Tigaran et al MS # 200 102432

EVIDENCE OF CARDIAC ISCHEMIA DURING SEIZURE IN DRUG REFACTORY EPILEPSY PATIENTS

Corresponding author: Simona Tigaran M.D., PhD.

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Table 1. Patients characteristics by MRI lesion–site, EEG focus, drugs and seizure frequency

where* indicates the patients with positive ST-segment changes

Pt no / MRI lesion / EEG focus / Number of Recorded
Seizures
Sec. Generalized (GTC)
Compl. Partial without Sec. Gen (CPS)
Simple partial (SP) / Drugs / Known monthly
Seizure
Frequency
1* / Left temp cavernous haemangioma + right parietal venous angioma / Left temp / 6 GTC
2 CPS
*in 1 GTC at 00:54 / Topiramate +
Clonazepam / 30
2 / Left hippocampus gliosis and mesial temporal sclerosis / No sz during monitoring / 0 / Vigabatrin / 4
3 / Left hippocampus gliosis / Left temp / 6 GTC / Lamotrigine / 3
4* / Left temp glioma or harmatoma / Left temp / 1 CPS
*in 1 CPS at 06:31 / Topiramate / 4
5 / Right hippocampus gliosis / Right and left temp / 7 SP / Oxcarbazepine +
Gabapentine / 6
6* / Left + right frontal contusions / Right frontal / 3 GTC
*in 1 GTC at 06:56 / Oxcarbazepine +
Gabapentine / 10
7* / Left hippocampus gliosis / Uncertain left temp / 1 CPS
1 GTC
*in 1 GTC at 08:48
after 90 min / Topiramate +
Vigabatrin + Clobazam / 5
8* / Right hippocampus gliosis / Right temp / 6 CPS
*in 1 CPS at 19:41 / Carbamazepine+
Topiramate + Lamotrigine +
Clobazam / 2
9* / Right hippocampus atrophy / Right and left temp / 9 GTC
*in 1 GTC at 01:00 / Topiramate + Clobazam / 7
10 / Left hippocamus gliosis / Left temp / 11 CPS / Topiramate +
Clobazam / 4
11 / Cortical atrophy, possible a left side WM solitar lesion / Presumably right temp
Intracranial monitoring required / 4 GTC
1 CPS / Oxcarbazepine +
Topiramate +
Vigabatrin / 7
12* / Left parietal contusion ?, ulegyria? / Multifocal / 6 GTC
4 CPS
* in 1 GTC at 01:16 / Carbamazepine / 15
13 / Right frontal contusion / Presumably right frontal
Intracranial monitoring required / 4 GTC / Oxcarbazepine +
Tiagabine / 6
14* / Right hippocampus atrophy with gliosis / Undeter-minable
Intracranial monitoring required / 7 CPS
1 SP
*in 1 CPS at 04:16 / Lamotrigine +
Topiramate / 5
15 / Left hippocampus sclerosis + right occipital cystic process / Left temp + right occipital / 5 GTC
5 CPS
2 SP / Oxcarbazepine +
Clobazam / 15
16* / Left temp tumor (gangliogliom?) / Left temp / 2 GTC
3 CPS
*in 1 GTC at 22:44 / Lamotrigine / 15
17 / Left hippocampus gliosis / Undeter-minable
Intracranial monitoring required / 16 CPS / Carbamazepine +
Clonazepam +
Lamotrigine +
Topiramate / 180
18 / Normal / Left + right temporo-frontal / 3 GTC
3 CPS / Clonazepam +
Topiramate +
Valproate / 4
19 / Right mesio-temp cystic tumor / Right temp / 1 GTC
5 CPS / Oxcarbazepine +
Topiramate +
Clobazam / 2
20 / Left hippocampus atrophy and left hemisphere atrophy / Right temp / 2 GTC
4 CPS / Topiramate +
Oxcarbazepine +
Clonazepam +
Lamotrigine / 20
21 / Right hippocampus gliosis / Right pre-temporo-frontal / 2 GTC
4 CPS / Clonazepam +
Carbamazepine / 30
22 / Left mesio-temp dermoid cyst and left hippocampus gliosis / Left temp / 4 GTC / Lamotrigine / 8
23 / Left hippocampus tumor? / Left fronto-temporal / 1 GTC
1 CPS / Topiramate +
Phenytoin +
Vigabatrin / 2
Median =6

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