Table 2. Annual Expected Health Impact by Individual Treatment Offered in Isolation Or

Table 2. Annual expected health impact by individual treatment offered in isolation or by combination of treatments

Intervention / treatment group / “Patients-to-be-treated” (% of all patients)* / Risk of death by treatment status group / No. of expected deaths / RRR for death / PPE-deaths
(% of all expected) / No. of readmissions
/patient / Expected readmissions due to all causes / RRR for readmission / PPE-readmissions
(% of all expected) / Readmissions (all causes) prevented as % of
all EMAs
Model 1 (optimal uptake of spironolactone, carvedilol and N-LEI by individual treatment)
S Alone / 169 (59%) / 0.32 / 54 / 0.30 [10] / 16 (18%) / 0.54 / 91 / 0.18 [10] / 16 (11%) / 0.14%
C Alone / 180 (63%) / 0.32 / 58 / 0.35 [30] / 20 (22%) / 0.54 / 97 / 0.2 [31] / 19 (13%) / 0.17%
N-LEI Alone / 243 (85%) / 0.32 / 78 / *** [11] / 0 (0%) / 0.54 / 131 / 0.23 [11] / 30 (20%) / 0.26%
Model 2 (optimal combined uptake of spironolactone and carvedilol by all eligible but untreated patients)
S Alone / 63 (22%) / 0.32 / 20 / 0.30 [10] / 6 / 0.54 / 34 / 0.18 [10] / 6
C Alone / 74 (26%) / 24 / 0.35 [30] / 8 / 40 / 0.2 [31] / 8
S + C / 106 (37%) / 34 / 0.55** / 19 / 57 / 0.34* / 20
No S/C / 43 (15%) / 14 / 0 / 0 / 23 / 0 / 0
Model 2 total / 286 / 92 / 33 (36%) / 154 / 34 (22%) / 0.29%
Model 3 (optimal combined uptake of spironolactone, carvedilol and N-LEI by all eligible but untreated patients)
S Alone / 9 (3%) / 0.32 / 3 / 0.30 [10] / 1 / 0.54 / 5 / 0.18 [10] / 1
C Alone / 11 (4%) / 4 / 0.35 [30] / 1 / 6 / 0.20 [31] / 1
N-LEI Alone / 37 (13%) / 12 / *** [11] / 0 / 20 / 0.23 [11] / 5
S + C / 16 (6%) / 5 / 0.55** / 3 / 9 / 0.34* / 3
C +N-LEI / 63 (22%) / 20 / 0.35** / 7 / 34 / 0.38* / 13
S + N-LEI / 53 (19%) / 17 / 0.30** / 5 / 29 / 0.37* / 11
S + C + N-LEI / 90 (31%) / 29 / 0.55** / 16 / 49 / 0.49* / 24
No S/C/N-LEI / 7 (2%) / 2 / 0 / 0 / 4 / 0 / 0
Model 3 total / 286 / 92 / 33 (36%) / 154 / 57 (37%) / 0.5%

S=Spironolactone, C=Carvedilol, N-LEI-Nurse-led educational intervention, RRR = Relative Risk Reduction, PPE = Prevented or Postponed Events, EMA = emergency medical admission

*See Appendix ** As per reference [35] *** Unclear