Supplementary Table S2 Functional Analysis of Nine Snps Significantly Associated With

Supplementary Table S2 Functional analysis of nine SNPs significantly associated with CRP levels in East-Asian meta-analysis using the FuncPred of SNPinfo and PolyPen-2

Gene / Chr / SNP / TFBS / Splicing / Splicing / Splicing / miRNA / miRNA / nsSNP / Stop / PolyPhen
(Site) / (ESE or ESS) / (abolish domain) / (miRanda) / (Sanger) / codon
IL6R / 1q21 / rs2228145 / -- / -- / Y / -- / -- / -- / Y / -- / possibly damaging
CRP / 1q23 / rs7553007 / -- / -- / -- / -- / -- / -- / -- / -- / --
GCKR / 2p23 / rs1260326 / -- / -- / -- / -- / -- / -- / Y / -- / possibly damaging
HNF1A / 7p21 / rs2097677 / -- / -- / -- / -- / -- / -- / -- / -- / --
CYP17A1 / 10q24.3 / rs1004467 / -- / -- / -- / -- / -- / Y / -- / -- / --
HNF1A / 12q24.2 / rs1169288 / -- / -- / -- / -- / -- / -- / Y / -- / benign
rs2464196 / -- / -- / -- / -- / -- / -- / Y / -- / benign
rs7310409 / -- / -- / -- / -- / -- / -- / -- / -- / --
APOE / 19q13.2 / rs429358 / -- / -- / -- / -- / -- / -- / Y / -- / benign

Chr, chromosome; ESE, exonic splicing enhancer; ESS, exonic splicing silencer; miRNA, micro Ribonucleic acid; nsSNP, non-synonymous single nucleotide polymorphism; TFBS, transcription factor binding site. The functional analysis of nine SNPs was performed in 2 Chinese (CHD and CHB) and Japanese (JPT) HapMap populations using SNP Function Prediction (FuncPred) of SNPinfo (http://snpinfo.niehs.nih.gov/cgi-bin/snpinfo/snpfunc.cgi) and PolyPhen-2 (http://genetics.bwh.harvard.edu/pph2) web servers.