Darrel Edmund Drachenberg Bsc, MD, FRCS(C)

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CURRICULUM VITAE

Darrel Edmund Drachenberg BSc, MD, FRCS(C)

Assistant Professor of Surgery, Director of Research,

Manitoba Prostate Centre and Section of Urology, Faculty of Medicine, University of Manitoba,

Chair, Genitourinary Disease Site Group, Cancer Care Manitoba

Academic office: (204) 237-2571

Clinical office: (204) 235-3713

Fax: (204) 237-3429

Email:

Teaching file/ Academic/Clinical:

Assistant Professor, Department of Surgery, Section of Urology –University of Manitoba

Academic Duties-Resident Teaching and Research, Medical School preceptorship and Curriculum Planning & Lectures

Perform majority of Oncology surgeries and all laparoscopic and minimally invasive procedures (brachytherapy, cryotherapy, HIFU, RFA) for the province of Manitoba population over 1 million people

Adept at all urologic laparoscopic procedures including laparoscopic Radical Nephrectomy, laparoscopic partial nephrectomy, laparoscopic adrenalectomy, laparoscopic radical prostatectomy, laparoscopic pyeloplasty

Experience with Urologic uses of ROBOTICS including AEOSOP and DA VINCI

Started the Manitoba Prostate Brachytherapy program, Cryotherapy program, and HIFU programs and RFA programs and continue to lead these minimally invasive approaches to treatment of prostate and renal cancers

Director of Research Department of Surgery, Section of Urology –University of Manitoba

Director of Research Manitoba Prostate Center

Chair- GU Oncology Disease Site Group- Cancer Care Manitoba –clinical trials management, basic science coordination, weekly multidisciplinary rounds organization, treatment guidelines for province of Manitoba GU cancers, etc

Chair Manitoba Medical Association –Urology Section

Quality Assurance Reviewer College of Physicians and Surgeons Manitoba Chapter

Residency

Chief Resident Dalhousie University- 1999-2000, in charge of resident education, departmental academic program, operative instruction to residents, tertiary care consult service, proficient in all operative urologic procedures

Examiner- 4th year medical school OSCE/Oral Examinations-1999-2000

Medical Student teaching in Urology- 1995-2000

Reviewer:

·  Reviewer – Canadian Urological Association Annual Meeting Scientific Committee (2011)

·  Reviewer -Urology (2010)

·  Reviewer – Journal of Canadian Urologival Association (2010)

·  Reveiwer – Canadian Journal of Urology (2010)

·  Reviewer – Lancet Oncology (2010)

·  Journal of Urology

·  Cancer Treatement Reviews

·  Editorial board member and reviewer of educational information of MDCONVERSATION- a company dedicated to dissemination of medical information to patients through the internet and computer based learning

Memberships:

Royal College of Physicians and Surgeons of Canada- Active Member

American Urological Association- Active Member

Canadian Urological Association- Active Member

Canadian Urological Association Exectuive Committee – Chair of the Socioeconomic committee

Canadian Urologic Oncology Group – Executive Committee member – Prairie Regional Head

Chair Genito-Urinary Oncology – Disease Site Group, Cancer Care Manitoba

Doctors Manitoba – Urology lead

Society of Urologic Oncology- Active Candidate Member

National Cancer Institute Canada – Exectuive Committee member

Endourological Society- Active Member

Manitoba Medical Association- Active Member

Canadian Medical Association- Active Member

CUA Scientific Committee (executive member)

Nova Scotia/ New Brunswick Medical Society- Past Member

British Columbia Medical Association- Past Member

Kidney Cancer Canada, Medical Advisory Board member & Executive Committee Member

Canadian Bladder Cancer Network – Executive Committee Member

CME Prostate Health.COM – Exectuive Committee Member

Education

Fellowship training: Urologic Oncology/Laparoscopic Urology

National Cancer Institute/National Institute of Health, Washington, DC

July 2000-June 2002- became adept at minimally invasive oncologic surgery with laparoscopy and percutaneous and laparoscopic radiofrequency ablation; experience with Urologic use of ROBOTICS including AEOSOP and DA VINCI. Became exposed to and mounted research projects in the molecular immunology of GU malignancies.

Awards and Honors

2000  Society of Urologic Oncology First Prize- Genetic Immunization with Prostate Specific Genes leading to Anti-prostate Autoimmunity as a novel model for Prostate Cancer Vaccination

2000 -2002 American Foundation of Urologic Diseases (AFUD)/National Cancer

Institute Research Scholar

Post Graduate Training: Urology Residency

Dalhousie University, Halifax, Nova Scotia

June 1995-June 2000

Awards and Honors

1999  Department of Urology Research Day First Prize-Autoimmune Prostatitis after Genetic Immunization with Probasin and Probasin/IL-12 by Gene Gun Technology and IM Injections

1999 Urology Times of Canada Writing Award Winner First Prize- “The Final Inning” Dissertation about dealing with Terminal Prostate Cancer

1999 Department of Urology Research Day First Prize- Telomerase Activity in Bladder Cancer and Exfoliated Cells in Urine

1998 Faculty of Medicine Research Day First Prize- Telomerase Activity in Bladder Cancer and Exfoliated Cells in Urine

Medical School:

University of British Columbia, Vancouver, British Columbia

August 1990-May 1995

Awards and Honors

1995 Rakesh-Goel Graduation Prize- for overall excellence in all clinical disciplines of medicine throughout medical school

1994 Outstanding Physician/Scientist Award - Society of Nuclear Medicine

19th annual western regional meeting The Use of PSA and Bone Scan in

Patients With Prostate Cancer at Time of Diagnosis

1993 B.C. Medical Services Foundation Bursary - for demonstration of academic excellence in the faculty of medicine

1993 Harold James Russell Memorial Bursary - for overall character and academic achievement

1993 Schom Memorial Bursary

1992 Samuel Diamond Scholarship - for academic excellence in Medicine

1991/92 Microtel Pacific Research Academic Achievement Scholarship

1991 Medical Research Council of Canada Undergraduate Research Award

Undergraduate University Studies:

Simon Fraser University, Burnaby, British Columbia

B.Sc., Molecular Biology / Certificate in Liberal Arts

Co-operative Education Degree

September 1984 - April 1990

Awards and Honors

1990&1991 Medical Research Council of Canada Undergraduate Research Award

1989&1990 Natural Science and Engineering Research Council Award 1988

Presidents Scholarship Microtel Pacific Research Centre - for outstanding academic achievement, citizenship, overall character and athletic ability

1985-1990 Microtel Pacific Research Academic Achievement Award

1985-1990 Deans Honor Roll of Simon Fraser University - for placing in top two

percent of university students

1984-1986 Provincial Academic Achievement Award

1984-1985 Chancellor's Scholarship, - S.F.U. for highschool academic excellence

Research Experience

Current Research Positions: Assistant Professor of Surgery, Director of Research

Manitoba Prostate Centre and Section of Urology, Faculty of Medicine, University of Manitoba

Chair, Genitourinary Oncology Disease Site Group

Cancer Care Manitoba

(Clinical Trial Activity 2010 as Principal Investigator)

PR11-A Phase III Study of Active Surveillance Therapy Against Radical Treatmentin Patients Diagnosed with Favourable Risk Prostate Cancer (START)

PRC.3— A Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatecomy Versus Immediate Radical Prostatectomy in Patients with High-Risk, Clinically Localized Prostate Cancer

REC.2— ASSURE: A Randomized Phase III Study of Adjuvant Sorafenib or Sunitinib for Unfavourable Renal Carcinoma

Tax 3503- ARandomized, Open-Label, Multi-Centre, Phase III, 2-Arm Study of Androgen Deprivation with Leuprolide,+/- Docetaxel for Clinically Asymptomatic Prostate Cancer Subjects with a Rising PSA Following Definitive Local Therapy .

PREVAIL- A Randomized Phase III Study of MDV 3100 vs Placebo in Chemo Naïve Metastatic Hormone Refractory Prostate Cancer

SALVAGE HIFU- A Phase III, Multi-Centre Investigation of the Sonablate 500-PC System Using High Intensity Focused Ultrasound (HIFU) for the Treatment of Locally Recurrent Prostate Cancer after Failed Radiotherapy

July 2002 – 2010 ATLAS: prostate cancer trial of immediate vs delayed chemo-hormonal therapy with LHRH agonist and taxotere for high risk prostate cancer treatment

CHICS: dose escalation bicalutamide for androgen independent prostate cancer

CORAL: the use of oral bisphosphonates ffoxamax to prevent bone loss in patients on androgen ablation therapy

Pseudomonas endotoxin Vincinium for the treatment of superficial BCG refractory bladder cancer

BL8: randomized phase III trial comparing immediate verses deferred chemotherapy after radical cystectomy in patients with pT3-pT4, and/or N+Mo transitional cell carcinoma of the bladder

BL. 11: a phase III study of Iressa® in Association with Intravesical BCG versus Intravesical BCG alone in high risk superficial transitional cell carcinoma of the bladder

PR7: a prospective phase 3 study randomising patients with rising PSAs after radiation therapy to either continuous or intermittent androgen suppression

PR8: a prospective phase 3 study randomising patients with newly diagnosed D2 prostate cancer toeither continuous vs intermittant androgen suppression

Comparison of prostate volumes pre and post brachytherapy implantation with MRI, CT and TRUS ultrasound

The effect of treatment volume on brachytherapy treatment planning post seed implantation in prostate brachytherapy

Circulating levels of spontaneous autoantibodies to NGF in patients with prostate cancer

In VITRO activity of anti NGF IgM to promote apoptosis and inhibit migration and cell growth and division of LN CAP prostate cancer cell line

Prostate cancer biomarkers discovery using high throughput proteomics

The expression of sonic hedgehog protein and cxcr 4 in BPH, PIN, localized and locally advanced and metastatic prostate cancer

The expression of Von Hippel Lindau gene in renal cell cancer of patients with Native Canadian heritage

The use of laparoscopic ligasure sealing system in urologic laparoscopy

The use of radio frequency ablation in patients with small renal masses

Cryotherapy for localized prostate cancer

Cryotherapy as salvage treatment after radiation failure for treatment of prostate cancer

MR diffusion imaging studies to differentiate benign from malignant renal lesions

The role of endorectal coil MRSI for diagnosis of localized prostate cancer

HIFU for localized prostate cancer and as salvage after radiation failure

Clinical and oncologic outcomes of cystectomy in patients in the WRHA for the treatment of muscle invasive bladder cancer-the last decade

July 2000-June 2002: Immunotherapy of Renal Cell Carcinoma and Prostatic Adenocarcinoma/mechanisms of antitumor immune response/ tumor vaccine development through dendrtitic cell-tumor fusion/telomerase (hTert) expression in dendrtic cell via infection with hTert retroviral expression vectors as a mechanism to generate antitumor immunity in RCC and CaP/G250 expression via retroviral vector infection of dendritic cells to generate antitumor immunity in RCC/allogeneic chimerized T-lymphocte antitumor response in RCC after allogeneic Bone Marrow Transplantation/ Antigen discovery in Renal cell carcinoma/prostate adenocarcinoma / Genotypic and Phenotypic differences in RCC characterized via differences in DNA microarray expression analysis in G250 positive and negative RCC and Von-hippel-lindau mutation positive and negative RCC/ Characterization of expression of G250 tumor antigen in RCC and VHL mutation analysis and the pathway of tumorigenesis of mutant VHLprotein and trans-membrane G250

Supervisors: Dr. WM. Linehan/Dr. R Childs

June 1995-June 2000: Dept. of Urology, Dalhousie University

Telomerase Activity in Urologic Malignancies/ Prostate Cancer Vaccine Development using PSMA Genetic Therapy/ A Model of Autoimmune Prostatitis Using Probasin/Il-12 Constructs, Genetic Immunization, and Gene Gun Technology

Supervisor: Dr. David Bell/Dr. Ken West

Radical Prostatectomy and Sexual Dysfunction

Supervisor: Dr. John Grantmyre

Patient Satisfaction after Hypospadius Repair

Supervisor: Dr. Peter Wentzell

May 1993-Aug.1993: Researcher,

Dept. of Urology/Dept. of Nuclear Medicine, UBC

Ability of Serum PSA to Predict Normal Bone Scans in Untreated Prostate Cancer (see publications below)

Supervisors: Dr. M.E. Gleave, M.D. & Dr. D. Coupland, M.D.

May 1991-Aug. 1991: Research Assistant, Dept. of Pathology, Vancouver General Hospital, Identification, Cloning, and Characterization of the Gene for Porphobilinogen Deaminase -to screen for patients with Acute Intermittent Porphyria.

Supervisor: Dr. Wes Schreiber, M.D.

May 1990-Aug. 1990: Research Assistant,

Dept. of Physiology, University to Manitoba

Identification and Characterization of Novel Immunosuppressive Proteins in Prostatic Secretions

Supervisor: Dr. R. Matusik, PhD

Jan. 1989-Jan. 1990: Co-operative Education Research Assistant

The Biomedical Research Centre, Vancouver, British Columbia Development of an in vitro model of Paracrine Oncogenesis through the creation of retroviral expression vectors encoding interleukin-1 . Supervisor: Dr. K. Leslie, M.D. , PhD.

Sept. 1988-Dec.1988: Teacher Advisor/Laboratory Instructor;

Simon Fraser University, Burnaby, British Columbia

Biology Department

Instructor of upper level genetic analysis course BISC 302.

Supervisor: Dr. C. L. Kemp, PhD

Grants

·  Canadian Urologic Association Scolorship Fund 2003-2004
40000/yr renewable for 2 years

·  Sanofi-Aventis Investigator Grant- $90000 - cryotherapy for prostate cancer

·  Novartis Investigator Grant- $50000 - Basic Science prostate cancer research into antibodies to NGF in localized and metastatic prostate cancer

·  Abbott Investigator Grant- $20000 towards prostate cancer research in basic sciences

Publications

·  Guideline for The Management of the Small Renal Mass(SRM). M. A.S. Jewett, R. Rendon, L. Lacombe, P. I. Karakiewicz, S. Tanguay, W. Kassouf, M. Leveridge, I. Cagiannos, A. Kapoor, S. Pautler, D. Drachenberg, R. Moore, M. Gleave, A. Evans, M. Haider. Canadian Urological Association - 2013

·  Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer. Michael A.S. Jewett, Kamal Mattar, Joan Basiuk, Christopher G. Morash, Stephen E. Pautler, D. Robert Siemens, Simon Tanguay, Ricardo A. Rendon, Martin E. Gleave, Darrel E. Drachenberg, Raymond Chow, Hannah Chung, Joseph L. Chin, Neil E. Fleshner, Andrew J. Evans, Brenda L. Gallie, Masoom A. Haiderm, John R. Kachuram, Ghada Kurban, Kimberly Fernandes, Antonio Finelli. European Association of Urology, 2011.

·  Associations between age and clinical outcomes after radical cystectomy: results from the Canadian Bladder Cancer Network Fairey A, Kassouf W, Aprikian A, Fradet Y, Lacombe L, Chin J, Izawa J, Cagiannos I, Lattouf J, Rendon R, Bell D, Drachenberg D, Estey E in press Urologic Oncology - 2010

·  Outcomes of cT1G3 bladder cancer treated with radical cystectomy Canadian Bladder Cancer Network experience; Izawa J, , Kassouf, W, Aprikian A, Fradet Y, Estey E, Fairey A,Rendon R, Cagiannos I, Lacombe L, Lattouf J-B, Bell D, Drachenberg D, Chin J. In press Journal of Canadian Urological Association - 2010

·  The incidence of prostate cancer and urothelial cancer in the prostate in cystoprostatectomy specimens: implications for oncologic surgery Sivalingam S, Drachenberg D- submitted Urology (Gold Journal) - 2010

·  Achieving pT0N0 at radical cystectomy: outcomes of 135 pT0N0 bladder cancer patients treated with radical cystectomy: the Canadian Bladder Cancer Network experience Sandhu, G, Kassouf, W, Aprikian A, Chin J, Fradet Y, Izawa J, Estey E, Fairey A,Rendon R, Cagiannos I, Lacombe L, Lattouf J-B, Bell D, Drachenberg D- submitted Journal of the Canadian Urological Association - 2010

·  Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer, M. Jewett, A. Finelli, I. Link; C. Morash, J. L Chin, S. Pautler, R. Siemens; S. Tanguay, R. A. Rendon, M. E. Gleave, D. Drachenberg, A. Evans, B. Gallie, M. Haider, J.Kachura, T. Panzarella, R. Chow, C. Ma, K. Mattar, N. Fleshner – submitted Journal of Clinical Oncology - 2010

·  Impact of histology on outcomes of radical cystectomy: a series from the Canadian Bladder Cancer Network,