Supplemental Table S4. Systematic review search phrases

Pubmed

Term 1: (Preterm birth and synonyms)

immatur* OR prematur* OR pre mature[all] OR preterm OR pre term[all] OR infant, low birth weight[mh] OR low birth weight*[all] OR low birthweight*[all] OR Small for date*[all] OR gestational age*[all] OR early labo*[all]

Term 2: (RS numbers for all candidate SNPs and synonyms)

rs 1800629[all] OR rs1800629 OR rs 1800610[all] OR rs 361525[all] OR rs 4986790[all] OR rs 5030737[all] OR rs 1800450[all] OR rs 1800451[all] OR rs 7096206[all] OR rs 7095891[all] OR rs 11003125[all] OR rs 2243250[all] OR rs 4073[all] OR rs 16944[all] OR rs 1800871[all] OR rs 1800795[all] OR rs 3813946[all] OR rs 1048971[all] OR rs 1715[all] OR rs 1982073[all] OR rs 1800469[all] OR rs 1061170[all] OR rs 602128[all] OR rs 243865[all] OR rs 6098[all] OR rs 6103[all] OR rs 1800576[all] OR rs 6025[all] OR rs 1801133[all] OR rs 1801131[all] OR rs 1799963[all] OR rs 16135[all] OR rs 16476[all] OR rs 429358[all] OR rs 7412[all] OR rs 1137933[all] OR rs 1800779[all] OR rs 4961[all] OR rs 1042714[all] OR rs1800610 OR rs361525 OR rs4986790 OR rs5030737 OR rs1800450 OR rs1800451 OR rs7096206 OR rs7095891 OR rs11003125 OR rs2243250 OR rs4073 OR rs16944 OR rs1800871 OR rs1800795 OR rs3813946 OR rs1048971 OR rs1715 OR rs1982073 OR rs1800469 OR rs1061170 OR rs602128 OR rs243865 OR rs6098 OR rs6103 OR rs1800576 OR rs6025 OR rs1801133 OR rs1801131 OR rs1799963 OR rs16135 OR rs16476 OR rs429358 OR rs7412 OR rs1137933 OR rs1800779 OR rs4961 OR rs1042714

Term 3: (Gene names, symbols and synonyms sourced from dbSNP)

Tumor necrosis factor [all] OR TNF-alpha [all] OR TNFSF2 OR TNFA OR DIF OR TNF-a [all] OR toll-like receptor 4 [all] OR TOLL OR CD284 OR TLR-4 [all] OR ARMD10 OR mannose-binding lectin [all] ORMBL OR MBP OR MBP1 OR MBL2D OR MBP-C [all] OR COLEC1 OR HSMBPC OR interleukin 4 [all] OR IL4 OR IL-4 [all] OR BSF1 OR BCGF1 OR BSF-1 [all] OR BCGF-1 [all] OR interleukin 8 [all] OR IL8 OR NAF OR GCP1 OR LECT OR LUCT OR NAP1 OR CXCL8 OR GCP-1 [all] OR LYNAP OR MDNCF OR MONAP OR NAP-1 [all] OR interleukin 1 beta [all] OR IL1-BETA [all] OR IL1F2 OR IL-1 [all] OR interleukin 10 [all] OR IL-10 [all] OR IL10A OR GVHDS OR TGIF OR CSIF OR interleukin 6 OR IL6 OR IL-6 [all] OR complement component receptor 2 [all] OR CR2 OR SLEB9 OR CD21 OR C3DR OR CR OR transforming growth factor beta 1 [all] OR TGFB1 OR TGFbeta OR TGFB OR DPD1 OR LAP OR CED OR complement factor H [all] OR CFH OR CFHL3 OR ARMS1 OR ARMD4 OR AMBP1 OR AHUS1 OR FHL1 OR HUS OR HF2 OR HF1 OR HF OR FH OR matrix metallopeptidase 3 [all] OR MMP3 OR STMY1 OR MMP-3 [all] OR CHDS6 OR STR1 OR STMY OR SL-1 [all] OR matrix metallopeptidase 2 OR MMP2 OR MMP-II [all] OR TBE-1 [all] OR CLG4A OR MONA OR CLG4 OR serpin peptidase inhibitor clade B [all] OR SERPINB2 OR HsT1201 OR PLANH2 OR PAI-2 [all] OR PAI2 OR PAI OR plasminogen activating inhibitor [all] OR thrombomodulin OR THBD OR THPH12 OR CD141 OR BDCA3 OR AHUS6 OR THRM OR TM OR F5 coagulation factor V [all] OR RPRGL1 OR THPH2 OR PCCF OR FVL OR methylenetetrahydrofolate reductase [all] OR MTHFR OR thrombin OR coagulation factor II [all] OR F2 OR RPRGL2 OR THPH1 OR PT OR neuropeptide Y [all] OR NPY OR PYY4 OR apolipoprotein E [all] OR APOE OR LDLCQ5 OR LPG OR AD2 OR nitric oxide synthase 2 inducible [all] OR NOS2 OR HEP-NOS [all] OR NOS2A OR INOS OR NOS OR nitric oxide synthase 3 [all] OR NOS3 OR ECNOS OR eNOS OR adducin 1 [all] OR ADD1 OR ADDA OR adrenoceptor beta 2 [all] OR ADRB2 OR BETA2AR OR ADRB2R OR ADRBR OR B2AR OR BAR

Term 4: (Synonyms for SNP)

Polymorphism, Single Nucleotide[mh] OR Single Nucleotide Polymorphism*[all] OR SNP* OR SNP OR SNPs

Strategy:

  • Literature limited to 2009- June 2012 (earlier references curated in PTBgene online database)
  • Term 1 AND Term 2 6
  • Term 1 AND Term 3 AND Term 473
  • Term 1 AND Term 4 424

Embase

Term 1: (Preterm birth and synonyms)

(immatur* OR prematur* OR ‘pre mature’ OR preterm OR ‘pre term’ OR ‘low birth weights’ OR ‘low birth weight’ OR ‘low birthweight’ OR ‘low birthweights’ OR ‘Small for dates’ OR ‘Small for date’ OR ‘gestational ages’ OR ‘gestational age’ OR ‘early labour’ OR ‘early labor’ OR ‘low birth weight’/exp)

Term 2: (RS numbers for all candidate SNPs and synonyms)

(‘rs 1800629’ OR rs1800629 OR ‘rs 1800610’ OR ‘rs 361525’ OR ‘rs 4986790’ OR ‘rs 5030737’ OR ‘rs 1800450’ OR ‘rs 1800451’ OR ‘rs 7096206’ OR ‘rs 7095891’ OR ‘rs 11003125’ OR ‘rs 2243250’ OR ‘rs 4073’ OR ‘rs 16944’ OR ‘rs 1800871’ OR ‘rs 1800795’ OR ‘rs 3813946’ OR ‘rs 1048971’ OR ‘rs 1715’ OR ‘rs 1982073’ OR ‘rs 1800469’ OR ‘rs 1061170’ OR ‘rs 602128’ OR ‘rs 243865’ OR ‘rs 6098’ OR ‘rs 6103’ OR ‘rs 1800576’ OR ‘rs 6025’ OR ‘rs 1801133’ OR ‘rs 1801131’ OR ‘rs 1799963’ OR ‘rs 16135’ OR ‘rs 16476’ OR ‘rs 429358’ OR ‘rs 7412’ OR ‘rs 1137933’ OR ‘rs 1800779’ OR ‘rs 4961’ OR ‘rs 1042714’ OR rs1800610 OR rs361525 OR rs4986790 OR rs5030737 OR rs1800450 OR rs1800451 OR rs7096206 OR rs7095891 OR rs11003125 OR rs2243250 OR rs4073 OR rs16944 OR rs1800871 OR rs1800795 OR rs3813946 OR rs1048971 OR rs1715 OR rs1982073 OR rs1800469 OR rs1061170 OR rs602128 OR rs243865 OR rs6098 OR rs6103 OR rs1800576 OR rs6025 OR rs1801133 OR rs1801131 OR rs1799963 OR rs16135 OR rs16476 OR rs429358 OR rs7412 OR rs1137933 OR rs1800779 OR rs4961 OR rs1042714)

Term 3: (Gene names, symbols and synonyms sourced from dbSNP)

(‘Tumor necrosis factor’OR ‘TNF-alpha’OR TNFSF2 OR TNFA OR DIF OR ‘TNF-a’ OR ‘toll-like receptor 4’ OR TOLL OR CD284 OR ‘TLR-4’ OR ARMD10 OR ‘mannose-binding lectin’ ORMBL OR MBP OR MBP1 OR MBL2D OR ‘MBP-C’ OR COLEC1 OR HSMBPC OR ‘interleukin 4’ OR IL4 OR ‘IL-4’ OR BSF1 OR BCGF1 OR ‘BSF-1’ OR ‘BCGF-1’ OR ‘interleukin 8’ OR IL8 OR NAF OR GCP1 OR LECT OR LUCT OR NAP1 OR CXCL8 OR ‘GCP-1’ OR LYNAP OR MDNCF OR MONAP OR ‘NAP-1’ OR ‘interleukin 1 beta’ OR ‘IL1-BETA’ OR IL1F2 OR ‘IL-1’ OR ‘interleukin 10’ OR ‘IL-10’ OR IL10A OR GVHDS OR TGIF OR CSIF OR ‘interleukin 6’ OR IL6 OR ‘IL-6’ OR ‘complement component receptor 2’ OR CR2 OR SLEB9 OR CD21 OR C3DR OR CR OR ‘transforming growth factor beta 1’ OR TGFB1 OR TGFbeta OR TGFB OR DPD1 OR LAP OR CED OR ‘complement factor H’ OR CFH OR CFHL3 OR ARMS1 OR ARMD4 OR AMBP1 OR AHUS1 OR FHL1 OR HUS OR HF2 OR HF1 OR HF OR FH OR ‘matrix metallopeptidase 3’ OR MMP3 OR STMY1 OR ‘MMP-3’ OR CHDS6 OR STR1 OR STMY OR ‘SL-1’ OR ‘matrix metallopeptidase 2’ OR MMP2 OR ‘MMP-II’ OR ‘TBE-1’ OR CLG4A OR MONA OR CLG4 OR ‘serpin peptidase inhibitor clade B’ OR SERPINB2 OR HsT1201 OR PLANH2 OR ‘PAI-2’ OR PAI2 OR PAI OR ‘plasminogen activating inhibitor’ OR thrombomodulin OR THBD OR THPH12 OR CD141 OR BDCA3 OR AHUS6 OR THRM OR TM OR ‘F5 coagulation factor V’ OR RPRGL1 OR THPH2 OR PCCF OR FVL OR ‘methylenetetrahydrofolate reductase’ OR MTHFR OR thrombin OR ‘coagulation factor II’ OR F2 OR RPRGL2 OR THPH1 OR PT OR ‘neuropeptide Y’ OR NPY OR PYY4 OR ‘apolipoprotein E ‘ OR APOE OR LDLCQ5 OR LPG OR AD2 OR ‘nitric oxide synthase 2 inducible’ OR NOS2 OR HEP-NOS OR NOS2A OR INOS OR NOS OR ‘nitric oxide synthase 3’ OR NOS3 OR ECNOS OR eNOS OR adducin 1 OR ADD1 OR ADDA OR ‘adrenoceptor beta 2’ OR ADRB2 OR BETA2AR OR ADRB2R OR ADRBR OR B2AR OR BAR)

Term 4: (Synonyms for SNP)

(‘Single Nucleotide Polymorphism’ OR ‘Single Nucleotide Polymorphisms’OR SNP*)

Strategy:

  • Literature limited to 2009- June 2012 (earlier references curated in PTBgene online database)
  • Term 1 AND Term 2 15
  • Term 1 AND Term 3 AND Term 4163
  • Term 1 AND Term 4839

Systematic Review literature selection:

  • Total citations imported  1521
  • Duplicates identified and deleted (541 removed)  980 remaining
  • Titles and abstracts scanned for relevance (902 removed)  78 remaining
  • 78 full papers assessed. SNPs from the cerebral palsy candidate panel were selected as preterm birth candidates. Where at least one paper had previously reported a positive association in a case-control study of Caucasians, the reference and SNP was retained. A list of these 78 papers can be provided upon request.