The Fragility of Statistically Significant Findings in Randomized Controlled Anaesthesiology Trials – a Systematic Review

SUPPLEMENTARY ONLINE CONTENT

Guido Mazzinari1, Lorenzo Ball2, Ary Serpa Neto3,4, Carlos L. Errando5,

Arjen M. Dondorp6, Lieuwe D. Bos4,Marcelo Gama de Abreu7,

PaoloPelosi2, Marcus J. Schultz4,6

Hospital de Manises, Valencia, Spain

1Research Group in Perioperative Medicine Hospital Universitario y Politecnico La Fe, Valencia, Spain

Policlinico San Martino Hospital – IRCCS for Oncology, Genoa,Italy

2Department of Surgical Sciences and Integrated Diagnostics

Hospital Israelita Albert Einstein, São Paulo, Brazil

3Department of Critical Care Medicine

Academic Medical Center, Amsterdam, The Netherlands

4Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A)

Consorcio Hospital General Universitario deValencia, Valencia, Spain

5Department of Anesthesiology, Resuscitation and Pain Treatment

Mahidol University, Bangkok, Thailand

6Mahidol Oxford Research Unit (MORU)

TechnischeUniversität Dresden, Dresden, Germany

7Department of Anesthesiology and Intensive Care Therapy

eTable 1 – List of Journals
Anesthesiology / Impact Factor1
Chest / 6.136
British Journal of Anaesthesia / 5.616
Anesthesiology / 5.264
Anesthesia & Analgesia / 3.827
Anaesthesia / 3.794
Regional Anesthesia and Pain Medicine / 3.459
European Journal of Anaesthesiology / 3.364
Journal of Neurosurgical Anesthesiology / 2.828
Canadian Journal of Anaesthesia / 2.139
ActaAnaesthesiologicaScandinavica / 2.049
International Journal of Obstetric Anesthesia / 2.040
Minerva Anestesiologica / 2.036
Journal of Cardiothoracic and Vascular Anesthesia / 1.519
Journal of Clinical Anesthesia / 1.284
Anaesthesia and Intensive Care / 1.283
General medicine
The New England Journal of Medicine / 59.558
The Lancet / 44.020
The Journal of American Medical Association / 37.680
British Medical Journal / 19.697
Annals of Internal Medicine / 16.593
1 2015 Journal Citation Reports Impact Factor

PubMed full search criteria

(1991 : 2016[dp]) AND (((((((((((((((("dead"[Title/Abstract] OR "death"[Title/Abstract] OR "died"[Title/Abstract] OR "mortality"[Title/Abstract] OR "surviv*"[Title/Abstract]) OR "delirium"[Title/Abstract] OR "cognitive dysfunction"[Title/Abstract]) OR "myocardial ischemia"[Title/Abstract] OR "perioperative ischemia"[Title/Abstract]) OR "venous thrombosis"[Title/Abstract]) OR "pulmon*"[Title/Abstract]) OR "renal insufficiency"[Title/Abstract] OR "acute kidney injury"[Title/Abstract] OR "acute renal failure"[Title/Abstract]) OR "blood transfusion"[mh]) OR "postoperative complication"[Title/Abstract] OR "postoperative complications"[mh]) OR "postoperative residual curarization"[Title/Abstract] OR "postoperative residual paralysis"[Title/Abstract] OR "postoperative residual neuromuscular block"[Title/Abstract] OR "postoperative residual neuromuscular blockade"[Title/Abstract]) OR "delayed emergence from anesthesia"[mh]) OR "failed intubation"[Title/Abstract] OR "airway management"[mh] OR "intubation, intratracheal"[mh] OR "laryngeal Masks"[mh]) OR "injections, epidural"[mh] OR "injections, spinal"[mh] OR "anesthesia, conduction"[mh]) OR "perioperative care"[mh]) OR "hemodynamics"[mh]) OR "surgical wound infection"[mh]) OR "cesarean section"[Title/Abstract] OR "postpartum hemorrhage"[Title/Abstract] OR "eclampsia"[Title/Abstract] OR "preeclampsia"[Title/Abstract] OR "pre-eclampsia"[Title/Abstract] OR "hellp syndrome"[Title/Abstract] OR "neonatal mortality"[Title/Abstract] OR "anesthesia, obstetrical"[mh]) OR ("anesthesia and analgesia"[mh]) NOT (pediatric[Title/Abstract] OR children[Title/Abstract] OR infant*[Title/Abstract] OR neonate*[Title/Abstract] OR protocol[Title/Abstract] OR fetal[Title/Abstract] OR post hoc[Title/Abstract]) AND (english[Language]) AND (randomized controlled trial[Publication Type]).

eTable2 – GRADE1 rank of outcomes
Importance of outcomes / GRADE rank / Outcome (examples)
9 /
  • Mortality

CRITICAL
Requiring major interventions, prolonged monitoring, or admission to ICU / 8 /
  • Organ failures, including major pulmonary complications, major cardiac events, kidney failure requiring RRT, delirium, need for inotropic drugs/vasopressors, severe stroke, pulmonary aspiration

7 /
  • CP bypass weaning failure
  • Mild stroke
  • Pulmonary embolism
  • Eclampsia/ HELLP syndrome
  • Post ERCP Pancreatitis

IMPORTANT
Requiring simple interventions / 6 /
  • Surgical infection
  • Cognitive dysfunction
  • Transient perioperative hemodynamic instability requiring drug treatment
  • Airway management faiure

5 /
  • Deep Vein Thrombosis (DVT)
  • Residual curarization
  • Arrythmia
  • Blood Transfusion
  • Regional block related complications (Spinal failure, diaphragmatic paralysis)

4 /
  • Surgical pain
  • Postduralpunction headache

LOW IMPORTANCE
Requiring no immediate actions / 3 /
  • Nausea

2 /
  • Hoarseness

1 /
  • Sore Throat

1Grading of Recommendations Assessment, Development, and Evaluation.
Trials with outcomes of low importance were excluded from the analysis.
eTable3 – List of studies included in the analysis
Year / Journal / Title / Outcome
Analyzed / Number of patients
2016 / Lancet / Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial. / Post ERCP Pancreatitis / 2600
2016 / JAMA / Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery. A Randomized Clinical Trial. / Reintubation / 300
2016 / BJA / Extrafascial injection for interscalene brachial plexus block reduces respiratory complications compared with a conventional intrafascial injection: a randomized, controlled, double-blind trial. / Diaphragmatic paralysis / 40
2016 / Lancet / Dexmedetomidine for prevention ofdeliriumin elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial / Delirium / 700
2016 / BJA / The effects of thermal softening of double-lumen endobronchial tubes on postoperative sore throat, hoarseness and vocal cord injuries: a prospective double-blind randomized trial. / Vocal Cords Injury / 140
2016 / Anesthesiology / Dexmedetomidineversus Propofol Sedation Reduces Delirium after Cardiac Surgery. A Randomized Controlled Trial. / Delirium / 185
2016 / J ClinAnesth / Total intravenousanesthesiawith propofol is associated with a lower rate of postoperativedeliriumin comparison with sevofluraneanesthesiain elderly patients / Delirium / 59
2016 / NEJM / Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. / Infection / 2013
2016 / NEJM / A Randomized Trial Comparing Skin Antiseptic Agents at Cesarean Delivery. / Infection / 1147
2015 / AnesthAnalg / Nicardipine is superior to esmolol for the management of postcraniotomy emergence hypertension: a randomized open-label study. / Hypertension Treatment / 52
2015 / RegAnesth Pain Med / Hemidiaphragmatic paralysis following ultrasound-guided supraclavicular versus infraclavicular brachial plexus blockade: a randomized clinical trial. / Diaphragmatic paralysis / 64
2015 / Anaesthesia / Incidence of intravascular injection and the spread of contrast media during S1 transforaminal epidural steroid injection by two approaches: anteroposteriorvs oblique / Vertebral IV Injection / 208
2015 / Anesthesiology / Effects of an Innovative Psychotherapy Program for Surgical Patients: Bridging Intervention inAnesthesiology--ARandomized Controlled Trial. / Psychological Followup / 220
2015 / JAMA / Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery. A Randomized Clinical Trial / AKI / 240
2015 / Chest / A Double-Blind Placebo-Controlled Study of the Effects of Olprinone, a Specifi c PhosphodiesteraseIII Inhibitor, for Preventing Postoperative Atrial Fibrillation in Patients Undergoing Pulmonary Resection for Lung Cancer / Arrythmia / 50
2015 / Anesthesiology / Transfusion Requirements in Surgical Oncology Patients A Prospective, Randomized Controlled Trial / Mortality / 198
2015 / BJA / Effects of sugammadex on incidence of postoperative residual neuromuscular blockade: a randomized, controlled study / Postoperative Residual Curarization / 154
2014 / BJA / 6% Hydroxyethyl starch (130/0.4) vs Ringer's lactate preloading before spinal anaesthesia for Caesarean delivery: the randomized, double-blind, multicentre CAESAR trial. / Hemodynamic / 167
2014 / JAMA / Colchicine for prevention of postpericardiotomy syndrome and postoperative atrial fibrillation: the COPPS-2 randomized clinical trial. / Adverse Cardiac Outcome / 360
2014 / J NeurosurgAnestheiol / A comparison of the GlideScope with the Macintosh laryngoscope for nasotracheal intubation in patients with ankylosingspondylitis. / Airway success / 60
2014 / EJA / The effect of adjusting tracheal tube cuff pressure during deep hypothermic circulatory arrest. A randomised trial / Subglottic
Aspiration / 24
2014 / EJA / Reduction in the incidence of acute kidney injury after aortic arch surgery with low-dose atrialnatriureticpeptide.Arandomised controlled trial / AKI / 50
2014 / Anesthesiology / Restrictive Deferred Hydration Combined with Preemptive Norepinephrine Infusion during Radical Cystectomy Reduces Postoperative Complications and Hospitalization Time. A Randomized Clinical Trial / Composite / 167
2014 / Anaesthesia / Prophylactic vs therapeutic blood patch for obstetric patients with accidental dural puncture – a randomised controlled trial / Post Dural Punction Headache / 116
2014 / EJA / Comparison of Aintree and Fastrach techniques for low-skill fibreoptic intubation in patients at risk of secondary cervical injury. A randomised controlled trial / Airway Success / 80
2014 / BJA / Tracheal intubation in patients with odentogenous abscesses and reduced mouth opening / Airway Failure / 100
2013 / BJA / Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction / Delirium / 1277
2013 / NEJM / A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery / Composite / 400
2013 / J CardiothoracVascAnesth / Morphine is a Reasonable Alternative to Haloperidol in the Treatment of Postoperative Hyperactive-Type Delirium After Cardiac Surgery / Delirium / 53
2013 / J NeurosurgAnesthesiol / BIS-guided Anesthesia Decreases Postoperative Delirium and Cognitive Decline / Cognitive Dysfunction / 921
2012 / AnesthAnalg / Reduction in Intraoperative Bacterial Contamination of Peripheral Intravenous Tubing Through the Use of a Passive Catheter Care System / Bacterial Contamination / 594
2012 / Anesthesiology / Early Treatment with Risperidone for Subsyndromal Delirium after On-pump Cardiac Surgery in the Elderly. A Randomized Trial / Delirium / 101
2012 / AnesthAnalg / Tranexamic Acid Reduces Blood Loss After Off-Pump Coronary Surgery: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study / Blood Transfusion / 260
2012 / Anesthesiology / Comparative effectiveness of the C-MAC video laryngoscope versus direct laryngoscopy in the setting of the predicted difficult airway / Airway Success / 300
2012 / Anesthesiology / Association between the apolipoprotein E4 and postoperativecognitive dysfunctionin elderly patients undergoing intravenous anesthesia and inhalation anesthesia / Cognitive dysfunction / 2000
2011 / Anesthesiology / Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery / Blood transfusion / 74
2011 / Anesthesiology / Intraoperativeacceleromyography monitoring reduces symptoms of muscle weakness and improves quality of recovery in the early postoperative period / Curarization / 155
2011 / Anesthesiology / Ultrasound imaging facilitates spinal anesthesia in adults with difficult surface anatomic landmarks / Spinal anesthesia success / 145
2011 / EJA / Effect of auditory evoked potential-guided anaesthesia on consumption of anaesthetics and early postoperative cognitive dysfunction: a randomised controlled trial / Cognitive dysfunction / 451
2011 / ActaAnaesthesiol Scand / Intraoperative warming and post-operative cognitive dysfunction after total knee replacement / Cognitive Dysfunction / 150
2011 / EJA / The influence ofresidual neuromuscular blockon the incidence of critical respiratory events. A randomised, prospective, placebo-controlled trial / Pulmonary / 114
2011 / JAMA / Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study / Pulmonary / 150
2011 / Anaesthesia / The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery / Cognitive dysfunction / 182
2011 / J NeurosurgAnesth / Deeper total intravenousanesthesiareduced the incidence of early postoperativecognitive dysfunctionafter microvascular decompression for facial spasm / Cognitive dysfunction / 96
2010 / Anesthesiology / Comparison of Single-use and Reusable Metal Laryngoscope Blades for Orotracheal Intubation during Rapid Sequence Induction of Anesthesia / Airway Failure / 1072
2010 / Anesthesiology / Perioperative Intravenous Amiodarone Does Not Reduce the Burden of Atrial Fibrillation in Patients Undergoing Cardiac Valvular Surgery / Arrythmia / 120
2010 / NEJM / Preventingsurgical-site infections in nasal carriers of Staphylococcus aureus / Infection / 918
2010 / NEJM / Apixaban versus Enoxaparin for Thromboprophylaxis after Hip Replacement / Composite / 5407
2010 / Anesthesiology / Cosyntropin for prophylaxis against postdural puncture headache after accidental dural puncture / PostduralPuncttion Headache / 95
2010 / Lancet / Effects of tranexamic acid ondeath, vascular occlusive events, andblood transfusionin trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. / Mortality / 20211
2010 / JAMA / Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: arandomized controlled trial / Lung transplant validity / 118
2009 / Minerva Anestesiol / Training resident anesthesiologists in adult challenging intubation comparing
Truview EVO2™ and Macintosh laryngoscope: a preliminary study / Airway Failure / 30
2009 / JAMA / Effects of Donor Pretreatment With Dopamine on Graft Function After Kidney Transplantation. A Randomized Controlled Trial / Dyalisis / 505
2009 / Chest / Prophylactic Nasal Continuous Positive Airway Pressure Following Cardiac
Surgery Protects From Postoperative Pulmonary Complications A Prospective, Randomized, Controlled Trial in 500 Patients / Pulmonary / 500
2009 / Anesthesiology / Continuous Perioperative Insulin Infusion Decreases Major Cardiovascular Events in Patients Undergoing Vascular Surgery. A Prospective, Randomized Trial / Composite / 242
2009 / Anesthesiology / Safety and Efficacy of Intensive Insulin Therapy in Critical Neurosurgical Patients / Hypoglucemia / 483
2009 / J CardiothoracVascAnesth / Ketamine Attenuates Delirium After Cardiac Surgery With
Cardiopulmonary Bypass / Delirium / 58
2009 / EJA / Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion in small adults: a prospective, randomized trial / Blood Transfusion / 120
2009 / ActaAnaesthesiol Scand / Ketamine attenuates post-operativecognitive dysfunctionafter cardiac surgery / Cognitive dysfunction / 52
2009 / BMJ / Does single application of topical chloramphenicol to high risk sutured wounds reduce incidence of wound infection after minor surgery? Prospective randomised placebo controlled double blind trial / Infection / 1014
2008 / AnesthAnalg / Tranexamic Acid and Aprotinin in Primary Cardiac Operations: An Analysis of 220 Cardiac Surgical Patients Treated with Tranexamic Acid or Aprotinin / Blood Transfusion / 220
2008 / Anesthesiology / Success of Tracheal Intubation with Intubating Laryngeal Mask Airways A Randomized Trial of the LMA Fastrach™ and LMA CTrach™ / Airway success / 271
2008 / BJA / Tracheal intubation of morbidly obese patients: a randomized trial comparing performance of Macintosh and Airtraq laryngoscopes / Airway Failure / 106
2008 / Lancet / Effects of extended-release metoprololsuccinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial / Composite / 9298
2008 / Anesthesiology / Intraoperativeacceleromyographic monitoring reduces the risk of residual neuromuscular blockade and adverse respiratory events in the postanesthesia care unit / Curarization / 185
2008 / BJA / Pentax-AWS, a new videolaryngoscope, is more effective than the Macintosh laryngoscope for tracheal intubation in patients with restricted neck movements: a randomized comparative study / Airway success / 203
2008 / J CardiothoracVascAnesth / Jugular bulb venous oxygen saturation during one-lung ventilation under sevoflurane- or propofol-based anesthesia for lung surgery / Cerebral desaturation / 52
2008 / NEJM / Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty / Deep Venous Thrombosis / 3364
2007 / J NeurosurgAnesthesiol / The Effect of Intensive Insulin Therapy on Infection Rate, Vasospasm, Neurologic Outcome, and Mortality in Neurointensive Care Unit After Intracranial Aneurysm Clipping in Patients With Acute Subarachnoid Hemorrhage. A Randomized Prospective Pilot Trial / Infection / 78
2007 / AnaesthInt Care / Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery / Delirium / 126
2007 / Anaesthesia / Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium / Curarization / 338
2007 / J CardiothoracVascAnesth / Fenoldopam infusion for renal protection in high-risk cardiac surgery patients: a randomized clinical study / AKI / 194
2006 / Anesthesiology / Comparison of Plastic Single-use and Metal Reusable Laryngoscope Blades for Orotracheal Intubation during Rapid Sequence Induction of Anesthesia / Airway Failure / 284
2006 / JAMA / Prevention of Nosocomial Infection in Cardiac Surgery by Decontamination
of the Nasopharynx and Oropharynx With ChlorhexidineGluconate. A Randomized Controlled Trial / Infection / 991
2006 / JAMA / Preoperative intensive inspiratory muscle training to prevent postoperative pulmonary complications in high-risk patients undergoing CABG surgery: a randomized clinical trial / Pulmonary / 279
2005 / J ClinAnesth / Intraoperativemyocardial ischemiain peripheral vascular surgery: generalanesthesiavs combined sciatic and femoral nerve blocks / Myocardial Ischemia / 50
2005 / Anesthesiology / Prevention of hypotension during spinal anesthesia for cesarean delivery: an effective technique using combination phenylephrine infusion and crystalloid cohydration / Hemodynamic / 112
2005 / JAMA / Prophylactic Oral Amiodarone for the Prevention of Arrhythmias that Begin Early After Revascularization, Valve Replacement, or Repair: PAPABEAR: arandomized controlled trial / Arrythmia / 601
2005 / JAMA / Continuous positive airway pressure for treatment of postoperative hypoxemia: arandomized controlled trial / Intubation / 209
2004 / AnaesthInt Care / Gum Elastic Bougie-guided Insertion of the ProSeal Laryngeal Mask Airway / Airway success / 100
2004 / AnesthAnalg / Continuous positive airway pressure versus noninvasive pressure support ventilation to treat atelectasis after cardiac surgery / Atelectasis / 150
2004 / JAMA / Surgical site infection and the routine use of perioperativehyperoxia in a general surgical population: arandomized controlled trial / Infection / 160
2004 / Can J Anaesth / Aprotinin decreases the incidence of cognitive deficit following CABG and cardiopulmonary bypass: a pilot randomized controlled study / Cognitive Dysfunction / 36
2003 / BJA / Randomized comparison of the classic Laryngeal Mask Airway with the Airway Management Device during anaesthesia / Airway Failure / 100
2003 / J NeurosurgAnesthesiol / Hemodynamic Stability, Myocardial Ischemia, and Perioperative Outcome After Carotid Surgery with Remifentanil/Propofol or Isoflurane/Fentanyl Anesthesia / Cardiac Ischemia / 59
2003 / ActaAnaesthesiol Scand / Slow rewarming improves jugular venous oxygen saturation during rewarming / Cerebral Oxygen Desaturation / 100
2003 / AnesthAnalg / Recovery of neuromuscular function after cardiac surgery: pancuronium versus rocuronium / Curarization / 82
2003 / Anesthesiology / Preoperative Cardiac Events in Elderly Patients with Hip Fracture Randomized to Epidural or Conventional Analgesia / Cardiac Event / 68
2002 / AnesthAnalg / Endotracheal Intubation with a Gum-Elastic Bougie in Unanticipated Difficult Direct Laryngoscopy: Comparison of a Blind Technique Versus Indirect Laryngoscopy with a Laryngeal Mirror / Airway Failure / 60
2002 / Anesthesiology / A Multicenter Study Comparing the ProSeal and Classic Laryngeal Mask Airway in Anesthetized, Nonparalyzed Patients / Airway success / 384
2002 / Can J Anaesth / Antidepressant treatment for chronic depressed patients should not be discontinued prior to anesthesia / Delirium / 80
2002 / EJA / Myocardial Ischemia in Ptients with Impaired Left VEntricular Function Undeergoing Coronary Artery Bypass Grafting - Milrinone versus Nifedipine / Cardiac Ischemia / 30
2002 / AnesthAnalg / The Effect of Lidocaine on Early Postoperative Cognitive Dysfunction After Coronary Artery Bypass Surgery / Cognitive Dysfunction / 118
2002 / Anesthesiology / Effectiveness of acute normovolemichemodilution to minimize allogeneicblood transfusionin major liver resections / Blood Transfusion / 78
2002 / Lancet / Do women withpre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial / Eclampsia / 10141
2002 / Lancet / Effect of preoperative smoking intervention onpostoperative complications: a randomised clinical trial / Composite / 120
2001 / AnesthAnalg / A Prospective Randomized Study of the Potential Benefits of Thoracic Epidural Anesthesia and Analgesia in Patients Undergoing Coronary Artery Bypass Grafting / Arrythmia / 420
2001 / Anesthesiology / Gel Lubrication of the Tracheal Tube Cuff Reduces
Pulmonary Aspiration / Pulmonary Aspiration / 36
2001 / AnesthAnalg / The Clinical Relevance of Embolic Events Detected by Transesophageal Echocardiography During Cemented Total Hip Arthroplasty: A Randomized Clinical Trial / Embolia / 120
2001 / Chest / Diltiazem treatment does not alter renal function after thoracic surgery / Arrythmia / 330
2001 / Lancet / Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomised multicentre trial / Composite / 317
2001 / Lancet / Oral amiodarone for prevention of atrial fibrillation after open heart surgery, the Atrial Fibrillation Suppression Trial (AFIST): a randomised placebo-controlled trial / Arrythmia / 220
2001 / BJA / Fast-track cardiac anaesthesia in the elderly: effect of two different anaesthetic techniques on mental recovery / Cognitive Dysfunction / 83
2001 / BJA / Autologousblood transfusionin total knee replacement surgery / Blood Transfusion / 231
2001 / J CardiothoracVascAnesth / Tranexamic acid in aortic valve replacement / Blood Transfusion / 300
2000 / AnaesthInt Care / The Prevention of Pulmonary Aspiration with Control of Tracheal Wall Pressure using a Silicone Cuff / Aspiration / 12
2000 / AnesthAnalg / Nitrous Oxide-Induced Increased Homocysteine Concentrations Are Associated with Increased Postoperative Myocardial Ischemia in Patients Undergoing Carotid Endarterectomy / Cardiac Ischemia / 90
2000 / Lancet / Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP)