Supplementary Table A. Definitions of fibrosis and steatosis utilized by each study

Study / Fibrosis / Steatosis
Huang
(2014)
Taiwan / No definition provided. / No definition provided.
El Ray
(2013)
Egypt / Metavir Score:
F0: No fibrosis
F1: Portal fibrosis without septa
F2: Portal fibrosis with a few septa
F3: Numerous septa without cirrhosis
F4: Cirrhosis / Assessed based on number of hepatocytes containing macrovesicular fat droplets:
0: Absent: <5%
1: Moderate: 5-30%
2: Severe: >30%
Petta
(2011)
Italy / 0: F1-F2
1: F3-F4: severe fibrosis / Assessed as the percentage of hepatocytes containing fat droplets.
-Mild: >5 to <10%
-Moderate/severe: >10%
Patel
(2011)
Multinational / Metavir Score / Graded as the percentage of hepatocytes containing macrovesicular fat droplets.
Grade 0: 0-5%
Grade 1: 6-30%
Grade 2: 31-60%
Grade 3: ≥61%
Younossi
(2009)
US / Metavir Score
Note: for the purpose of this study, stage 2-4 were considered “advanced fibrosis.” / Comparisons were made according to the extent of steatosis: Grade 0: none
Grade 1: ≤33%
Grade 2: >33%
Nieminen
(2009)
Finland / Metavir Score / Classified into four degrees based on the proportion of hepatocytes with macrovesicularsteatosis:
S0: no steatosis or <5% of hepatocytes involved
S1: mild: 6-33% of hepatocytes involved
S2: moderate: 34-66%
S3: severe: >66%
Cross
(2009)
UK / IshakScore:
F3-F6: significant fibrosis
F5-F6: cirrhosis
Stage 0: No fibrosis (normal)
Stage 1: Fibrous expansion of some portal areas ± short fibrous septa.
Stage 2: Fibrous expansion of most portal areas ± short fibrous septa.
Stage 3: Fibrous expansion of most portal areas with occasional portal-to-portal bridging.
Stage 4: Fibrous expansion of portal areas with marked bridging as well as portal-to-central.
Stage 5: Marked bridging with occasional nodules (incomplete cirrhosis)
Stage 6: Cirrhosis, probable or definite. / KleinerSystem:
SO: <5% steatosis
S1:5-33%
S2: 33-66%
S3: >66%
Hu, SX
(2009)
US / Modified Knodell Scoring System:
Stage 0: Absence of hepatic fibrosis
Stage 3-4: Advanced hepatic fibrosis / Grade 0: Absence of steatosis
Grade 1: <30% of hepatocytes affected
Grade 2: 30-70%
Grade 3: >70%
Moucari
(2008)
France / Metavir Score / Assessed as the percentage of hepatocytes containing macrovesicular fat droplets.
Grade 0: Absent: <5%
Grade 1: Moderate: 5-30%
Grade 2: Severe: >30%
Petta
(2008)
Italy / Scheuer score:
Grade 0: none
Grade 1: enlarged, fibrotic portal tracts
Grade 2: periportal or portal-portal septa but intact architecture
Grade 3: fibrosis with architectural distortion but no obvious cirrhosis.
Grade 4: probable or definite cirrhosis / Steatosis was assessed as the percent of hepatocytes containing macrovesicular fat droplets. Subjects were considered to have steatosis in the presence of fat droplets in ≥5% of hepatocytes.
Alsatie
(2007)
US / Metavir Score / Grade 0: absent
Grade 1: <33% of hepatocytes affected
Grade 2: 33-66%
Grade 3: >66%
Lo Iacono
(2007)
Italy / Metavir Score / Assessed as percent of hepatocytes containing fat droplets and scored according to Bruno et al. Only macrovesicularsteatosis was taken into account.
-Grade 0: no steatosis
-Grade 1: <33% hepatocytes affected
-Grade 2: 33-66%
-Grade 3: >66% of hepatocytes showed fat storage.
Verma
(2006)
US / Ishak Score / Graded from 0-4 depending on % of hepatocytes containing fat:
0= no fat
1+=<5%
2+=6-33%
3+=34-66%
4+=67-100%
Muzzi
(2005)
Switzerland / Metavir Score / Score 0: Absent or minimal: <1% of hepatocytes affected
Score 1: Mild: <30%
Score 2: Moderate: 30-60%
Score 3: >60 hepatocytes affected
Fartoux
(2005)
France / Metavir Score / Steatosis was graded according to the percentage of hepatocytes containing cytoplasmic vacuoles. Only macrovesicularsteatosis was taken into account. Steatosis was classified as significant when >10% of hepatocytes were affected.
Rubbia-Brandt
(2004)
Multinational / Metavir Score / -Grade 0: Absent: <1% of total hepatocytes
-Grade 1: Mild: 1-30%
-Grade 2: Moderate: 30-60%
-Grade 3: Severe : >60%
Hu, KQ
(2004)
US / Knodell Scoring System:
Stage 0: Absence of hepatic fibrosis
Stage 3-4: Advanced hepatic fibrosis / -Grade 0: none
-Grade 1: <30%
-Grade 2: 30-70%
-Grade 3: >70%
Castera,
(2003)
France / Metavir Score / Graded on two liver biopsies as follows:
Mild: involving <10% of hepatocytes
Moderate: 10-30%
Severe: >30%
Ortiz
(2002)
Spain / Stages of fibrosis were evaluated separately according to the methods of Desmet et al.
0: none
1: periportal fibrous expansion
2: porto-portal septa
3: porto-central septa
4: cirrhosis / No definition given.
Ong
(2001)
US / Ishak Score
Mild or No fibrosis: <3
Advanced Fibrosis: 3 / -Grade 0: none
-Grade 1: ≤33%
-Grade 2: >33%