This 1 CU Class Will Be Offered Every Year Beginning Spring 2018

Topics in Translational Neuroscience

This 1 CU class will be offered every year beginning spring 2018

This course will introduce graduate students in neuroscience and related disciplines to basic mechanisms and clinical features of major categories of nervous system disease. Each two-hour classwill consist of two parts; a formal lecture followed by a seminar on the same topic.The formal basic science lectures will discuss genetic, molecular, and cellular mechanisms relevant to the disease examined while the seminar will illustrate how that information can be used is the clinical setting to promote further discovery and inform treatment. Some of the seminars will be associated with the Clinical Neuroscience Training Program (CNST) to provide the opportunity to interact with medical students and clinicians. The course will rely on assigned readings of primary research papers and discussions during class.

Purpose

While many NIH programs support research experiences for new basic and new clinician scientists, not all of these trainees have the opportunity to receive formal course work and training experience needed to move across the broad range of disciplines needed to translate basic discoveries in to proven therapies. Areas of potential overlap include hypothesis development, the design of clinical research projects, biostatistics, epidemiology, and the legal, ethical and regulatory issues related to clinical research.

The course consists of lectures, discussions, and oral presentations of original papers by the class and is oriented for both pharmacology and non-pharmacology majors.

01-12-2018: Introduction to the course (NGG students only)JMEC 505EW

12-1:Mariella De Biasi

01-19-2018 Topic1.Impulse control disorders (ICDs)and the dopaminergic system (NGG-CNST): Smilow10-146

12-1 PM Dopamine/Impulse part-I: Mariella De Biasi

1-2PM Translational/clinical impulse control : hoarding – Daniel Weintraub, MD, Department of Psychiatry, PSOM

01-26-2018 Topic 2.Impulse control disorders (ICDs)and the dopaminergic system (NGG) Location TBD

12-1PM Dopamine/Impulse part II–Mariella De Biasi

1-2 PM: Translational Addiction studies: Becky Ashare/ Loughhead

02-02-2018 Topic 3. Hunger circuits and Obesity/Eating Disorders (NGG)Smilow 12-146

12-1PM: De Biasi/Nicholas Betley/ Harvey Grill

1-2PM: Translational/clinical Compulsive eating – Hayes/Wadden

02-09-2018 Topic 4. Synaptogenesis/circuit-ogenesis & schizophrenia (NGG and CNST) JMEC 515EW

12-1 PM synaptic deficits and IPSc cell technology Ming/Song, Anderson

[or: thalamcortical/fronto striatal circuitry]

1-2PM Neural circuitry of negsympstoms/psychosis.Dan Wolf MD.PhD, Department of Psychiatry, PSOM

02-16-2018 Topic 5.Fear Circuitry & Anxiety Disorders (NGG)Smilow 12-146

12-1: circuitry of fear &anxiety. De Biasi/ Eisch/Muzzio

1-2: translational/clinical anxiety – Sheline/Kaczurkin

02-23-2018 Topic 6: Neuroinflammation (NGG and CNST) JMEC 506

12-1: Immunotherapy and basic immunomechanisms in Alzheimer’s andNeuro-autoimmune diseases. Alon Monsonego, Ben-Gurion University, Israel

1-2p: MS and the immune system. Amit Bar-Or MD, Department of Neurology, PSOM

03-02-2018 Topic 7 Proliferation, Apoptosis & Glioblastoma (NGG)Smilow 12-146

12-1PM: Neural proliferation/apoptosis -?[Yuanquan Song]

1-2PM: Translational tumor immunotherapy: Vonderheide/ O’Rourke/June

03-09-2018 Spring Break- no class

03-16-2018 Topic 8 Olfaction or Audition (NGG & CNST) Smilow 10-146

12-1PM: Ma, Mainland, Gottfried (olf) or Maria Geffen (audit)

1-2 PM: Translational: Noam Cohen (olf), Eliades (audit)

03-23-2018 Topic 9 Visual system & Retinal degeneration (NGG & CNST)JMEC 506

12-1PM: visual/retinal physiology Gustavo Aguirre, Jessica Morgan

1-2 PM: Translational talk: retinal gene therapy: bennett, ben kim, geoffaguirre

03-30-2018 Topic 10 Olfaction or AuditionSmilow 12-146

12-1PM: Ma, Mainland, Gottfried (olf) or Maria Geffen (audit)

1-2 PM: Translational: Noam Cohen (olf), Eliades (audit)

04-06-2018 Topic 11 PainSmilow 12-146

12-1PM: Somatosensory mechanisms of pain & itch – WenquinLuo ?

1-2PM: Translational pain – Beth Winkelstein/ Tom Scott

04-13-2018 Topic 12 Spinal cord injury Smilow 12-146

12-1PM: Axonal outgrowth/critical windows: Granato, Kalb?

1-2PM:Translational/clinical neural repair -Bayatmakou (survivor), Wolfe, Cullen,

04-20-2018 Topic 13 Traumatic Brain Injury MINISYMPOSIUM (3 hr) (NGG and CNST)Smilow10-146

12-1PM: TBI: Kiva Cohen

1-3 PM: Translational TBI (Kiva decides)

?neurosurgeon?[cnst did isaacchen already] critical care?

Neuroradiology

Neurorehab?

Patient/Survivor - Candace Grant triathlete