Curriculum vitae for Patrik Brundin
Personal data
/ Name PatrikBrundinDate of birthDecember 26, 1961
Position title /
Professor of Neuroscience
Institution and Location
/Degree
/Year(s)
/Field of Study
Lund University, Sweden
/M.D.
/1992
/Medicine
Lund University, Sweden
/Ph.D.
/1988
/Medical Science
Lund University, Sweden
/B.Sc.
/1983
/Medicine
United World College of the Atlantic, Wales
/I.B.
/1980
/Natural sciences
Professional Positions
2000 / Appointed professor in Neuroscience at Lund University, Sweden.2000-2000 / Professor of Experimental Neuropathology at Copenhagen University, DK
1999 / Permanent position as Associate professor of Neuroscience at Lund University.
1998 / Lecturer in Experimental Medicine at Lund University.
1995-1998 / Swedish Medical Research Council research position.
1994 / License to practice medicine (läkarlegimitation).
1994 / Neurology, clinical training (3 mo.).
1992-1994 / 80% clinical internship, 20% research associate.
1990-1992 / Clinical program Lund Medical School.
1988-1990 / Post-doctoral position at the Dept of Medical Cell Research, Lund University.
1983-1988 / Graduate student (supervisor Anders Björklund).
1981-1988 / Various junior teaching positions.
Honors, Awards, Other Professional Activities
2002-today2001-today
1996-2001
1987-today
2001
2001 / Coordinator of the EC-sponsored Marie Curie Training Site on “Neurodegeneration, cell rescue and brain repair”.
Coordinator of the EC-sponsored Concerted Action on “Early Pathogenetic Markers for Slow Neurodegenerative Diseases”.
Dissertation of 7 PhD students and 1 Master student.
Participation in clinical trials with intracerebral grafts in 19 Parkinsonian patients.
Awarded the Catedra Santiago Grisolía Chair Prize, Valencia, Spain.
Presented with The Outstanding Young Persons of the World Award for research and academic leadership by the Swedish Junior Chamber.
2000 / Coorganiser of the international conference entitled "The role of mitochondria in apoptosis and neurodegeneration", June 2000.
1999 / Chairman of the Gordon conference entitled "CAG triplet repeat disorders" July 15-20, 2001 Mount Holyoke College, MA, USA.
1999 / Awarded Dr Eric K. Fernström Foundation's Prize to Young Swedish Scientists.
1999 / Harvard Macy Program for Leaders in Medical Education, Boston, USA.
1999 / Chairman of Research Strategy 2000 Group, Medical Faculty, Lund.
1999 / Organizer of the international conferences entitled "CAG triplet repeat expansion. in neurologic disease" and "The future of neural grafting in Parkinson's disease" at Wallenberg Neuroscience Center, Lund University, Sweden.
1999-today / Editorial board of Experimental Neurology.
1998-today / Editorial board of Neuroscience.
1998-today / Section editor for neuroscience in Cell Transplantation.
1997-2000 / Chairman of the "Experimental Work" Group in the EU-sponsored Concertation of the European strategies for intervention in Parkinson's disease with special emphasis on functional neurosurgery (NIPD).
1997 / Project evaluation committee for the National Network in Neuroscience, Sweden.
1997-1999 / Chairman of the Neurobiology Club in Lund.
1995 / Founder of the Section for Neuronal Survival, Lund University.
1994-today / Member of the editorial board of Cell Transplantation.
1994 / Awarded the Swedish Medical Research Council grant for young promising scientists.
1994-today / President of NECTAR (Network for European CNS Transplantation and Restoration).
1994 / New Investigator lecture award, Montreal Neurology Institute.
1990 / Member of the local organizing committee for the international
Fernström symposium on Intracerebral transplantation in movement
disorders: experimental basis and clinical experiences".
1990-today / Member of over 25 thesis review committees.
1989 / Presented with the Oscar II award for best medical thesis in Lund 1988-1987.
Selected peer-reviewed publications (in chronological order)
(Publications selected from 135 original papers and 60 review articles/book chapters/commentaries)
1.Isacson O, Brundin P, Kelly PAT, Gage FH and Björklund A (1984) Functional neuronal replacement by grafted striatal neurons in ibotenic acid lesioned rat striatum. Nature 311: 458-460.
2.Brundin P, Nilsson OG, Strecker RE, Lindvall O, Åstedt B and Björklund A (1986) Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp Brain Res 65: 235-240.
3. Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, Åstedt B, Lindvall O and Björklund A (1988) Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp Brain Res 70: 192-208.
4. Lindvall O, Brundin P, Widner H, Rehncrona S, Gustavii B, Frackowiak R, Leenders KL, Sawle G, Rothwell JC, Marsden CD and Björklund A (1990) Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science 247: 574-577.
Wictorin K, Brundin P, Gustavii B, Lindvall O and Björklund A (1990) Reformation of long axonal pathways in adult rat central nervous system by human forebrain neuroblasts. Nature 347: 556-558.
6. Grabowski M, Brundin P and Johansson BB (1993) Functional integration of cortical grafts in infarcted rat neocortex. Annal Neurol 34: 362-368.
7. Nakao N, Frodl EM, Widner H, Carlson E, Eggerding FA, Epstein CJ and Brundin P (1995) Overexpressing Cu/Zn-superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nature Med 1: 226-231.
8. Grasbon-Frodl EM, Nakao N, Lindvall O and Brundin P (1996).Phenotypic development of the human embryonic striatal primordium: a study of cultured and grafted neurons from the lateral and medial ganglionic eminences. Neuroscience 73: 171-183.
9.Grasbon-Frodl EM, Andersson A and Brundin P (1996) Lazaroid treatment prevents death of cultured rat embryonic mesencephalic neurons following glutathione depletion. J Neurochem 67: 1653-1660.
10.Nakao N and Brundin P (1997) Effects of a-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid. Neuroscience 76: 749-761.
11.Barkats M, Nakao N, Grasbon-Frodl EM, Biland-Bleuel A, Revah F, Mallet J and Brundin P (1997) Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase. Neuroscience 78: 703-713.
12.Duan W-M, Widner H, Cameron RM and Brundin P (1998) Quinolinic acid-induced inflammation in the striatum does not impair the survival of neural allografts in the rat. Eur J Neurosc 10: 2595-2606.
13.Schierle GS, Hansson O, Leist M, Nicotera P, Widner H and Brundin P (1999) Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nature Med 5: 97-100.
14.Hansson O, Petersén Å, Leist M, Nicotera P, Castilho RF and Brundin P (1999) Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity. Proc Natl Acad Sci USA 96: 8727-8732.
15.Schierle GS, Leist M, Martinou J-C, Widner H, Nicotera P and Brundin P (1999) Differential effects of Bcl-2 overexpression on fiber outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants. Eur J Neurosci 11: 3073-308.
16.Piccini P, Brooks DJ, Bjorklund A, Gunn RN, Grasby PM, Rimoldi O, Brundin P, Hagell P, Rehncrona S, Widner H, Lindvall, O (1999) Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nature Neurosci 2:1137-1140.
17.Brundin P, Pogarell O, Hagell P, Piccini P, Widner H, Schrag A, Kupsch A, Crabb L, Odin P, Gustavii B, Björklund A, Brooks DJ, David Marsden C, Oertel WH, Quinn NP, Rehncrona S and Lindvall O (2000) Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease. Brain 123: 1380-1390.
18. Lotharius J, Barg S, Wiekop P, Lundberg C, Raymond HK, Brundin P (2002). Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. Journal of Biological Chemistry, in press.
19. Hagell P, Piccini P, Björklund A, Brundin P, Rehncrona S, Widner H, Crabb L, Pavese N, Oertel WH, Quinn N, Brooks DJ, and Lindvall O (2002). Dyskinesias following neural transplantation in Parkinson's disease. Nature Neuroscience 5:627-628.