Dr. Afaf K.El-Ansary

Department of Organic Chemistry
Faculty of /Pharmacy, Cairo University

E-mail:

Tel: 22909395 Mobile: 0101415696

Work History

October 2003 – Present:

Professor in Organic Chemistry Department. Faculty of Pharmacy,. Cairo University.

1993 – 2003:

Assistant professor in Organic Chemistry Department, Faculty of Pharmacy, Cairo University.

1987 – 1993:

A lecturer in Organic Chemistry Department, Faculty of Pharmacy, Cairo University.

1979 – 1987:

A doctoral candidate in Organic Chemistry Department, Faculty of Pharmacy, Cairo University.

1974 – 1979:

A researcher in Organic Chemistry Department, Faculty of Pharmacy, Cairo University.

Teaching qualifications courses

1 – First year:

Hydrocarbons, Alkyl halides, Alcohols, Ethers, Carbonyl compounds, Amines, Carboxylic acids and its derivatives.

2 – Second year:

Aromaticity, Aromatic amines, Arenas, Aromatic carbonyl compounds, Heterocyclic compounds.

3 – Post graduate:

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Topics in organic reactions.

Supervision of Master degree Thesis at the Organic Chemistry Department, Cairo University, which concerns:

1 - Synthesis of certain pyrimidine derivatives of possible biological importance.

2 - Synthesis of some substituted isoxazole derivatives as chemotherapeutic agents.

3 - Synthesis of fused pyridazine heterocycles of pharmaceutical interest.

4 - Synthesis of some new triazino-quinazoline derivatives of expected pharmacological activity.

5 - Synthesis of some substituted pyridazine - 2 — thione of biological stud-,.

Supervision of Ph.D. Thesis at the Organic Chemistry Department. Cairo U nip ersit-,. which concerns:

1 - Synthesis of certain pyrazolopyrimidines and pyrazolotriazines of pharmaceutical interest.

2 - New approaches to the synthesis of thiazole, thiophene and other heterocyclic deriavatives for biological study.

3 — Certain heterocyclic compounds containing pyramidine nucleus: Synthesis, anticancer activity and molecular modeling investigations.

Publications

1.  Synthesis of some Quinazolone derivatives structurally related to certain sedatives, hypnotics and anticonvulsant agents.

A.K. El-Ansary, S.Botors and M.Khalifa; Die Pharmazie. 34, 11, P.5 (1979).

2.  Synthesis and Cyclocondensation Reactions of 4(5)- Imidazolylmcthylan-iinochalcones.

K.M.Ghoneim, S.E.El-Basil, A.N. Osman and A.K. El-Ansary; Ezvot. J. Chem., 32, 1, P.41 (1989).

3.  deravitives structurally related to

I Synthesis of 2-Amino-2-Thiazoline -2 -Thi azo line deravit'

Antihistaininis agents.

K.M.Ghoneim, S.E.El-Basil, A.N. Osman and A.K. El-Ansary; Egypt. J. Pharm. Sci., Vol.31, No. 1-4, P.41 (1990).

4.  Synthesis and Cyclocondensation of 2-Arylidene-Aminothiazolines with Chloroacetyl chloride and Mercaptoacetic acid.

K.M.Ghoneim, S.E.El-Basil, A.N. Osman and A.K. El-Ansary; Egypt. J. Phann. Sci., Vol.31, No. 1-4, P.41 (1990).

5.  Synthesis and Cardiotonic properties of 6-(3-Pyridyl) Nicontinonitrile derivatives. I

M.M. Badran, S.El-Mellgl*e and A.K. El-Ansary; Revue Roumaine de Chimie, 34, 11-12, PP. 209 (1989).

6.  Synthesis, Reactions and Antimicrobial Activity of certain Azlactone derivatives of Thiophene.

M.M. Kandeel, A.K. El-Ansary and S. El-Meligie; Proceedings of XXI conference of Phaiinaceutical Sciences, P. 335 (1990).

7.  Synthesis of some derivatives of 3-Acetylindole of Potential Biological Activity.

A.A El-Gendy, M.A.H. Ismail, A.K. El-Ansary and N.A. Abdou; Bull. Fac. Phan-n. Cairo Univ., Vol. 28, No. 2, PP. 47 (1990).

8.  Synthesis and Screening of Analgestic Activity of certain 1, 3 Diketone derivatives.

A.K. El-Ansary; Egypt. J. Phaini. Sci., Vol.32, No. 3-4, PP. 709 (1991).

9.  Synthesis of Novel Furan containing DNA minor groove binding Oligopeptides related to Netropsin for pharmaceutical interest.

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O.M. El-Badry, M.A.H. Ismail, M.M. Kandeel and A.K. El-Ansary; Alex. J. Phann. Sci., Vol. 6, (3), 247 (1992).

10.  Synthesis of 2-[3-Substituted Ai-i-iino-27Hydroxy'Propylthio]-1-Methyl-5-Oxo2-hi-lidazolinone derivatives of pharmaceutical interest. A new method for Desulphurization of -2-Thiohydantoins.

M.A.H. Ismail, O.M. El-Badry, M.M. Kandeel and A.K. El-Ansary; Alex. J. Phann. Sci., Vol. 6, (3), 259 (1992).

11.  Synthesis of some Novel 4(3H)-Quinazolinones as Antibacterial Agents. A.K. El-Ansary, M.M. Kandeel, M.A.H. Ismail, O.M. EL-Badry and A.M. ElNabrawy; Bull. Fac. Phann. Cairo Univ.. Vol. 30, No. 2, PP. 115 (1992).

12.  Synthesis and Mass Soectral Studies of sore 1-[2-Benzimidazolyl] or F6- Methyl-4(1 H)-Pyrimi dmione-2-yl] - 5 -Sub stituted Phenyl-'-Meth I-D,Ta

V z o I e Sz.

K.M. Youssef, M.M. Kandeel and A.K. El-Ai-isary: EL-vpt. J. Pham-,, Sc'..Vol. 33, No. 5-6, PP. 1099, (1992).

13.  Synthesis and Antimicrobial Activity of certain Pyrinndine derivatives. M.M. El-Anany, L.N. Soliman, A.K. El-Ansary, H.H. Kadry and A. Abdel Aziz; Bull. Fac. Phan-n. Cairo Univ.. Vol. 37, No. 3, P. 53, 1999.

14.  New method for preparing Novel 3-Alkyl-2-Thioxo-1,3-Diazaspiro[4.5]- Decan-4-One and 4-Alkylimino-3-Oxa-I -Azaspiro[4.5]-Decaiie-2-Thiol'ic derivatives having potential biological activities.

M.A.H. Ismail, Salwa El-Meligie and Afaf K. El-Ansary-, Eavpt. J. Phann. Sci. 40, No. 1, P. 79, 1999.

15.  Synthesis and Pharmacological activities of certain

P yrazo lotri azo lop yrimi dine and Pyrazolotriazepine derivatives.

M.A. Shaaban, A.H. Abou Seir, A.K. El-ANsary, H.H. Kadry and H.A. Abd El-Latif-, Bull. Fac. Phann. Cairo Univ., Vol. 39, P. 67, 2001.

16.  2-(2-Arylvinyl)-7-Substituted Quinazolin-4(3H)-Ones: Synthesis, Reactions and Antimicrobial Activity.

S. El-Maliaie, A.K. El-Ansary, M.M. Said and M.M.M. Hussein; Indian Journal of Chemistry, Vol. 40B, P. 62, 2001.

17.  Synthesis and Anti -In fl amatory Activity of some Thieno [2,3d] Pyrimidmone derivatives.

A.K. El-Ansary and A.H. Omar; Bull. Fac. Phann. Cairo Univ., Vol. 39, No. 1, P. 17, 2001.

IS. Synthesis and Biological Activity of some Novel Triazolothiadiazoles and Triazolothiadiazines.

Mahal M. Kandeel, Afaf K. El-Ansary a,-id Nayera A. Moneib; Alex. J. Phann. Sci., Vol. 16(1), P. 19, 2002.

19.  Synthesis and Antimicrobial Evaluation of osome New 1,2,4-Triazine

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derivatives.

A.K. El-Arisary, Bull. Fac. Phan-ri. Cairo Univ., Vol. 40, No. 3, P. 97, 2002

20.  Synthesis and Antimicrobial Activity of Spiroheterocycles related to I -Oxa-4- Th1aspiro[4.6]Undecan-2-One.

A.K. El-Ansary and M.M. Said; Az. J. Pbarm. Sci.. Vol. 30, P. 11, 2002.

Synthesis and Antimicrobial Activity of some Substituted Isoxazole derivatives.

F.A. El-Telbany, S.M.S. Roshdy, A.K. El-Ansary and K.O.A. Mohamed; Bull. Fac. Pharm. Cairo Univ., Vol. 40, No. 2, P. 11, 2002.

Education

n  Bachelor of Pharmaceutical Sciences, Honors Degree, Cairo University. 1974.

n  Master of Sciences Degree in Organic Chemistry, Cairo University, 1979.

n  Doctor of Philosophy in Organic Chemistry, Cairo University, 19S7.

Personal Data

Date of Birth: 14 February, 1952 Place of Birth: Cairo, Egypt Nationality: Egyptian

Marital Status: Married