Manuscript ID# 720862, Corresponding Author: David Vaillancourt, Phd 1

Manuscript ID# 720862, Corresponding author: David Vaillancourt, PhD | 1

Table e-1. Summary of antiparkinsonian medication taken by PD, MSA, and PSP patients.

# / Medication – Baseline / Drug Class / Dosage, mg (tab) / Freq / Medication – 1 Yr. / Drug Class / Dosage, mg (tab) / Freq
PD01 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 4 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 25/250
1 / x 5
x 1
PD02 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 3 / Carbidopa/Levodopa / Dopaminergic / 25/100 (1.5) / x 3
PD03 / -- / -- / -- / -- / Pramipexole / Dopamine agonist / 1 / x 3
PD04 / Carbidopa/Levodopa / Dopaminergic / 25/100 (1.5) / x 5 / Carbidopa/Levodopa
Ropinirole / Dopaminergic
Dopamine agonist / 25/100
0.5 / x 6
x 2
PD05 / Ropinirole
Ropinirole ext. release
Rasagiline / Dopamine agonist
Dopamine agonist
MAO-B inhibitor / 2
12
0.5 / x 1
x 1
x 1 / Carbidopa/Levodopa
Ropinirole ext. release
Rasagiline / Dopaminergic
Dopamine agonist
MAO-B inhibitor / 25/100 (0.5)
14
1 / x 2
x 1
x 1
PD06 / Carbidopa/Levodopa / Dopaminergic / 25/100 (2) / x 4 / Carbidopa/Levodopa
Pramipexole / Dopaminergic
Dopamine agonist / 25/100 (2)
1 / x 3
x 3
PD07 / Carbidopa/Levodopa
Ropinirole
Amantadine / Dopaminergic
Dopamine agonist
NMDA agonist / 25/100 (1.5)
2
100 / x 4
x 2
x 3 / Carbidopa/Levodopa
Ropinirole
Amantadine / Dopaminergic
Dopamine agonist
NMDA agonist / 25/100 (1.5)
2
100 / x 4
x 7
x 3
PD08 / Carbidopa/Levodopa
Entacapone / Dopaminergic
COMT inhibitor / 37.5/150
200 / x 3
x 3 / Carbidopa/Levodopa / Dopaminergic / 50/200 / x 3
PD09 / Carbidopa/Levodopa
Pramipexole / Dopaminergic
Dopamine agonist / 25/100
1.5 / x 4
x 3 / Carbidopa/Levodopa
Pramipexole / Dopaminergic
Dopamine agonist / 25/100 (2)
1.5 / x 4
x 3
PD10 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 25/100
1 / x 4
x 1 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 25/100 (1.5)
1 / x 6
x 1
PD11 / Carbidopa/Levodopa
Carbidopa/Levodopa sustained release / Dopaminergic
Dopaminergic / 50/200
50/100 / x 1
x 3 / Carbidopa/Levodopa sustained release
Rasagiline / Dopaminergic
MAO-B inhibitor / 50/200
1 / x 5
x 1
PD12 / -- / -- / -- / -- / -- / -- / -- / -
PD13 / Carbidopa/Levodopa
Entacapone
Ropinirole
Apomorphine / Dopaminergic
COMT inhibitor
Dopamine agonist
Dopamine agonist / 25/100 (2)
200
12
20 / x 5
x 5
x 1
x 3 / Carbidopa/Levodopa
Ropinirole
Amantadine
Selegiline / Dopaminergic
Dopamine agonist
NMDA agonist
MAO-B inhibitor / 25/100 (2.5)
12
100
5 / x 5
x 1
x 2
x 2
PD14 / Carbidopa/Levodopa / Dopaminergic / 25/100 (2) / x 4 / Carbidopa/Levodopa
Amantadine / Dopaminergic
NMDA agonist / 25/100 (2)
100 / x 5
x 2
PD15 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 4 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 4
PD16 / Pramipexole
Rasagiline / Dopamine agonist
MAO-B inhibitor / 0.5
0.5 / x 3
x 1 / Pramipexole
Rasagiline / Dopamine agonist
MAO-B inhibitor / 1
0.5 / x 3
x 1
PD17 / Carbidopa/Levodopa / Dopaminergic / 25/100 (0.5) / x 4 / Carbidopa/Levodopa
Rotigotine transdermal patch / Dopaminergic
Dopamine agonist / 25/100 (2)
8 / x 3
x 1
PD18 / Pramipexole / Dopamine agonist / 1.5 / x 3 / Carbidopa/Levodopa
Pramipexole / Dopaminergic
Dopamine agonist / 25/100
4.5 / x 3
x 1
PD19 / Carbidopa/Levodopa
Ropinirole / Dopaminergic
Dopamine agonist / 25/100 (2)
5 / x 3
x 3 / Carbidopa/Levodopa
Ropinirole / Dopaminergic
Dopamine agonist / 25/100 (2)
5 / x 3
x 3
PD20 / Pramipexole / Dopamine agonist / 0.5 / x 3 / Carbidopa/Levodopa
Pramipexole / Dopaminergic
Dopamine agonist / 25/100
1.0 / x 3
x 3
PD21 / Carbidopa/Levodopa
Ropinirole / Dopaminergic
Dopamine agonist / 25/100
25 / x 3
x 1 / Carbidopa/Levodopa
Ropinirole / Dopaminergic
Dopamine agonist / 25/100
12 / x 4
x 1
PD22 / Carbidopa/Levodopa sustained release
Pramipexole
Rasagiline / Dopaminergic
Dopamine agonist
MAO-B inhibitor / 25/100 (1.5)
1
1 / x 3
x 3
x 1 / Carbidopa/Levodopa
Pramipexole / Dopaminergic
Dopamine agonist / 25/100 (1.5)
1 / x 3
x 3
PD23 / Carbidopa/Levodopa
sustained release
Ropinirole / Dopaminergic
Dopamine agonist / 50/200
2 / x 3
x 3 / Pramipexole
Amantadine / Dopamine agonist
NMDA agonist / 0.5
100 / x 3
x 2
PD24 / Carbidopa/Levodopa
Amantadine / Dopaminergic
NMDA agonist / 25/100
100 / x 4
x 2 / Carbidopa/Levodopa
Amantadine / Dopaminergic
NMDA agonist / 25/100
100 / x 4
x 2
PD25 / Carbidopa/Levodopa / Dopaminergic / 25/100 (2) / x 4 / Carbidopa/Levodopa / Dopaminergic / 25/100 (2) / x 4
PD26 / Carbidopa/Levodopa / Dopaminergic / 25/100 (2) / x 4 / Carbidopa/Levodopa
Rotigotine transdermal patch / Dopaminergic
Dopamine agonist / 25/100 (2)
4 / x 4
x 1
PD27 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 1 / Carbidopa/Levodopa
Carbidopa/Levodopa sustained release
Pramipexole / Dopaminergic
Dopaminergic
Dopamine agonist / 25/100
25/100
0.5 / x 4
x 1
x 3
PD28 / Carbidopa/Levodopa
Rotigotine transdermal patch / Dopaminergic
Dopamine agonist / 25/100
6 / x 4
x 1 / Carbidopa/Levodopa
Rotigotine transdermal patch / Dopaminergic
Dopamine agonist / 25/100
4 / x 4
x 1
PD29 / Carbidopa/Levodopa
Pramipexole
Selegiline
Amantadine / Dopaminergic
Dopamine agonist
MAO-B inhibitor
NMDA agonist / 25/100
0.5
5
100 / x 3
x 3
x 2
x 2 / Carbidopa/Levodopa
Pramipexole
Selegiline
Amantadine / Dopaminergic
Dopamine agonist
MAO-B inhibitor
NMDA agonist / 25/100
1.5
5
100 / x 3
x 3
x 2
x 2
PD30 / -- / -- / -- / -- / Carbidopa/Levodopa
Carbidopa/Levodopa sustained release
Pramipexole / Dopaminergic
Dopaminergic
Dopamine agonist / 25/100
50/200
0.5 / x 3
x 1
x 3
PD31 / Carbidopa/Levodopa / Dopaminergic / 25/100 (2) / x 3 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 3
PD32 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 25/100
1 / x 3
x 1 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 25/100
1 / x 4
x 1
PD33 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 50/200
1 / x 3
x 1 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 50/200
1 / x 3
x 1
PD34 / Rasagiline / MAO-B inhibitor / 1 / x 1 / Rasagiline
Pramipexole / MAO-B inhibitor
Dopamine agonist / 1
1.5 / x 1
x 3
PD35 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 25/100 (1.5)
1 / x 3
x 1 / Carbidopa/Levodopa
Rasagiline / Dopaminergic
MAO-B inhibitor / 25/100 (1.5)
1 / x 3
x 1
PD36
PD37
PD38 / Carbidopa/Levodopa
Rasagiline
Carbidopa/Levodopa
Ropinirole ext. release
Carbidopa/Levodopa / Dopaminergic
MAO-B inhibitor
Dopaminergic
Dopamine agonist
Dopaminergic / 25/100 (1.5)
1
25/100 (1.5)
12
25/100 (2) / x 4
x 1
x 5
x 1
x 4 / Carbidopa/Levodopa
Rasagiline
Carbidopa/Levodopa
Ropinirole ext. release
Carbidopa/Levodopa / Dopaminergic
MAO-B inhibitor
Dopaminergic
Dopamine agonist
Dopaminergic / 25/100
1
25/100
12
25/100 (2) / x 5
x 1
x 6
x 1
x 4
PD39
PD40
PD41 / Carbidopa/Levodopa
Ropinirole
Carbidopa/Levodopa
Carbidopa/Levodopa
Rasagiline / Dopaminergic
Dopamine agonist
Dopaminergic
Dopaminergic
MAO-B inhibitor / 25/100
6
25/100
25/100
1 / x 3
x 1
x 3
x 4
x 1 / Carbidopa/Levodopa
Ropinirole
Carbidopa/Levodopa
Carbidopa/Levodopa sustained release
Carbidopa/Levodopa / Dopaminergic
Dopamine agonist
Dopaminergic
Dopaminergic
Dopaminergic / 25/100 (1.5)
8
25/100(1.5)
50/200
25/100 (1.5) / x 4
x 1
x 3
x 1
x 4
PD42
PD43
PD44 / Rotigotine transdermal patch
Carbidopa/Levodopa
Carbidopa/Levodopa sustained release
Rasagiline
-- / Dopamine agonist
Dopaminergic
Dopaminergic
MAO-B inhibitor
-- / 6
25/100
25/100
1
-- / x 1
x 3
x 1
x 1
-- / Carbidopa/Levodopa
Rotigotine transdermal patch
Rasagiline
Carbidopa/Levodopa
Carbidopa/Levodopa sustained release
Carbidopa/Levodopa / Dopaminergic
Dopamine agonist
MAO-B inhibitor
Dopaminergic
Dopaminergic
Dopaminergic / 25/100
12
1
25/100
25/100
25/100 / x 3
x 1
x 1
x 3
x 1
x 3
PD45 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 3 / Carbidopa/Levodopa / Dopaminergic / 25/100 / x 3
PD46
MSA01
MSA02
MSA03
MSA04
MSA05
MSA06
MSA07
MSA08
MSA09
MSA10
MSA11
MSA12
MSA13
PSP01
PSP02
PSP03
PSP04
PSP05
PSP06
PSP07
PSP08
PSP09
PSP10
PSP11
PSP12
PSP13
PSP14
PSP15
PSP16
PSP17
PSP18
PSP19 / Carbidopa/Levodopa
Entacapone
Amantadine
--
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Ropinirole
--
Amantadine
Carbidopa/Levodopa
--
--
--
--
--
Amantadine
--
--
Carbidopa/Levodopa
--
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Rasagiline
Carbidopa/Levodopa
Rasagiline
Carbidopa/Levodopa
--
Carbidopa/Levodopa
Pramipexole
Carbidopa/Levodopa
--
Carbidopa/Levodopa
Pramipexole
Carbidopa/Levodopa
Rasagiline
Amantadine
Pramipexole
Carbidopa/Levodopa
Carbidopa/Levodopa
Ropinirole / Dopaminergic
COMT inhibitor
NMDA agonist
--
Dopaminergic
Dopaminergic
Dopaminergic
Dopamine agonist
--
NMDA agonist
Dopaminergic
--
--
--
--
--
NMDA agonist
--
--
Dopaminergic
--
Dopaminergic
Dopaminergic
Dopaminergic
MAO-B inhibitor
Dopaminergic
MAO-B inhibitor
Dopaminergic
--
Dopaminergic
Dopamine agonist
Dopaminergic
--
Dopaminergic
Dopamine agonist
Dopaminergic
MAO-B inhibitor
NMDA agonist
Dopamine agonist
Dopaminergic
Dopaminergic
Dopamine agonist / 25/100
200
100
--
25/100(2)
50/200
25/100
2
--
100
25/100
--
--
--
--
--
100
--
--
25/100(2)
--
25/100(2)
25/100(3)
25/100
1
25/100(2)
1
25/100 (3/4)
--
25/100(2)
0.25
25/100 (2)
--
25/100 (1.5)
1
25/100
1
100
0.25
25/100
25/100(3)
1 / x 7
x 6
x 2
--
x 3
x 7
x 6
x 2
--
x 2
x 3
--
--
--
--
--
x 2
--
--
x 3
--
x 3
x 3
x 3
x 1
x 3
x 1
x 4
--
x 4
x 3
x 3
--
x 4
x 3
x 3
x 1
x 2
x 3
x 1
x 4
x 2 / Amantadine
--
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Ropinirole
Carbidopa/Levodopa
Amantadine
Carbidopa/Levodopa
Carbidopa/Levodopa
--
--
--
--
--
--
Carbidopa/Levodopa
Amantadine
--
--
Carbidopa/Levodopa
--
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Pramipexole
Carbidopa/Levodopa
--
Carbidopa/Levodopa
Carbidopa/Levodopa
Carbidopa/Levodopa
Pramipexole
Carbidopa/Levodopa
Carbidopa/Levodopa
Ropinirole / NMDA agonist
--
Dopaminergic
Dopaminergic
Dopaminergic
Dopamine agonist
Dopaminergic
NMDA agonist
Dopaminergic
Dopaminergic
--
--
--
--
--
--
Dopaminergic
NMDA agonist
--
--
Dopaminergic
--
Dopaminergic
Dopaminergic
Dopaminergic
Dopaminergic
Dopaminergic
Dopamine agonist
Dopaminergic
--
Dopaminergic
Dopaminergic
Dopaminergic
Dopamine agonist
Dopaminergic
Dopaminergic
Dopamine agonist / 100
--
25/100
50/200
25/100(3)
2
25/100
100
25/100(2)
25/100
--
--
--
--
--
--
25/100
100
--
--
25/100(2)
--
25/100(2)
25/100(2)
25/100
25/100
25/100(2)
0.5
25/100 (1.5)
--
25/100 (1.5)
25/100
25/100
0.25
25/100
25/100
3 / x 2
--
x 4
x 8
x 6
x 1
x 2
x 2
x 4
x 2
--
--
--
--
--
--
x 3
x 3
--
--
x 3
--
x 3
x 3
x 4
x 3
x 4
x 3
x 3
--
x 3
x 3
x 6
x 3
x 1
x 4
x 2

Figure e-1 Regions of interest