E. Scott Swenson, MD, PhD
102 Yankee Peddler Path
Madison, CT 06443
Education
University of Cincinnati MD 1999
University of Cincinnati PhD 1997 Biomedical Science
Oberlin College BA 1985 Biology and Psychobiology
Medical/Scientific Experience
Assistant Professor, Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. Appointment July 1, 2007 – present.
Associate Director, Postgraduate Training Program in Digestive Diseases, Department of Internal Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. Appointment July 1, 2011 – present.
Attending Physician, Internal Medicine, Yale New Haven Hospital, New Haven, CT.
Appointment July 1, 2007 - present.
Instructor, Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. Appointment July 1, 2006 – June 30, 2007.
Attending Physician, Gastroenterology, West Haven Veteran’s Affairs Medical Center, West Haven, CT. Appointment November 1, 2005 - Present.
Postdoctoral Fellow, Laboratory Medicine, Yale University School of Medicine, New Haven, CT. October 2002-June 2006. Advisor: Diane Krause, MD, PhD.
Research topic: Regeneration of liver from bone marrow stem cells.
Clinical Fellow, Digestive Diseases, Yale University School of Medicine, New Haven, CT.
July 2001-June 2005. Fellowship Director: Deborah Proctor, MD.
Intern/Resident in Internal Medicine. Yale-New Haven Hospital, New Haven CT.
July 1999-June 2001. Residency Director: Cyrus Kapadia, MD.
Student, Physician Scientist Training Program, University of Cincinnati, OH.
July 1991 - May 1999. PhD, December 1997. MD, June 1999
PhD Advisor: Ralph A. Giannella, MD
Thesis title: Transcriptional regulation of the guanylin/heat-stable enterotoxin receptor: Role of HNF-4 in intestine-specific gene transcription.
Assistant Scientist, Pharmaceutical Research and Development, Pfizer Inc, Groton, CT.
October 1988 - June 1991. Supervisor: William Curatolo, PhD.
Research Assistant, Nutrition/Metabolism Lab, New England Deaconess Hospital/
Harvard Medical School, Boston, MA. October 1985 - October 1988.
Supervisors: Bruce Bistrian, MD, PhD and George Blackburn, MD, PhD.
Hemodialysis Technician, Cape Cod Artificial Kidney Center, Yarmouth, MA.
Summers 1981 - 1985. Supervisor: James Reimer, MD.
Staff Appointments:
Yale New Haven Hospital, New Haven CT: July 2007 – present.
Veteran’s Administration Medical Center, West Haven, CT: November 2005 – present.
Licensure and Board Certification:
State of Connecticut Medical License #040636
-Effective July 8, 2002. Renewal due April 30, 2012.
State of Connecticut Department of Consumer Protection
Practitioner Registration #32853
-Effective October 16, 2002. Renewal due February 28, 2012.
United States Drug Enforcement Administration Registration #BS9895410
-Effective date July 28, 2006. Renewal due February 29, 2012.
State of Connecticut Department of Consumer Protection
Controlled Substance Laboratory Registration #CSL.0000852
-Effective November 29, 2007. Renewal due January 31, 2012.
United States Drug Enforcement Administration Registration, Research #RS0361852
-Effective date January 10, 2008, renewal due February 28, 2012.
National Provider Identification Number: 1902996481
Internal Medicine, American Board of Internal Medicine, August 2003.
-Renewal due 2013.
Gastroenterology, American Board of Internal Medicine, November 2005.
-Renewal due 2015.
Advanced Cardiac Life Support, recertification April 2010
-Recertification due April 2012.
Society Membership:
American Association for the Study of Liver Diseases
American Gastroenterological Association
American Pancreatic Association
International Society for Stem Cell Research
Yale Stem Cell Center
Yale Liver Center
Juvenile Diabetes Research Foundation: Network of Pancreatic Donors with Diabetes
Publications
1. Whole body leucine, phenylalanine, and tyrosine kinetics in end-stage liver disease before and after transplantation (1987). RLK Shanbhogue, BR Bistrian, K Lakshman, L Crosby, S Swenson, D Wagner, RL Jenkins, and GL Blackburn. Metabolism 36: 1047-1053. PMID 3312934.
2. Twenty-four hour urinary creatinine: A simple technique for estimating resting energy expenditure in normal population and in the hospitalised patients (1987). RLK Shanbhogue, BR Bistrian, S Swenson, and GL Blackburn. Clinical Nutrition 6: 221-225.
3. Effect of structured lipid-enriched total parenteral nutrition in rats bearing Yoshida sarcoma (1990). LE Crosby, ES Swenson, VK Babayan, GL Blackburn, and BR Bistrian. J. Nutr. Biochem. 1: 41-47. PMID 15539164.
4. Metabolic effects of medium chain triglyceride-enriched total parenteral total parenteral nutrition in rats bearing Yoshida sarcoma (1990). ES Swenson, LE Crosby, VK Babayan, GL Blackburn, and BR Bistrian. J. Nutr. Biochem 1: 462-470. PMID 15539237.
5. Persistence of metabolic effects after long term oral feeding of a structured triglyceride derived from medium chain triglyceride and fish oil in burned and normal rats (1991). ES Swenson, KM Selleck, VK Babayan, GL Blackburn, and BR Bistrian. Metabolism 40: 484-490. PMID 2023535.
6. Dietary fat as determinant of protein-sparing actions of structured triglycerides (1992). CJ Gollaher, ES Swenson, EA Mascioli, VK Babayan, GL Blackburn, and BR Bistrian. Nutrition 8: 348-353. PMID 1421780.
7. Intestinal permeability enhancement for proteins, peptides, and other polar drugs: Mechanisms and potential toxicity (1992). ES Swenson and WJ Curatolo. Adv. Drug Deliv. Rev. 8: 39-92.
8. Intestinal permeability enhancement: Efficacy, acute local toxicity, and reversibility (1994). ES Swenson, WB Milisen, and W Curatolo. Pharm. Res. 11: 1132-1142. PMID 7971714.
9. Intestinal permeability enhancement: Structure-activity relationships for nonylphenoxy-polyoxyethylene surfactant permeability enhancers (1994). ES Swenson, WB Milisen, and W Curatolo. Pharm. Res. 11: 1501-1504. PMID 7855060.
10. The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine (1996). ES Swenson, EA Mann, ML Jump, DP Witte, and RA Giannella. Biochem. Biophys. Res. Comm. 225: 1009-1014. PMID 8780725.
11. Localization of guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12. EA Mann, ES Swenson, NG Copeland, DJ Gilbert, NA Jenkins, T Taguchi, JR Testa, and RA Giannella (1996). Genomics 34: 265-267. PMID 8661067.
12. Hepatocyte nuclear factor 4 regulates intestinal expression of guanylyl cyclase C, the guanylin/heat-stable enterotoxin receptor (1999). ES Swenson, EA Mann, ML Jump, and RA Giannella. Am. J. Physiol. 276: G728-G736. PMID 10070050.
13. Thyroid transcription factor-1, thyroglobulin, cytokeratin y, and cytokeratin 2 in thyroid neoplasms (2000). PA Bejerano, YE Nikiforov, ES Swenson, and PW Biddinger. Appl. Immunohistochem. Mol. Morph 8: 189-194. PMID 10981870.
14. Smads 2 and 3 are differentially activated by TGF-beta in quiescent and activated hepatic stellate cells: Constitutive nuclear localization of smads in activated cells is TGF-beta independent (2003). C Liu, MD Gaca, ES Swenson, VF Velluci, M Reiss, and RG Wells. J. Biol. Chem. 278(13): 11721-11728. PMID 12547835.
15. Cirrhosis and portal hypertension (2004). Chap. 45 in Field Guide to Internal Medicine. ES Swenson. Lippincott, Williams and Wilkins, Philadelphia, PA.
16. Dose and time-dependent oval cell reaction in acetaminophen-induced murine liver injury (2005). AV Kofman, G Morgan, A Kirschenbaum, J Osbeck, M Hussain, S Swenson and ND Theise. Hepatology 41(6): 1252-126. PMID 15880565.
17. Smad2 and smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization (2005). M Uemura, ES Swenson, MDA Gaca, FJ Giordano, M Reiss, RG Wells. Mol. Biol. Cell. 16:4214-4224. PMID 15987742.
18. Engraftment of bone marrow derived epithelial cells (2005). JS Van Arnam, E Herzog, J Grove, E Bruscia, E Ziegler, S Swenson, DS Krause. Stem Cell Reviews 1:21-28.
19. The commonly used b-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis (2007). JK Guo, EC Cheng, L Wang, ES Swenson, TA Ardito, M Kashgarian, L Cantley, DS Krause. Transgenic Res. 16: 829-834. PMID 17594530.
20. Limitations of green fluorescent protein (GFP) as a cell lineage marker (2007). ES Swenson, JG Price, T Brazelton, DS Krause. Stem Cells 25: 2593-2600. PMID 17615263.
21. Induced pluripotent cells mimicking human embryonic stem cells. M Mohamadnejad M, ES Swenson (2008). Arch Iran Med. 11: 125-8. PMID 18154436.
22. Physiological variations in stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration. ES Swenson, R Kuwahara, DS Krause, ND Theise (2008). Liver International 28: 308-318. NIHMS186601.
23. The hepatic stem cell niche: identification by label retaining cell assay. R Kuwahara, AV Kofman, CS Landis, ES Swenson, E Barendswaard, ND Theise ND (2008). Hepatology 47:1994-2002. NIHMS186599.
24. Hepatocyte nuclear factor-1 as marker of hepatic epithelial phenotype reveals bone marrow-derived hepatocytes, but not oval cells, after liver injury in mice. ES Swenson, I Guest, Z Ilic, M Mazzeo, P Lizardi, C Hardiman, S Sell, DS Krause. Stem Cells 2008;26:1768-1777. NIHMS186592
25. Chimeric mice reveal clonal development of pancreatic acini, but not islets. ES Swenson, T Nottoli, J McGrath, ND Theise, DS Krause. Biochem Biophys Res Commun 2008;379:526-531. PMID 19116141. PMC2657659.
26. Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. ES Swenson, ND Theise. Clin Exp Gastro 2010;3:1-10.
27. Adenosine inhibits bone marrow mesenchymal stem cell chemotaxis by down-regulation of Rac1. M Mohamadnejad, MA Sohail, A Watanabe, DS Krause, ES Swenson, WZ Mehal. Hepatology 2010;51:963-73. PMID 20044808, PMC2840188.
28. The blood vessels of Prometheus (editorial). ES Swenson and DS Krause. The Hematologist 2011;8:8.
Honors and Awards:
Student Travel Award - Digestive Disease Week, American Gastroenterological Association, San Diego, CA, 1995. Poster: Human guanylyl cyclase C promoter directs intestinal expression of luciferase reporter gene in transgenic mice.
Graduate Student Research Forum - University of Cincinnati, Cincinnati, OH, 1997.
Poster: Hepatocyte nuclear factor 4 regulates intestinal expression of guanylyl cyclase C. Honorable Mention Award.
Samuel Kushlan Research Award – Yale University School of Medicine, Division of Digestive Diseases, New Haven, CT, 2005. Award presented to one Yale GI Fellow annually.
Travel Scholarship – Stem Cells in Gastrointestinal Development, Regeneration and Neoplasia, American Gastroenterological Association, Reston VA, 2006. Poster: An improved protocol for identifying marrow-derived cells in the liver and gastrointestinal tract.
Research Funding:
Ongoing:
NIH-NIDDK Mentored Clinical Scientist Career Development (K08) Award
1K08-DK073404
Title: “Liver injury and repopulation by bone marrow stem cells”
Mentor: Diane S. Krause, Yale University School of Medicine
Effective Dates: 7/1/2006 through 6/30/2011
Total Direct Costs: $621,565
NIH-NIDDK Small grant program for NIDDK K01/K08/K23 recipients
1R03DK088166-01A1
Title: “Investigation of the liver progenitor niche using CK19 lineage tracing”
Effective dates: 10/1/2010 – 9/30/2012
Total direct costs: $100,000 (mouse colony expenses, laboratory supplies)
Completed:
Yale Center of Excellence in Molecular Hematology, Pilot Project Award
Title: “Liver injury and repopulation by bone marrow stem cells”
Effective dates: 9/1/2006 through 8/31/2007
Total direct costs: $10,000
Yale Liver Center Pilot Project Award (P30)
Title: “Bone marrow mesenchymal stem cell transplantation for liver disease”
Effective Dates: 9/1/2008 through 8/31/2009
Total direct costs: $20,000 (supplies and research expenses)
National Organization for Rare Diseases
Tyrosinemia Pilot Project Award
“Bone marrow mesenchymal stem cell transplantation for liver disease”
Effective dates: 11/1/2008 through 10/31/2009
Total direct costs: $30,000 (toward salary support for postdoctoral fellow)
NIH-NIDDK ARRA Administrative Supplement
1K08-DK073404
Title: “Liver injury and repopulation by bone marrow stem cells”
Effective dates: 7/01/2009 - 6/30/2010
Total direct costs: $52,531 (supports salary of a postdoctoral associate for one year)
Reviewer:
Clinical Gastroenterology and Hepatology
Gastroenterology
Hepatology
Stem Cells
Cytotherapy
UK Stem Cell Foundation
Burroughs Wellcome Trust
Journal of Clinical Gastroenterology
Liver International
Cloning and Stem Cells
Cell Stem Cell
Nature Cell Biology
BMC Gastroenterology
International Society for Stem Cell Research (Endodermal Stem Cells)
Mentoring activities:
Camille Hardiman
University of Pennsylvania
Yale BioSTEP Summer Research Program, 2006
Current position: Graduate Student, Molecular, Cellular and Developmental Biology, Yale University School of Medicine, New Haven, CT
Maria Mazzeo, MD
Yale University School of Medicine
Medical Student Thesis, 2006-2007
“The role of bone marrow-derived cells in a model of hepatic regeneration”
Current position: Resident in Anesthesiology, Weill Cornell Medical College, New York, NY
Jennifer Przybylo
Yale University
Undergraduate Research, 2007-2008
Received the Boell Award for excellence in senior research for her presentation:
“Is cell-cell fusion in the liver a physiological or pathological process, and can it be modeled in vitro?”
Current Position: Master’s Degree Program in Bioinformatics, Cambridge University, UK
Mehdi Mohamadnejad, MD
Assistant Professor, University of Tehran, Iran
Visiting Assistant Professor, Yale University School of Medicine, 2007-2009
Research topic: Bone marrow mesenchymal stem cells for treatment of liver disease
Current position: Fellow, Advanced Endoscopy and Endoscopic Ultrasound, Indiana University School of Medicine, Indianapolis, IN.
Julie Xanthopoulos
Student, MD/PhD Program
Yale University School of Medicine
Graduate student thesis, 2008 – present
Shared advisee with Fred Gorelick (Internal Medicine and Molecular, Cell and Developmental Biology)
Research topic: Investigation of the role of polyploidy in the exocrine pancreas
Preclinical clerkship tutor
Yale University School of Medicine
2008-2010
Instruct first and second-year medical students in taking medical history and performing physical examination
Bo Liu, MD
Associate Professor, Sun Yat-sen University, Guangzhou, China
Visiting Assistant Professor, Yale University School of Medicine
2009-2011
Research topic: Liver repopulation by bone marrow mesenchymal stem cells.
Guoyi Wu MD, PhD
Postdoctoral Associate
2010-2011
Research topic: Cell fusion in the liver.
Organizer, Yale Stem Cell Journal Club
Fall 2006 – Spring 2010
This monthly meeting brings together a diverse group of researchers and clinicians to discuss research-in-progress or review new published papers related to stem cell research.
Course Director, Digestive Diseases Case Conference Series
July 2011 – present
This weekly CME-approved case conference provides continuing education for medical students, medical residents, gastroenterology fellows and attending physicians. The topics include a broad spectrum of diseases including hepatic, pancreatic and biliary disease, gastrointestinal luminal disorders, inflammatory bowel disease, intestinal motility disorders, and gastrointestinal malignancies.
Didactic teaching and invited lectures:
Connecticut United for Research Excellence (CURE), Teacher Training Program
New Haven, CT
“Stem cell therapy for liver disease – prospects and challenges”
June 2007
Yale University
Molecular, Cell and Developmental Biology 601
“Directed differentiation of embryonic stem cells for therapy”
October 2007
Yale University
Internal Medicine Research Conference
“Stem cell research: Opportunities and challenges for gastroenterology”
March 17, 2008
VA Connecticut Health Care
Hepatitis C Resource Center, Liver Update