Current CTU studies Apr 14
STUDIES OPEN TO RECRUITMENT
TRIAL No. / STUDY DESCRIPTION / P.I. / CONTACT / SPONSOR/ PORTFOLIO / DATE OPENED /BMT
ON/2011/3861
PRoT4 (Prophylactic Transfer of CD4 Lymphocytes) / Multicentre randomised phase II study to evaluate the efficacy of prophylactic transfer of CD4 lymphocytes after T-cell depleted reduced intensity HLA-identical sibling transplantation for indolent non-Hodgkin's lymphoma and CLL / Dr S Robinson / Jon Heywood
Research Nurse
x 26741/bleep 2852
Helen Saldanha
Trial Coordinator
x 26740 / CRUK (NIHR) / 26/10/2012
ON/2012/4116
UK HAPLO Study / A UK multicentre phase II study of haploidentical stem cell transplantation in patients with haematological / Dr R Protheroe / Jon Heywood
Research Nurse
x 26741/bleep 2852
Helen Saldanha
Trial Coordinator
x 26740 / UCL (NIHR) / 26/06/2013
BRAIN
ON/3468
BR14
EORTC 26053/22054
Adjuvant
Location of trial treatment: Outpatient oral chemotherapy and Radiotherapy / Phase III trial on Concurrent and Adjuvant Temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON Intergroup trial. / Dr K Hopkins / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Angela Webb
Research Nurse
x 26753/bleep 2195
Matt Baxter
Asst CTU Manager
x 26734 / EORTC (NIHR) / 26/04/2011
ON/4041
OPARATIC
eCRF
Location of trial treatment: NBT surgery & oral outpatient chemotherapy. / A Cancer Research UK Phase I trial of olaparib (AZD2281), an oral PARP Inhibitor, in combination with extended low-dose oral temozolomide in patients with relapsed glioblastoma / Dr K Hopkins / Angela Webb
Research Nurse
x 26753/bleep 2195
Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Matt Baxter
Asst. CTU Manager
x 26735 / CRUK (NIHR) / 15/11/2012
ON/4315
ACT IV / An International, Randomised, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma / Dr K Hopkins / Angela Webb
Research Nurse
x 26753/bleep 2195
Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Matt Baxter
Asst. CTU Manager
x 26735 / Commercial / 02/08/2013
ON/4297
TAVAREC / Randomised trial assessing the significance of Bevacizumab in recurrent grade II and Grade III gliomas. The TAVAREC trial. / Dr C Herbert / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Angela Webb
Research Nurse
x 26753/bleep 2195
Matt Baxter
Asst. CTU Manager
x 26735 / EORTC (NIHR) / 22/01/2014
ON/4382
TAMIGA / A double-blind, placebo-controlled, randomized, Phase IIIb trial evaluating the efficacy and safety of standard of care (SOC) +/-continuous bevacizumab treatment following progression of disease (PD) in patients with glioblastoma (GBM) after first (1st)-line treatment with radiotherapy, temozolomide and bevacizumab (MO28347) / Dr K Hopkins / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Angela Webb
Research Nurse
x 26753/bleep 2195
Matt Baxter
Asst. CTU Manager
x 26735 / Commerical (NIHR) / 31/01/2014
BREAST
ON/3235 MOSS
Location of trial treatment: LG2 R/T Pre-treatment / The tumour bed as target for breast irradiation following breast conserving surgery / Dr A Bahl / Dana Weston
Research Radiographer
x 22433/bleep 2436
Sylvia Pearson
Snr Trial Coordinator
x 26747 / Investigator led / 24/08/2010
ON HOLD FROM 01-Apr-13
ON/3241
IMPORT HIGH
Location of trial treatment: LG2 Radiotherapy / Randomised trial testing dose escalated intensity modulated radiotherapy in women with higher than average local tumour recurrence risk after breast conservation surgery and appropriate systemic therapy for early breast cancer / Dr A Bahl / Dana Weston
Research Radiographer
x 26754/bleep 2436
Dorothy Griffiths
Research Radiographer
x 26739/bleep 3013
Helen Saldanha
Trial Coordinator
x 26740 / ICR (NIHR) / 19/07/2011
ON/2010/3589
BIG 3-07 (TROG 07.01)
Location of trial treatment: LG2 Radiotherapy / BIG 3-07 (TROG 07.01) A Randomised Phase III Study of Radiation Doses and Fractionation Schedules for Ductal Carcinoma in Situ (DCIS) of the Breast / Dr A Bahl / Dorothy Griffiths
Research Radiographer
x 26739/bleep 3013
Dana Weston
Research Radiographer
x 26754/bleep 2436
Helen Saldanha
Trial Coordinator
x 26740 / Lothian Health Board (NIHR) / 21/11/2011
ON/3810
FAST FORWARD
Location of trial treatment: LG2 Radiotherapy / Randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer / Dr A Bahl / Dana Weston
Research Radiographer
x 26754/bleep 2436
Dorothy Griffiths
Research Radiographer
x 26739/bleep 3013
Helen Saldanha
Trial Coordinator
x 26740 / ICR / NIHR / 06/02/2012
ON/3941
ARISTACAT
Location of trial treatment: CDU / ARomatase Inhibition plus/minus SaracaTinib as Advanced breast CAncer Therapy: a randomised phase II study of aromatase inhibition plus/minus the src-inhibitor AZD0530 in post-menopausal women with advanced breast cancer / Dr J Braybrooke / Liz Allison
Research Nurse
x 26736/bleep 2999
Seonaid Wright
Research Nurse
x 26755/bleep 2459
Angela Webb
Research Nurse
x 26753/bleep 2195
Robert Hollister
Trial Coordinator
x 26742 / Common Services Agency (NIHR) / 04/10/2012
ON/4082
OPTIMA
Location of trial treatment: CDU / Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis / Dr J Braybrooke / Seonaid Wright
Research Nurse
x 26755/bleep 2459
Robert Hollister
Trial Coordinator
x 26742 / UCL (NIHR) / 12/03/2013
ON/4220
KATHERINE / BO27938 - NCRN384 / A Randomised, Multicentre, Open-Label Phase III Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine Versus Trastuzumab as Adjuvant Therapy for Patients With Her2-Positive Primary Breast Cancer who have Residual Tumour present pathologically in the breast or axillary lyph nodes following preoperative therapy / Dr J Braybrooke / Seonaid Wright
Research Nurse
x 26755/bleep 2459
Liz Allison
Research Nurse
x 26736/bleep 2999
Angela Webb
Research Nurse
x 26753/bleep 2195
Robert Hollister
Trial Coordinator
x 26742 / Commercial (NIHR) / 28/06/2013
COLORECTAL
ON/1707
NSCCG
{Also open at NBT}
observational – genetic epidemiology
Location of trial treatment: Blood sample only / National Study of Colorectal Cancer Genetics / Dr S Falk / Helen Boal
Clinical Trials Officer
x 26737/bleep 6342 / ICR
(NIHR) / 14/04/2004
ON/2776
FOxTROT
(589)
adjuvant
{Cross-site trial with NBT}
Location of trial treatment: CDU / Fluoropyrimidine, Oxaliplatin & Targeted Receptor pre-Operative Therapy for colon cancer / Mr M Thomas / Liz Allison
Research Nurse
x 26736/bleep 2999
Jon Heywood
Research Nurse
x 26741/bleep 2852
Angela Webb
Research Nurse
x 26753/bleep 2195
Paul Armenise
Trial Coordinator
x 26743 / Uni of B’ham (NIHR) / 08/07/2008
ON/3529
FOXFIRE
neo-adjuvant
Location of trial treatment: CDU & Oxford / An open-label randomised trial of 5-fluorouracil, oxaliplatin and folinic acid +/- interventional radio-embolisation as first line treatment for patients with unresectable liver-only or liver-predominant metastatic colorectal cancer / Dr S Falk / Liz Allison
Research Nurse
x 26736/bleep 2999
Jon Heywood
Research Nurse
x 26741/bleep 2852
Angela Webb
Research Nurse
x 26753/bleep 2195
Paul Armenise
Trial Coordinator
x 26743 / Uni of Oxford (NIHR) / 08/08/2011
ON/3562
ARISTOTLE
neo-adjuvant
Location of trial treatment: CDU & Treatment floor / A phase III trial comparing standard versus novel CRT as pre-operative treatment for MRI defined locally advanced rectal cancer / Dr S Falk / Liz Allison
Research Nurse
x 26736/bleep 2999
Jon Heywood
Research Nurse
x 26741/bleep 2852
Angela Webb
Research Nurse
x 26753/bleep 2195
Paul Armenise
Trial Coordinator
x 26743 / UCL (NIHR) / 01/02/2012
ON3912
ACORN
Location of trial treatment: Observatoinal only / Avastin COloRectal Non-interventional study- an observational study of avastin® (bevacizumab) in combination with chemotherapy for treatment of first line metastatic colorectal adenocarcinoma / Dr S Falk / Helen Boal
Clinical Trials Officer
x 26737/bleep 6342
Paul Armenise
Trial Coordinator
x 26743 / Commercial / 20/06/2012
ON/4206
COPERNICUS / A Phase II study of neoadjuvant chemotherapy given before short course preoperative radiotherapy (SCPRT) as treatment for patients with MRI-staged operable rectal cancer at high risk of metastatic relapse / Dr S Falk / Liz Allison
Research Nurse
x 26736/bleep 2999
Jon Heywood
Research Nurse
x 26741/bleep 2852
Angela Webb
Research Nurse
x 26753/bleep 2195
Paul Armenise
Trial Coordinator
x 26743 / Cardiff University / 24/10/2013
ON/4378
FOCUS-4 / Molecular selection of therapy in colorectal cancer: a molecularly-stratified randomised controlled trials programme / Dr S Falk / Liz Allison
Research Nurse
x 26736/bleep 2999
Jon Heywood
Research Nurse
x 26741/bleep 2852
Angela Webb
Research Nurse
x 26753/bleep 2195
Paul Armenise
Trial Coordinator
x 26743 / MRC (NIHR) / Opening imminently
GYNAE
ON/3790
ICON 8
Location of trial treatment: CDU / An international phase III randomised trial of dose-fractionated chemotherapy compared to standard three-weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer / Dr H Booz / Seonaid Wright
Research Nurse
x 26755/bleep 2459
Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Robert Hollister
Trial Coordinator
x 26742 / MRC (NIHR) / 25/11/2011
ON/3925
DESKTOP III
Location of trial treatment: CDU / A randomised multicentre study to compare the efficacy of additional tumour debulking surgery versus chemotherapy alone for recurrent platinum-sensitive ovarian cancer / Dr J Murdoch / Seonaid Wright
Research Nurse
x 26755/bleep 2459
Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Robert Hollister
Trial Coordinator
x 26742 / Commercial (NIHR) / 01/03/2013
ON/4295
OSCAR 1 / An observational study of avastin® (bevacizumab) as first line therapy in patients with advanced ovarian cancer / Dr A Walther / Helen Boal
Clinical Trials Officer
x 26737/bleep 6342
Robert Hollister
Trial Coordinator
x 26742 / Commercial (NIHR) / 02/08/2013
ON/4176
TRIOC / A Randomised Parallel Group Double-Blind Phase II Study to Assess the Activity of Trovax® (MVA-5T4) Versus Placebo in Patients with Relapsed Asymptomatic Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer / Dr A Walther / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Seonaid Wright
Research Nurse
x 26755/bleep 2459
Jon Heywood
Research Nurse
x 26741/bleep 2852
Robert Hollister
Trial Coordinator
x 26742 / UCL (NIHR) / Opening imminently
ON/2013/4463
BriTROC-1 / The UK Translational Research in Ovarian Cancer Collaborative Sample collection study to investigate the role of Homologous Recombination Deficiency in platinum sensitivity in recurrent high grade serous ovarian cancer / Dr A Walther / Seonaid Wright
Research Nurse
x 26755/bleep 2459
Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Robert Hollister
Trial Coordinator
x 26742 / NHS Greater Glasgow & Clyde (NIHR) / Opening imminently
HAEMATOLOGY
CH/1799
Leukaemia Samples
(594)
ALL
sample study
Location of trial treatment: N/A blood study / The use of allogeneic T-lymphocytes (CTL) in adults with acute leukaemia (The use of cytotoxic t-lymphocytes (CTCs) as adoptive immunotherapy in patients with acute lymphoblastic leukaemia after bone marrow transplant / Dr J Bird / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Lisa Mayne
Trial Coordinator
x 26746 / National Blood Service / 01/03/2008
ON/3067 AML 17
1st line
eCRF
Location of trial treatment: Ward 62 and Haem Day Unit / Working parties on leukaemia in adults and children trial in acute myeloid leukaemia or high risk myelodysplastic syndrome 17 / Dr P Mehta / Jon Heywood
Research Nurse
x 26741/bleep 2852
Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Lisa Mayne
Trial Coordinator
x 26746 / Cardiff University
(NIHR) / 09/07/2009
ON/3149
Cytarabine Sensitivity
sample study
Location of trial treatment: Sample study / Cytarabine Sensitivity Study - Bacterial Biosensors for rapid pre-screening of chemotherapy efficacy / Dr P Mehta / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Lisa Mayne
Trial Coordinator
x 26746 / Frimley Park Hospital (NIHR) / 18/12/2009
ON/3418
UKALL 14
1st line
Location of trial treatment: Ward 62 and Haem Day Unit / A randomised trial for adults with newly diagnosed acute lymphoblastic leukaemia / Prof D Marks / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Lisa Mayne
Trial Coordinator
x 26746 / UCL (NIHR) / 04/02/2011
ON/3290
PASS
eCRF
Location of trial treatment: N/A / A non-interventional observational post authorisation safety study of subjects treated with lenalidomide / Dr J Bird / Dr J Bird,
x 21120
Call CTU on
x 26733 / Commercial / 29/06/2010
ON/3368
MYELOMA XI
1st line
Also recruiting at NBT
Location of trial treatment: Outpatient oral chemotherapy and Haem Day Unit / Randomised comparisons in myeloma patients of all ages of thalidomide, lenalidomide and bortezomib combinations, and maintenance lenalidomide / Dr J Bird / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Emily Foulstone
Trial Coordinator
x 26738 / CTRU Leeds (NIHR) / 12/05/2011
ON/3613
REVEAL
1st line
Location of trial treatment: Haem Day Unit / A Pilot Study of Relapsed or Refractory Patients Using Velcade (Bortezomib) Combination Chemotherapy in AL Amyloidosis / Dr J Bird / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Emily Foulstone
Trial Coordinator
x 26738 / UCL (NIHR) / 13/04/2012
ON/3532
PNH Registry
eCRF
Location of trial treatment: Outpatients / The Paroxysmal Nocturnal Haemoglobinuria (PNH) Registry (M07-001) / Dr P Mehta / Helen Boal
Clinical Trials Officer
x 26737/bleep 6342
Lisa Mayne
Trial Coordinator
x 26746 / Commercial (NIHR) / 23/09/2011
ON/3722
LI-1
Location of trial treatment: Ward 62 and Haem Day Unit / A Programme of Development for older patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome / Dr P Mehta / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Lisa Mayne
Trial Coordinator
x 26746 / Cardiff Uni / NIHR / 23/03/2012
CH/3875
UKALL 2011
Location of trial treatment: Ward 62 and Haem Day Unit / United Kingdom National Randomised Trial For Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011 / John Moppett (BCH)
Prof D Marks (BHOC Lead) / Vicki Kitchker
Research Nurse
x 26744/bleep 3279
Jon Heywood
Research Nurse
x 26741/bleep 2852
Lisa Mayne
Trial Coordinator
x 26746 / Uni of Birmingham (NIHR) / 06/06/2012
PA/2519 MDSBio
Location of trial treatment: Haem Day Unit for BM / Outpatients / Molecular and functional characterisation of bone marrow function in normal subjects, myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML) and secondary disorders of haematopoiesis / Dr P Mehta / Vicki Kitchker