Appendix Published Epidemiological Studies of Nsaids Use and Risk of Parkinson S Disease

Appendix e-1. The reasons for using analgesics and reproducibility of self-reported analgesic uses in the Nurses’ Health study

The reasons for using these analgesics were previously investigated in the NHS cohort. (e1,e2) In a sample of 200 NHS participants in 1990 (e2), the major reasons for aspirin use included arthritis and musculoskeletal pain (40%), headache (25%), headache and musculoskeletal pain (15%), primary prevention of cardiovascular disease (8%), or other reasons (11%). In another survey among 4238 NHS participants in 1999, (e1) the major reasons for using ibuprofen and acetaminophen were muscle/joint pain (84% and 65%, respectively); headache (5% and 24%); backache (5% and 4%); and other reasons (6% and 8%). The reproducibility of self-reported analgesic uses was also evaluated in 1996 by asking 350 NHS participants to recall their uses in 1992 (unpublished data). The recalled data were then compared with those reported in the 1992 biennial survey: the correlation was 0.75 for aspirin, 0.63 for non-aspirin NSAIDs, and 0.74 for acetaminophen (all p<0.001).

e-References:

e1. Curhan GC, Knight EL, Rosner B, Hankinson SE, Stampfer MJ. Lifetime nonnarcotic analgesic use and decline in renal function in women. Arch Intern Med 2004;164:1519-1524.

e2. Manson JE, Stampfer MJ, Colditz GA, Willett WC, Rosner B, Speizer FE, Hennekens CH. A prospective study of aspirin use and primary prevention of cardiovascular disease in women. Jama 1991;266:521-527.