Supplementary Table 4: miRNAs in germ cell tumors, page 1
Supplementary Table 4
Deregulated miRNAs and their function in Germ Cell Tumors
Abbrevations: for gene symbols see text or Entrez Gene (
Sample characteristics: aCarcinoma in situ and normal tubules. bSeminomas/embryonal carcinomas/teratomas/yolk sac tumors/spermatocytic seminomas. cSeminomas/non-seminomas/spermatocytic seminomas/normal testis.
References to the studies: see at the end of this Supplementary Table or the corresponding references in the text of the manuscript.
No. / miRNA / Study / Ref. No. in Text / Material / Patients/ Samples / Expression / Function / Target1 / miR-17-5p / Novotny et al. / 111 / Frozen tissue / 3-4 eacha / Upregulated in carcinoma in situ / E2F3
2 / miR-20a / Novotny et al. / 111 / Frozen tissue / 3-4 each / Upregulated in carcinoma in situ / E2F3
3 / miR-302a cluster / Gillis et al. / 108 / Frozen tissue / 15/14/8/4/3b / Upregulated in seminomas vs. spermatocytic seminomas, downregulated in both vs. normal testis
4 / miR-371-373 cluster / Gillis et al. / 108 / Frozen tissue / 15/14/8/4/3b / Upregulated in seminomas vs. spermatocytic seminomas, downregulated in both vs. normal testis
5 / miR-372 / Voorhoeve et al. / 110 / Frozen tissue / 32/21/4/4c / Upregulated in seminomas vs. spermatocytic seminomas, downregulated in both vs. normal testis / RAS-mediated cell growth arrest
6 / miR-373 / Voorhoeve et al. / 110 / Frozen tissue / 32/21/4/4c / Upregulated in seminomas vs. spermatocytic seminomas, downregulated in both vs. normal testis / RAS-mediated cell growth arrest
References
Gillis, A. J. et al.High-throughput microRNAome analysis in human germ cell tumours. J. Pathol.213, 319-328 (2007).
Novotny, G. W. et al. Analysis of gene expression in normal and neoplastic human testis: new roles of RNA. Int. J. Androl.30, 316-326 (2007).
Voorhoeve, P. M. et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell124, 1169-1181 (2006).