT3,BID,PIK3R2,TRAF1,FHIT,PIK3C2A,APAF1,IKBKE,SIN3A,CCNE1,TRAF2,CDKN1B,PTGS2,BIRC2
IL-15 Signaling / 7.07946E-08 / 2.34423E-06 / RAF1,RELA,PIK3CA,IL15RA,JAK1,MAPK1,MAPK3,PIK3R1,PIK3R5,KRAS,MAPK13,JAK2,PIK3R4,NFKB1,IL2RB,MAPK11,BCL2,PTK2,LCK,MAP2K2,PIK3C3,PIK3CG,MRAS,AKT3,PIK3R2,MAP2K1,ATM,STAT6,PIK3C2B,STAT5A,NRAS,PIK3C2A,IL15,TYK2,PLCG1,STAT3,NFKB2,RAC3,IL17A,PIK3R3,BCL2L1,TRAF2,MAPK14,SYK,PIK3R6,PIK3CD,CSF2
LPS-stimulated MAPK Signaling / 8.70964E-08 / 2.69153E-06 / MAP2K4,RAF1,MAPK1,MAPK3,PIK3R1,SRF,KRAS,MAPK13,PIK3R4,IKBKB,IKBKG,PAK1,MAP2K2,PIK3CG,MRAS,PRKD3,PRKD1,ATM,PIK3C2B,MAP3K14,PRKCQ,NFKB2,ATF2,PIK3R3,PRKCD,PIK3R6,PIK3CD,PRKCH,MAP2K3,MAP2K6,RELA,PIK3CA,PIK3R5,MAP3K5,NFKB1,MAPK11,NFKBIA,JUN,MAP3K7,PIK3C3,CREB1,PRKCE,PIK3R2,MAP2K1,PRKCA,NRAS,PIK3C2A,ATF1,IKBKE,FOS,TLR4,MAPK14,PRKCI,PRKCB
Growth Hormone Signaling / 9.33254E-08 / 2.75423E-06 / SOCS1,MAPK1,MAPK3,PIK3R1,SOCS6,SRF,PDPK1,PIK3R4,PIK3CG,PRKD3,PRKD1,ATM,STAT5A,PIK3C2B,PTPN6,PRKCQ,STAT3,SLC2A4,ONECUT1,PIK3R3,PLCG2,IRS1,PRKCD,IGFBP3,PIK3R6,PIK3CD,PRKCH,RPS6KA1,PIK3CA,SOCS2,PIK3R5,RPS6KA3,JAK2,IGF1,PIK3C3,RPS6KB2,CEBPA,PRKCE,PIK3R2,RPS6KA2,STAT1,PRKCA,PIK3C2A,PLCG1,SOCS4,GH1,FOS,PRKCI,RPS6KA5,SOCS7,PRKCB

Supplementary Table 2:Top 20 MEF2C Ingenuity Conical pathways for all binding sites when conditioning on the common consensus motif

Canonical Pathways (MEF2C: All Genes - main motif) / P-value / B-H Multiple testing correction p-value / Molecules
Molecular Mechanisms of Cancer / 1E-13 / 6.30957E-11 / RAP2B,RAF1,RAPGEF1,BMP4,PIK3R1,TAB2,ARHGEF1,KRAS,MAPK13,RBL1,ZBTB17,BMP8A,BBC3,HIPK2,PRKD1,ATM,PRKCQ,TCF3,RAP1A,CDH1,MAX,GAB1,IRS1,ARHGEF18,PAK7,PIK3CD,CFLAR,NOTCH1,ARHGEF9,GNAL,MAP2K6,FYN,TCF4,ARHGEF7,LRP6,CTNNA1,PSEN2,JAK2,MAP3K5,GNA14,FZD1,CASP6,HHAT,JUN,PIK3C3,BID,PRKCE,PIK3R2,CTNNB1,CASP8,PMAIP1,GNA12,MDM2,CDKN1A,PRKCB,MAP2K4,GAB2,JAK1,MAPK1,SMAD3,PIK3R4,MYC,TGFBR2,E2F6,CAMK2D,RHOB,MAP2K2,MAPK3,GSK3B,RASA1,SMAD1,CDK6,RALBP1,RHOQ,CBL,RND3,PRKCD,PRKACG,PRKCH,LEF1,ADCY10,CYCS,FNBP1,BMP3,PIK3R5,ABL1,HIF1A,E2F3,NFKB1,RHOH,CDKN2B,BCL2,BRAF,NFKBIA,NLK,MAP3K7,BMPR1A,PRKAR1B,SMAD4,ARHGEF2,PRKCA,SRC,ARHGEF12,GNAS,PIK3C2A,ADCY3,SMAD7,XIAP,FZD8,NF1,FOXO1,BCL2L11,WNT5A
B Cell Receptor Signaling / 5.01187E-13 / 1.31826E-10 / MAP2K4,RAF1,GAB2,MAPK1,PIK3R1,KRAS,MAPK13,MAP3K4,PIK3R4,PTEN,PAX5,PTPRC,MAP3K10,CAMK2D,MAP2K2,MAPK3,PPP3R1,GSK3B,ATM,ETS1,MAP3K14,PTPN6,PRKCQ,PPP3CC,MALT1,TCF3,CREB5,ATF2,SYNJ2,GAB1,INPP5F,SYK,PLCG2,PIK3CD,PIK3AP1,BCL2A1,MAP2K6,CAMK4,POU2F2,ABL1,PIK3R5,INPPL1,MAP3K5,NFKB1,NFATC1,NFKBIA,JUN,MAP3K7,PIK3C3,INPP5B,CREB1,CD22,PIK3R2,PPP3CA,VAV2,PIK3C2A,CSK,MAP3K1,INPP5D,EBF1,FOXO1,VAV3,LYN,MAP3K8,PRKCB
PI3K Signaling in B Lymphocytes / 2.29087E-09 / 3.98107E-07 / FYN,RAF1,CAMK4,ATF7,MAPK1,PDIA3,PIK3R1,ABL1,ATF6,KRAS,PLEKHA4,NFKB1,NFATC1,PTEN,BLK,PTPRC,NFKBIA,JUN,CAMK2D,MAP2K2,PPP3R1,MAPK3,FOXO3,CREB1,IRS2,PIK3R2,PLCL1,PPP3CA,VAV2,IL4R,ATF3,ITPR2,PPP3CC,PLCL2,MALT1,ITPR1,INPP5D,ATF2,CBL,CD180,CD40,VAV3,PLCG2,IRS1,SYK,LYN,PIK3CD,PIK3AP1,PRKCB
PDGF Signaling / 7.76247E-09 / 9.54993E-07 / MAP2K4,RAF1,JAK1,MAPK1,PDGFA,PIK3R1,PIK3R5,ABL1,INPPL1,KRAS,JAK2,PIK3R4,MYC,JUN,MAP2K2,MAPK3,INPP5B,PIK3C3,CAV1,SPHK1,PIK3R2,STAT1,RASA1,PRKCA,ATM,SRC,PIK3C2A,MAP3K1,INPP5D,PDGFB,SYNJ2,INPP5F,PLCG2,PIK3CD,PRKCB
IL-3 Signaling / 1.04713E-08 / 9.54993E-07 / RAF1,GAB2,RAPGEF1,JAK1,MAPK1,PIK3R1,PIK3R5,KRAS,JAK2,PIK3R4,JUN,MAP2K2,PPP3R1,PIK3C3,MAPK3,PRKCE,PIK3R2,STAT1,PRKD1,PPP3CA,ATM,PRKCA,STAT5A,PTPN6,PRKCQ,PIK3C2A,PPP3CC,INPP5D,FOXO1,PRKCD,PRKCH,PIK3CD,PRKCB
Thrombopoietin Signaling / 1.09648E-08 / 9.54993E-07 / GAB2,RAF1,MAPK1,PIK3R1,PIK3R5,KRAS,JAK2,PIK3R4,MYC,JUN,MAP2K2,PIK3C3,MAPK3,PRKCE,IRS2,PIK3R2,STAT1,PRKD1,ATM,PRKCA,STAT5A,PRKCQ,PIK3C2A,PRKCD,PLCG2,PRKCH,PIK3CD,PRKCB
RANK Signaling in Osteoclasts / 1.8197E-08 / 1.34896E-06 / MAP2K6,MAP2K4,RAF1,CAMK4,MAPK1,PTK2B,PIK3R1,TAB2,PIK3R5,MAP3K5,MAPK13,MAP3K4,PIK3R4,NFKB1,NFATC1,MAP3K10,NFKBIA,JUN,MAP2K2,MAP3K7,PPP3R1,MAPK3,PIK3C3,TRAF5,PIK3R2,PPP3CA,ATM,SRC,MAP3K14,PIK3C2A,MITF,MAP3K1,PPP3CC,XIAP,CBL,MAP3K8,PIK3CD
Prolactin Signaling / 2.45471E-08 / 1.58489E-06 / RAF1,FYN,SOCS1,MAPK1,PRL,PIK3R1,PIK3R5,KRAS,JAK2,PIK3R4,NR3C1,TCF7,MYC,JUN,MAP2K2,PIK3C3,MAPK3,PRKCE,PIK3R2,PRLR,STAT1,PRKD1,ATM,PRKCA,STAT5A,PRKCQ,PIK3C2A,PRKCD,IRS1,PLCG2,PRKCH,PIK3CD,PRKCB
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis / 3.31131E-08 / 1.7378E-06 / MAP2K4,SOCS1,RAF1,TRAF3,MAPK1,PIK3R1,KRAS,PIK3R4,TCF7,IL18R1,IL1R2,MYC,VEGFA,TLR10,CAMK2D,MAP2K2,MAPK3,PPP3R1,TRAF5,GSK3B,PLCL1,PRKD1,ATM,IL8,MAP3K14,PRKCQ,IL37,PPP3CC,PLCL2,CREB5,TCF3,PDGFB,ATF2,IL33,IL1RN,PRKCD,PLCG2,PIK3CD,PRKCH,LEF1,IL6ST,MAP2K6,TCF4,IL1A,SFRP2,CAMK4,PDGFA,PDIA3,LRP6,PIK3R5,CEBPD,FZD1,JAK2,CCL5,NFKB1,NFATC1,IRAK1,JUN,NLK,NFKBIA,MAP3K7,PIK3C3,CREB1,PRKCE,PIK3R2,MAPKAPK2,CTNNB1,PPP3CA,PRKCA,TRAF1,SRC,VCAM1,C5AR1,PIK3C2A,IL10,DAAM1,IL15,IL1R1,IL17A,FZD8,TLR5,CSF2,WNT11,TCF7L2,RYK,WNT5A,PRKCB
Erythropoietin Signaling / 3.31131E-08 / 1.7378E-06 / SOCS1,RAF1,MAPK1,PIK3R1,PIK3R5,KRAS,JAK2,PIK3R4,NFKB1,JUN,NFKBIA,MAP2K2,PIK3C3,MAPK3,PRKCE,PIK3R2,PRKD1,ATM,PRKCA,STAT5A,SRC,PTPN6,PRKCQ,PIK3C2A,EPOR,CBL,PRKCD,PLCG2,PRKCH,PIK3CD,PRKCB