Parasites & Pestilence:

Infectious Public Health Challenges

HB 153

Spring 2006

D. Scott Smith, MD, MSc., DTM&H

Email:

Office: (650) 299-2742 Home: 650 344-8181

Office Hours: Wed 12 noon to 2pm in HumBio Bldg 80 Room 111

Teaching Assistants: David

Natalie

Michael

Maddie

Class Website:

Or:

Where:Building 200, Room 303

Office Hours Wednesdays 12noon to 2pm in Building 80, Room 111

When: Wednesday afternoons 2:15 – 5:05pm April 4th to June 7th, 2006

Guest Lecturers and Speakers (in order of appearance)

Karen Smith, MD, MPHTuberculosis Control Officer, Napa County

Brian Blackburn, MDClinical Asst. Professor, Department of Medicine, Infectious Disease

Chindi A. Peavey, Ph.D.Vector Ecologist, San Mateo County

Michele Jay-Russell, DVM, MPVM, DACVPM, Acting Chief, Veterinary Public Health Section, California Department of Health Services

Schedule of Lecture Topics

Class

NumberDateTopic Lecturer

  1. April 5th, 2006 Introduction to microbial interactions with humans Smith

Course overview: the TDR target diseases Global Burden of Disease

Introductions / Pictures for website

Readings: M&V Chapter 2, pp. 6-21

  1. April 12, 2006Tissue Nematodes

Onchocerciasis (River Blindness)Smith

Lymphatic Filariasis: The case for eradication?

Reading: M&V pp. 274-301

Trematodes

SchistosomiasisSmith

Reading: M&V pp. 181-196

  1. April 19, 2006Blood and Tissue ProtozoaSmith

African Trypanosomiasis* (Sleeping Sickness)

American Trypanosomiasis* (Chagas’ Disease)

Reading: M&V pp. 107-127

Reading response discussionTAs

Workshop and Lab (at Med School)

Approaching the parasitic disease projectTAs

Reading response #1 DUE (see Coursework)

4. April 26, 2006Gastrointestinal ParasitesSmith

Ascariasis (A. lumbricoides)

Hookworm (Ancylostoma duodenale, N. americanus)

Echinococcosis (E.granulosus)

Video: Echinococcal cyst surgery

Reading: M&V pp. 240-246 (ascaris); pp 248-255 (hookworm)

pp. 224-231 (echinococcus)

M. Howitt: GI challenges in developing countries (H. pylori)

M. Moule: Oncogenesis & Parasites

5. May 3, 2006LeprosySmith

Tuberculosis: A Global Perspective Karen Smith

Review: Multidrug-resistant tuberculosis: public health challenges, by Coker RJ, Trop Med Int Health. 2004 Jan;9(1):25-40 (see Coursework)

"ParaSite Project Updates" DUE (Check-up)

Make MidTerm Questions: due Sunday 5/7/06 at 5pm

*** May 7, 2006 Midterm Review – 8pm, Location TBA *** TAs

6. May 10, 2006MidTerm “Quiz”

Malaria

A. Malaria in Emergency Response: Tsunami in IndonesiaSmith

B. Vectors and Genetics of Malaria Disease Cycles and Intervention Strategies

Reading: M&V pp. 79-106

M. Moule: Malaria & Vectors/ Insect Lifecycles.

*ParaSite Tutorial 7-9pm, Sunday May 14,2006 and Monday May 15, 2006, in Meyer Library, 2nd Floor Computer Lab

Schedule of Lecture Topics

Class

NumberDateTopic Lecturer

7. May 17, 2006Outbreak Investigation National (CDC) Blackburn

Leishmaniasis*Smith

Reading: M&V pp. 127-139

Toxoplasmosis*

Reading response discussionTAs

Reading response #2 DUE (see Coursework)

8. May 24, 2006Outbreak Investigations (lepto, rabies, Q-fever)Jay

Medically important ArthropodsPeavy

(and emerging diseases: West Nile Virus, Lyme Disease)

Reading: M&V pp. 322-351

Web ParaSite Projects DUE

9. May 31, 2006Bioterrorism and other PestilenceTBA

ParaSite Project Presentations IClass

Lab section at the Medical School

10. June 7, 2006Selected Zoonoses: local and current challengesSmith

ParaSite Project Presentations IIClass

Important Dates

Friday June 2nd, 6-8pm– Final Exam Review Session place TBATAs

June 3th, 3 pm Saturday “Pot Luck” of Gastronomic Delights at Dr. Smith’s House

June 9th, 2006, Friday, Final Exam 12:15 – 3:15pm

Course Readings

Course Text Book: Markell and Voge's Medical Parasitology
by Edward K. Markell, David T. John, Wojciech A. Krotoski, Ninth Edition, 2006

Selected further readings:

  1. Michele Barry, M.D., FACP. Diseases without Borders: Globalization's
    Challenge to the ASTMH A Call for Public Advocacy and Activism.
    Presidential Address, November 2002
  2. Duane J. Gubler, Sc. D. Prevention and Control of Tropical Diseases in
    the 21st Century: Back to the Field
    Presidential Address, December 2000.
  3. Mass Treatment to Eliminate Filariais in Papua New Guinea, N Engl J Med 2002; 347:1841-1848, Dec 5, 2002
  4. Plagues and Peoples, William H. McNeill
  5. Man and Microbes: Disease and Plagues in History and Modern Times,
    Arno Karlen
  6. Communicable Diseases Manual, 2000
  7. New Guinea Tapeworms and Jewish Grandmothers: Tales of Parasites and People, Robert S. Desowitz
  8. The Malaria Capers : More Tales of Parasites and People, Research and Reality
    by Robert S. Desowitz

Class Format

2-3 patient case vignettes

Didactic and Socratic Lectures

Question and Answer Session and Discussion

Microscopy Sessions on relevant days

Workshops: preparing your projects

Grading

15%Class participation (includes emailing exam questions, class discussion participation, reading responses)

15%Midterm quiz

25%(Web) ParaSite Project (and presentation)

45%Final exam

Grading will not be done on a curve, so everyone can do well if the effort is made and there is evidence of learning.

Students will be encouraged to participate in events on campus relevant to the course content, including lectures and rounds such as the infectious disease grand rounds at the medical school, fellow’s lectures, and special guest speaker’s symposia.

Students are encouraged to participate in summer projects related to the content of this course; and every effort will be made to align students with mentors and parasite projects or research.

Letters of recommendation will be considered for those in the top 25% of the class.

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