Appendix 2. Univariate survival analysis (log-rank test)

Parameters

/ Survival (days)
Median (95% CI) / p value

Sex

/
Female
/ 11 (9 ; 13)
/
Male
/ 8 (7 ; 9) / .007
Age, years
/

< 50

/ 8 (6 ; 10)
/

[50;75[

/ 9 (8; 11) / .208
/

75

/ 8 (7; 13)

Number of metastatic sites

< 2 / 9 (8 ; 11)
2 / 8 (7 ; 10) / .102
KPS, %
> 30 / 17 (13; 20)
30 / 8 (7; 8) / < .001

Hemoglobin, g/dL

8.0 / 10 (8; 13)
> 8.0 / 9 (8; 10) / .395

Leucocytes, G/L

15.0 / 10 (9 ; 11)
> 15.0 / 6 (5 ; 7) / < .001

Lymphoytes, G/L

> .5 / 10 (8 ; 11)
.5 / 8 (7 ; 9) / .002

Platelets, G/L

> 50 / 9 (8 ; 10)
50 / 7 (5 ; 11) / .054

PT, %

> 45 / 10 (9 ; 11)
45 / 5 (3 ; 7) / < .001

aPTT

1.2 / 10 (8 ; 11)
> 1.2 / 8 (6 ; 9) / .011

Albumin, g/L

> 25 / 11 (9 ; 14)
25 / 8 (7 ; 9) / .001

Transthyretin, g/L

> .05 / 11 (10 ; 12)
.05 / 6 (5 ; 7) / < .001

AST, x ULN

/

3

/ 11 (9 ; 12)
/

> 3

/ 5 (4 ; 6) / < .001

LDH, x ULN

/

2

/ 10 (9 ; 11)
/

> 2

/ 7 (6 ; 8) / < .001

Total bilirubin, µmol/L

/

25

/ 11 (10 ; 13)
> 25 / 6 (5 ; 6) / < .001

Albumin-corrected calcium, mmol/L

/

2.55

/ 11(9 ; 12)
> 2.55 / 7 (7 ; 8) / .005

Creatinin, µmol/L

/

110

/ 10 (9 ; 11)
> 110 / 6 (4 ; 7) / <.001

Urea, mmol/L

12 / 11 (10 ; 13)
> 12 / 5 (4 ; 6) / < .001

Total Cholesterol, mmol/L

< 4 / 8(8 ; 10)
> 4 / 9 (8 ; 11) / .432

Parameters

/ Survival (days)
Median (95% CI) / p value

HDL Cholesterol, mmol/L

> .5 / 10 (9 ; 12)
.5 / 7 (6 ; 8) / <.001

CRP, mg/L

50 / 13 (11 ; 15)
> 50 / 8 (7 ; 9) / <.001

Alpha-1 acid glycoprotein, g/L

1.2 / 9 (6 ; 16)
> 1.2 / 9 (8 ; 11) / .729
Abbreviations : CI, confidence interval ; KPS, Karnofsky Performance Status ; PT, prothrombin time ; aPTT, activated Partial Thromboplastin Time ; AST, aspartate aminotransferase; ULN, Upper limit of normal ; LDH, lactate dehydrogenase ; HDL, high density lipoprotein ; CRP, C reactive protein.