Article title: EFFECT OF ROSEMARY POLYPHENOLS ON HUMAN COLON CANCER CELLS: TRANSCRIPTOMIC PROFILING AND FUNCTIONAL ENRICHMENT ANALYSIS.

Journal name: Genes and Nutrition

Author names: Alberto Valdés, Virginia García-Cañas*, Lourdes Rocamora-Reverte, Ángeles Gómez-Martínez, José Antonio Ferragut, Alejandro Cifuentes

*Author for correspondence. Laboratory of Foodomics, CIAL (CSIC), Nicolas Cabrera 9, 28049 Madrid, Spain.

Supplementary Table S1. Primer sequences and LNA probes used in this work to perform RT-qPCR analyses.

Gene symbol (Accession N.) / Sequence (5’-3’) / LNA probe Number
HMOX1 (AY460337) / For: GTCAGGCAGAGGGTGATAGAAG / 42
Rev: CCTTGGTGTCATGGGTCAG
OSGIN1 (AY258066) / For: CTTCTACGCCCAGACACAGAC / 12
Rev: GGATCACCATGGAGCCTTC
DUSP1 (X68277) / For: GGACAACCACAAGGCAGAC / 17
Rev: CCTGGCAGTGGACAAACA
ARRDC3 (AB037797) / For: AGTGCTTGTGATGACTTTGAGAG / 39
Rev: ACGAGAGGGGCAGGATG
MUC1 (J05581) / For: CGATCGTAGCCCCTATGAGA / 66
Rev: TGCCACTGCTGGGTTTG
GAPDH (AF261085) / For: AGCCACATCGCTCAGACAC / 60
Rev: GCCCAATACGACCAAATCC
IPO8 (U77494) / For: CCAAGGGGTGGTTCATTCTA / 38
Rev: GCCACAGCTCTTCATCCTCA
PPIA (X52851) / For: TGCTGGACCCAACACAAAT / 48
Rev: CACATGCTTGCCATCCAA
B2M (AB021288) / For: CTATCCAGCGTACTCCAAAGATT / 42
Rev: TGGATGAAACCCAGACACATAG

Supplementary Table S2. Differentially expressed genes in colon cancer cell line SW480.

Gene symbol / FC1 / Adjusted p-value / Gene symbol / FC1 / Adjusted p-value / Gene symbol / FC1 / Adjusted p-value
ABCB1 / 3.5 / 0.0176592 / AREG / 6.0 / 0.0003591 / BRD2 / 2.2 / 0.0001913
ABCB7 / 0.6 / 0.0018713 / ARHGAP11A / 0.4 / 0.0028746 / BRF2 / 3.2 / 0.0003395
ABCC2 / 1.8 / 0.0198280 / ARHGEF10 / 0.6 / 0.0117810 / BRIP1 / 0.6 / 0.0238895
ABCC9 / 1.8 / 0.0035797 / ARHGEF17 / 0.6 / 0.0281941 / BRPF1 / 1.7 / 0.0072314
ABHD3 / 2.3 / 0.0057071 / ARHGEF3 / 1.8 / 0.0021539 / BTG2 / 5.4 / 0.0042176
ABHD4 / 3.1 / 0.0009546 / ARHGEF9 / 0.6 / 0.0377541 / BTK / 1.9 / 0.0317652
ABHD5 / 2.5 / 0.0001373 / ARID3B / 2.3 / 0.0193562 / BTN2A3 / 1.6 / 0.0310706
ABI2 / 0.6 / 0.0005176 / ARID5A / 1.9 / 0.0046399 / BUB1B / 0.6 / 0.0210150
ABI3 / 1.9 / 0.0036346 / ARID5B / 2.4 / 0.0074608 / BUD31 / 1.7 / 0.0236899
ABL2 / 4.3 / 0.0000505 / ARL4D / 5.7 / 0.0000801 / C10orf114 / 0.6 / 0.0268380
ABTB2 / 1.7 / 0.0336786 / ARMCX3 / 1.6 / 0.0107593 / C11orf41 / 0.5 / 0.0226402
ACRC / 3.7 / 0.0019311 / ARMCX6 / 2.0 / 0.0222217 / C11orf67 / 2.1 / 0.0039687
ACTA2 / 0.6 / 0.0236900 / ARPM1 / 2.1 / 0.0277691 / C11orf96 / 1.8 / 0.0193204
ADAM22 / 0.5 / 0.0084212 / ARRDC2 / 2.2 / 0.0028908 / C12orf41 / 1.7 / 0.0151693
ADCY6 / 0.6 / 0.0105454 / ARRDC3 / 7.7 / 0.0000013 / C12orf44 / 2.1 / 0.0002212
ADM / 13.5 / 0.0000038 / ARRDC4 / 5.3 / 0.0000022 / C12orf59 / 0.5 / 0.0008485
ADRB2 / 1.9 / 0.0229307 / ARSE / 0.5 / 0.0030656 / C13orf29 / 2.1 / 0.0036584
AEN / 1.7 / 0.0041971 / ASPM / 0.4 / 0.0003605 / C13orf31 / 2.6 / 0.0017595
AFAP1L2 / 0.6 / 0.0050395 / ATF3 / 3.2 / 0.0017987 / C14orf139 / 0.6 / 0.0112370
AGBL5 / 0.6 / 0.0263160 / ATG12 / 1.8 / 0.0006369 / C14orf50 / 1.9 / 0.0488073
AGL / 0.4 / 0.0000539 / ATG14 / 2.0 / 0.0010897 / C15orf57 / 1.8 / 0.0035797
AGPAT9 / 2.9 / 0.0012637 / ATG16L1 / 1.8 / 0.0064102 / C16orf72 / 1.6 / 0.0020331
AGRN / 0.5 / 0.0136387 / ATG4A / 2.3 / 0.0078996 / C16orf87 / 1.8 / 0.0084641
AHSA1 / 1.8 / 0.0028845 / ATL1 / 1.8 / 0.0009799 / C17orf73 / 0.5 / 0.0090082
AJAP1 / 0.4 / 0.0002194 / ATP10D / 2.4 / 0.0112652 / C19orf63 / 0.6 / 0.0049468
AKAP6 / 0.5 / 0.0007501 / ATP11C / 0.6 / 0.0291558 / C1orf103 / 1.9 / 0.0169194
AKR1B1 / 4.3 / 0.0003707 / ATP1B1 / 1.8 / 0.0146609 / C1orf201 / 2.9 / 0.0003697
AKR1B10 / 6.7 / 0.0003212 / ATP2B4 / 2.0 / 0.0046144 / C1orf52 / 1.9 / 0.0101234
AKR1C1 / 3.9 / 0.0027715 / ATP9A / 1.8 / 0.0184854 / C1orf9 / 1.8 / 0.0063525
AKR1C2 / 4.5 / 0.0015158 / ATPBD4 / 0.6 / 0.0134592 / C1S / 1.8 / 0.0231829
ALDH1A2 / 0.6 / 0.0033640 / ATRX / 0.5 / 0.0114219 / C20orf111 / 2.1 / 0.0031978
ALDH2 / 2.1 / 0.0002729 / AVPI1 / 7.7 / 0.0000071 / C21orf34 / 0.4 / 0.0010673
ALDH5A1 / 0.5 / 0.0020960 / AXIN2 / 0.6 / 0.0028417 / C2orf42 / 1.8 / 0.0044551
ALDH7A1 / 0.6 / 0.0050395 / AZIN1 / 1.6 / 0.0045618 / C2orf55 / 0.6 / 0.0089289
ALDOC / 2.5 / 0.0030560 / B3GNT1 / 0.6 / 0.0294298 / C3orf52 / 4.1 / 0.0000537
ALG10 / 0.6 / 0.0465056 / B3GNT5 / 3.2 / 0.0006088 / C3orf58 / 1.9 / 0.0060737
ALG1L / 0.5 / 0.0305701 / B4GALNT1 / 2.5 / 0.0004639 / C5orf13 / 0.5 / 0.0060768
ALKBH1 / 1.7 / 0.0110895 / BAG3 / 4.8 / 0.0000007 / C5orf32 / 2.0 / 0.0002130
ALOX5AP / 2.1 / 0.0166010 / BAIAP2L1 / 1.9 / 0.0194970 / C5orf41 / 2.0 / 0.0072772
ALOXE3 / 9.5 / 0.0000265 / BAK1 / 2.0 / 0.0030439 / C5orf42 / 0.6 / 0.0116727
ALS2 / 2.0 / 0.0215343 / BBS2 / 0.5 / 0.0035511 / C6orf145 / 2.1 / 0.0002130
ANGPTL4 / 2.3 / 0.0012367 / BCAM / 0.3 / 0.0004693 / C6orf204 / 1.7 / 0.0026842
ANKMY2 / 1.7 / 0.0025815 / BCKDHB / 0.6 / 0.0065826 / C7orf29 / 0.6 / 0.0050153
ANKRD20A2 / 1.7 / 0.0067210 / BCL10 / 2.0 / 0.0018547 / C7orf53 / 3.1 / 0.0014521
ANKRD20A8P / 1.7 / 0.0283040 / BCL11A / 0.5 / 0.0072511 / C7orf60 / 2.0 / 0.0035797
ANKRD37 / 2.6 / 0.0187651 / BCL2L11 / 3.0 / 0.0006394 / C7orf64 / 1.8 / 0.0077826
ANKRD42 / 2.2 / 0.0000285 / BCL3 / 2.0 / 0.0103109 / C8orf84 / 0.6 / 0.0270683
ANKRD57 / 1.8 / 0.0008313 / BCL6 / 4.7 / 0.0004693 / C9orf25 / 2.0 / 0.0064077
ANO4 / 0.2 / 0.0000095 / BEND6 / 2.0 / 0.0047091 / C9orf30 / 1.6 / 0.0012219
ANPEP / 1.7 / 0.0441125 / BEX4 / 1.9 / 0.0090765 / C9orf72 / 2.9 / 0.0265082
ANTXR1 / 0.5 / 0.0007245 / BHLHE40 / 4.4 / 0.0001706 / CA12 / 2.0 / 0.0045438
ANTXR2 / 1.6 / 0.0368430 / BHLHE41 / 3.9 / 0.0008797 / CA2 / 6.2 / 0.0024040
AOAH / 1.7 / 0.0427310 / BLOC1S1 / 0.5 / 0.0002194 / CAB39L / 2.3 / 0.0304297
AP4B1 / 2.9 / 0.0014036 / BLVRB / 2.0 / 0.0020769 / CACNB1 / 2.3 / 0.0001415
APCDD1 / 0.5 / 0.0243137 / BPGM / 2.1 / 0.0005791 / CAD / 0.6 / 0.0193245
ARC / 13.3 / 0.0001781 / BRAP / 1.7 / 0.0034926 / CALB1 / 5.6 / 0.0015515
CALCRL / 0.4 / 0.0117466 / CKS2 / 1.8 / 0.0356519 / DEPDC1B / 0.6 / 0.0363222
CALD1 / 0.6 / 0.0407619 / CLCF1 / 1.9 / 0.0054467 / DFNB31 / 1.7 / 0.0038570
CALHM3 / 0.4 / 0.0017217 / CLIC5 / 0.5 / 0.0049046 / DHTKD1 / 0.6 / 0.0034925
CAMK1D / 0.6 / 0.0143074 / CLIP2 / 1.9 / 0.0196809 / DKFZp451A211 / 2.9 / 0.0073647
CAMTA1 / 1.8 / 0.0194799 / CLIP4 / 2.0 / 0.0006225 / DLG1 / 0.6 / 0.0062667
CAP2 / 0.6 / 0.0026720 / CLK1 / 3.7 / 0.0090426 / DLGAP5 / 0.6 / 0.0130200
CASC5 / 0.6 / 0.0021493 / CLSTN2 / 0.5 / 0.0016489 / DLL1 / 3.3 / 0.0160707
CASD1 / 0.5 / 0.0018660 / CLU / 2.1 / 0.0027715 / DLX2 / 2.5 / 0.0212459
CASP3 / 1.9 / 0.0021113 / CMTM4 / 0.5 / 0.0039022 / DLX3 / 6.0 / 0.0029122
CASP4 / 1.8 / 0.0020084 / CNKSR3 / 2.7 / 0.0001781 / DLX5 / 1.8 / 0.0137402
CASP7 / 2.5 / 0.0007248 / CNN1 / 2.2 / 0.0053414 / DNAH17 / 2.0 / 0.0014910
CASP9 / 1.7 / 0.0026412 / CNN3 / 1.7 / 0.0084641 / DNAJA4 / 5.3 / 0.0003763
CBLB / 1.8 / 0.0380440 / CNNM4 / 2.5 / 0.0000652 / DNAJB1 / 6.2 / 0.0000002
CBX4 / 2.5 / 0.0080096 / CNPY1 / 0.4 / 0.0038095 / DNAJB2 / 2.0 / 0.0011569
CBX5 / 0.6 / 0.0116179 / CNTNAP3 / 0.6 / 0.0084334 / DNAJB4 / 4.7 / 0.0002356
CC2D2A / 0.5 / 0.0160878 / COL1A2 / 0.4 / 0.0007322 / DNAJB5 / 3.3 / 0.0090542
CCDC109B / 0.5 / 0.0185546 / COL6A3 / 0.3 / 0.0005615 / DNAJB9 / 3.6 / 0.0001727
CCDC126 / 2.4 / 0.0021567 / COQ10B / 2.1 / 0.0011695 / DNAJC24 / 1.8 / 0.0103109
CCDC9 / 2.0 / 0.0011931 / CP110 / 0.6 / 0.0281941 / DNAJC27 / 2.3 / 0.0021801
CCL2 / 1.7 / 0.0047877 / CPA4 / 2.4 / 0.0237273 / DNTTIP2 / 1.6 / 0.0020510
CCL26 / 8.4 / 0.0005104 / CPEB2 / 3.9 / 0.0003161 / DOPEY2 / 2.5 / 0.0008210
CCNA1 / 1.8 / 0.0178316 / CPEB3 / 1.7 / 0.0223592 / DPYD / 0.5 / 0.0009649
CCNB2 / 0.6 / 0.0297660 / CPEB4 / 2.3 / 0.0010970 / DPYSL2 / 0.5 / 0.0193204
CCNE1 / 2.2 / 0.0006537 / CPT1A / 1.7 / 0.0307958 / DSC2 / 2.5 / 0.0002824
CCNF / 0.6 / 0.0394169 / CREB5 / 1.9 / 0.0101234 / DSP / 0.6 / 0.0026566
CCNL1 / 2.6 / 0.0003040 / CREM / 2.1 / 0.0004079 / DUSP1 / 11.4 / 0.0000004
CCR7 / 3.4 / 0.0038095 / CRISPLD2 / 1.9 / 0.0053150 / DUSP10 / 11.6 / 0.0003022
CCRN4L / 3.9 / 0.0000537 / CRYAB / 46.6 / 0.0000001 / DUSP16 / 2.5 / 0.0078480
CD109 / 0.5 / 0.0321486 / CRYM / 1.9 / 0.0006491 / DUSP4 / 1.7 / 0.0085851
CD22 / 2.5 / 0.0275340 / CSRNP1 / 5.5 / 0.0017987 / DUSP5 / 6.4 / 0.0000652
CD24 / 1.9 / 0.0255238 / CST7 / 2.9 / 0.0002407 / DUSP8 / 3.3 / 0.0117466
CD302 / 0.4 / 0.0053326 / CSTB / 1.7 / 0.0026575 / DYNLL2 / 1.7 / 0.0215280
CD47 / 0.5 / 0.0091955 / CTH / 2.8 / 0.0002130 / DYRK3 / 1.8 / 0.0038654
CD55 / 2.9 / 0.0000295 / CTR9 / 1.6 / 0.0117516 / E2F6 / 1.8 / 0.0003092
CD68 / 8.2 / 0.0000071 / CTSL1 / 3.8 / 0.0001516 / EAF2 / 1.8 / 0.0129931
CD83 / 1.7 / 0.0496311 / CTSL2 / 2.5 / 0.0037704 / EBF2 / 0.6 / 0.0068596
CDA / 2.0 / 0.0035987 / CWC25 / 1.9 / 0.0013846 / ECM1 / 2.4 / 0.0006828
CDC37L1 / 2.3 / 0.0069308 / CX3CL1 / 2.7 / 0.0101362 / ECT2 / 0.6 / 0.0020423
CDC42EP2 / 2.1 / 0.0111748 / CXCL16 / 1.7 / 0.0451088 / EDAR / 0.4 / 0.0187651
CDC42EP4 / 1.7 / 0.0264895 / CXCL2 / 1.7 / 0.0065176 / EDN1 / 2.5 / 0.0070428
CDC7 / 0.5 / 0.0145253 / CYB5R1 / 1.9 / 0.0010326 / EEPD1 / 1.8 / 0.0040771
CDKN1A / 4.9 / 0.0003824 / CYLD / 3.1 / 0.0001235 / EFNB2 / 1.7 / 0.0168179
CDKN2AIP / 2.4 / 0.0002787 / CYP4F11 / 4.9 / 0.0012219 / EGF / 1.7 / 0.0071885
CDR2 / 1.7 / 0.0008847 / CYP4F3 / 7.5 / 0.0001201 / EGLN3 / 2.1 / 0.0009276
CEACAM1 / 2.6 / 0.0098044 / CYR61 / 7.0 / 0.0001085 / EGR1 / 2.6 / 0.0007653
CEBPB / 4.3 / 0.0000339 / DAAM1 / 2.0 / 0.0113257 / EGR2 / 7.1 / 0.0041809
CEBPG / 1.6 / 0.0357081 / DACH1 / 0.4 / 0.0043285 / EGR3 / 5.0 / 0.0030436
CELSR2 / 0.6 / 0.0008847 / DAGLB / 1.8 / 0.0031623 / EID3 / 1.7 / 0.0262893
CENPE / 0.4 / 0.0072938 / DAPK3 / 1.7 / 0.0299259 / EIF1AD / 1.7 / 0.0005615
CENPF / 0.4 / 0.0002102 / DCLRE1B / 1.7 / 0.0291735 / EIF2AK3 / 1.8 / 0.0015596
CEP78 / 0.5 / 0.0008747 / DCUN1D3 / 2.0 / 0.0006419 / EIF4A2 / 1.7 / 0.0447098
CGB5 / 0.5 / 0.0237013 / DDAH1 / 0.6 / 0.0026272 / EIF4E / 2.3 / 0.0001373
CGREF1 / 0.6 / 0.0116829 / DDHD2 / 0.6 / 0.0071709 / EIF4G3 / 0.6 / 0.0026272
CHAC1 / 2.6 / 0.0182323 / DDIT3 / 11.3 / 0.0000037 / EIF5 / 1.6 / 0.0389478
CHML / 0.5 / 0.0002482 / DDIT4 / 12.0 / 0.0011053 / EIF5A2 / 2.1 / 0.0018768
CHRFAM7A / 1.6 / 0.0237273 / DDR2 / 2.1 / 0.0013338 / ELFN1 / 1.7 / 0.0378204
CIDECP / 1.6 / 0.0168801 / DDX60 / 2.1 / 0.0236900 / ELL / 2.0 / 0.0009546
CIT / 0.6 / 0.0069308 / DEDD2 / 4.2 / 0.0001779 / ELL2 / 4.6 / 0.0002419
CITED2 / 3.8 / 0.0000743 / DENND2C / 5.1 / 0.0004579 / ELMO1 / 0.4 / 0.0004443
CKAP2L / 0.6 / 0.0050134 / DEPDC1 / 0.5 / 0.0168756 / ELOVL7 / 2.4 / 0.0117541
ENO2 / 2.0 / 0.0089770 / FLNC / 3.9 / 0.0002164 / GPX7 / 0.6 / 0.0043213
ENPP2 / 4.3 / 0.0006603 / FLOT2 / 0.6 / 0.0085445 / GREB1L / 0.5 / 0.0090082
ENTPD7 / 2.5 / 0.0030656 / FLT1 / 2.1 / 0.0116829 / GRHL1 / 3.2 / 0.0001373
EPAS1 / 7.0 / 0.0000004 / FLVCR2 / 1.8 / 0.0221786 / GRPR / 0.6 / 0.0058676
EPB41L4A / 0.5 / 0.0287620 / FNIP2 / 3.0 / 0.0012219 / GTF2B / 2.0 / 0.0006335
EPC1 / 2.0 / 0.0006828 / FOLR1 / 0.6 / 0.0095918 / GTF2IRD2B / 2.2 / 0.0489178
EPHB3 / 2.8 / 0.0011338 / FOS / 20.8 / 0.0000740 / GTSE1 / 0.5 / 0.0092723
ERAP1 / 1.7 / 0.0117895 / FOSB / 24.7 / 0.0000316 / GXYLT2 / 0.5 / 0.0186786
ERBB3 / 0.4 / 0.0133836 / FOSL1 / 2.5 / 0.0007883 / GYG2 / 0.5 / 0.0017987
EREG / 2.6 / 0.0006646 / FOSL2 / 1.6 / 0.0425920 / GZMA / 0.5 / 0.0126130
ERGIC1 / 0.5 / 0.0016858 / FOXN3 / 0.6 / 0.0019020 / H6PD / 0.6 / 0.0090082
ERRFI1 / 4.0 / 0.0000316 / FRG2 / 3.4 / 0.0346337 / HAAO / 0.6 / 0.0330276
ESPL1 / 0.6 / 0.0098072 / FRMD6 / 2.2 / 0.0013780 / HBEGF / 10.2 / 0.0000086
ETNK2 / 2.6 / 0.0001858 / FRS2 / 2.4 / 0.0003059 / HBP1 / 2.3 / 0.0002305
ETS1 / 3.4 / 0.0003697 / FSD1L / 1.9 / 0.0292981 / HCN1 / 0.5 / 0.0079281
ETS2 / 2.1 / 0.0036275 / FSTL5 / 0.5 / 0.0063873 / HDAC5 / 1.8 / 0.0066661
ETV3 / 1.7 / 0.0016897 / FTH1 / 1.7 / 0.0041899 / HELLS / 0.5 / 0.0435506
EXOC6 / 0.6 / 0.0195139 / FXYD2 / 1.7 / 0.0026855 / HERPUD1 / 1.7 / 0.0097079
EXPH5 / 0.6 / 0.0292028 / FZD1 / 0.6 / 0.0075762 / HES1 / 3.1 / 0.0011437
F13A1 / 0.3 / 0.0009546 / FZD7 / 1.7 / 0.0130359 / HEY1 / 3.5 / 0.0069668
F2RL2 / 9.8 / 0.0018746 / GADD45A / 6.3 / 0.0000029 / HEY2 / 0.5 / 0.0117810
F3 / 3.5 / 0.0006040 / GADD45B / 6.6 / 0.0000514 / HHIP / 0.4 / 0.0092608
FAM101B / 1.8 / 0.0198153 / GADD45G / 2.0 / 0.0496269 / HIATL1 / 2.1 / 0.0221786
FAM102A / 4.0 / 0.0001706 / GATA2 / 2.6 / 0.0023684 / HIST1H1B / 0.4 / 0.0098044
FAM105A / 0.4 / 0.0057038 / GATA3 / 1.9 / 0.0041150 / HIST1H1D / 0.5 / 0.0230121
FAM108B1 / 1.8 / 0.0014199 / GATS / 0.6 / 0.0338068 / HIST1H2AK / 0.4 / 0.0356457
FAM120C / 0.6 / 0.0185263 / GATSL1 / 0.5 / 0.0029903 / HIST1H4H / 2.4 / 0.0006828
FAM122B / 0.5 / 0.0083215 / GBP1 / 1.6 / 0.0498821 / HIST2H2BF / 3.6 / 0.0015162
FAM129A / 6.0 / 0.0004556 / GBP3 / 2.0 / 0.0047091 / HIVEP2 / 2.3 / 0.0171739
FAM133B / 1.7 / 0.0135928 / GBX2 / 2.2 / 0.0092435 / HK2 / 1.7 / 0.0090082
FAM160A1 / 2.1 / 0.0101115 / GCC1 / 1.8 / 0.0085861 / HKDC1 / 4.5 / 0.0003040
FAM167A / 0.6 / 0.0086979 / GCLM / 2.5 / 0.0050890 / HLTF / 0.6 / 0.0003040
FAM169A / 0.5 / 0.0193103 / GCM1 / 1.8 / 0.0014980 / HMCN1 / 0.5 / 0.0119154
FAM180A / 2.8 / 0.0117810 / GCNT3 / 3.1 / 0.0031978 / HMOX1 / 24.6 / 0.0000001
FAM25B / 1.7 / 0.0231442 / GCNT4 / 3.3 / 0.0085445 / HNMT / 0.4 / 0.0053838
FAM36A / 0.6 / 0.0013994 / GCOM1 / 1.7 / 0.0377541 / HPD / 3.6 / 0.0076692
FAM40B / 2.6 / 0.0001103 / GDA / 0.5 / 0.0013994 / HPGD / 0.5 / 0.0458262
FAM46A / 2.7 / 0.0369966 / GDF15 / 10.4 / 0.0000145 / HPS5 / 1.7 / 0.0044574
FAM46B / 2.2 / 0.0252629 / GDPD3 / 2.1 / 0.0227184 / HRH1 / 2.1 / 0.0012373