Supporting Information for
Development of fast and robust multiresidual LC-MS/MS method for determination of pharmaceuticals in soils
O. Golovko1, O. Koba1, G. Fedorova1, R. Kodesova2, R. Grabic1
1 University of South Bohemia in Ceské Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zatisi 728/II, 389 25 Vodnany, Czech Republic
2 Czech University of Life Sciences Prague, Department of Soil Science and Soil Protection, Kamycka 129, 16521 Prague 6, Czech Republic
To whom correspondence should be addressed. E-mail:
Content
Table SI 1: Selected soils and soil properties. 2
Table SI 2. LC gradient for the elution of target compounds, Cogent Bidentate C18 column. 4
TableSI 3. The efficiency of three different extraction procedures for 91 pharmaceuticals 5
Table SI 4. Minimum, maximum and median recovery of 44 compounds from 13 soil types at three concentration levels. 14
Table SI 5.Matrix effects for 44 target compounds. 17
Table SI 1Selected soils and soilproperties: pHH2O; pHKCl; SOC - soil organic content; CaCO3- content, CEC -cation exchange capacity; HA - soil hydrolytic acidity;EA - exchangeable acidity; BCS- basic cation saturation; SCS- sorption complex saturation; salinity;ds- particle density; clay, silt and sand contents (%).
Soil Acronym / Location / Soil type / pHH2O / pHKCl / SOC(%) / CaCO3
(%) / CEC
(mmol + kg-1) / HA
(mmol + kg-1) / EA
(mmol + kg-1)
P / Předbořice / Hamplic Cambisol B / 5.99 / 5.10 / 2.58 / 0.05 / 155 / 42.4 / 1.32
J / Jince / Hamplic Cambisol C / 5.30 / 4.39 / 1.71 / 0.67 / 132 / 50.5 / 2.84
H / Humpolec / Hamplic Cambisol A / 5.37 / 4.41 / 1.64 / 0.18 / 175 / 50.5 / 2.65
W / Vysoké nad Jizerou / Dystric Cambisol / 5.59 / 4.67 / 2.17 / 0.10 / 186 / 54.1 / 1.89
X / Milčice / Stagnic Chernozem Siltic / 8.07 / 7.40 / 3.2 / 20.87 / 315 / 3.6 / 0.95
L / Velké Chvalovice / Chernozem Arenic / 6.36 / 5.90 / 1.16 / 0 / 92.6 / 14.4 / 1.13
E / Semice / Arenosol Epieutric / 5.38 / 4.30 / 0.69 / 0.05 / 45.5 / 19.8 / 2.27
D / Praha Suchdol / Hamplic Chernozem B / 7.97 / 7.19 / 2.09 / 4.07 / 261 / 4.5 / 1.13
S / Hněvčeves / Haplic Luvisol / 6.51 / 5.66 / 0.88 / 0.18 / 155 / 15.3 / 0.95
C / Čáslav / Greyic Phaeozem / 7.73 / 5.31 / 1.24 / 0.55 / 166 / 4.5 / 0.76
Q / Písková Lhota / Sand / 8.71 / 8.46 / 0.08 / 0.1 / 10.6 / 0.45 / 0.66
U / Praha Suchdol / Loess / 8.44 / 7.41 / 0.36 / 20.5 / 191 / 3.6 / 1.13
I / Ivanovice na Hané / Hamplic Chernozem A / 7.17 / 6.30 / 1.67 / 0.07 / 218 / 10.8 / 0.85
Average value / 6.81 / 5.88 / 1.49 / 3.64 / 161.8 / 21.1 / 1.42
Standard deviation / 1.25 / 1.37 / 0.88 / 7.64 / 81.7 / 20.5 / 0.73
Range / 3.41 / 4.16 / 3.12 / 20.9 / 304 / 53.6 / 2.18
Soil Acronym / Location / Soil type / BCS
(mmol + kg-1) / SCS
(%) / Salinity
(µS cm−1) / ds
(g cm-3) / Clay
(%) / Silt
(%) / Sand
(%)
P / Předbořice / Hamplic Cambisol B / 113 / 72.7 / 70.4 / 2.55 / 2.07 / 43.94 / 53.99
J / Jince / Hamplic Cambisol C / 81.6 / 61.8 / 59.4 / 2.59 / 5.27 / 56.51 / 38.22
H / Humpolec / Hamplic Cambisol A / 125 / 71.2 / 138 / 2.59 / 7.46 / 48.33 / 44.21
W / Vysoké nad Jizerou / Dystric Cambisol / 132 / 70.9 / 50.2 / 2.59 / 2.56 / 58.35 / 39.09
X / Milčice / Stagnic Chernozem Siltic / 311 / 98.9 / 173 / 2.50 / 14.7 / 45.78 / 39.53
L / Velké Chvalovice / Chernozem Arenic / 78.2 / 84.4 / 99.7 / 2.61 / 2.14 / 21.40 / 76.46
E / Semice / Arenosol Epieutric / 25.7 / 56.5 / 32.3 / 2.63 / 5.02 / 10.98 / 84.00
D / Praha Suchdol / Hamplic Chernozem B / 256 / 98.3 / 119 / 2.51 / 6.52 / 64.16 / 29.32
S / Hněvčeves / Haplic Luvisol / 140 / 90.1 / 48.8 / 2.59 / 7.41 / 76.74 / 15.85
C / Čáslav / Greyic Phaeozem / 162 / 97.3 / 104 / 2.54 / 4.41 / 75.39 / 20.20
Q / Písková Lhota / Sand / 10.2 / 95.8 / 45.0 / 2.65 / 0 / 0 / 100
U / Praha Suchdol / Loess / 188 / 98.1 / 98.6 / 2.60 / 7.51 / 48.31 / 44.18
I / Ivanovice na Hané / Hamplic Chernozem A / 207 / 95.0 / 88.0 / 2.53 / 5.91 / 76.37 / 17.72
Average value / 141 / 83.9 / 86.6 / 2.58 / 5.45 / 48.17 / 46.36
Standard deviation / 85.8 / 15.3 / 40.9 / 0.05 / 3.65 / 24.53 / 26.07
Range / 301 / 42.4 / 141 / 0.15 / 14.7 / 76.74 / 84.15
Table SI 2LC gradient for the elution of target compounds, Cogent Bidentate C18 column.
Time, min / Mobile phase composition/vol. % / Flow rate,μL min−1
water (0.1 % FA) / ACN (0.1 % FA)
0.00 / 100 / 0 / 300
1.00 / 100 / 0 / 300
7.00 / 60 / 40 / 350
9.00 / 0 / 100 / 400
10.00 / 0 / 100 / 400
10.01 / 100 / 0 / 300
13.00 / 100 / 0 / 300
ACN - acetonitrile
FA - formic acid
Table SI 3The efficiency of three different extraction procedures for 91 pharmaceuticals:
- 63 pharmaceuticals are marked violet color;
- 44 pharmaceuticals are marked bold;
- pharmaceuticals which were removed from second step of experiment because of unsatisfied recoveries are written italic;
1)P-1: extraction with acetonitrile and water (1/1 v/v with 0.1% formic acid) followed by extraction with acetonitrile, 2-propanol, and water (3/3/4 v/v/v with 0.1% formic acid);
2)P-2: extraction with acetonitrile and water (1/1 v/v with 0.1% formic acid);
3)P-3: extraction with methanol and water (2/1 v/v with 0.1% formic acid)
1_P / 1_J / 1_H / 1_W / 1_X / 1_L / 1_E / 1_D / 1_S / 1_C / 1_Q / 1_U / 1_IDiclofenac / 86% / 99% / 72% / 80% / 87% / 96% / 110% / 81% / 83% / 92% / 102% / 107% / 90%
Codeine / 87% / 92% / 72% / 92% / 115% / 106% / 100% / 88% / 120% / 106% / 95% / 115% / 126%
Tramadol / 116% / 63% / 97% / 78% / 122% / 89% / 60% / 99% / 113% / 117% / 90% / 113% / 121%
Atenolol / 107% / 105% / 92% / 101% / 79% / 94% / 89% / 60% / 76% / 67% / 123% / 62% / 64%
Metoprolol / 95% / 106% / 82% / 75% / 73% / 95% / 82% / 88% / 81% / 80% / 94% / 136% / 110%
Bisoprolol / 101% / 112% / 104% / 85% / 81% / 107% / 95% / 97% / 93% / 95% / 107% / 130% / 124%
Furosemide / 94% / 95% / 90% / 79% / 88% / 92% / 82% / 91% / 107% / 115% / 127% / 113% / 97%
Cilazapril / 112% / 108% / 107% / 100% / 96% / 108% / 100% / 85% / 92% / 91% / 120% / 91% / 87%
Irbesartan / 125% / 87% / 91% / 93% / 86% / 65% / 86% / 74% / 91% / 66% / 73% / 108% / 70%
Felodipine / 86% / 99% / 72% / 87% / 99% / 98% / 113% / 85% / 82% / 92% / 97% / 118% / 102%
Sotalol / 110% / 106% / 98% / 104% / 91% / 103% / 99% / 72% / 84% / 84% / 135% / 79% / 73%
Valsartan / 82% / 103% / 73% / 87% / 84% / 104% / 122% / 79% / 90% / 95% / 103% / 109% / 90%
Verapamil / 66% / 79% / 54% / 65% / 50% / 63% / 63% / 51% / 64% / 70% / 82% / 69% / 52%
Diltiazem / 63% / 76% / 49% / 62% / 48% / 64% / 66% / 46% / 60% / 62% / 75% / 64% / 47%
Clarithromycin / 84% / 90% / 66% / 80% / 73% / 93% / 104% / 71% / 73% / 77% / 98% / 66% / 66%
Trimethoprim / 94% / 90% / 80% / 84% / 75% / 83% / 81% / 60% / 63% / 63% / 133% / 69% / 51%
Sulfamethoxazole / 112% / 119% / 113% / 104% / 105% / 119% / 100% / 104% / 122% / 110% / 116% / 119% / 106%
Clindamycine / 71% / 84% / 60% / 70% / 66% / 81% / 85% / 63% / 63% / 73% / 99% / 70% / 55%
Roxithromycin / 73% / 84% / 60% / 69% / 64% / 84% / 81% / 61% / 62% / 76% / 97% / 67% / 67%
Sulfadiazine / 110% / 111% / 98% / 102% / 96% / 117% / 98% / 106% / 119% / 99% / 101% / 123% / 103%
Sulfathiazole / 108% / 109% / 106% / 96% / 98% / 119% / 98% / 101% / 118% / 105% / 116% / 122% / 104%
Sulfapyridine / 112% / 114% / 105% / 99% / 101% / 124% / 96% / 103% / 115% / 105% / 115% / 116% / 98%
Sulfamerazine / 120% / 110% / 113% / 108% / 115% / 113% / 112% / 94% / 111% / 117% / 134% / 118% / 106%
Sulfamoxol / 128% / 106% / 104% / 111% / 124% / 124% / 124% / 87% / 91% / 94% / 148% / 84% / 97%
Sulfamethazine / 120% / 121% / 116% / 104% / 112% / 127% / 103% / 111% / 127% / 116% / 124% / 128% / 110%
Sulfamethizole / 111% / 116% / 108% / 100% / 95% / 113% / 96% / 99% / 120% / 108% / 118% / 111% / 99%
Sulfamethoxypyridazine / 112% / 120% / 109% / 101% / 105% / 119% / 99% / 105% / 123% / 112% / 116% / 118% / 104%
Sulfadimethoxine / 109% / 121% / 110% / 102% / 101% / 118% / 97% / 103% / 117% / 108% / 112% / 117% / 104%
Sulfaquinoxaline / 114% / 116% / 112% / 104% / 102% / 123% / 100% / 105% / 123% / 109% / 119% / 124% / 104%
Sulfaphenazole / 114% / 120% / 110% / 101% / 105% / 122% / 100% / 107% / 121% / 110% / 116% / 122% / 107%
Sulfasalazine / 72% / 68% / 60% / 63% / 85% / 94% / 113% / 82% / 111% / 119% / 78% / 57% / 120%
Oseltamivir / 95% / 91% / 117% / 92% / 115% / 104% / 105% / 84% / 126% / 114% / 111% / 75% / 133%
Carbamazepine / 86% / 103% / 78% / 78% / 88% / 92% / 107% / 80% / 86% / 97% / 91% / 113% / 89%
Oxazepam / 80% / 102% / 69% / 76% / 66% / 86% / 93% / 65% / 77% / 80% / 89% / 83% / 71%
Memantine / 87% / 90% / 72% / 87% / 90% / 85% / 94% / 82% / 108% / 100% / 99% / 99% / 113%
Clonazepam / 123% / 117% / 122% / 116% / 120% / 126% / 123% / 97% / 111% / 114% / 136% / 115% / 104%
Naloxone / 89% / 84% / 79% / 88% / 129% / 99% / 118% / 113% / 117% / 118% / 98% / 160% / 132%
Sertaline / 79% / 82% / 88% / 67% / 60% / 79% / 60% / 61% / 84% / 64% / 90% / 72% / 67%
Ropinirole / 96% / 102% / 82% / 71% / 73% / 91% / 82% / 92% / 79% / 90% / 103% / 144% / 107%
Bupropion / 128% / 125% / 113% / 122% / 116% / 129% / 126% / 60% / 113% / 116% / 158% / 104% / 95%
Venlafaxine / 65% / 65% / 50% / 68% / 66% / 58% / 61% / 65% / 75% / 73% / 70% / 72% / 82%
Citalopram / 70% / 69% / 36% / 58% / 47% / 62% / 45% / 59% / 65% / 62% / 82% / 65% / 52%
Paroxetine / 75% / 78% / 70% / 68% / 54% / 67% / 61% / 66% / 74% / 74% / 92% / 87% / 69%
Haloperidol / 74% / 73% / 65% / 59% / 54% / 69% / 52% / 68% / 74% / 68% / 84% / 85% / 65%
Amitriptyline / 66% / 75% / 67% / 62% / 49% / 73% / 63% / 65% / 64% / 67% / 65% / 74% / 70%
Mianserin / 115% / 78% / 81% / 89% / 62% / 56% / 83% / 53% / 69% / 49% / 82% / 79% / 45%
Rosuvastatin / 113% / 103% / 116% / 111% / 107% / 123% / 104% / 89% / 108% / 95% / 131% / 88% / 88%
Bezafibrate / 88% / 101% / 77% / 78% / 79% / 82% / 68% / 77% / 97% / 85% / 100% / 106% / 89%
Fenofibrate / 81% / 84% / 118% / 84% / 106% / 130% / 99% / 94% / 126% / 79% / 84% / 95% / 97%
Atorvastatin / 54% / 56% / 74% / 57% / 84% / 82% / 78% / 64% / 64% / 76% / 132% / 109% / 64%
Glibenclamide / 96% / 97% / 93% / 85% / 88% / 102% / 77% / 92% / 102% / 88% / 105% / 96% / 92%
Glimepiride / 99% / 95% / 116% / 90% / 80% / 103% / 79% / 93% / 99% / 87% / 93% / 98% / 109%
Fexofenadine / 76% / 96% / 62% / 77% / 73% / 87% / 109% / 66% / 72% / 105% / 100% / 105% / 90%
Clemastine / 69% / 80% / 60% / 66% / 61% / 77% / 81% / 60% / 60% / 67% / 92% / 74% / 60%
Atracurium / 96% / 94% / 64% / 82% / 101% / 77% / 83% / 84% / 99% / 98% / 81% / 107% / 111%
Dicycloverine / 74% / 73% / 73% / 62% / 50% / 78% / 69% / 67% / 60% / 71% / 73% / 88% / 71%
Flecainide / 118% / 111% / 101% / 108% / 94% / 112% / 104% / 60% / 87% / 88% / 126% / 84% / 80%
Flutamide / 102% / 102% / 90% / 76% / 87% / 93% / 72% / 87% / 92% / 92% / 82% / 92% / 94%
Finasteride / 104% / 114% / 97% / 100% / 96% / 110% / 85% / 130% / 120% / 112% / 111% / 126% / 95%
Loperamide / 77% / 84% / 69% / 66% / 70% / 78% / 93% / 67% / 71% / 79% / 90% / 95% / 72%
Fluconazole / 118% / 123% / 130% / 113% / 110% / 95% / 120% / 97% / 99% / 91% / 97% / 130% / 106%
Terbinafine / 120% / 85% / 95% / 94% / 72% / 64% / 94% / 64% / 74% / 60% / 79% / 85% / 56%
Terbutaline / 127% / 121% / 106% / 118% / 111% / 130% / 116% / 62% / 127% / 130% / 154% / 130% / 101%
Donepezil / 38% / 31% / 21% / 30% / 7% / 12% / 9% / 5% / 13% / 11% / 40% / 12% / 7%
Buprenorphine / 83% / 72% / 65% / 73% / 41% / 56% / 52% / 23% / 23% / 27% / 94% / 33% / 20%
Repaglinide / 133% / 112% / 101% / 114% / 133% / 119% / 88% / 66% / 94% / 114% / 153% / 132% / 92%
Budenoside / 129% / 142% / 128% / 138% / 142% / 158% / 147% / 72% / 99% / 97% / 145% / 104% / 116%
Hydroxyzine / 70% / 55% / 35% / 55% / 35% / 36% / 14% / 17% / 26% / 27% / 118% / 42% / 18%
Mirtazapine / 21% / 6% / 6% / 9% / 60% / 11% / 1% / 30% / 16% / 33% / 50% / 82% / 17%
Dipyridamole / 18% / 2% / 2% / 6% / 5% / 2% / 2% / 1% / 0% / 1% / 51% / 12% / 0%
Orphenadrine / 79% / 56% / 52% / 72% / 34% / 34% / 48% / 21% / 36% / 24% / 51% / 34% / 26%
Promethazine / 94% / 47% / 39% / 68% / 52% / 41% / 66% / 24% / 33% / 24% / 79% / 36% / 24%
Disopyramide / 70% / 60% / 46% / 65% / 38% / 34% / 15% / 20% / 29% / 29% / 63% / 32% / 27%
Chlorprothixene / 104% / 74% / 70% / 87% / 58% / 54% / 79% / 37% / 68% / 46% / 77% / 67% / 43%
Cyproheptadine / 118% / 86% / 80% / 106% / 65% / 60% / 85% / 41% / 67% / 44% / 74% / 65% / 48%
Clomipramine / 108% / 82% / 78% / 94% / 60% / 57% / 81% / 38% / 67% / 43% / 72% / 63% / 46%
Desloratadine / 15% / 6% / 3% / 6% / 31% / 6% / 1% / 9% / 6% / 11% / 52% / 39% / 6%
Levomepromazine / 111% / 58% / 52% / 87% / 69% / 54% / 58% / 22% / 20% / 15% / 92% / 59% / 18%
Telmisartan / 94% / 40% / 43% / 55% / 155% / 48% / 7% / 81% / 47% / 91% / 158% / 174% / 45%
Flumequine / 20% / 16% / 8% / 10% / 3% / 12% / 16% / 2% / 4% / 3% / 12% / 3% / 4%
Fluphenazine / 89% / 53% / 30% / 66% / 101% / 67% / 22% / 40% / 43% / 58% / 149% / 87% / 40%
Erythromycin / 41% / 15% / 18% / 23% / 48% / 18% / 6% / 39% / 34% / 38% / 62% / 75% / 21%
Perphenazine / 50% / 14% / 14% / 26% / 42% / 13% / 3% / 10% / 7% / 9% / 59% / 37% / 6%
Meclozine / 53% / 30% / 21% / 38% / 12% / 11% / 5% / 6% / 7% / 6% / 44% / 16% / 4%
Sulconazole / 77% / 58% / 59% / 60% / 59% / 43% / 67% / 47% / 50% / 42% / 64% / 83% / 39%
Flupentixol / 91% / 50% / 49% / 70% / 65% / 41% / 27% / 37% / 36% / 32% / 62% / 63% / 37%
Miconazole / 78% / 62% / 66% / 66% / 60% / 45% / 71% / 49% / 51% / 42% / 67% / 87% / 39%
Alfuzosin / 32% / 23% / 18% / 26% / 0% / 3% / 1% / 1% / 6% / 4% / 22% / 3% / 2%
Dihydroergotamine / 92% / 86% / 75% / 85% / 79% / 82% / 79% / 40% / 62% / 65% / 122% / 89% / 55%
Ranitidine / 19% / 8% / 6% / 14% / 10% / 6% / 1% / 4% / 8% / 10% / 53% / 14% / 5%
Diphenhydramine / 44% / 39% / 24% / 35% / 15% / 19% / 11% / 8% / 12% / 13% / 65% / 16% / 9%
2_P / 2_J / 2_H / 2_W / 2_X / 2_L / 2_E / 2_D / 2_S / 2_C / 2_Q / 2_U / 2_I
Diclofenac / 43% / 37% / 52% / 34% / 62% / 47% / 34% / 42% / 34% / 55% / 47% / 51% / 46%
Codeine / 104% / 106% / 90% / 92% / 96% / 91% / 94% / 104% / 92% / 96% / 127% / 84% / 87%
Tramadol / 138% / 146% / 153% / 127% / 94% / 128% / 109% / 100% / 105% / 132% / 139% / 117% / 114%
Atenolol / 105% / 117% / 102% / 98% / 124% / 110% / 119% / 98% / 104% / 108% / 116% / 101% / 93%
Metoprolol / 99% / 85% / 72% / 112% / 80% / 102% / 94% / 73% / 83% / 70% / 102% / 79% / 78%
Bisoprolol / 90% / 77% / 66% / 100% / 72% / 89% / 84% / 67% / 76% / 64% / 89% / 70% / 70%
Furosemide / 42% / 38% / 46% / 39% / 65% / 45% / 36% / 49% / 38% / 46% / 56% / 61% / 51%
Cilazapril / 72% / 53% / 54% / 59% / 73% / 62% / 48% / 61% / 48% / 55% / 73% / 70% / 57%
Irbesartan / 60% / 54% / 62% / 52% / 90% / 64% / 46% / 64% / 52% / 69% / 68% / 65% / 70%
Felodipine / 45% / 41% / 54% / 38% / 53% / 46% / 36% / 40% / 38% / 59% / 48% / 52% / 51%
Sotalol / 124% / 130% / 113% / 106% / 121% / 110% / 120% / 143% / 116% / 133% / 132% / 112% / 120%
Valsartan / 41% / 37% / 51% / 33% / 65% / 47% / 36% / 46% / 36% / 54% / 44% / 45% / 53%
Verapamil / 44% / 39% / 43% / 39% / 41% / 49% / 33% / 38% / 32% / 41% / 52% / 38% / 35%
Diltiazem / 58% / 57% / 56% / 58% / 57% / 68% / 49% / 50% / 48% / 53% / 76% / 47% / 49%
Clarithromycin / 97% / 124% / 114% / 67% / 97% / 90% / 87% / 94% / 103% / 62% / 129% / 99% / 72%
Trimethoprim / 115% / 109% / 114% / 125% / 115% / 130% / 111% / 116% / 112% / 110% / 105% / 116% / 89%
Sulfamethoxazole / 88% / 84% / 109% / 61% / 118% / 89% / 105% / 114% / 86% / 128% / 80% / 112% / 100%
Clindamycine / 96% / 126% / 106% / 63% / 109% / 92% / 90% / 102% / 110% / 62% / 124% / 95% / 78%
Roxithromycin / 61% / 66% / 58% / 68% / 55% / 65% / 52% / 50% / 52% / 50% / 80% / 46% / 51%
Sulfadiazine / 90% / 73% / 74% / 100% / 83% / 95% / 87% / 83% / 82% / 82% / 91% / 91% / 87%
Sulfathiazole / 95% / 95% / 102% / 75% / 126% / 96% / 114% / 114% / 99% / 120% / 94% / 116% / 107%
Sulfapyridine / 86% / 89% / 97% / 74% / 120% / 94% / 108% / 109% / 91% / 109% / 89% / 107% / 101%
Sulfamerazine / 82% / 79% / 94% / 68% / 116% / 89% / 105% / 101% / 88% / 113% / 78% / 102% / 95%
Sulfamoxol / 125% / 184% / 99% / 118% / 155% / 115% / 129% / 117% / 98% / 75% / 162% / 87% / 123%
Sulfamethazine / 90% / 87% / 99% / 73% / 125% / 96% / 107% / 113% / 94% / 117% / 87% / 105% / 102%
Sulfamethizole / 92% / 87% / 100% / 63% / 122% / 88% / 106% / 111% / 88% / 116% / 85% / 103% / 99%
Sulfamethoxypyridazine / 89% / 90% / 102% / 69% / 123% / 95% / 111% / 111% / 90% / 117% / 87% / 107% / 103%
Sulfadimethoxine / 87% / 82% / 106% / 61% / 118% / 87% / 105% / 109% / 82% / 122% / 78% / 108% / 95%
Sulfaquinoxaline / 83% / 81% / 104% / 60% / 116% / 87% / 103% / 108% / 81% / 123% / 80% / 109% / 95%
Sulfaphenazole / 75% / 71% / 94% / 50% / 100% / 73% / 89% / 96% / 71% / 111% / 69% / 99% / 82%
Sulfasalazine / 60% / 48% / 45% / 36% / 57% / 65% / 79% / 46% / 50% / 57% / 61% / 35% / 46%
Oseltamivir / 106% / 99% / 92% / 107% / 97% / 121% / 95% / 82% / 108% / 85% / 102% / 81% / 76%
Carbamazepine / 76% / 74% / 79% / 81% / 88% / 91% / 64% / 72% / 77% / 81% / 93% / 74% / 84%
Oxazepam / 69% / 66% / 71% / 73% / 66% / 76% / 61% / 57% / 65% / 69% / 78% / 62% / 67%
Memantine / 79% / 78% / 77% / 85% / 60% / 86% / 60% / 60% / 61% / 79% / 81% / 62% / 67%
Clonazepam / 78% / 55% / 59% / 62% / 63% / 68% / 54% / 60% / 53% / 67% / 72% / 75% / 60%
Naloxone / 112% / 111% / 102% / 93% / 113% / 98% / 107% / 121% / 85% / 95% / 124% / 92% / 95%
Sertaline / 74% / 56% / 60% / 54% / 48% / 66% / 60% / 53% / 48% / 60% / 72% / 62% / 49%
Ropinirole / 74% / 63% / 53% / 73% / 55% / 70% / 67% / 52% / 56% / 49% / 76% / 56% / 53%
Bupropion / 98% / 95% / 114% / 116% / 90% / 124% / 85% / 112% / 100% / 149% / 90% / 114% / 115%
Venlafaxine / 118% / 104% / 110% / 120% / 88% / 112% / 75% / 100% / 90% / 125% / 105% / 104% / 107%
Citalopram / 66% / 48% / 41% / 54% / 44% / 54% / 44% / 43% / 41% / 44% / 69% / 50% / 41%
Paroxetine / 59% / 44% / 42% / 48% / 39% / 48% / 46% / 42% / 41% / 45% / 67% / 49% / 36%
Haloperidol / 65% / 53% / 54% / 52% / 45% / 62% / 58% / 55% / 51% / 62% / 65% / 67% / 49%
Amitriptyline / 138% / 128% / 140% / 166% / 86% / 102% / 119% / 129% / 125% / 102% / 121% / 92% / 160%
Mianserin / 57% / 53% / 56% / 58% / 55% / 61% / 44% / 42% / 44% / 52% / 84% / 43% / 47%
Rosuvastatin / 74% / 55% / 52% / 50% / 55% / 60% / 47% / 58% / 47% / 64% / 59% / 61% / 50%
Bezafibrate / 65% / 53% / 61% / 53% / 74% / 64% / 55% / 69% / 55% / 73% / 66% / 76% / 67%
Fenofibrate / 39% / 28% / 41% / 23% / 34% / 40% / 37% / 44% / 31% / 61% / 36% / 52% / 36%
Atorvastatin / 3% / 4% / 10% / 2% / 21% / 8% / 7% / 25% / 9% / 19% / 38% / 23% / 23%
Glibenclamide / 53% / 37% / 50% / 32% / 40% / 47% / 42% / 51% / 38% / 59% / 39% / 62% / 45%
Glimepiride / 55% / 36% / 54% / 36% / 46% / 53% / 45% / 53% / 43% / 61% / 47% / 64% / 49%
Fexofenadine / 54% / 58% / 66% / 51% / 62% / 61% / 44% / 56% / 50% / 71% / 78% / 64% / 56%
Clemastine / 45% / 42% / 50% / 40% / 39% / 50% / 41% / 36% / 35% / 48% / 59% / 43% / 38%
Atracurium / 82% / 71% / 56% / 87% / 64% / 78% / 71% / 55% / 59% / 51% / 86% / 58% / 52%
Dicycloverine / 129% / 115% / 134% / 150% / 75% / 93% / 112% / 113% / 110% / 97% / 116% / 86% / 140%
Flecainide / 63% / 50% / 50% / 57% / 44% / 54% / 44% / 43% / 38% / 46% / 64% / 54% / 38%
Flutamide / 92% / 70% / 85% / 77% / 73% / 85% / 83% / 83% / 72% / 108% / 87% / 99% / 81%
Finasteride / 63% / 26% / 23% / 35% / 28% / 28% / 27% / 27% / 29% / 34% / 32% / 34% / 30%
Loperamide / 47% / 44% / 56% / 40% / 44% / 50% / 41% / 42% / 38% / 59% / 58% / 49% / 43%
Fluconazole / 140% / 164% / 105% / 166% / 123% / 110% / 101% / 105% / 115% / 109% / 168% / 119% / 119%
Terbinafine / 48% / 41% / 54% / 36% / 44% / 50% / 39% / 40% / 33% / 52% / 57% / 47% / 38%
Terbutaline / 128% / 138% / 116% / 114% / 127% / 119% / 126% / 150% / 128% / 139% / 136% / 120% / 131%
Donepezil / 55% / 42% / 37% / 51% / 35% / 44% / 39% / 39% / 35% / 39% / 66% / 44% / 33%
Buprenorphine / 62% / 39% / 40% / 48% / 46% / 51% / 52% / 41% / 26% / 33% / 65% / 34% / 29%
Repaglinide / 58% / 44% / 44% / 45% / 52% / 48% / 38% / 56% / 35% / 57% / 64% / 67% / 44%
Budenoside / 76% / 59% / 56% / 67% / 57% / 76% / 63% / 65% / 60% / 75% / 79% / 77% / 47%
Hydroxyzine / 80% / 66% / 59% / 77% / 60% / 73% / 54% / 63% / 60% / 69% / 89% / 75% / 58%
Mirtazapine / 35% / 28% / 24% / 29% / 73% / 33% / 7% / 61% / 22% / 54% / 76% / 61% / 60%
Dipyridamole / 12% / 1% / 1% / 2% / 13% / 2% / 2% / 2% / 0% / 0% / 66% / 4% / 0%
Orphenadrine / 41% / 40% / 40% / 42% / 34% / 43% / 34% / 31% / 31% / 38% / 60% / 34% / 30%
Promethazine / 44% / 26% / 25% / 39% / 40% / 41% / 36% / 30% / 14% / 20% / 85% / 19% / 19%
Disopyramide / 125% / 138% / 83% / 145% / 91% / 98% / 71% / 90% / 90% / 88% / 167% / 91% / 90%
Chlorprothixene / 46% / 44% / 47% / 44% / 37% / 46% / 40% / 34% / 37% / 47% / 70% / 42% / 37%
Cyproheptadine / 58% / 60% / 63% / 59% / 52% / 63% / 52% / 45% / 50% / 58% / 88% / 51% / 50%
Clomipramine / 51% / 52% / 54% / 47% / 42% / 52% / 42% / 37% / 39% / 51% / 74% / 44% / 42%
Desloratadine / 13% / 9% / 5% / 10% / 47% / 8% / 1% / 28% / 6% / 15% / 45% / 28% / 29%
Levomepromazine / 97% / 29% / 22% / 57% / 82% / 43% / 33% / 58% / 5% / 9% / 143% / 39% / 33%
Telmisartan / 51% / 26% / 28% / 30% / 74% / 36% / 9% / 77% / 25% / 66% / 67% / 96% / 53%
Flumequine / 22% / 13% / 11% / 14% / 6% / 20% / 23% / 9% / 12% / 11% / 24% / 8% / 11%
Fluphenazine / 44% / 26% / 24% / 32% / 49% / 34% / 13% / 48% / 22% / 43% / 67% / 51% / 35%
Erythromycin / 26% / 16% / 13% / 18% / 57% / 23% / 6% / 51% / 16% / 33% / 42% / 32% / 45%
Perphenazine / 29% / 15% / 17% / 24% / 52% / 24% / 7% / 35% / 9% / 18% / 70% / 31% / 29%
Meclozine / 44% / 36% / 50% / 29% / 41% / 43% / 32% / 42% / 33% / 62% / 55% / 47% / 39%
Sulconazole / 36% / 31% / 42% / 26% / 41% / 38% / 32% / 36% / 27% / 47% / 48% / 44% / 35%
Flupentixol / 45% / 36% / 39% / 37% / 62% / 47% / 16% / 46% / 31% / 54% / 77% / 52% / 45%
Miconazole / 37% / 33% / 46% / 27% / 39% / 39% / 34% / 36% / 28% / 50% / 50% / 47% / 36%
Alfuzosin / 113% / 223% / 93% / 133% / 95% / 87% / 79% / 89% / 118% / 84% / 209% / 159% / 136%
Dihydroergotamine / 52% / 43% / 43% / 49% / 42% / 49% / 46% / 44% / 40% / 45% / 64% / 50% / 37%
Ranitidine / 37% / 22% / 27% / 30% / 58% / 38% / 13% / 42% / 25% / 39% / 87% / 41% / 40%
Diphenhydramine / 53% / 43% / 37% / 49% / 33% / 44% / 36% / 35% / 33% / 37% / 72% / 40% / 32%
3_P / 3_J / 3_H / 3_W / 3_X / 3_L / 3_E / 3_D / 3_S / 3_C / 3_Q / 3_U / 3_I
Diclofenac / 104% / 78% / 84% / 86% / 70% / 58% / 89% / 63% / 77% / 52% / 65% / 88% / 58%
Codeine / 78% / 76% / 60% / 73% / 51% / 65% / 59% / 38% / 49% / 47% / 109% / 47% / 39%
Tramadol / 116% / 63% / 97% / 78% / 122% / 89% / 53% / 99% / 113% / 117% / 90% / 113% / 121%
Atenolol / 107% / 105% / 92% / 101% / 79% / 94% / 89% / 60% / 76% / 67% / 123% / 62% / 64%
Metoprolol / 137% / 131% / 122% / 125% / 104% / 122% / 117% / 81% / 95% / 87% / 145% / 80% / 84%
Bisoprolol / 130% / 123% / 123% / 122% / 105% / 122% / 120% / 75% / 93% / 92% / 147% / 86% / 80%
Furosemide / 94% / 95% / 90% / 79% / 88% / 92% / 82% / 91% / 107% / 115% / 127% / 113% / 97%
Cilazapril / 112% / 108% / 107% / 100% / 96% / 108% / 100% / 85% / 92% / 91% / 120% / 91% / 87%
Irbesartan / 125% / 87% / 91% / 93% / 86% / 65% / 86% / 74% / 91% / 66% / 73% / 108% / 70%
Felodipine / 108% / 84% / 85% / 88% / 84% / 59% / 95% / 72% / 85% / 59% / 74% / 99% / 66%
Sotalol / 110% / 106% / 98% / 104% / 91% / 103% / 99% / 72% / 84% / 84% / 135% / 79% / 73%
Valsartan / 92% / 69% / 73% / 79% / 61% / 53% / 75% / 54% / 75% / 50% / 65% / 86% / 54%
Verapamil / 51% / 29% / 27% / 35% / 11% / 13% / 13% / 10% / 14% / 10% / 20% / 13% / 9%
Diltiazem / 113% / 73% / 80% / 86% / 54% / 52% / 74% / 46% / 58% / 39% / 66% / 59% / 41%
Clarithromycin / 126% / 83% / 94% / 91% / 57% / 58% / 79% / 52% / 64% / 50% / 81% / 69% / 45%
Trimethoprim / 94% / 90% / 80% / 84% / 75% / 83% / 81% / 53% / 63% / 63% / 133% / 69% / 51%
Sulfamethoxazole / 146% / 133% / 137% / 135% / 142% / 144% / 138% / 117% / 135% / 142% / 160% / 137% / 132%
Clindamycine / 100% / 68% / 73% / 80% / 48% / 51% / 71% / 40% / 54% / 42% / 76% / 70% / 33%
Roxithromycin / 116% / 84% / 83% / 84% / 50% / 55% / 76% / 49% / 54% / 40% / 71% / 63% / 36%
Sulfadiazine / 145% / 134% / 141% / 133% / 139% / 145% / 137% / 125% / 139% / 147% / 164% / 133% / 132%
Sulfathiazole / 134% / 123% / 126% / 123% / 134% / 137% / 137% / 114% / 128% / 138% / 167% / 128% / 119%
Sulfapyridine / 129% / 115% / 122% / 116% / 121% / 124% / 120% / 103% / 115% / 122% / 149% / 118% / 112%
Sulfamerazine / 120% / 110% / 113% / 108% / 115% / 113% / 112% / 94% / 111% / 117% / 134% / 118% / 106%
Sulfamoxol / 128% / 106% / 104% / 111% / 124% / 124% / 124% / 87% / 91% / 94% / 148% / 84% / 97%
Sulfamethazine / 129% / 121% / 120% / 117% / 128% / 128% / 124% / 100% / 118% / 122% / 145% / 122% / 115%
Sulfamethizole / 127% / 120% / 128% / 122% / 134% / 137% / 136% / 97% / 117% / 115% / 144% / 122% / 108%
Sulfamethoxypyridazine / 137% / 128% / 128% / 127% / 134% / 136% / 131% / 104% / 124% / 127% / 151% / 134% / 120%
Sulfadimethoxine / 144% / 133% / 136% / 132% / 143% / 143% / 140% / 110% / 132% / 134% / 155% / 133% / 128%
Sulfaquinoxaline / 141% / 128% / 133% / 126% / 139% / 144% / 135% / 110% / 131% / 132% / 160% / 130% / 127%
Sulfaphenazole / 122% / 114% / 115% / 113% / 120% / 123% / 117% / 103% / 120% / 125% / 145% / 130% / 112%
Sulfasalazine / 69% / 54% / 34% / 44% / 28% / 62% / 73% / 21% / 40% / 31% / 53% / 4% / 31%
Oseltamivir / 96% / 64% / 57% / 88% / 65% / 69% / 77% / 102% / 88% / 49% / 54% / 55% / 64%
Carbamazepine / 148% / 105% / 120% / 116% / 99% / 81% / 120% / 94% / 115% / 85% / 91% / 130% / 90%
Oxazepam / 130% / 95% / 102% / 101% / 61% / 65% / 101% / 58% / 78% / 48% / 77% / 70% / 56%
Memantine / 105% / 113% / 99% / 103% / 104% / 116% / 114% / 76% / 98% / 90% / 140% / 77% / 83%
Clonazepam / 123% / 117% / 122% / 116% / 120% / 126% / 123% / 97% / 111% / 114% / 136% / 115% / 104%
Naloxone / 105% / 103% / 83% / 107% / 79% / 97% / 86% / 38% / 62% / 60% / 132% / 70% / 52%
Sertaline / 149% / 139% / 140% / 135% / 130% / 149% / 149% / 104% / 124% / 122% / 175% / 116% / 109%
Ropinirole / 99% / 109% / 104% / 100% / 80% / 89% / 71% / 46% / 115% / 74% / 100% / 111% / 91%
Bupropion / 128% / 125% / 113% / 122% / 116% / 129% / 126% / 60% / 113% / 116% / 158% / 104% / 95%
Venlafaxine / 105% / 98% / 83% / 100% / 56% / 72% / 62% / 43% / 53% / 52% / 135% / 51% / 39%
Citalopram / 38% / 36% / 23% / 32% / 16% / 19% / 12% / 13% / 16% / 15% / 36% / 13% / 11%
Paroxetine / 98% / 93% / 76% / 86% / 67% / 78% / 74% / 39% / 67% / 66% / 137% / 67% / 52%
Haloperidol / 102% / 96% / 77% / 92% / 62% / 71% / 60% / 35% / 63% / 60% / 141% / 66% / 43%
Amitriptyline / 128% / 113% / 144% / 90% / 174% / 102% / 146% / 82% / 138% / 171% / 93% / 173% / 131%
Mianserin / 115% / 78% / 81% / 89% / 62% / 56% / 83% / 53% / 69% / 49% / 82% / 79% / 45%
Rosuvastatin / 113% / 103% / 116% / 111% / 107% / 123% / 104% / 89% / 108% / 95% / 131% / 88% / 88%
Bezafibrate / 134% / 129% / 114% / 125% / 135% / 137% / 126% / 72% / 123% / 116% / 138% / 124% / 114%
Fenofibrate / 161% / 148% / 133% / 139% / 153% / 148% / 152% / 90% / 157% / 162% / 187% / 172% / 148%
Atorvastatin / 54% / 56% / 74% / 57% / 84% / 82% / 78% / 64% / 64% / 76% / 132% / 109% / 64%
Glibenclamide / 131% / 123% / 127% / 121% / 131% / 135% / 131% / 105% / 130% / 132% / 155% / 144% / 115%
Glimepiride / 134% / 131% / 131% / 128% / 132% / 136% / 133% / 113% / 134% / 140% / 160% / 142% / 125%
Fexofenadine / 107% / 84% / 96% / 87% / 58% / 60% / 78% / 66% / 70% / 50% / 73% / 72% / 50%
Clemastine / 103% / 74% / 68% / 86% / 55% / 50% / 70% / 35% / 56% / 37% / 72% / 56% / 39%
Atracurium / 43% / 41% / 25% / 38% / 16% / 20% / 13% / 7% / 12% / 11% / 29% / 12% / 10%
Dicycloverine / 130% / 114% / 136% / 97% / 183% / 104% / 150% / 66% / 123% / 151% / 83% / 168% / 127%
Flecainide / 118% / 111% / 101% / 108% / 94% / 112% / 104% / 54% / 87% / 88% / 126% / 84% / 80%
Flutamide / 236% / 225% / 211% / 218% / 225% / 225% / 216% / 123% / 205% / 206% / 226% / 206% / 212%
Finasteride / 104% / 97% / 90% / 93% / 90% / 100% / 95% / 47% / 98% / 90% / 112% / 106% / 80%
Loperamide / 111% / 83% / 80% / 103% / 68% / 64% / 90% / 44% / 73% / 52% / 71% / 78% / 57%
Fluconazole / 118% / 123% / 131% / 113% / 110% / 95% / 120% / 97% / 99% / 91% / 97% / 130% / 106%
Terbinafine / 120% / 85% / 95% / 94% / 72% / 64% / 94% / 64% / 74% / 58% / 79% / 85% / 56%
Terbutaline / 127% / 121% / 106% / 118% / 111% / 130% / 116% / 62% / 127% / 130% / 154% / 130% / 101%
Donepezil / 38% / 31% / 21% / 30% / 7% / 12% / 9% / 5% / 13% / 11% / 40% / 12% / 7%
Buprenorphine / 83% / 72% / 65% / 73% / 41% / 56% / 52% / 23% / 23% / 27% / 94% / 33% / 20%
Repaglinide / 133% / 112% / 101% / 114% / 133% / 119% / 88% / 66% / 94% / 114% / 153% / 132% / 92%
Budenoside / 129% / 142% / 128% / 138% / 142% / 158% / 147% / 72% / 99% / 97% / 145% / 104% / 116%
Hydroxyzine / 70% / 55% / 35% / 55% / 35% / 36% / 14% / 17% / 26% / 27% / 118% / 42% / 18%
Mirtazapine / 21% / 6% / 6% / 9% / 60% / 11% / 1% / 30% / 16% / 33% / 50% / 82% / 17%
Dipyridamole / 18% / 2% / 2% / 6% / 5% / 2% / 2% / 1% / 0% / 1% / 51% / 12% / 0%
Orphenadrine / 79% / 56% / 52% / 72% / 34% / 34% / 48% / 21% / 36% / 24% / 51% / 34% / 26%
Promethazine / 94% / 47% / 39% / 68% / 52% / 41% / 66% / 24% / 33% / 24% / 79% / 36% / 24%
Disopyramide / 70% / 60% / 46% / 65% / 38% / 34% / 15% / 20% / 29% / 29% / 63% / 32% / 27%
Chlorprothixene / 104% / 74% / 70% / 87% / 58% / 54% / 79% / 37% / 68% / 46% / 77% / 67% / 43%
Cyproheptadine / 118% / 86% / 80% / 106% / 65% / 60% / 85% / 41% / 67% / 44% / 74% / 65% / 48%
Clomipramine / 108% / 82% / 78% / 94% / 60% / 57% / 81% / 38% / 67% / 43% / 72% / 63% / 46%
Desloratadine / 15% / 6% / 3% / 6% / 31% / 6% / 1% / 9% / 6% / 11% / 52% / 39% / 6%
Levomepromazine / 111% / 58% / 52% / 87% / 69% / 54% / 58% / 22% / 20% / 15% / 92% / 59% / 18%
Telmisartan / 94% / 40% / 43% / 55% / 155% / 48% / 7% / 81% / 47% / 91% / 158% / 174% / 45%
Flumequine / 20% / 16% / 8% / 10% / 3% / 12% / 16% / 2% / 4% / 3% / 12% / 3% / 4%
Fluphenazine / 89% / 53% / 30% / 66% / 101% / 67% / 22% / 40% / 43% / 58% / 149% / 87% / 40%
Erythromycin / 41% / 15% / 18% / 23% / 48% / 18% / 6% / 39% / 34% / 38% / 62% / 75% / 21%
Perphenazine / 50% / 14% / 14% / 26% / 42% / 13% / 3% / 10% / 7% / 9% / 59% / 37% / 6%
Meclozine / 53% / 30% / 21% / 38% / 12% / 11% / 5% / 6% / 7% / 6% / 44% / 16% / 4%
Sulconazole / 77% / 58% / 59% / 60% / 59% / 43% / 67% / 47% / 50% / 42% / 64% / 83% / 39%
Flupentixol / 91% / 50% / 49% / 70% / 65% / 41% / 27% / 37% / 36% / 32% / 62% / 63% / 37%
Miconazole / 78% / 62% / 66% / 66% / 60% / 45% / 71% / 49% / 51% / 42% / 67% / 87% / 39%
Alfuzosin / 32% / 23% / 18% / 26% / 0% / 3% / 1% / 1% / 6% / 4% / 22% / 3% / 2%
Dihydroergotamine / 92% / 86% / 75% / 85% / 79% / 82% / 79% / 40% / 62% / 65% / 122% / 89% / 55%
Ranitidine / 19% / 8% / 6% / 14% / 10% / 6% / 1% / 4% / 8% / 10% / 53% / 14% / 5%
Diphenhydramine / 44% / 39% / 24% / 35% / 15% / 19% / 11% / 8% / 12% / 13% / 65% / 16% / 9%
Table SI 4Minimum, maximum and median recovery of 63 compounds from 13 soil types at three concentration levels:
Amount of soil samples – it is shown amount of samples with extraction efficiency from 55% to 135%.
Compounds / Recovery (%) / Recovery (%) / Recovery (%) / Amount of soil samples10 ng/g / 100 ng/g / 1000 ng/g
min / max / median / min / max / median / min / max / median / 10 ng/g / 100 ng/g / 1000 ng/g
Analgesics/anti-inflammatories
Diclofenac / 44% / 72% / 59% / 51% / 79% / 61% / 72% / 110% / 90% / 10 / 10 / 13
Codeine / 68% / 103% / 88% / 78% / 109% / 88% / 72% / 126% / 100% / 13 / 13 / 13
Tramadol / 92% / 137% / 114% / 91% / 138% / 108% / 60% / 122% / 99% / 12 / 12 / 13
Anti-hypertensive (cardiovascular) drug
Atenolol / 87% / 130% / 118% / 85% / 129% / 113% / 60% / 123% / 89% / 13 / 13 / 13
Metoprolol / 95% / 130% / 108% / 96% / 135% / 105% / 73% / 136% / 88% / 13 / 13 / 13
Bisoprolol / 88% / 123% / 99% / 89% / 128% / 104% / 81% / 130% / 101% / 13 / 13 / 13
Furosemide / 19% / 57% / 30% / 50% / 88% / 71% / 79% / 127% / 94% / 1 / 12 / 13
Cilazapril / 41% / 68% / 54% / 49% / 73% / 60% / 85% / 120% / 100% / 7 / 11 / 13
Irbesartan / 39% / 66% / 46% / 39% / 63% / 50% / 65% / 125% / 86% / 3 / 3 / 13
Felodipine / 39% / 67% / 49% / 45% / 65% / 51% / 72% / 118% / 97% / 4 / 4 / 13
Sotalol / 60% / 104% / 86% / 55% / 101% / 74% / 72% / 135% / 98% / 13 / 13 / 13
Valsartan / 46% / 77% / 54% / 53% / 87% / 66% / 73% / 122% / 90% / 6 / 12 / 13
Verapamil / 38% / 68% / 55% / 46% / 68% / 55% / 50% / 82% / 64% / 8 / 9 / 9
Diltiazem / 40% / 67% / 55% / 42% / 65% / 52% / 46% / 76% / 62% / 8 / 4 / 9
Antibiotics (ATB)
Clarithromycin / 87% / 131% / 104% / 100% / 150% / 120% / 66% / 104% / 77% / 13 / 10 / 13
Trimethoprim / 91% / 144% / 113% / 95% / 136% / 108% / 51% / 133% / 80% / 11 / 13 / 12
Sulfamethoxazole / 93% / 144% / 114% / 89% / 123% / 103% / 100% / 122% / 110% / 12 / 13 / 13
Clindamycine / 76% / 105% / 82% / 78% / 128% / 96% / 55% / 99% / 70% / 13 / 13 / 13
Roxithromycine / 40% / 71% / 54% / 40% / 77% / 52% / 60% / 97% / 69% / 5 / 5 / 13
Sulfadiazine / 67% / 85% / 76% / 69% / 100% / 78% / 96% / 123% / 103% / 13 / 13 / 13
Sulfathiazole / 65% / 81% / 75% / 67% / 103% / 80% / 96% / 122% / 106% / 13 / 13 / 13
Sulfapyridine / 51% / 68% / 58% / 51% / 82% / 63% / 96% / 124% / 105% / 12 / 11 / 13
Sulfamerazine / 51% / 64% / 60% / 59% / 94% / 72% / 94% / 134% / 113% / 10 / 13 / 13
Sulfomoxol / 42% / 51% / 47% / 40% / 67% / 48% / 84% / 148% / 106% / 0 / 5 / 12
Sulfamethazine / 51% / 68% / 58% / 51% / 80% / 61% / 103% / 128% / 116% / 9 / 9 / 13
Sulfamethizole / 48% / 66% / 57% / 52% / 76% / 60% / 95% / 120% / 108% / 10 / 10 / 13
Sulfamethoxypyridazine / 53% / 76% / 65% / 62% / 95% / 77% / 99% / 123% / 112% / 12 / 13 / 13
Sulfadimethoxine / 65% / 84% / 76% / 70% / 106% / 84% / 97% / 121% / 109% / 13 / 13 / 13
Sulfaquinoxaline / 56% / 82% / 67% / 62% / 95% / 74% / 100% / 124% / 112% / 13 / 13 / 13
Sulfaphenazole / 50% / 69% / 55% / 48% / 75% / 59% / 100% / 122% / 110% / 9 / 8 / 13
Sulfasalazine / 69% / 148% / 114% / 66% / 128% / 96% / 57% / 120% / 82% / 12 / 10 / 13
Oseltamivir / 55% / 116% / 105% / 60% / 133% / 102% / 75% / 133% / 105% / 13 / 13 / 13
Antidepressants/psychiatric drugs
Carbamazepine / 88% / 127% / 101% / 88% / 127% / 102% / 78% / 113% / 89% / 13 / 13 / 13
Oxazepam / 43% / 62% / 52% / 43% / 68% / 55% / 65% / 102% / 80% / 4 / 7 / 13
Memantine / 48% / 83% / 60% / 47% / 73% / 58% / 72% / 113% / 90% / 12 / 9 / 13
Clonazepam / 43% / 66% / 54% / 50% / 71% / 57% / 82% / 124% / 97% / 6 / 8 / 13
Naloxone / 63% / 129% / 99% / 59% / 113% / 80% / 79% / 160% / 113% / 13 / 13 / 12
Sertaline / 37% / 54% / 45% / 37% / 62% / 48% / 60% / 90% / 72% / 0 / 3 / 13
Ropinirole / 57% / 79% / 67% / 62% / 92% / 75% / 71% / 144% / 91% / 13 / 13 / 13
Bupropion / 96% / 143% / 115% / 89% / 131% / 103% / 60% / 158% / 116% / 11 / 13 / 12
Venlafaxine / 73% / 128% / 95% / 78% / 117% / 96% / 50% / 82% / 66% / 13 / 13 / 12
Citalopram / 72% / 140% / 87% / 76% / 130% / 98% / 36% / 82% / 62% / 12 / 13 / 9
Paroxetine / 62% / 94% / 69% / 72% / 118% / 85% / 54% / 92% / 70% / 13 / 13 / 12
Haloperidol / 47% / 69% / 58% / 44% / 70% / 52% / 52% / 85% / 68% / 8 / 6 / 11
Amitriptyline / 86% / 121% / 99% / 86% / 139% / 99% / 49% / 75% / 66% / 13 / 11 / 12
Mianserin / 48% / 103% / 70% / 61% / 97% / 75% / 45% / 115% / 78% / 12 / 13 / 10
Lipid regulators
Rosuvastatin / 43% / 70% / 52% / 52% / 74% / 60% / 88% / 131% / 107% / 5 / 11 / 13
Bezafibrate / 41% / 66% / 57% / 47% / 72% / 60% / 68% / 106% / 85% / 9 / 8 / 13
Fenofibrate / 43% / 86% / 57% / 45% / 80% / 55% / 79% / 130% / 95% / 9 / 7 / 13
Atorvastatin / 7% / 57% / 19% / 9% / 68% / 37% / 54% / 132% / 74% / 1 / 2 / 12
Antidiabetics
Glibenclamide / 51% / 75% / 58% / 58% / 92% / 67% / 77% / 105% / 93% / 10 / 13 / 13
Glimepiride / 52% / 75% / 61% / 59% / 94% / 72% / 79% / 116% / 95% / 12 / 13 / 13
Antihistamine
Fexofenadine / 63% / 105% / 82% / 66% / 102% / 77% / 62% / 109% / 87% / 13 / 13 / 13
Clemastine / 71% / 103% / 85% / 77% / 128% / 93% / 44% / 92% / 67% / 13 / 13 / 13
Muscle relaxant
Atracurium / 51% / 82% / 60% / 52% / 76% / 65% / 64% / 111% / 94% / 12 / 12 / 13
Dicicloverine / 49% / 112% / 92% / 48% / 90% / 73% / 50% / 88% / 71% / 12 / 12 / 12
Antiarrhythmic agent
Flecainide / 42% / 64% / 57% / 42% / 65% / 55% / 60% / 126% / 101% / 8 / 7 / 13
Antiandrogen
Flutamide / 79% / 134% / 106% / 76% / 138% / 110% / 72% / 102% / 92% / 13 / 12 / 13
Urological
Finasteride / 47% / 74% / 57% / 48% / 77% / 64% / 85% / 130% / 110% / 9 / 10 / 13
Antipropulsive
Loperamide / 41% / 68% / 53% / 46% / 71% / 61% / 66% / 95% / 77% / 6 / 8 / 13
Antifungal
Fluconazole / 73% / 124% / 90% / 71% / 102% / 82% / 91% / 130% / 110% / 13 / 13 / 13
Terbinafine / 74% / 112% / 86% / 81% / 133% / 94% / 56% / 120% / 79% / 13 / 13 / 13
β2-adrenergic receptor agonist
Terbutaline / 83% / 118% / 98% / 68% / 113% / 80% / 62% / 154% / 121% / 13 / 13 / 12
Table SI 5 Matrix effects for 44target compounds: pharmaceuticals which had matrix effect more than 30% are marked bold;
Pharmaceuticals / P / J / H / W / X / L / E / D / S / C / Q / U / IAnalgesics/anti-inflammatories
Diclofenac / 1% / 12% / 16% / 14% / 13% / 10% / 15% / 19% / 17% / 15% / 20% / 22% / 5%
Codeine / -13% / -9% / -4% / 1% / 4% / 2% / -1% / 11% / -3% / 5% / 2% / 6% / -8%
Tramadol / -30% / -18% / -12% / -8% / -1% / -8% / -5% / 5% / -7% / 4% / 3% / 8% / -11%
Anti-hypertensive (cardiovascular) drug
Atenolol / -112% / -101% / -71% / -77% / -65% / -7% / -6% / -80% / -84% / -67% / -87% / -74% / -13%
Metoprolol / -22% / -10% / -2% / 4% / -5% / -7% / -10% / -6% / -9% / 2% / -6% / -4% / -14%
Bisoprolol / -3% / 10% / 18% / 24% / 16% / 11% / 12% / 15% / 11% / 20% / 13% / 17% / 7%
Sotalol / -18% / 3% / 7% / 14% / 11% / 47% / 39% / 10% / 6% / 10% / 9% / 14% / 40%
Valsartan / 4% / 25% / 23% / 27% / 18% / 20% / 18% / 25% / 19% / 15% / 19% / 26% / 8%
Antibiotics (ATB)
Clarithromycin / -2% / 11% / 14% / 20% / -1% / 3% / 4% / 17% / 8% / 10% / -4% / 14% / -9%
Trimethoprim / -10% / 3% / 4% / 7% / 0% / 1% / 6% / 4% / 5% / 8% / 6% / 8% / 1%
Sulfamethoxazole / -6% / 6% / 6% / 9% / 2% / 10% / -4% / 3% / 5% / 10% / 5% / 2% / 3%
Clindamycine / 4% / 16% / 18% / 21% / -2% / 8% / 5% / 10% / 6% / 9% / -8% / 10% / -9%
Sulfadiazine / 6% / 22% / 20% / 22% / 12% / 18% / 19% / 17% / 20% / 17% / 14% / 16% / 17%
Sulfathiazole / 2% / 21% / 18% / 20% / 11% / 14% / 16% / 15% / 16% / 14% / 12% / 16% / 16%
Sulfapyridine / 4% / 21% / 17% / 20% / 13% / 12% / 14% / 14% / 15% / 13% / 8% / 12% / 14%
Sulfamerazine / 3% / 17% / 14% / 15% / 1% / 6% / 5% / 9% / 11% / 5% / 5% / 8% / 6%
Sulfamethazine / 7% / 23% / 22% / 21% / 17% / 17% / 19% / 18% / 15% / 12% / 12% / 17% / 15%
Sulfamethizole / 1% / 20% / 16% / 20% / 15% / 15% / 15% / 17% / 16% / 14% / 14% / 17% / 13%
Sulfamethoxypyridazine / 9% / 24% / 20% / 22% / 12% / 17% / 14% / 16% / 16% / 13% / 10% / 14% / 13%
Sulfadimethoxine / -7% / 12% / 10% / 11% / 1% / 4% / 7% / 4% / 4% / 0% / 3% / 8% / 1%
Sulfaquinoxaline / 6% / 25% / 23% / 23% / 16% / 19% / 20% / 21% / 19% / 16% / 20% / 24% / 16%
Sulfaphenazole / 1% / 18% / 13% / 18% / 11% / 12% / 13% / 15% / 13% / 10% / 12% / 14% / 9%
Sulfasalazine / 4% / 17% / 17% / 20% / 15% / 16% / 6% / 18% / 16% / 22% / 11% / 13% / 18%
Oseltamivir / -28% / -17% / -11% / -7% / -8% / -6% / -2% / 6% / -10% / 0% / 3% / 5% / -5%
Antidepressants/psychiatric drugs
Carbamazepine / -29% / -10% / -11% / -4% / -11% / -15% / -12% / -6% / -8% / -7% / -8% / -4% / -18%
Memantine / -2% / 0% / 7% / 13% / 19% / 13% / 14% / 21% / 10% / 21% / 17% / 19% / 7%
Naloxone / -25% / -27% / -8% / -17% / 8% / 39% / 29% / 6% / -16% / 5% / 3% / 14% / 36%
Ropinirole / 9% / 16% / 29% / 29% / 22% / 18% / 15% / 19% / 16% / 26% / 21% / 25% / 16%
Bupropion / 27% / 22% / 31% / 30% / 35% / 34% / 33% / 39% / 28% / 39% / 39% / 40% / 30%
Venlafaxine / -13% / -9% / -1% / 5% / 10% / 4% / 6% / 17% / 4% / 14% / 13% / 18% / 1%
Citalopram / -22% / -16% / -15% / -4% / -26% / -17% / -21% / -10% / -17% / -11% / -35% / -16% / -51%
Paroxetine / 32% / 34% / 39% / 41% / 27% / 33% / 35% / 36% / 34% / 36% / 29% / 40% / 16%
Amitriptyline / -21% / -6% / -14% / 0% / -6% / -6% / -5% / -3% / -3% / -3% / -16% / -8% / -26%
Mianserin / 0% / 0% / 4% / 13% / -8% / 4% / 2% / 9% / 0% / 10% / -9% / 4% / -24%
Lipid regulators
Rosuvastatin / 8% / 30% / 24% / 32% / 15% / 17% / 21% / 19% / 22% / 20% / 13% / 19% / 12%
Bezafibrate / 15% / 23% / 26% / 25% / 22% / 20% / 22% / 25% / 26% / 24% / 25% / 28% / 17%
Antidiabetics
Glibenclamide / 20% / 36% / 36% / 37% / 33% / 28% / 34% / 35% / 39% / 31% / 34% / 37% / 26%
Glimepiride / 22% / 35% / 37% / 37% / 33% / 32% / 35% / 38% / 38% / 35% / 40% / 43% / 29%
Antihistamine
Fexofenadine / 24% / 42% / 37% / 43% / 33% / 30% / 31% / 32% / 31% / 30% / 17% / 22% / 25%
Clemastine / 27% / 31% / 40% / 40% / 25% / 32% / 31% / 35% / 33% / 35% / 28% / 38% / 14%
Muscle relaxant
Atracurium / -11% / -10% / -1% / 1% / 6% / -2% / -4% / 5% / -7% / 7% / 9% / 11% / -6%
Urological
Finasteride / 30% / 37% / 45% / 41% / 38% / 36% / 41% / 44% / 41% / 41% / 48% / 51% / 33%
Antifungal
Fluconazole / -3% / 8% / 9% / 15% / 8% / 9% / 0% / 9% / 10% / 15% / 4% / 3% / 4%
β2-adrenergic receptor agonist
Terbutaline / -84% / -76% / -56% / -64% / -41% / 3% / -4% / -53% / -58% / -42% / -46% / -33% / 2%
positive values correspond to ion suppression, negative - to ion enhancement
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