Supplementary information S1 (table) | Published examples of endogenous genes modified by TALENs

Organism Type / Gene Name / Modification Type / TALEN Construction Platform / Reference
Arabidopsis / ADH1 / NHEJ / Golden Gate - Voytas / Cermak et al. 1
Bovine / GGTA / NHEJ / Golden Gate - Voytas - Goldy / Carlson et al. 2
Bovine / ACAN / NHEJ / Golden Gate - Voytas - Goldy / Carlson et al. 2
Bovine / GDF8 / NHEJ / Golden Gate - Voytas - Goldy / Carlson et al. 2
Bovine / PRNP / NHEJ / Golden Gate - Voytas - Goldy / Carlson et al. 2
C. elegans / ben-1 / NHEJ / Proprietary - Sangamo / Wood et al. 3
Cricket / Gb′lac2 / NHEJ / Proprietary - Cellectis / Watanabe et al. 4
Fruit Fly / yellow / NHEJ / Standard Cloning - B.Zhang / Liu et al. 5
Human / 4-Oct / HR / Proprietary - Sangamo / Hockemeyer et al. 6
Human / PITX3 / HR / Proprietary - Sangamo / Hockemeyer et al. 6
Human / PPP1R12C (AAVS1) / HR / Proprietary - Sangamo / Hockemeyer et al. 6
Human / ABL1 / NHEJ / FLASH / Reyon et al. 7
Human / AKT2 / NHEJ / FLASH / Reyon et al. 7
Human / ALK / NHEJ / FLASH / Reyon et al. 7
Human / APC / NHEJ / FLASH / Reyon et al. 7
Human / ATM / NHEJ / FLASH / Reyon et al. 7
Human / AXIN2 / NHEJ / FLASH / Reyon et al. 7
Human / BAX / NHEJ / FLASH / Reyon et al. 7
Human / BCL6 / NHEJ / FLASH / Reyon et al. 7
Human / BMPR1A / NHEJ / FLASH / Reyon et al. 7
Human / BRCA1 / NHEJ / FLASH / Reyon et al. 7
Human / BRCA2 / NHEJ / FLASH / Reyon et al. 7
Human / CBX3 / NHEJ / FLASH / Reyon et al. 7
Human / CBX8 / NHEJ / FLASH / Reyon et al. 7
Human / CCND1 / NHEJ / FLASH / Reyon et al. 7
Human / CDC73 / NHEJ / FLASH / Reyon et al. 7
Human / CDK4 / NHEJ / FLASH / Reyon et al. 7
Human / CHD4 / NHEJ / FLASH / Reyon et al. 7
Human / CHD7 / NHEJ / FLASH / Reyon et al. 7
Human / CTNNB1 / NHEJ / FLASH / Reyon et al. 7
Human / CYLD / NHEJ / FLASH / Reyon et al. 7
Human / DDB2 / NHEJ / FLASH / Reyon et al. 7
Human / ERCC2 / NHEJ / FLASH / Reyon et al. 7
Human / EWSR1 / NHEJ / FLASH / Reyon et al. 7
Human / EXT1 / NHEJ / FLASH / Reyon et al. 7
Human / EXT2 / NHEJ / FLASH / Reyon et al. 7
Human / EZH2 / NHEJ / FLASH / Reyon et al. 7
Human / FANCA / NHEJ / FLASH / Reyon et al. 7
Human / FANCC / NHEJ / FLASH / Reyon et al. 7
Human / FANCF / NHEJ / FLASH / Reyon et al. 7
Human / FANCG / NHEJ / FLASH / Reyon et al. 7
Human / FES / NHEJ / FLASH / Reyon et al. 7
Human / FGFR1 / NHEJ / FLASH / Reyon et al. 7
Human / FH / NHEJ / FLASH / Reyon et al. 7
Human / FLCN / NHEJ / FLASH / Reyon et al. 7
Human / FLT4 / NHEJ / FLASH / Reyon et al. 7
Human / FOXO1 / NHEJ / FLASH / Reyon et al. 7
Human / FOXO3 / NHEJ / FLASH / Reyon et al. 7
Human / GLI1 / NHEJ / FLASH / Reyon et al. 7
Human / HDAC1 / NHEJ / FLASH / Reyon et al. 7
Human / HDAC2 / NHEJ / FLASH / Reyon et al. 7
Human / HDAC6 / NHEJ / FLASH / Reyon et al. 7
Human / HMGA2 / NHEJ / FLASH / Reyon et al. 7
Human / HOXA13 / NHEJ / FLASH / Reyon et al. 7
Human / HOXA9 / NHEJ / FLASH / Reyon et al. 7
Human / HOXC13 / NHEJ / FLASH / Reyon et al. 7
Human / JAK2 / NHEJ / FLASH / Reyon et al. 7
Human / KRAS / NHEJ / FLASH / Reyon et al. 7
Human / MAP2K4 / NHEJ / FLASH / Reyon et al. 7
Human / MDM2 / NHEJ / FLASH / Reyon et al. 7
Human / MET / NHEJ / FLASH / Reyon et al. 7
Human / MLH1 / NHEJ / FLASH / Reyon et al. 7
Human / MSH2 / NHEJ / FLASH / Reyon et al. 7
Human / MUTYH / NHEJ / FLASH / Reyon et al. 7
Human / MYC / NHEJ / FLASH / Reyon et al. 7
Human / MYCL1 / NHEJ / FLASH / Reyon et al. 7
Human / MYCN / NHEJ / FLASH / Reyon et al. 7
Human / NBN / NHEJ / FLASH / Reyon et al. 7
Human / NCOR1 / NHEJ / FLASH / Reyon et al. 7
Human / NCOR2 / NHEJ / FLASH / Reyon et al. 7
Human / PDGFRA / NHEJ / FLASH / Reyon et al. 7
Human / PDGFRB / NHEJ / FLASH / Reyon et al. 7
Human / PHF8 / NHEJ / FLASH / Reyon et al. 7
Human / PMS2 / NHEJ / FLASH / Reyon et al. 7
Human / PTCH1 / NHEJ / FLASH / Reyon et al. 7
Human / PTEN / NHEJ / FLASH / Reyon et al. 7
Human / RARA / NHEJ / FLASH / Reyon et al. 7
Human / RBBP5 / NHEJ / FLASH / Reyon et al. 7
Human / RECQL4 / NHEJ / FLASH / Reyon et al. 7
Human / RET / NHEJ / FLASH / Reyon et al. 7
Human / RUNX1 / NHEJ / FLASH / Reyon et al. 7
Human / SDHB / NHEJ / FLASH / Reyon et al. 7
Human / SDHC / NHEJ / FLASH / Reyon et al. 7
Human / SDHD / NHEJ / FLASH / Reyon et al. 7
Human / SETDB1 / NHEJ / FLASH / Reyon et al. 7
Human / SIRT6 / NHEJ / FLASH / Reyon et al. 7
Human / SMAD2 / NHEJ / FLASH / Reyon et al. 7
Human / SS18 / NHEJ / FLASH / Reyon et al. 7
Human / SUZ12 / NHEJ / FLASH / Reyon et al. 7
Human / TFE3 / NHEJ / FLASH / Reyon et al. 7
Human / TP53 / NHEJ / FLASH / Reyon et al. 7
Human / TSC2 / NHEJ / FLASH / Reyon et al. 7
Human / VHL / NHEJ / FLASH / Reyon et al. 7
Human / XPA / NHEJ / FLASH / Reyon et al. 7
Human / XPC / NHEJ / FLASH / Reyon et al. 7
Human / MAOA / NHEJ / Solid Phase - Wang / Wang et al. 8
Human / PPP1R12C (AAVS1) / NHEJ / Golden Gate - F. Zhang / Sanjana et al. 9
Human / CCR5 / NHEJ / Golden Gate - Lahaye / Mussolino et al. 10
Human / ICRR6 / NHEJ / Golden Gate - Lahaye / Mussolino et al. 10
Human / HPRT / NHEJ / Golden Gate - Voytas / Cermak et al. 1
Human / HBB / NHEJ / Golden Gate - Voytas / Sun et al. 11
Human / CCR5 / NHEJ / Unpublished / Kim et al. 12
Human / CCR5 / NHEJ / Proprietary - Sangamo / Miller et al. 13
Porcine / SRY / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / RELA (p65) / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / DMD / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / AMELY / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / LDLR / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / RAG2 / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / IL2Rg / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / GHRHR / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / GGTA / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Porcine / GDF8 / NHEJ / Golden Gate- Voytas - Goldy / Carlson et al. 2
Rat / IgM / NHEJ / Proprietary - Sangamo / Tesson et al. 14
Rat / BMPR2 / NHEJ / Golden Gate - Voytas (modified) / Tong et al. 15
Rice / Os11N3 / NHEJ / Golden Gate - Yang / Li et al. 16
Silkworm / BmBlos2 / NHEJ / Gene Synthesis (F. Zhang) / Ma et al. 17
Xenopus / noggin / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Xenopus / ptf1a/p48 / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Xenopus / ets1 / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Xenopus / hhex / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Xenopus / vpp1 / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Xenopus / foxd3 / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Xenopus / sox9 / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Xenopus / grp78/bip / NHEJ / Golden Gate - Voytas (modified) / Lei et al. 18
Yeast / ade2 / NHEJ / Golden Gate - Yang / Li et al. 19
Yeast / lys3 / NHEJ / Golden Gate - Yang / Li et al. 19
Yeast / ura3 / NHEJ/HR / Golden Gate - Yang / Li et al. 19
Zebrafish / ponzr1 / NHEJ/ssODN / Golden Gate - Voytas - Goldy / Bedell et al. 20
Zebrafish / crhr1 / NHEJ/ssODN / Golden Gate - Voytas - Goldy / Bedell et al. 20
Zebrafish / moesina / NHEJ / Golden Gate - Voytas - Goldy / Bedell et al. 20
Zebrafish / ppp1cab / NHEJ / Golden Gate - Voytas - Goldy / Bedell et al. 20
Zebrafish / cdh5 / NHEJ / Golden Gate - Voytas - Goldy / Bedell et al. 20
Zebrafish / elmo1 / NHEJ / FLASH / Cade et al. 21
Zebrafish / epas1b / NHEJ / FLASH / Cade et al. 21
Zebrafish / fh / NHEJ / FLASH / Cade et al. 21
Zebrafish / hif1ab / NHEJ / FLASH / Cade et al. 21
Zebrafish / ptpmt1 / NHEJ / FLASH / Cade et al. 21
Zebrafish / scl6a3 / NHEJ / FLASH / Cade et al. 21
Zebrafish / bmi1 / NHEJ / FLASH / Moore et al. 22
Zebrafish / Ikzf1 / NHEJ / FLASH / Moore et al. 22
Zebrafish / jak3 / NHEJ / FLASH / Moore et al. 22
Zebrafish / myod / NHEJ / FLASH / Moore et al. 22
Zebrafish / phf6 / NHEJ / FLASH / Moore et al. 22
Zebrafish / gria3 / NHEJ / REAL / Sander et al. 23
Zebrafish / hey2 / NHEJ / REAL / Sander et al. 23
Zebrafish / golden / NHEJ / Golden Gate - Voytas (modified) / Dahlem et al. 24
Zebrafish / ryr3 / NHEJ / Golden Gate - Voytas (modified) / Dahlem et al. 24
Zebrafish / tbx6 / NHEJ / Golden Gate - Voytas (modified) / Dahlem et al. 24
Zebrafish / ryr1a / NHEJ / Golden Gate - Voytas (modified) / Dahlem et al. 24
Zebrafish / dip2a / NHEJ / Standard Cloning - B.Zhang / Huang et al. 25
Zebrafish / tnikb / NHEJ / Standard Cloning - B.Zhang / Huang et al. 25

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